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For a 300 MW coal-fired unit, the regenerative heat exchanger is used to design a regenerative heat exchanger cooling water collection and hot air reheat white smoke treatment and water recovery system. According to the system design scheme, the unit performance test is carried out under full load condition. The results show that: this system can effectively solve the white smoke phenomenon of smoke. In the process of reducing the smoke temperature from 54.1 °C to 40.2 °C, a total of 8.68 t/h of water is analyzed, and the water in the flue gas is effectively recovered. It reduces the concentration of particulate matter in the smoke, which has a certain positive impact on the ultra-low emission of flue gas. However, a certain amount of hot secondary air is extracted to heat the tail flue gas, resulting in an increase of coal consumption for power generation by 0.987 g/(kW h). Therefore, the cooling and water collection and hot air reheat technology of regenerative heat exchanger has certain limitations, and the technology of smoke waste heat recovery will be the key development and application direction in the future

ABSTRACTIn ovarian carcinogenesis and progression, long non-coding RNAs (lncRNAs) have been shown to have a role, although the underlying processes remain a mystery. By modulating the degree of autophagy in ovarian cancer cells, we sought to learn more about the function lncRNA HOXA11-AS plays in the development of ovarian cancer. The expression of HOXA11-AS in ovarian normal cells and ovarian cancer cell lines was measured using R package and qRT-PCR. Ovarian cancer cells expressed HOXA11-AS substantially higher than normal cells, while cisplatin-resistant cells expressed HOXA11-AS significantly higher than ovarian cancer cells. Next, we studied the prognostic data of HOXA11-AS in ovarian cancer in the Tissue Cancer Genome Atlas (TCGA). In the next step, lentiviral transfection of ovarian cancer cells A2780, OVCAR3, and A2780/DDP (cisplatin-resistant) were performed, and HOXA11-AS knockdown was found to significantly inhibit cell viability, migration, and invasion of A2780 and OVCAR3 cells, and promote apoptosis by CCK-8 assay, transwell assay, cell cycle, and apoptosis assay, and promoted the sensitivity of A2780/DDP cells to cisplatin. It has been shown by the western blot test that HOXA11-AS knockdown increases the amount of cellular autophagy in cells. In contrast, adding the autophagy inhibitor 3-methyladenine (3-MA) to HOXA11-AS cells knocked down in vivo reduced its anti-tumor properties. As a whole, this study found that HOXA11-AS knockdown increased the expression of autophagy-related proteins and improved cisplatin sensitivity, decreased ovarian cancer cell proliferation, and promoted cell apoptosis. This study provides new insights into the role of HOXA11-AS in ovarian cancer regulation.

The work presented here describes a highly sensitive and simple electrochemical sensor for the detection of Sudan I dye based on a nanocomposite made of MoS2heterogeneous nanosheets (1T@2H-MoS2) and carboxylated carbon nanotubes (cMWCNTs) (1T@2H-MoS2/cMWCNTs). XPS results indicate that the content of 1T phase MoS2was estimated to be 72% in 1T@2H-MoS2. Electron microscopy results show that the tubular cMWCNTs are uniformly interwoven in MoS2nanosheets to form a three-dimensional network structure. Due to the synergistic electrocatalytic ability and high electroactive surface area, the 1T@2H-MoS2/cMWCNTs modified electrode demonstrated excellent analytical performance for Sudan I, including simple operation, good stability and a wide linear range from 5.00 × 10−9to 2.00 × 10−6mol L−1and 2.00 × 10−6to 1.00 × 10−4mol L−1with an ultra-low detection limit of 1.56 × 10−9mol L−1. The recoveries of Sudan I from spiked real samples (chilli powder and ketchup) were in the range of 95.60% to 106.10% with low RSD (<5%), indicating that the 1T@2H-MoS2/cMWCNTs modified electrode is a promising tool for the analysis of illegal Sudan I in food samples.

•BCA suppresses isoflurane-induced viability reduction, oxidative stress, and apoptosis in SH-SY5Y cells.•BCA enhances isoflurane-induced activation of Nrf2/ARE pathway.•Knockdown of Nrf2 inhibits BCA protection against isoflurane-induced neurotoxicity.

ABSTRACTThis project aimed to investigate the protective mechanism of sufentanil pretreatment on myocardial ischemia-reperfusion injury (IRI). An in vivorat model of myocardial IRI and an in vitrocultured cardiomyocyte model of hypoxia-reoxygenation (H/R) were used to confirm the anti-oxidation and anti-autophagy effects of sufentanil. The interaction between miR-125a and damage-regulated autophagy regulator 2 (DRAM2) was verified by luciferase reporter assay. We showed that pretreatment with sufentanil suppressed myocardial damage caused by IRI in rats by inhibiting oxidative stress and mitochondrial autophagy. Furthermore, the cardioprotective mechanism of sufentanil was mediated by miR-125a. MiR-125a targeted DRAM2 to ameliorate cardiomyocyte autophagy and oxidative injury following H/R treatment. In conclusion, our results demonstrated that sufentanil pretreatment produced a protective effect against myocardial IRI via regulating miR-125a/DRAM2 signaling axis.

Tuberculosis (TB) ranks as the leading cause of death from a single infectious agent (ranking more lethal than HIV/AIDS) over the course of the past decade. More concerning is that reports of multi-drug-resistant (MDR) and extensively drug-resistant (XDR) strains of TB have been dramatically increasing. It continues to become ever more clear that novel anti-TB drugs with improved efficacies and reduced toxicities are urgently needed. We report here the discovery of 12 new ilamycin analogues, ilamycins G–R (1–12), bearing various nonproteinogenic amino acids, along with ilamycins E1(13) and F (14), from a 200 L scale culture of the marine-derived mutant actinomycete Streptomyces atratusSCSIO ZH16 ΔilaR. Importantly, bioassays against Mycobacterium tuberculosisH37Rv revealed that all 12 new agents displayed antitubercular activities with MIC values ranging from 0.0096 to 10 μM. The structures of 1–12were elucidated on the basis of HRESIMS, 1D and 2D NMR, and X-ray single-crystal diffraction studies. In addition, compound 10was found to be moderately cytotoxic against a panel of tumor human cell lines. From these data we can formulate tentative structure–activity relationships for the antitubercular and antitumor activities of the ilamycins.

As an ω-conopeptide originally discovered from Conus striatus, SO-3 contains 25 amino acid residues and three disulfide bridges. Our previous study has shown that this peptide possesses potent analgesic activity in rodent pain models (mouse and rat), and it specifically inhibits an N-type calcium ion channel (Cav2.2). In the study presented here, we investigated the key amino acid residues for their inhibitory activity against Cav2.2 expressed in HEK 293 cells and analgesic activity in mice. To improve the inhibitory activity of SO-3, we also evaluated the effects of some amino acid residues derived from the corresponding residues of ω-peptide MVIIA, CVID, or GVIA. Our data reveal that Lys6, Ile11, and Asn14 are the important functional amino acid residues for SO-3. The replacement of some amino acid residues of SO-3 in loop 1 with the corresponding residues of CVID and GVIA improved the inhibitory activity of SO-3. The binding mode of Cav2.2 with SO-3 amino acids in loop 1 and loop 2 may be somewhat different from that of MVIIA. This study expanded our knowledge of the structure–activity relationship of ω-peptides and provided a new strategy for improving the potency of Cav2.2 inhibitors.

In order to solve the problem of mine water treatment in the production process of coal mine enterprises, the source and characteristics of mine water are introduced, and the zero discharge technology of mine water is studied and applied in engineering, the zero discharge technology of mine water includes three stages: pretreatment, concentration and reduction, and evaporation and crystallization. The results show that: for the mine water with TDS mass concentration of 3200 mg/L, coagulation clarification process is used for pretreatment, reverse osmosis+DTRO is used for concentration and reduction, MVR is used for evaporation and crystallization, the TDS concentration of concentrated water after treatment is 142000 mg/l, the recovery rate of the system is 84.5%, and the TDS of final water production is about 418 mg/l, which meets the design and reuse requirements. The sodium sulfate produced in the evaporation crystallization stage is about 4.9 t/h, and its purity is 99.12%, which can be used as chemical raw material.

With the continuous opening of China’s electricity market, power generation enterprises have shifted from planned operation mode to market competition mode. Guided by the idea of index, the power market trading index system of power generation enterprises is established by comprehensively considering the four aspects of electricity trading price, market activity, settlement timeliness and market benefit. This paper selects A company as an example to demonstrate the scientificity and practicability of the index system. Finally, according to the result of the case analysis, some suggestions are given to improve the market competitiveness of power generation enterprises.