1. Association between Fibroblast Growth Factor Receptor 4 Gly388Arg Polymorphism and Ischaemic Stroke
- Author
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Zhang, HF, Zhao, KJ, Yang, PF, Fang, YB, Zhang, YH, Liu, JM, and Huang, QH
- Abstract
Objective: Fibroblast growth factors (FGFs) and their receptors (FGFRs) play important roles in the vascular system. The FGFR4rs351855 (Gly388Arg) poly morphism has been shown to be a risk factor for many diseases. This case-control study investigated the association between the FGFR4Gly388Arg polymorphism and susceptibility to ischaemic stroke in the Chinese population.Methods: The FGFR4Gly388Arg polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in patients with ischaemic stroke and healthy controls.Results: Frequencies of genotypes GA and AA, and prevalence of the A allele, were significantly lower in ischaemic stroke patients (n= 952) than in controls (n= 986). Genotype AA and allele A were significantly more frequent in stroke patients with, than in those without, diabetes.Conclusion: These results suggested that the GA genotype, AA genotype and A allele of FGFR4Gly388Arg polymorphism are all associated with decreased risk of ischaemic stroke in the Chinese population.
- Published
- 2012
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