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A refractory high entropy alloy Ti62Nb12Mo12Ta12W2was prepared by mechanical alloying and spark plasma sintering. The microstructure and mechanical properties of the Ti62Nb12Mo12Ta12W2alloy were analyzed. The experimental results show that the microstructure of the alloy is composed of two BCC phases, an FCC precipitated phase, and the precipitated phase which is a mixture of TiC, TiN and TiO. The alloy exhibits good room temperature compressive properties. The plasticity of the sample sintered at 1550 °C can reach 10.8%, and for the sample sintered at 1600 °C, the yield strength can be up to 2032 MPa, in the meantime the plasticity is 9.4%. The alloy also shows high strength at elevated temperature. The yield strength of the alloy exceeds 420 MPa at 900 °C, and value of which is still above 200 MPa when the test temperature reaches 1000 °C. Finally, the compressive yield strength model at room temperature is constructed. The prediction error of the model ranges from − 7.9% to − 12.4%, expressing fair performance.

A surface double-coupling engineering is developed via constructing a spinel-like interlayer to mitigate bulk strain, curb surface-side reactions, and assist stable and durable Li-rich Mn-based cathode materials.

An oxygen vacancies-induced surface multicomponent integration strategy is developed via a universal citric acid-assisted chemical delithiation method to comprehensively overcome the rate-dependent degradation mechanism in layered lithium-rich cathode materials.

Oncolytic viruses have emerged as new powerful therapeutic agents for cancer therapy by specifically lysing cancer cells while activating innate immune responses at the same time. However, due to the thorny issues of safety concerns and host immune reaction, the clinical application of oncolytic viruses is still limited. Herein, we report a rationally designed oncolytic virus-like nanoparticles (OV-NPs) composed of stimulator of interferon genes (STING)-stimulating polymer loaded with therapeutic genes for cancer immunotherapy. After injection into tumor, the OV-NPs carrying OX40L plasmid could reprogram tumor cells to express OX40L immune checkpoint molecules and activate the STING pathway for cooperatively enhancing antitumor immunity, with a tumor suppression rate of 92.3% in B16F10 tumor model and 78.7% in MC38 tumor model without causing any toxicity. The OV-NPs could be further applied in carrying other plasmids (IL-12) and utilization in gene combination therapy. This study should inspire designing synthetic OV-NPs as alternative strategies for extending oncolytic virus application in cancer immunotherapy.

ABSTRACTUsing a large sample of Chinese A-share listed firms during 2008–2017, this study investigates whether and how the informal hierarchy of independent directors affects two types of agency costs. We find that the informal hierarchy of independent directors is negatively correlated with the two types of agency costs and the negative effect is robust to alternative empirical designs. Moreover, our further research indicates that ownership structure matters for the performance of independent directors. We provide empirical evidence for optimizing the independent director team structure and improving corporate governance.

OX40 (CD134, TNFRSF4) is a member of the tumor necrosis factor receptor superfamily that can be activated by its cognate ligand OX40L (CD252, TNFSF4) and functions as a pair of T cell costimulatory molecules. The interaction between OX40 and OX40L (OX40/OX40L) plays a critical role in regulating antitumor immunity, including promoting effector T cells expansion and survival, blocking natural regulatory T cells (Treg) activity, and antagonizing inducible Treggeneration. However, current OX40 agonists including anti-OX40 monoclonal antibodies (aOX40) have serious side effects after systemic administration, which limits their clinical success and application. Herein, we propose a strategy to reprogram tumor cells into OX40L-expressing “artificial” antigen-presenting cells (APCs) by OX40L plasmid-loaded nanoparticles for boosting antitumor immunity in situ. A novel gene transfection carrier was prepared by a modular hierarchical assembly method, which could efficiently transfect various tumor cells and express OX40L proteins on their surface. These surface-decorated OX40L proteins were proved to stimulate T cell proliferation in vitro while stimulating strong antitumor immune responses in vivo. Importantly, this in situ reprogramming strategy did not induce any toxicity as observed in aOX40 treatment, thus providing a novel method for immune checkpoint stimulator application.

Cities are generally warmer than their adjacent rural land, a phenomenon known as the urban heat island (UHI). Often accompanying the UHI effect is another phenomenon called the urban dry island (UDI), whereby the humidity of urban land is lower than that of the surrounding rural land1–3. The UHI exacerbates heat stress on urban residents4,5, whereas the UDI may instead provide relief because the human body can cope with hot conditions better at lower humidity through perspiration6,7. The relative balance between the UHI and the UDI—as measured by changes in the wet-bulb temperature (Tw)—is a key yet largely unknown determinant of human heat stress in urban climates. Here we show that Twis reduced in cities in dry and moderately wet climates, where the UDI more than offsets the UHI, but increased in wet climates (summer precipitation of more than 570 millimetres). Our results arise from analysis of urban and rural weather station data across the world and calculations with an urban climate model. In wet climates, the urban daytime Twis 0.17 ± 0.14 degrees Celsius (mean ± 1 standard deviation) higher than rural Twin the summer, primarily because of a weaker dynamic mixing in urban air. This Twincrement is small, but because of the high background Twin wet climates, it is enough to cause two to six extra dangerous heat-stress days per summer for urban residents under current climate conditions. The risk of extreme humid heat is projected to increase in the future, and these urban effects may further amplify the risk.

The soybean aphid Aphis glycinesMatsumura is a predominant insect pest in Asia and North America and causes great losses to soybean. The release of genome data for A. glycineswill facilitate gene function research in the future. However, suitable reference genes for A. glycinesunder various experimental conditions are scarce. To search for appropriate reference genes for A. glycines, nine candidate reference genes, including Act, α-Tub, β-Tub, RPS12, RPS18, RPL5, RPL27, EF1α, and Fer, were tested under six experimental conditions to evaluate their suitability for use in the normalization of qRT‒PCR data. Results showed that EF1αand RPS12were optimal for the developmental stages of A. glycines, RPS18and RPS12were appropriate for wing dimorphism, β-Tuband RPS18were suitable for different tissues and RPL5, and α-Tubcould be used for normalization at different temperatures. β-Tuband EF1αcould be proposed as reference genes for insecticide treatment, and RPL5and RPS12were found to be the most stable reference genes in different photoperiods. The results provide appropriate reference genes for analyzing gene expression in A. glycinesand contribute to future research on the molecular physiology and biochemistry of A. glycines.

The presence of substantial evidence regarding the association between dietary niacin intake and cognitive impairment among the elderly remains limited, with inconsistent findings. Thus, the objective of this study was to assess the aforementioned relationship, utilizing data obtained from the National Health and Nutrition Examination Survey (NHANES).

This paper investigates the boundedness and stability of a class of nonlinear hybrid neutral stochastic differential delay systems with Lévy jumps and different structures. The coefficients in this system satisfy the local Lipschitz condition and a suitable Khasminskii-type condition, and the state space of the system is separated into two subsets, the existence uniqueness, asymptotic boundedness, and exponential stability of the system are obtained by designing a new Lyapunov function and applying the M-matrix technique as well as dealing with the non-differentiable delay function. Different with the existing work, we not only consider the neutral term, but also the case of the delay function being bounded and non-differentiable. At last, numerical examples are performed to manifest the obtained results. [ABSTRACT FROM AUTHOR]

Virus-like particle (VLP) vaccines had shown great potential during the COVID-19 pandemic, and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures. However, the time-consuming and complicated processes in establishing a current recombinant-protein–based VLP vaccine has limited its quick launch to the out-bursting pandemic. To simplify and optimize VLP vaccine design, we herein report a kind of viromimetic polymer nanoparticle vaccine (VPNVax), with subunit receptor-binding domain (RBD) proteins conjugated to the surface of polyethylene glycol-b-polylactic acid (PEG-b-PLA) nanoparticles for vaccination against SARS-CoV-2. The preparation of VPNVax based on synthetic polymer particle and chemical post-conjugation makes it possible to rapidly replace the antigens and construct matched vaccines at the emergence of different viruses. Using this modular preparation system, we identified that VPNVax with surface protein coverage of 20%–25% had the best immunostimulatory activity, which could keep high levels of specific antibody titers over 5 months and induce virus neutralizing activity when combined with an aluminum adjuvant. Moreover, the polymer nano-vectors could be armed with more immune-adjuvant functions by loading immunostimulant agents or chemical chirality design. This VPNVax platform provides a novel kind of rapidly producing and efficient vaccine against different variants of SARS-CoV-2 as well as other viral pandemics.A polymeric nanoparticle-based two-step strategy was reported to rapidly construct viromimetic vaccines against SARS-CoV-2 or other pandemics.

Reconstruction of bone defects, especially the critical-sized defects, with mechanical integrity to the skeleton is important for a patient's rehabilitation, however, it still remains challenge. Utilizing biomaterials of human origin bone tissue for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural bone tissue with regard to its properties. However, not only efficacious and safe but also cost-effective and convenient are important for regenerative biomaterials to achieve clinical translation and commercial success. Advances in our understanding of regenerative biomaterials and their roles in new bone formation potentially opened a new frontier in the fast-growing field of regenerative medicine. Taking inspiration from the role and multicomponent construction of native extracellular matrix (ECM) for cell accommodation, the ECM-mimicking biomaterials and the naturally decellularized ECM scaffolds were used to create new tissues for bone restoration. On the other hand, with the going deep in understanding of mesenchymal stem cells (MSCs), they have shown great promise to jumpstart and facilitate bone healing even in diseased microenvironments with pharmacology-based endogenous MSCs rescue/mobilization, systemic/local infusion of MSCs for cytotherapy, biomaterials-based approaches, cell-sheets/-aggregates technology and usage of subcellular vesicles of MSCs to achieve scaffolds-free or cell-free delivery system, all of them have been shown can improve MSCs-mediated regeneration in preclinical studies and several clinical trials. Here, following an overview discussed autogenous/allogenic and ECM-based bone biomaterials for reconstructive surgery and applications of MSCs-mediated bone healing and tissue engineering to further offer principles and effective strategies to optimize MSCs-based bone regeneration.

Cancer vaccines artificially stimulate the immune system against cancer and are considered the most promising treatment of cancer. However, the current progress in vaccine research against cancer is still limited and slow, partially due to the difficulties in identifying and obtaining tumor-specific antigens. Considering surgery as the first choice for tumor treatment in most cases, the authors evaluated whether the resected tumor can be directly used as a source of tumor antigens for designing personalized cancer vaccines. Based on this idea, herein, the authors report a dynamic covalent hydrogel-based vaccine (DCHVax) for personalized postsurgical management of tumors. The study uses proteins extracted from the resected tumor as antigens, CpG as the adjuvant, and a multi-armed poly(ethylene glycol) (8-arm PEG)/oxidized dextran (ODEX) dynamically cross-linked hydrogel as the matrix. Subcutaneous injection of DCHVax recruits dendritic cells to the matrix in situand elicits robust tumor-specific immune responses. Thus, it effectively inhibits the postoperative growth of the residual tumor in several murine tumor models. This simple and personalized method to develop cancer vaccines may be promising in developing clinically relevant strategies for postoperative cancer treatment.

Peritoneal seeding represents one of the most frequent sites of metastasis for late-stage gastrointestinal and gynecological cancer. At present, the major treatment method for peritoneal metastatic carcinoma (PMC) is the combination of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). Nevertheless, the 5 year survival rate of patients after these treatments is still far from satisfactory. Here, we report a biodegradable implant co-loaded with doxorubicin (DOX) and anti-PD-1 monoclonal antibody (aPD-1) (BI@DOX+aPD-1) for a combination of immunogenic chemotherapy and immune checkpoint therapy for PMC postoperative treatment. The bio-implant is fabricated with oxidized dextran (ODEX) and 4-arm poly(ethylene glycol) amine (4-arm PEG-NH2) by Schiff’s base reaction at mild conditions, with DOX and aPD-1 loaded inside during and after the fabrication process, respectively. In vitrostudies confirmed the slow and sustained release of DOX and aPD-1 from the bio-implants. In vivostudies showed that the bio-implants could be gradually degraded and maintain relatively high concentrations of therapeutic agents in the mouse abdomen. In a murine CT26 PMC model, the BI@DOX+aPD-1 resulted in a 89.7% tumor-suppression rate after peritoneal implantation. Importantly, the combination therapy of DOX and aPD-1 in the bio-implant showed an excellent synergistic effect with a Qvalue of 2.35. This easy-fabricated bio-implant combined with DOX and aPD-1 should be promising for clinical PMC postoperative treatment.

The transition to renewable plastics will require the development of substitutes with existing industrial standards and manufacturing processes. Polyurethanes (PU), versatile plastics, are traditionally dominated by aromatic diisocyanates, which are challenging to derive from renewable sources. However, for higher biocontent, it is crucial to utilize aliphatic diisocyanates, which can be sourced from renewable plant or algae waste streams. Historically, PU foams relied on aromatic diisocyanates for essential hard segments, resulting in desired physical properties. Here, we report the generation of high-performance renewable and biodegradable PU foams utilizing aliphatic diisocyanates and aromatic polyols, translating hard segments into the polyester polyol component using biosourced furan dicarboxylic acid (FDCA) monomers. We demonstrate that an FDCA-based PU is suitable for foams with performance characteristics that meet commercial tolerances and can biodegrade under backyard compost conditions. This demonstrates steps toward redesigning traditional petrochemical-based polymers to accommodate new biological monomers.

In recent years, the use of nanotechnologies to improve immunotherapy efficiency has attracted increasing interest in preventive and therapeutic cancer vaccine design. However, current nanocarriers are restricted by difficulties in the systematic spatial coordinative transport of antigens, which greatly hampers the immune response efficacy of nanovaccines. Herein, we designed a mannan-decorated stimulator of the interferon genes (STING)-activating vaccine carrier for spatial coordinative stimulation of antigen-specific immune responses and elicitation of robust antitumor immunity. Mannan-decoration as the shell could significantly enhance the lymph node draining ability of the nanovaccines, especially in CD8+dendritic cells (DCs). Azole molecule end-capped polylactic acid-polyethylenimine (PLA-PEI-4BImi) with innate stimulating activity was applied as the inner core for coordinating antigen-presenting cell activation and antigen cross-presentation. In the in vivo therapy study, single usage of this nanovaccine could achieve a 93% tumor suppression rate in the B16-OVA tumor model, which is superior to the commercialized aluminum adjuvant. This study demonstrates that a rational design of vaccine carriers for solving spatial transmission issues could greatly improve cancer vaccine efficiencies.

Subtropical lakes are important source of atmospheric methane (CH4). This study aims to investigate spatial variations of CH4flux in Lake Taihu, a large (area 2400 km2) and shallow (mean depth 1.9 m) eutrophic lake in Eastern China. The lake exhibited high spatial variations in pollution level, macrophyte vegetation abundance, and algal growth. We measured the diffusion CH4flux via the transfer coefficient method across the whole lake. In addition, data obtained with the flux gradient and the eddy covariance methods were used in conjunction with the data on the diffusion flux to estimate the contribution by ebullition. Results from 3 years' measurements indicated high spatial variabilities in the diffusion CH4flux. The spatial pattern of the diffusion CH4emission was correlated with water clarity, dissolved oxygen concentration, and the spatial distributions of algal and submerged vegetation. In comparison to the transfer coefficient method, the eddy covariance and the flux gradient method observed a lake CH4flux that was 3.39 ± 0.58 (mean ± 1 standard deviation) and 1.95 ± 0.36 times higher in an open‐water eutrophic zone and in a habitat of submerged macrophytes, respectively. The result implied an average of 71% and 49% ebullition contribution to the total CH4flux in the two zones. The annual mean diffusion CH4flux of the whole lake was 0.54 ± 0.30 g m−2yr−1. Our CH4emission data suggest that the average CH4emission reported previously for lakes in Eastern China was overestimated. Methane flux showed large seasonal and spatial variationsThe highest fluxes were observed in a highly eutrophic zone and a shallow zone dominated by submerged macrophytesThe annual mean CH4flux in this large and shallow eutrophic lake was much lower than suggested previously for lakes in China

The capability of synchrotron radiation to produce ultrabright emission has attracted considerable interest over the last half a century. To date, magnetic undulators with a period of several centimetres are commonly used for wiggling relativistic electrons in a modulated field. Here, we propose a novel compact undulator with a period down to the submillimetre level based on a spontaneous electric field that is driven by a femtosecond laser. Both the guided energetic electrons and the gyrotron-like undulator are spontaneously produced by irradiating a thin metallic wire with an intense laser pulse. An intense radial electric field instantaneously created on the wire can guide the electrons' helical motion along the wire and induce periodic THz emission. We have demonstrated that this scheme can produce intense THz sources with a conversion efficiency of 1% that are frequency-tunable by adjusting the diameter of the wire. Amplified emission of THz radiation by more than tenfold has been observed.

A fluorination-induced integrated structure design strategy is developed via alcohols assisted sol-gel method to comprehensively enable the reversible cationic-anionic redox chemistry in cation-disordered rocksalt cathodes.

Mechanoluminescence (ML) materials enable the transformation of mechanical stimuli into optical signals. However, current ML devices have limited luminescent programmability and mechanical tunability due to the relatively simple geometries as restricted by the conventional fabrication techniques. Here, we develop a strategy that is applicable for various types of zinc sulfide (ZnS)-based phosphors for allowing the fabrication of ML elastomer into complex 2D or 3D geometries with periodic cellular structures. We demonstrate that different cellular structures with tunable mechanical properties enable programmable structure-dependent ML behaviors including anisotropic and isotropic luminescence. We further exploit the quantitative structure-stress-luminescence relationship, which provides fundamental knowledge support for designing next-generation ML-based stress sensors and wearable devices.

Objective: As one of the most common primary headaches in clinical practice, migraine affects the learning ability and life quality of college students worldwide, posing a heavy burden on individuals and society. This study aims to investigate the incidence of migraine among Chinese medical college students and to explore its characteristics and typical triggers. Method: From July 2019 to July 2020, North Sichuan Medical College in Sichuan province, China preliminarily screened migraine cases using ID-Migraine through cluster sampling. College students with positive ID-Migraine results would be included in this study if they were further diagnosed with migraine by neurologists based on ICHD-3. After the ethical review, patients’ personal and headache information would be collected, and the frequency, severity, onset time, and related triggers of migraine would be measured. Results: The preliminary screening covered 8783 college students. The overall prevalence rate of migraine is 6.57%, 5.90% in men and 6.77% in women. The prevalence rate of migraine is higher for students in the first and second grades (8.01%, 8.05%), and students with a family history of migraine are more likely to suffer from migraine (OR = 1.509, 95% CI 1.060–2.148, P= 0.022 < 0.005). Staying up late (n= 329, 57.01%), stress (n= 319, 55.29%), catch a cold (n= 313, 54.25%) and sleep disorders (n= 302, 52.34%) are the common triggers. Conclusion: Migraine is common among college students in North Sichuan Medical College. The incidence is higher among lower grade students, female students, and students with a family history of migraine. Improving sleep quality and reducing stress may be effective in relieving migraines.

Room-temperature dielectric switching materials are highly desirable for many potential industrial applications in smart electronic/electrical engineering fields, but they suffer from key limitation of poor integration of remarkable dielectric switching properties, promising scalability, and low cost. Here, a general solution to solve this problem is demonstrated to attain an excellent cost/performance balance. By mixing ionic liquids (ILs) with polyethylene glycol (PEG), an all-organic composite enables an ultrahigh dielectric switching ratio above 320.6 at 34.2 Hz, almost 100% dielectric constant retention after 500 cycles, the highest attainable to a ∼35 °C wide thermal hysteresis loop, and tunable dielectric transition temperature. Also, the PEG/ILs can defeat the conflict of dielectric switching properties versus cost, namely impressive dielectric switching properties are achieved through simple mixing of commercialized components without solvent. The findings offer promise for highly efficient, scalable, low-cost, and environmentally friendly preparation of high-performance room-temperature dielectric switching materials.

Temperature sensors based on linear relationships between temperature and outputs are highly appreciated due to their high accuracy, simplicity, and convenience of use. However, the utility of linear response temperature sensors is restricted by the difficulties in dealing with some specific measurement requirements and synchronous realization of good linearity, low cost, and adequate vibration or impact resistance. Herein, an efficient strategy combining linear response, low cost, promising sensitivity, excellent vibration or impact resistance, as well as good adaptability to the measurements of curved temperature fields or spatial temperature in one temperature sensing material is proposed. The linear thermo-responsive poly(vinylidene fluoride)/ionic liquid composite fibrous films are constructed at room temperature by the solution blow spinning, providing an efficient, continuous, low-energy, and low-cost fabrication pathway and ensuring the satisfactory flexibility to withstand vibration or impact. The electrode and interfacial polarizations under strong interaction constraints of the fiber matrix contributes to a good linear dielectric response relationship between the temperature and dielectric constant, resulting in R-square up to 0.99981. The dipole polarization capability promoted by the high polar phase ratio of PVDF improves its temperature sensitivity. Specifically, the linear dielectric response relationship exhibits an important frequency dependence, allowing the temperature response sensitivity to be adjusted and improved by frequency. Meanwhile, the fibrous films also show excellent stability and repeatability over 100 thermal cycles. This work provides a novel route to design and fabricate linear response temperature sensing materials.

In this work, we experimentally demonstrate a 200% enhancement of terahertz (THz) wave amplitude generated by femtosecond laser filamentation in air. The experimental setup simply uses a semicircular phase plate to generate two parallel filaments. Temporally overlapped THz pulses from two filaments coherently add up, giving rise to significant enhancement of the THz pulse amplitude. It has been foreseen that further enhancement would be achieved if the design of phase plates could be optimized to generate a filament array. This simple method makes full use of the laser energy and could potentially open a new approach to remotely enhance the THz emission in air.

Surgery remains the most preferred treatment options for colorectal cancer (CRC). Paradoxically, local recurrence and distant metastasis are usually accelerated postsurgery as a consequence of local and systemic immunosuppression caused by surgery. Therefore, modulating tumor postoperative immune microenvironment and activating systemic antitumor immunity are necessary supplementaries for CRC therapy. Here, an in‐situ‐sprayed immunotherapeutic gel loaded with anti‐OX40 antibody (iSGels@aOX40) is reported for CRC postsurgical treatment. The iSGel is formed instantly after spraying with strong adhesion ability via crosslinking between tannic acid (TA) and poly(l‐glutamic acid)‐g‐methoxy poly(ethylene glycol)/phenyl boronic acid (PLG‐g‐mPEG/PBA). TA not only serves as one component of the iSGel but also relieves the postsurgical immunosuppressive microenvironment by inhibiting the activity of cyclo‐oxygenase‐2 (COX‐2). The aOX40 serves as an immune agonistic antibody and is released from the iSGel in a constant manner lasting for over 20 days. In a subcutaneous murine CRC model, the iSGels@aOX40 results in complete inhibition on tumor recurrence. In addition, the cured mice show resistance to tumor re‐challenge, suggesting that immune memory effects are established after the iSGels@aOX40 treatment. In an orthotopic CRC peritoneal metastatic model, the iSGels@aOX40 also remarkably inhibits the growth of the abdominal metastatic tumors, suggesting great potential for clinical CRC therapy. An in‐situ‐sprayed immunotherapeutic gel loaded with anti‐OX40 antibody (iSGels@aOX40) is designed for colorectal cancer (CRC) postsurgical treatment. After spraying at the tumor resection bed, the iSGels@aOX40 gradually releases tannic acid (TA) and aOX40, both inhibiting postoperative inflammation and immunosuppression at the tumor resection bed, and stimulating constant T‐cell activation for tumor eradication.

Sulfur(VI) fluoride exchange (SuFEx) click chemistry has offered a facile and reliable approach to produce polysulfates and polysulfonates. However, the current SuFEx polymerization methods lack precise control of target molecular weight and dispersity. Herein, we report the first chain-growth SuFEx polycondensation process by exploiting the unique reactivity and selectivity of S–F bonds under SuFEx catalysis. Given the higher reactivity of iminosulfur oxydifluoride versus fluorosulfate, the chain-growth SuFEx polycondensation is realized by using an iminosulfur oxydifluoride-containing compound as the reactive chain initiator and deactivated AB-type aryl silyl ether-fluorosulfates bearing an electron-withdrawing group as monomers. When 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) was utilized as the polymerization catalyst, precise control over the polymer molecular weight and polydispersity was achieved. The resulting polymers possess great thermal stability but are easily degradable under mild acidic and basic conditions.

This study aimed to explore the correlation of sodium ferulate and the renal protective effect on computed tomography pulmonary angiography in patients suffering from pulmonary hypertension. This prospective study enrolled 92 consecutive patients with pulmonary hypertension diagnosed by echocardiography, and all included patients underwent computed tomography pulmonary angiography after admission. The participants were randomized, divided into sodium ferulate group (n= 49) and control group (n= 43), of which patients in the sodium ferulate group received intravenous sodium ferulate 3.0 g per day from 12 h before computed tomography pulmonary angiography examination to 72 h after that, and patients in the control group were provided with routine treatment. Renal function was assessed by measuring serum creatinine, estimated glomerular filtration rate, Cystatin-C as well as 24 h, 48 h, and 72 h after computed tomography pulmonary angiography, followed by the calculation of the incidence of contrast-induced nephropathy for contrast-induced nephropathy and non-contrast-induced nephropathy grouping. Besides, renal resistive index was determined via Doppler ultrasound examination before, after 1 h and 24 h after computed tomography pulmonary angiography. There were no significant differences between the two groups in serum creatinine at baseline and 24 h after computed tomography pulmonary angiography (P> 0.05, respectively), but at 48 h and 72 h, it was lower in the sodium ferulate group (P< 0.05). There were no significant differences of estimated glomerular filtration rate between the two groups (P> 0.05). The level of Cystatin-C at 48 h and 72 h after computed tomography pulmonary angiography was lower than in the sodium ferulate group (P< 0.05). Contrast-induced nephropathy was identified in nine patients (9.78%). Sodium ferulate was associated with a decline in the incidence of contrast-induced nephropathy (4.08 vs. 16.28 %, P< 0.05). Compared to patients with contrast-induced nephropathy, lower renal resistive index were observed at 1 h and 24 h after computed tomography pulmonary angiography in patients without contrast-induced nephropathy (P< 0.05). Infusion of sodium ferulate before and after computed tomography pulmonary angiography was associated with a decline in incidence of contrast-induced nephropathy.