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WHEN I SI my first elk in Yellowstone Park, I couldn't believe my eyes. I was fascinated. I was raised in the East and had read about the big animals [...]

WHEN EDITOR in Chief David Draper suggested I write a few columns about some of my high-adventure hunts, it took me only a half second to come up with this [...]

WHEN SALAMONIE Jaw eased the canoe onto the rocky shore of the small island, I thought he was going to take care of nature's call. Instead, he produced a large [...]

IT WAS the perfect spot for an elk camp. A small creek flowed through a timbered basin surrounded by large open meadows. It was 15 miles from the trailhead and [...]

WHEN FRANCIS MOSE invited me to hunt deer with him in the Adirondack Mountains, I was thrilled. Born in nearby Quebec, Mose was widely known as the best whitetail hunter [...]

IN THE WORLD of baseball, a grand slam occurs when the bases are loaded and the batter hits a home run. In the world of hunting, a slam means successfully [...]

WHEN THE black dot in the distance moved, I realized I wasn't looking at another stump. I pulled my pickup well off the highway and set up my spotting scope. [...]

THE MULE DEER doe lay on the highway, her body shattered from the collision with a vehicle. All of her legs were broken, blood issued from her ears and nose, [...]

'HUNTING isn't supposed to just be about the kill,' they say. We often hear that lament when the hunt is unsuccessful. Those words are supposed to be comforting and conciliatory, [...]

'THE FIRST TIME a caveman beaned a monkey on the head with a rock from a slingshot they deemed it unfair chase.' So said the late Jack Ward Thomas, noted [...]

ABSTRACTThermal shock resistivity is one of the most important characteristics of the concrete. There are numerous research papers, which investigate the reduction of fundamental engineering properties after Ordinary Portland cement [...]

TO SAY I was excited about this hunt would be a colossal understatement. I was ecstatic. As I drove my pickup north into Canada, I pictured the mother of all [...]

IN 1972 Jack O'Connor retired from his job as shooting editor for Outdoor Life magazine. I was crestfallen, as were countless other readers. O'Connor, considered the Dean of American Shooting [...]

THESE BEAR being so hard to die rather intimedates us all. I must confess that I do not like the gentlemen and had reather fight two Indians than one bear [...]

MOST OF US use some sort of call or technique to Coax a game animal into range. Voice calls are employed to deceive turkeys, geese, ducks, deer, elk, moose and [...]

I DIDN'T KNOW it when I walked into a saloon in Gardiner, Montana, in 1985, but I was about to learn something that would dramatically change the way we hunt [...]

Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven by chronic T cell antigen receptor (TCR) stimulation over days to weeks. However, we know little about the interplay between CD8+T cell function, cell division and epigenetic remodeling within hours of activation. Here, we assessed early CD8+T cell differentiation, cell division, chromatin accessibility and transcription in tumor-bearing mice and acutely infected mice. Surprisingly, despite robust activation and proliferation, TST had near complete effector function impairment even before undergoing cell division and had acquired hallmark chromatin accessibility features previously associated with later dysfunction/exhaustion. Moreover, continued tumor/antigen exposure drove progressive epigenetic remodeling, ‘imprinting’ the dysfunctional state. Our study reveals the rapid divergence of T cell fate choice before cell division in the context of tumors versus infection.

ABSTRACT In this paper, alkali-activated fly ash (geopolymer) samples were microstructurally analysed after thermal shock. The prepared samples were heated at 1000[degrees]C, and then quenched in water to room temperature. [...]

LIKE MOST hunters, I hold onto my antlers after each hunt. In the past, I'd send the best ones to a taxidermist and put the others in a pile in [...]

WHEN LEWIS and Clark made their epic journey up the Missouri River to find a water route to the Pacific in 1804 they encountered a deer that looked nothing like [...]

WHEN THE fresh elk rubs glared at me from destroyed saplings and the area reeked of pungent elk odor, I knew I was in a bull's backyard. I motioned to [...]

IF WE hunt enough, were likely to have a bizarre experience that qualifies for the old saying: 'You can't make this up.' I knew a man high up in the [...]

THE SHOT was a no-brainer. The black bear stood in the snow 75 yards away. I was positive it would soon be wearing my tag. When I touched off the [...]

MY FIRST shotgun was a Winchester Model 50 12 gauge I bought on an installment plan from a guy who mostly sold appliances. The gun, along with a washing machine [...]

GET A GUN! outfitter Reggie Collingwood shouted. 'Somebody get a gun!' 'What is it?' I asked. 'Just get a gun!' he repeated with urgency. I had just saddled my horse, [...]

THE HUNT was on. For me, it would be a hunt to remember. I invited Bradford O'Connor Jack O'Connor's son, to hunt antelope. I'd met Brad at an outdoor expo [...]

JACK MADE a good hit on the buck. As he approached the deer, he hoped there would be no ground shrinkage. He wasn't disappointed. It was a nice eight-point whitetail, [...]

'BACK UP! I just saw something dark in the willows.' I figured my wife, Madonna, had seen a shadow or a stump, but I put the pickup into reverse anyway. [...]

I WALKED into Cody's historic Irma Hotel to meet five hunters and their outfitter in the saloon. I was eager to hear about their hunt. I'd met the hunters while [...]

The pancreatic islets are composed of discrete hormone-producing cells that orchestrate systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell transcriptomic approach. One subset of beta cells marked by high CD63 expression is enriched for the expression of mitochondrial metabolism genes and exhibits higher mitochondrial respiration compared with CD63lobeta cells. Human and murine pseudo-islets derived from CD63hibeta cells demonstrate enhanced glucose-stimulated insulin secretion compared with pseudo-islets from CD63lobeta cells. We show that CD63hibeta cells are diminished in mouse models of and in humans with type 2 diabetes. Finally, transplantation of pseudo-islets generated from CD63hibut not CD63lobeta cells into diabetic mice restores glucose homeostasis. These findings suggest that loss of a specific subset of beta cells may lead to diabetes. Strategies to reconstitute or maintain CD63hibeta cells may represent a potential anti-diabetic therapy.

The purpose of this study was to examine various lipid classes as well as the protein content in rainbow trout ovaries. A total of 80 samples of Oncorhynchus mykiss(Walbaum 1792) were collected from Kokernag and Verinag hatcheries (Jammu and Kashmir, India) between 2017 and 2019. The mature stage in female fish had the highest gonadosomatic index (GSI) and minimal GSI in the spent stage. Higher lipid content of the ovary was reported during the mature stage (36%), as compared to other pre-breeding stages. Similarly, lipid classes also showed fluctuation during the development of the ovary. The lipid classes, i.e. glycolipids, free fatty acids, cholesterol and triglycerides, had a higher content in the mature stage, while the phospholipid content was higher in the mature stage. The protein content was also higher in the mature ovary than in the other developmental stages. The study provides reference values for various biochemical parameters in rainbow trout that could be useful for population monitoring programs and for the development of diets and management methods for fish production under controlled conditions.

WHENEVER YOU hunt away from home in a strange, unfamiliar area, you're at a serious disadvantage. It helps if you hunt with someone who knows the country, you've scouted the [...]

A FEW years ago, during an epic nasty winter in the Rockies, a man parked his pickup next to the highway west of Cody, Wyoming hiked up a drainage, and [...]

RECENTLY, a friend shot at a big buck and was disappointed when it ran off. He'd made what he thought was a solid hit, judging by the reaction of the [...]

I LOOKED around me and wondered how in the world I'd gotten into this situation. I was 'ledged up,' trapped in a place where there was no obvious escape. I'd [...]

I EASED over rocks in the frozen creek, bewildered by the loud tapping sound just upstream and around a bend. I'd never heard anything like it before in the outdoors. [...]

Low temperatures usually cause guns to gummed up the lubricant, thus causing hunters to face the problem of the firing pin to be sluggish. Various problems faced by hunters during low temperatures with their guns are presented.

'IF YOU'RE EVER lost in the woods, stay calm.' Sound advice, but it's seldom possible to achieve. Whoever wrote those famous words undoubtedly had never been lost, nor had the [...]

THE WILDFIRE was close, too close. Our local Homeland Security office issued pre-evacuation orders to everyone who lived on our mountain. I was in denial. This couldn't be happening. I [...]

'HURRY UP and shoot a bird so we can go home,' my buddy said. Everyone had met their limits but me. I needed one more. As if on cue, the [...]

HAVE YOU ever had something happen to you while hunting that was so bizarre, so inconceivable, that you still, many years later, cannot understand the incident? It happened to me [...]

WAKE UP, KIDS, I whispered. 'I hear a loon.' Janette, 8, and Dan, 6, reluctantly emerged from their sleeping bags and sat up. And there it was: the sound I'd [...]