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Drivers of social commerce usage have been the focus of scholars, but mobile social commerce is currently a sparsely researched area and therefore worth considering. Drawing on the socio-technical systems perspective and attachment theory, this article aims to examine the effect of social and technical enablers on user attachment and whether attachment influences users' shopping and sharing intentions. Results of an empirical study (N=305 active Pinduoduo users) indicate that emotional attachment directly impacts users' intentions, while functional attachment does so indirectly through emotional attachment. Besides, social and technical factors impact emotional and functional attachment, respectively. The study provides further insights about the impact of social and technical factors on attachment and attachment on MSC intention, and contributes to MSC research and practice by developing and validating the role of MSC platforms attributes in forming users' s-commerce behavioral outcomes.

Despite the promise of targeted tyrosine kinase inhibitors (TKIs), such as sunitinib, in the extension of survival time in patients with clear cell renal cell carcinoma (ccRCC) progression or metastasis, the patients eventually succumb to inevitable drug resistance. Protein degradation executed by the ubiquitin-dependent proteasome system played an important role in determining the sensitivity of ccRCC to sunitinib. Here, we applied the bioinformatic analysis to identify that E3 ligase RBCK1 was elevated in the sunitinib-resistant renal cancer cell lines or patient specimens. The subsequent in vitro or in vivo studies demonstrated that RBCK1 contributed to decreasing the sensitivity of ccRCC to sunitinib. Then, we showed that inhibition of RBCK1 inactivated the AKT and MAPK signaling pathways, which might be one of the main reasons why RBCK1 induces sunitinib resistance in ccRCC cells. Mechanistically, our results indicated that RBCK1 promotes the degradation of ANKRD35 and that ANKRD35 destabilizes MITD1 by binding with SUMO2 in ccRCC cells. In addition, we showed that the RBCK1-ANKRD35-MITD1-ANXA1 axis regulates the phosphorylation of AKT and ERK and contributes to the dysregulation of sunitinib in ccRCC cells. Therefore, we identified a novel mechanism for regulating the sensitivity of sunitinib in ccRCC. Therefore, we elucidated a novel mechanism by which RBCK1 regulates sunitinib sensitivity in ccRCC.

In view of the problem that enterprises are not quick enough to respond to market changes in current construction engineering project management, this paper proposes to use the improved C4.5 decision tree to optimize construction project management. Firstly, the optimization attributes of construction project management are constructed. Relevant experts are hired to score the attributes and project risks. Then, the evaluation is discretized by rough set theory. Finally, the C4.5 decision tree algorithm is applied to utilize the project information and generate the decision tree of project management optimization, find out the classification rules affecting the optimal management of engineering projects, analyze the implementation of construction projects, and give personalized tips, so as to achieve effective control and optimization of enterprise engineering projects.