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AbstractBackground:We conducted a review of the safety and outcomes of endovascular intervention in patients with internal carotid artery dissection (ICAD). Summary:A literature review was performed. PubMed and Medline databases were searched from inception to September 2012 with the key words ‘carotid artery' (title), ‘dissection' (title) and ‘endovascular' (title/abstract). All studies were included which reported outcomes of endovascular intervention in ICAD and provided information about technical and clinical results. After screening, we included 23 articles. In total, 201 patients (128 male and 73 female) were included in the eligible studies. The mean age was 46.7 years (range 13-83 years). Of the 201 patients, the causes of the carotid dissections were traumatic in 69 (34.3), spontaneous in 115 (57.2) and iatrogenic in 17 (8.5). The technical success rate was 99.1. The overall rate of major cardiovascular events in the perioperative period was 4. No procedure-related deaths occurred. Imaging follow-up data (mean follow-up time 16.5 months) demonstrated that only 3.3 of patients had intimal hyperplasia or in-stent restenosis or occlusion of a treated vessel. Clinical follow-up data (mean follow-up period 20.9 months) showed that only 2.1 of patients had a recurrent transient ischemic attack in the territory of the treated vessel. Key Messages:Endovascular intervention with stenting or stent-graft-supported angioplasty in selected patients with ICAD is promising. However, further evaluation is warranted to provide more evidence to support the feasibility of endovascular procedures in treating ICAD.© 2013 S. Karger AG, Basel