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I. E. Markó [Université catholique de Louvain, Belgium]—Novel Orthoesters in Organic Synthesis.S. J. Harwood [GlaxoSmithKline, UK]—The Synthesis of Stable Labelled Ketamine.Th. Moenius, R. Salter, B. Wietfeld, P. Burtscher, C. Zueger [Novartis, Switzerland]—C‐13, C‐14, N‐15 Labelling of the 4‐Cyanobenzyl bromide – A Versatile Labelling Building Block.J. Clayden [University of Manchester, UK]—Synthesis and Stereocontrol with Lithiated Amides.R. Salter, K. Bordeaux, P. Burtscher, Y. Metz, Th. Moenius, I. Rodriguez, R. Ruetsch, R. Voges, C. Zueger [Novartis, Switzerland]—Isotopic Labelling of STI571 and its Metabolites in the Development of Gleevec®.J. M. Gardiner, W. Stimpson, N. Panchal [University of Manchester, UK], J. Herbert, G. J. Ellames [Sanofi‐Aventis, UK]—Synthesis of Labelled Carbohydrates.M. Beller [Rostock University, Germany]—Homogeneous Catalysis – A Powerful Tool for the Synthesis of Pharmaceuticals.J. Kozempel, J. Kadeřávek, L. Lešetický, O. Lebeda [University of Prague, Czech]—Preparation of Ortho‐radiohalogenated Phenylazides and Triazenes, Versatile Building Blocks for Indirect Labelling.K. Wähälä, P. Kiuru, E. Leppälä, M. Pohjoispää, K. Parikka, B. Raffaelli [University of Helsinki, Finland]—Controlled Polydeuteration of Estrogenic Compounds.J. M. Herbert [Sanofi‐Aventis, UK]—Catalyst Stability in Iridium‐mediated Isotope Exchange.C. G. M. Janssen, W.L.M. Verluyten, M. Vliegen [Johnson & Johnson Pharmaceutical, Belgium]—Pd/C Catalysed Hydrogenolytic H/T Exchange in Solvents, Effects on Solvents and Product in a Bromine‐tritium Exchange Reaction.P. Mäding, F. Füchtner, R. Bergmann, J. Pietzsch, C. Hultsch, F. Wüst [Forschungszentrum Rossendorf, Germany]—A New Module‐Assisted Synthesis of the Versatile, Bifunctional Labelling Agent [18F]SFB: From Radiochemistry to Applications.M. Scheunemann, J. Vercouillie, St. Fischer, J. Steinbach [Institut für Interdisziplinäre Isotopenforschung Leipzig, Germany], D. Sorger, U. Großmann, O. Sabri, R. Schliebs [University Leipzig, Germany]—Syntheses and First Biological Evaluation of 18F Labelled Bicyclic Analogues of Vesamicol as Potential VAChT Imaging Agents.

RAD001 2, a new immunosuppressant, was labelled in its hydroxyethyl side chain as well as in the rapamycin skeleton using carrier-free lithium triethylborotritide and tributyltin tritide (TBTT), respectively. The tritium labelling of the rapamycin moiety followed Curran's strategy of intramolecular hydrogen transfer. Our studies demonstrated that base-free TBTT is essential for a successful reaction. Copyright © 2000 John Wiley & Sons, Ltd.