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Background: Obesity is a growing health problem worldwide. Obesity is not only closely associated with increased incidence of various comorbidties, such as diabetes and hypertension, but also serves as an independent risk factor for progression of renal insufficiency. Significant weight reduction appears to be the most important therapeutic approach to the management of obesity-related renal dysfunction. Methods: We report a case of a female patient with morbid obesity with stage V chronic kidney disease whose renal function was improved and stabilized following substantial weight loss after Rouxen- Y gastric bypass. Results: The present case showed that surgical treatment of morbid obesity could improve or stabilize creatinine in patients with chronic renal failure. The reduction of glomerular hyperfiltration and blood pressure as well as improved insulin resistance might have contributed to the decrease in serum creatinine level in the patient. Conclusion: Bariatric surgery can be performed safely on patients with chronic renal disease and might have a role in retarding the progression of renal dysfunction in carefully selected patients with morbid obesity. [ABSTRACT FROM AUTHOR]