Search

AbstractBackground:The chemokine (C-X3-C motif) ligand 1 (CX3CL1), also called fractalkine (FKN), has recently been reported to be involved in osteoclastogenic process and pathological bone destruction.Objective:This study aimed to investigate the link between serum CX3CL1/FKN levels with disease progression of postmenopausal osteoporotic patients.Methods:A total of 53 women with postmenopausal osteoporosis (PMOP group), 51 postmenopausal non-osteoporotic female patients (PMNOP group) and 50 premenopausal non-osteoporotic healthy women of childbearing age (control group) were enrolled in the study. The bone mineral density (BMD) for all subjects was determined via dual-energy X-ray absorptiometry of the lumbar spine, femoral neck, internal trochanter, total hip, greater trochanter and Ward’s triangle. The levels of FKN in the serum were examined using the enzyme-linked immunosorbent assay method. The serum bone resorption markers TRACP-5b, NTX levels, inflammation markers IL-1β and IL-6 as well as oestrogen-2(E2) were also detected in all participants. The visual analogue scores (VAS) and Oswestry Disability Index (ODI) for low back pain were recorded in PMOP females for evaluation of osteoporotic pain and function.Results:FKN levels were significantly higher in postmenopausal osteoporotic patients compared with postmenopausal non-osteoporotic females (139.8 ± 44.3 pg/mL VS 116.5 ± 23.1 pg/mL, p < 0.05) and healthy controls (139.8 ± 44.3 pg/mL VS 109.7 ± 19.4 pg/mL, p < 0.05). Serum FKN concentrations were negatively associated with BMD at femoral neck (r = −0.394, p = 0.004), total hip(r = −0.374, p = 0.006), internal trochanter(r = −0.340, p = 0.013), greater trochanter(r = −0.376, p = 0.006), Ward’s triangle(r = −0.343, p = 0.012), L1–L4 lumbar spine(r = −0.339, p = 0.013) and positively associated with VAS (r = 0.321, p = 0.019) and ODI (r = 0.377, p = 0.005) scores, bone turnover makers (TRACP-5b:r = 0.341, p = 0.012; NTX:r = 0.364, p = 0.007)as well as inflammation markers (IL-1β: r = 0.396, p = 0.003; IL-6:r = 0.355, p = 0.009) in postmenopausal osteoporotic patients.Conclusions:Serum FKN may serve as a novel biomarker for assessing disease progression and a new potential therapeutic target for anti-resorptive treatment in osteoporosis patients.

A variety of loadings of Cobalt oxide (Co3O4) was successfully supported on the reduced graphene (Co3O4/rGO) as the catalyst to activate peroxymonosulfate (PMS) to generate sulfate radicals (SO4−•) for degrading Orange II in water. The crystal structure of Co3O4/rGO with different loadings was characterized by X-ray diffraction (XRD), and their catalytic activity was compared in the same conditions. The result showed that the catalyst has an optimum Co3O4 loading. Using the 70.7% loading of Co3O4 in Co3O4/rGO as the catalyst, 100% decomposition could be achieved within 4 min with 1 mM Orange II, 0.05g/L catalyst, and 10 mM PMS.

For solving the control problem of smart Building equipments in remote, introduce a design method of smart Building network which can realize the remote control of building electrical equipments by STC89C516RD+ and mobile telephone module of TC35I, give the Building networks mode, describe the software and hardware design of embedded gateway and its control method to the building electrical equipments in detail. The test result indicates that the capability of this system is stable and dependable, The result s was effect , it could meet the design challenge. and validates this scheme. The proposed program has the characteristics of high applicability and practical significance.

A facile and reproducible method for the synthesis of Ag3PO4/AlPO4-5 photocatalyst has been developed to improve the photocatalytic activity of Ag3PO4. The innovation of this method is to in situ deposit Ag3PO4 nanoparticles onto the AlPO4-5 surface forming a composite photocatalyst. The improved activity of the Ag3PO4/AlPO4-5 composite photocatalyst for the degradation of rhodamine B (RhB) under visible light irradiation is attributed to the increased surface area and the enhanced absorption of RhB.

The method of the impacting to manufacture micro-pits is put forward in order to reduce friction between Piston ring and Cylinder liner, and improve the effective of air compressor. Method and principium of the impacting to manufacture micro-pits is recounted. The cylinder liner is set on principal axis of the rotating lathe. The tool can feed toward axis or radial direction. The micro-pits deepness is controlled by axis feeding, and distance between two micro-pits is controlled by radial feeding. The motor drives eccentricity wheel, so that the tool engender the low frequency vibration. The micro-pits are manufactured by the tools on low-frequency vibration. The effective of micro-pits processing is improved because the matrix tools were designed and manufactured. The depth of micro-pits can be controlled, so that it is even. The dynamic lubrication is built up between the cylinder and the piston, because the distributing regulation and the structural parameter can be controlled, and the micro-pits distribute evenly and independently. A theoretic model was presented to study the lubrication performance, The theory of dynamic lubrication of the honeycomb micro-pits was researched. The air compressor cylinder liners were manufactured. The tests of air compressors which cylinder liners have no micro-pits and air compressors which cylinder liners have micro-pits were done. The test result proves that friction between Piston ring and Cylinder liner is reduced, and the effective of air compressor is improved because of micro-pits.

The surface quality of cylindrical rollers has a great influence on the working life of rolling bearings. In the paper, double-side lapping machine and flannelette pads are applied to polish the cylindrical surface of rollers. After 20 min polishing, rollers with smooth surface are obtained and the roundness of the rollers have a improvement of about 0.3 μm, which means that the polishing process based on double-side lapping method can effectively improve the surface quality and geometric accuracy of cylindrical rollers.

The rolling element is the most important component of rolling bearings. Its geometric accuracy and consistency affect greatly the performance and working life of bearings. In this paper, a standard Taguchi L9(34) orthogonal array(oa) is designed to analyse how abrasive size, rotating speed of plates, deflection angle of carrier holes and other factors impacting on precision of cylindrical roller process and achieved the optimized parameters combination by adopting evaluation of Signal-to-Noise ratio and ANOVA analysis(analysis of variance). Under the optimized lapping condition, the roundness,pand s can reach , and respectively.

Eccentric dual rotated-plates lapping is used for bearing balls finishing. The trajectory of ball in lapping is crucial for the ball’s geometric precision after finishing. The present work is to set up the model of eccentric dual rotated-plates lapping machine and simulate the ball processing in kinematics, and research the effect of carrier on the ball trajectory, through calculating the ball’s kinetic parameters of revolution speed, rotation speed and spin angle, and drawing the ball trajectory.

In the chemical mechanical polishing process (CMP) ，the groove shape of polishing pad is one of the most critical elements that directly influences the quality and efficiency of CMP. This review paper describes the basic patterns of groove shape and that the patterns shape of polishing pad how to effect on quality and efficiency of CMP. The effect comparison between various sorts of groove shape and their effects on polishing is described. It is intended to help reader to gain a more comprehensive view on groove shape of polishing pad, and to be instrumental for research and development new groove shape of polishing pad for CMP.

A photocatalytic process combined with ammonia-water method was developed for flue gas desulfurization. With the photocatalytic technology we can not only achieve the purpose of solving the problem of SO2 emissions but also realize the desire of hydrogen production from water splitting. CdS loaded with Pt were selected for the photocatalytic gas desulfurization. It was found that Pt/CdS showed a high activity for hydrogen production from ammonia sulfite solution, which is the prime product of ammonia-water method for flue gas desulfurization.

Dual Rotated Plates (DRP) eccentric lapping mode is developed on the base of traditional eccentric lapping mode for precise balls. Spin angle is an important target of expressing ball rotation in the lapping process. Whether lapping track can uniformly cover the ball surface or not is directly determined by the variation of the spin angle. Applying virtual prototype technology and ADAMS (Automatic Dynamic Analysis of Mechanical Systems) to simulate the ceramic ball lapping track in DRP eccentric lapping mode. And these results are compared to traditional one. At the same condition, the DRP eccentric lapping mode owns better lapping uniformity than traditional one and it is easy to apply to science for the simplicity of structure and control. The result may offer theoretical basis for high-precision ceramic balls machining.

The semi-fixed abrasive tool (SFAT) is a new tool used in the ultra-precision machining. Based on the theory of particle flow code (PFC), the abrasive particle motion characteristics of SFAT are studied in SFAT processing which is divided to workpiece pressing progress and workpiece tangential moving progress. It is conclusion that the particles are fallen out the tool surface due to the fracture of bonds under the normal force of workpiece point in the workpiece pressing progress; the particles contacting the workpiece are moved on every hand while some particles fall out the surface at the edge of abrasive tool in the workpiece tangential moving progress, and the maximum value of binding agent holding force is computed.

Photocatalytic activity of BiVO4 for the water oxidation was found extensively improved by Mo doping. The highest activity of Mo doped BiVO4 for O2 evolution appeared when the photocatalysts was doped by 0.2 at % Mo. The XRD patterens showed that the crystal structure of the photocatalyst was changed by Mo doping. The color and UV-Vis absorption spectra of the photocatalysts were also changed before and after the catalysts were doped by Mo.

Spin angle is an important target of expressing ball rotation in the lapping process. Whether lapping track can uniformly cover the ball surface or not is directly determined by the variation of the angle. The simulation of spin angle track of the ball based on ADAMS (Automatic Dynamic Analysis of Mechanical Systems) with Dual Rotation Plates Lapping Method by applying virtual prototype technology and using ADAMS is given by the article. The track based on ADAMS is similar with the track of using mathematical theory on the whole. The simulation results show that DRP lapping method owns better lapping uniformity and it is easy to apply to science for the simplicity of structure and control. The spherical lapping uniformity will be further studied with ADAMS in a convenient way.

The V-groove angle of the machine is considered as one of important factors affecting the processing and the ball’s precision. To study its effect, the three-dimensional model of RDP lapping machine is built and a series of simulations at different V-groove angles are carried out, using the software ADAMS based on the RDP principle. The influence of three parameters including spin angle, spin angular velocity and revolution angular velocity are discussed by observing and analyzing the simulation results. It is concluded that some optimized V-groove angles can improve the sphericity of ball; some ones can induce the balls to move back and roll during some periods of the processing.

Pure laparoscopic radical resection of hilar cholangiocarcinoma is still a challenging procedure, in which laparoscopic lymphadenectomy, hemihepatectomy with caudate lobectomy, and hepaticojejunostomy were included [1–4]. Relative report is rare in the world up to now. Hilar cholangiocarcinoma has a poor prognosis, especially when it occurs with lymph node metastasis or vessel invasion [5, 6]. We recently had a patient who underwent a pure laparoscopic extended right hepatectomy and lymph node dissection and hepaticojejunostomy for a type IIIa hilar cholangiocarcinoma. The tumor was 20 × 15 × 12 mm in diameter and located in the right bile duct and common hepatic duct. Radiological examination showed that hepatic artery and portal vein was not invaded. After the division and mutilation of the right hepatic artery and the right portal vein, short hepatic veins were divided and cut off with clip and ultrasound knife from the anterior face of the vena cava. Mobilization was performed after the devascularization of the right liver, followed by the transection of liver parenchymal with CUSA and ultrasound knife. Finally, left hepatic bile duct jejunum Roux-en-Y reconstruction was performed. This patient underwent successfully with a totally laparoscopic procedure. An extended right hepatectomy (right hemihepatectomy combined with caudate lobectomy) and complete lymph node dissection and hepaticojejunostomy were performed in this operation. The operation time was nearly 590 min, and the intraoperative blood loss was about 300 ml. No obvious complication was observed and the postoperative hospital stay was 11 days. The final diagnosis of the hilar cholangiocarcinoma with no lymph node metastasis was pT2bN0M0 stage II (American Joint Committee on Cancer, AJCC). Pure laparoscopic resection for hilar cholangiocarcinoma was proved safe and feasible, which enabled the patient to recover early and have an opportunity to receive chemotherapy as soon as possible. We present a video of the described procedure.