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Helicobacter pyloriinfection is usually acquired in early childhood and it can persist throughout life without antibiotic treatment. This study aimed to compare the accuracy of the noninvasive H. pyloriStool Antigen Test-applied on the stool samples with the invasive gold standart Rapid Urease Test-applied on the gastric biopy samples of patients with upper gastrointestinal complaints. After endoscopy, biopsy and stool specimens were taken in 122 patients. The infectionwas detected with rapid urease test which is accepted as gold standart test. Rapid, one-step H. pyloricard test was applied to all patients stool specimens. In this study 106 of the 122 patients (86.8%) were positive for H. pyloriinfection, while 16 of the 122 patients (13.2%) were negative. H. pyloricard test was negative in 13 of the 16 patients and was positive in 98 of the 106. The sensitivity, specifity, positive and negative predictive values were 92.45%, 81.25%, 97.02%, and 61.90%, respectively. H. pyloricard test is rapid, easy, noninvasive and inexpensive methods for detection H. pyloriinfection. This test showed high sensitivity and specificity. Additionally, it may be a good alternative to invasive tests for the detection of H. pyloriinfections especially in children.