95 results on '"Yoo, Tae-Hyun"'
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2. Higher potassium intake is associated with a lower risk of chronic kidney disease: population-based prospective study
3. Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial
4. Coronary Artery Calcification Score and the Progression of Chronic Kidney Disease
5. Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial
6. Risk improvement and adverse kidney outcomes in patients with chronic kidney disease: findings from KNOW-CKD
- Abstract
Background: Many trials have attempted to slow the progression of chronic kidney disease (CKD) by modifying specific risk factors, but without achieving satisfactory results. We aimed to evaluate the association between the degree of improvement in multiple risk factors and adverse kidney outcomes. Methods: This was a prospective observational study of 839 patients with CKD G3-G4. The main predictors were the number of improved risk factors between baseline and year one as follows: a decrease in proteinuria, systolic blood pressure, phosphate, and uric acid, and an increase in hemoglobin and bicarbonate from the baseline status to out of the target range. The primary outcome was a composite one, including CKD progression (50% decline in eGFR or kidney replacement therapy) and all-cause death. Results: Patients whose risk factors eventually improved had more unfavorable baseline profiles of the six considered factors. During 3097.8 person-years of follow-up (median 3.5 years per patient), the composite outcome occurred in 48.0% of patients (incidence rate, 13.0 per 100 person-years). Compared with an improvement of no risk factors, the adjusted HRs (95% CI) for improvement of 1 and ≥ 2 risk factors were 0.96 (0.76–1.22) and 0.53 (0.37–0.75), respectively. The association was not affected by diabetic status or CKD severity. Among the risk factors, proteinuria accounted for the greatest contribution to CKD progression. Conclusions: In patients with CKD G3-G4, improvement in multiple factors was associated with a decreased risk of CKD progression, suggesting the importance of multifactorial risk management. Graphical abstract:
7. Association Between Proton Pump Inhibitor Exposure and Acute Kidney Injury After Cardiac Surgery
8. Bidirectional association between SBP variability and arterial stiffness in patients with chronic kidney disease: findings from KNOW-CKD study
9. Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy
10. Creatinine–cystatin C ratio and mortality in cancer patients: a retrospective cohort study
11. Ideal cardiovascular health duration and risk of chronic kidney disease and cardiovascular disease
12. Clinical significance of hemodialysis quality of care indicators in very elderly patients with end stage kidney disease
13. Association between the transtubular potassium gradient and progression of chronic kidney disease: results from KNOW-CKD
- Abstract
Background: The transtubular potassium gradient which reflects potassium secretion by the kidney through the cortical collecting duct, has not yet been tested as a surrogate marker of kidney function decline. Here, we investigate the relationship between the transtubular potassium gradient and chronic kidney disease (CKD) progression. Methods: We studied 1672 patients from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort. The transtubular potassium gradient was calculated using a standard equation. The study endpoint was CKD progression, defined as a composite of a ≥ 50% decrease in estimated glomerular filtration rate (eGFR) from baseline values or end-stage kidney disease. Results: During a median follow-up of 4.1 years (7149 person-years), 441 participants reached the endpoint. In cause-specific competing risk analysis, the highest tertile was associated with a significantly lower risk of an adverse kidney outcome compared with the lowest tertile [hazard ratio (HR), 0.73; 95% confidence interval (CI), 0.55–0.97]. When the transtubular potassium gradient was treated as a continuous variable, an increase of 1 in the transtubular potassium gradient was associated with a 6% lower risk of CKD progression (95% CI, 0.90–0.99). This association was particularly evident in patients with an eGFR ≥ 45 mL/min/1.73 m
2 . A time-updated transtubular potassium gradient model showed similar results. The predictive performance of the transtubular potassium gradient was significantly less than that of the eGFR, but similar to that of proteinuria, serum bicarbonate, and urine osmolality. Conclusions: A higher transtubular potassium gradient is associated with a significantly lower risk of CKD progression, suggesting that it may offer insights into the prognosis of CKD. Graphic abstract:
14. Association Between Progression of Coronary Artery Calcification and Development of Kidney Failure with Replacement Therapy: Findings from KNOW-CKD Study
15. Nocturnal Systolic Blood Pressure Dipping and Progression of CKD
16. Systolic blood pressure and chronic kidney disease progression in patients with primary glomerular disease
17. Association of Blood Pressure With the Progression of CKD: Findings From KNOW-CKD Study
18. Smoking Cessation and Coronary Artery Calcification in CKD
19. Plasma Levels of Polyunsaturated Fatty Acids and Adverse Kidney Outcomes
20. Difference Between Estimated GFR Based on Cystatin C Versus Creatinine and Incident Atrial Fibrillation: A Cohort Study of the UK Biobank
21. Association between dietary magnesium intake and incident chronic kidney disease: a prospective observational cohort study
22. A Diet Rich in Vegetables and Fruit and Incident CKD: A Community-Based Prospective Cohort Study
23. Findings from the KNOW-CKD Study indicate that higher systolic blood pressure time in target range is associated with a lower risk of chronic kidney disease progression
24. Effect of ambulatory blood pressure monitoring guided antihypertensive treatment on renal progression in patients with chronic kidney disease: a randomized comparative study
25. Association of Reproductive Lifespan Duration and Chronic Kidney Disease in Postmenopausal Women
26. Alcohol Consumption and Progression of Chronic Kidney Disease: Results From the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease
27. Aerobic Exercise Capacity and Kidney Function Decline in Heart Failure with Preserved Ejection Fraction Patients
28. The 2021 KDIGO Blood Pressure Target and the Progression of CKD: Findings from KNOW-CKD
29. SIRT3 Activation with Viniferin Treatment Ameliorates Features of Diabetes-Induced Tubular Injury Through Restoration of Mitochondrial Function
30. Volume Control Strategy and Patient and Kidney Survival in Sepsis-Associated AKI Receiving Continuous Kidney Replacement Therapy: A Randomized Controlled Trial
31. Histone Acetyltransferase p300 Inhibition Attenuates Kidney Fibrosis Under Diabetic Conditions
32. Preoperative Serum Creatinine-to-Cystatin C Ratio and Risk of AKI After Cardiac Surgery
33. Pharmacologic Pyruvate Kinase M2 Activation Maintains Mitochondrial Metabolism by Regulating the Interaction Between HIF-1α and PGC-1α in Diabetic Kidney Disease
34. The Relationship Between Smoking Cessation and Atherosclerotic Cardiovascular Disease Development Among Patients with CKD
35. Lactobacillus acidophilus KBL409 Protects Against Kidney Injury via Improving Mitochondrial Function with CKD
36. Association Between Systolic Blood Pressure Time in Target Range and Progression of CKD: Findings from KNOW-CKD Study
37. Systolic Blood Pressure Modifies the Relationship Between Coronary Artery Calcification and Adverse Kidney Outcome: Results from KNOW-CKD
38. Reno-Protective Effect of Haptoglobin and Hemopexin by Inhibiting Ferroptosis in Ischemic Reperfusion AKI
39. Klotho plays a protective role against glomerular hypertrophy in a cell cycle-dependent manner in diabetic nephropathy
40. Obesity, Metabolic Abnormality, and Progression of CKD
41. High and low sodium intakes are associated with incident chronic kidney disease in patients with normal renal function and hypertension
42. Characteristics and Clinical Outcomes of End-Stage Renal Disease Patients on Peritoneal Dialysis for over 15 Years: A Single-Center Experience
43. Warfarin Use in Patients With Atrial Fibrillation Undergoing Hemodialysis
44. PS-C27-6: HIGH BRACHIAL-ANKLE PULSE WAVE VELOCITY IS ASSOCIATED WITH THE RENAL OUTCOME IN CHRONIC KIDNEY DISEASE PATIENTS WITH HYPERTENSION
45. PS-C27-5: ASSOCIATION BETWEEN ANKLE-BRACHIAL INDEX AND KIDNEY OUTCOMES IN PATIENTS WITH HYPERTENSION
46. Short-term Blood Pressure Variability and Incident CKD in Patients With Hypertension: Findings From the Cardiovascular and Metabolic Disease Etiology Research Center–High Risk (CMERC-HI) Study
47. Association of Plant Protein Intake With Risk of Incident CKD: A UK Biobank Study
48. Normal body mass index with central obesity has increased risk of coronary artery calcification in Korean patients with chronic kidney disease
49. High-Dose Versus Conventional-Dose Continuous Venovenous Hemodiafiltration and Patient and Kidney Survival and Cytokine Removal in Sepsis-Associated Acute Kidney Injury: A Randomized Controlled Trial
50. Can early initiation of continuous renal replacement therapy improve patient survival with septic acute kidney injury when enrolled in early goal-directed therapy?
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