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La thrombolyse intraveineuse est la thérapie pharmacologique la plus utilisée pour le traitement des accidents vasculaires cérébraux ischémiques (AVCi). Mais le mauvais pronostic vital persiste encore.

L’accident vasculaire cérébral (AVC) est la deuxième cause de décès dans le monde et la première cause de décès et handicap en Chine. Les données sur le pronostic vital chez les jeunes patients après attaque ischémique restent limitées.

•Transfusion-transmitted infections (TTIs) have become a major concern, jeopardizing the safe use of blood in clinical practice.•We assessed TTI seroprevalence in hospitalized patients and voluntary blood donors in Zhejiang Province.•Positive blood cultures pose a risk to the health of blood recipients with low immunity, and seriously compromise the safe use of blood in clinical practice.•Expanding the pathogen categories of blood screening programs and adopting scientifically sound transfusion methods could improve blood quality and ensure blood safety.

There is evidence and international consensus on the advantages and potential of a polypill for established cardiovascular disease patients to improve adherence in the secondary prevention of cardiovascular disease. This study aimed to estimate the numbers of stroke patients who would be eligible for the polypill strategy in China, and the suitable composition of a polypill, based on data of the China National Stroke Prevention Project.

In order to improve the survival ability and rapid response ability of the carrier craft, a new rapid transfer alignment method of the strapdown inertial navigation system (SINS) on a rocking base is put forward. In the method, the aircraft carrier does not need any form of movement. Meantime, interfering motions such as rolling, pitching, and yawing motions caused by sea waves are effectively used. Firstly, the deck flexure deformation model is made. Secondly, the state space model of transfer alignment is presented. Finally, the feasibility of this method is validated by the simulation. Simulation results show that the misalignment angle error can be estimated and reach an anticipated precision--0.2 mrad in 5 s, while the deck deformation angle error can be estimated and reach a better precision--0.1 mrad in 20 s. [ABSTRACT FROM AUTHOR]

With the increasing requirement of communication rate and capacity, Raman amplifiers are becoming the most promising technologies in optical communication systems. There are many patents about Raman amplifiers. In this paper, some important inventions in the patents about Raman amplifiers published since the last 3 years will be presented as typical examples. This paper will introduce various types of inventions about Raman amplifiers individually: multipleorder Raman amplifiers, tunable multimode pump sources Raman amplifiers, automatic gain control Raman amplifiers and lumped Raman amplifiers with a highly-nonlinear medium. These inventions are classified from the principle of Raman amplification effect, the implementation way, deployment mode and optical materials and devices to realize innovation. Above all, Raman amplifiers are developing towards greater capacity, lower noise and nonlinearity, higher gain and longer fiber span lengths.

Expression of nitric oxide synthase (NOS) in the developing eye of zebrafish was studied by NADPH-diaphorase staining technique. NOS activity was first observed in the optic primordium and the lens placode at 5-somite stage, and remained basically unchanged up to the prim-5 stage. Upon hatching, NOS activity was nearly equally detected in the gangalion cell layer and the photoreceptor layer in the developing retina. However, it began declining in the inner plexiform layer and the inner nuclear layer at this stage. NOS activity disappeared in the lens although the anterior lens epithelium was strongly stained. Two days after hatching, NOS activity was still strong in the photoreceptor layer, but decreased markedly in the gangalion cell layer, the inner plexiform layer and the inner nuclear layer with the retinal patterning. These suggested that nitric oxide (NO), the product of NOS, is not only involved in the modulation of patterning and differentiation of the retinal cells but also in the regulation of proliferation, and differentiation of the lens fibrocytes.

The risk factors for cardiovascular diseases (CVDs) are more prevalent in the Chinese population, and therefore, increase the incidence of CVD. In general, CVD morbidity and mortality will remain an upward trend in the next 10 years. Cardiovascular disease is the leading cause of death in China, which accounts for >40% of deaths from any cause. The burden of CVD is substantial and has become an important public health issue. Measures for the prevention and treatment of CVD in China should be further enforced without delay. Since 2005, the National Center for Cardiovascular Diseases has organized experts of cardiology, neurology, nephrology, diabetes, epidemiology, community health, health economics, biostatistics, and other related fields to compile the annual Report on Cardiovascular Diseases in China. The report aims to provide a timely review of the trend of the epidemic of CVD and to assess the progress of prevention and control of CVD. We present an abstract from the Report on Cardiovascular Diseases in China (2014), including trends in CVD, morbidity and mortality of major CVD, up-to-date assessment of risk factors, as well as health resources for CVD, and a profile of medical expenditure, with the aim of providing evidence for decision making in CVD prevention and control programmes in China, and of delivering the most authoritative information on CVD prevention and control for all citizens.

Despite great advances in lipid-lowering therapy, the gender-based disparities in lipid goal success among Chinese coronary heart disease (CHD) patients receiving lipid-lowering treatment remained uncharacterized. Furthermore, little is known about potential causes for this gender imbalance. This cross-sectional trial included 25 697 patients treated with lipid-lowering agents from 122 centres between April 2012 and October 2012; data for 9420 participants with CHD were analysed in the present study; all underwent clinical examination and had their latest fasting lipid profiles while on lipid-lowering therapy recorded. Logistic regression was used to explore possible factors associated with gender disparity in goal attainment rates, and to what extent each factor contributes. Of 9420 CHD patients (42.5% women) evaluated, women had a significantly lower overall low-density lipoprotein cholesterol (LDL-C) success rate than men (46.2 vs. 62.7%, P < 0.0001). Among CHD patients with diabetes, only 31.5% of women and 46.4% of men (P < 0.0001) attained the optional LDL-C target of <80 mg/dL. More than half (54.0%) of female patients failed to attain their non-high-density lipoprotein cholesterol (HDL-C) goal. Approximately 7.5, 8.8, 7.5, and 6.8% of gender disparity in LDL-C goal attainment rate was attributable to the gender difference in use of an anti-diabetic, anti-hypertensive, anti-platelet treatment, and the dosage of statin treatment, respectively. Although great improvements have been made over the past decade, there is still a preventive gap in high-risk and very high-risk CHD patients regarding LDL-C and non-HDL-C levels and that this gap is apparently greater in women.