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IMMACULATE may appear to be all about evil nuns. In the movie's grisly opening, four nuns break a runaway sister's leg. Another holy mob tries to skewer the protagonist, Sister [...]

Expectations can be misleading. Jordan Rudess is renowned for his dazzling, technical keyboard skills that have been proudly placed under the spotlight on Dream Theater's albums for the last 25 [...]

Background: Worldwide, countries are examining whether to implement 1-dose human papillomavirus (HPV) vaccination instead of using 2 doses. To inform policy, we sought to project the population-level impact and efficiency of switching from 2-dose to 1-dose gender-neutral routine HPV vaccination in Canada. Methods: We used HPV-ADVISE, an individual-based transmission-dynamic model of HPV infections and diseases, to mathematically model vaccination programs in 2 provinces, Quebec, a province with high HPV vaccination coverage (around 85%), and Ontario, which has lower coverage (around 65%). We examined non-inferior and pessimistic scenarios of the efficacy (vaccine efficacy of 98% or 90%) and average vaccine duration (lifelong, 30 yr, or 25 yr) of 1 dose compared with 2 doses (98% vaccine efficacy, lifelong vaccine duration). Our main outcomes were the relative reduction in HPV-16 (by sex) and cervical cancers, and the number of doses needed to prevent 1 cervical cancer. Results: Our model projected that 1-dose HPV vaccination would avert a similar number of cervical cancers as 2 doses in Canada, under various scenarios. Under the most pessimistic scenario (25-yr vaccine duration), 1-dose vaccination would avert fewer cervical cancers than 2 doses, by about 3 percentage points over 100 years. All 1-dose scenarios were projected to lead to elimination of cervical cancer (< 4 cervical cancers/100 000 female-years) and to be a substantially more efficient use of vaccine doses than a 2-dose scenario (1-dose v. no vaccination = 8001000 doses needed to prevent 1 cervical cancer; incremental doses for 2-dose v. 1-dose vaccination > 10 000 doses needed to prevent 1 additional cervical cancer). Interpretation: If the average duration of 1-dose protection is longer than 25 years, a 1-dose HPV vaccination program would protect those vaccinated during their peak ages of sexual activity and prevent a similar number of HPV-related cancers as a 2-dose program, while being a more efficient use of vaccine doses., In April 2022, the World Health Organization (WHO) Strategic Advisory Group of Experts on Immunization (SAGE) announced that human papillomavirus (HPV) vaccination with a single dose could be considered for [...]

IN THE EARLY 1600s, English settlers in colonial Jamestown were struggling to stay alive. Colony resident William Strachey (1572-1621) recorded that between 1607 and 1610, more than 80 percent of [...]

There are some artists who provide a cerebral conversation, which renews our faith that musicians still exist who deserve more than fleeting attention. Pure Reason Revolution's Jon Courtney is one [...]

Behavioral correlates to happiness (i.e., indices of happiness) have been used as means of measuring happiness in individuals with developmental disabilities. However, research has not yet evaluated the possibility that indices of happiness/unhappiness (IHUs) may signal the presence of a setting event that could affect other behaviors. The purpose of this study was to assess the relation between indices of happiness/unhappiness (IHUs) and challenging behavior with a 14-year-old boy diagnosed with autism spectrum disorder. A conditional probability calculation was used to evaluate the relation between IHUs, demand type, and challenging behavior. Results indicated that different IHUs predicted specific topographies of challenging behavior given demands to transition or engage in academic tasks., Author(s): Jacqueline D. Wilson [sup.1] [sup.2], Caitlyn A. Federico [sup.1] [sup.2], Jesse Perrin [sup.1] [sup.2], Cody Morris [sup.1] Author Affiliations: (1) https://ror.org/004qfsw40, grid.430064.5, 0000 0000 9900 6074, Department of Psychology, [...]

Enhancing rail integrity through improved rail inspection techniques continues to be an essential element of railway safety. This article explores the expansion of the Rail Flaw Library of Associated Defects [...]

In recent years, the Army has encountered challenges in meeting its recruiting and retention goals. (1) This raises critical questions: Could these challenges stem from our treatment of personnel, or [...]

A 9-year-old previously healthy boy, who was up to date on routine vaccinations, presented to the emergency department of a community hospital in July with a 1-day history of fever, [...]

Remaining compliant with regulatory agencies and reducing greenhouse gas emissions are now part of nearly all rubber product manufacturing. Finding efficient, economical and environmentally responsible ways to clean, without cleaning [...]

If you've spent a minute or two in the industry, you've seen a lot of changes to the way we repair and paint vehicles. There was a time we used [...]

'It's funny because our debut album, Identity, has just celebrated its 15th anniversary,' says Airbag's guitarist Bjorn Riis with a hint of wistfulness. 'I sat down and listened to the [...]

Derek Sherinian is more bashful and reserved than usual. The former Dream Theater and Sons Of Apollo keyboard player has been known to be somewhat scathing of his old bandmates. [...]

Whatever you choose to call it: 'difficult second album syndrome' or 'sophomore slump', it remains a threatening, hovering spectre for bands that have created cracking debut records. Whether caused by [...]

When thinking about landscaping your garden, it's a good idea to pinpoint any elements you like and want to keep, and use this as your starting point, particularly if you're [...]

For Marie Antoinette (1755-1793), the last Queen of France before the French Revolution, her hair was a tool of politics and statecraft. She used her elaborate hairstyles to mark significant [...]

A new understanding of hearing could not only fix tinnitus, but reverse some types of deafness too, discovers Clare Wilson WORKING as a DJ in Liverpool, UK, a decade ago, [...]

WHY DO WE CONSTANTLY NEED TO REVISIT THE FUNDAMENTALS OF PAINT PREPARATION? BECAUSE NOTHING IS FASTER OR MORE PROFITABLE THAN DOING THE JOB ONE TIME. The history of paint as [...]

In July 1520, Hernan Cortes (1485-1547) and his group of soldiers were holed up in one of Moctezuma's royal palaces in Tenochtitlan, the capital of the Aztec Empire They were [...]

When Kayla Furton moved back to her childhood home in 2016 with her husband and three young children, she had no plans of ever leaving. Nestled in the small town [...]

At the end of the Civil War, the U.S. Army had a surplus of career officers and soldiers, and assigned them to try to deal with the growing conflicts between […]

Ancient Romans loved their dogs. They bred and trained them to be hunters, shepherds, watch flogs, fighters, and small lap dogs. Relatives of many of the breeds we know today, [...]

Cosmic Connections: Poetry in the Age of Disenchantment, by Charles Taylor (Belknap Press, 640 pp., $37.95) Charles Taylor is one of the few contemporary philosophers to have become a familiar [...]

Byline: Jasmine Gould-Wilson 'It could be the next numbered Final Fantasy. It could be a completely different brand' In the wake of industry-wide layoffs, Final Fantasy 7 Rebirth director Naoki [...]

Byline: Ben Wilson Victor Osimhen and Ryan Gravenberch also make the FC 25 FC Pro Live tracker The FC 25 FC Pro Live tracker brings back one of the most [...]

Byline: Mark Wilson Leak suggests DJI could trade skies for carpets * A leaked image suggests DJI could be planning to launch a robot vacuum * It could be called [...]

Byline: Mark Wilson Quartet of primes are great news for Canon fans * Sigma has announced four APS-C prime lenses for Canon's RF mount * All have bright f/1.4 apertures, [...]

Byline: Iain Wilson Fortnite Chapter 6 launches in December 2024 and is now confirmed to include a permanent return of Fortnite OG When does Fortnite Chapter 6 start is a [...]

From Camden, Alabama but graving up m Pontiac, Michigan, keyboardist, vocalist and songwriter RONNIE MCNEIR took classical piano lessons at 10 but stopped soon after and taught himself to play [...]

Singer, songwriter, multi-instrumentalist and Eels frontman Mark 'E' Everett has been through the ringer. But after open heart surgery following Eels 2023 Lockdown Huricane tour, he's back with a new [...]

Byline: Ben Wilson Haaland, Bonmati and Palmer get OP cards in your FC 25 Trailblazers guide FC 25 Trailblazers Team 2 has landed, and sees Vinicius Jr added to the [...]

Byline: Jasmine Gould-Wilson Opinion | The latest Sims 4 expansion has the potential to be the series' best since its third generation There are so many things to love about [...]

Byline: Mark Wilson It's only been 67 years, Google... * The web version of Google Calendar has been given an official dark mode * The feature is rolling out globally [...]

The role of a president has become extraordinarily complex. To be successful, one must be adroit at both managing and leading change. The role of president as caretaker is a [...]

Byline: Ben Wilson All details of the WWE 2K24 Bray Wyatt Pack price and contents including Uncle Howdy The WWE 2K24 Bray Wyatt Edition DLC is 2K's way of injecting [...]

Byline: Mark Wilson The iPad mini 7 is now official - and the tablet's specs reveal that Apple has cut a few corners to keep its price tag low. Now [...]

Byline: Mark Wilson GoPro-eclipsing powerhouse could get successor soon The Insta360 Ace Pro from November 2023 remains the most powerful action camera we've tested, but that looks likely to change [...]

Byline: Ben Wilson Mbappe, De Bruyne and Swanson top the FC 25 Total Rush tracker The FC 25 Total Rush tracker is underway, although sadly these new cards don't upgrade [...]

Byline: Ben Wilson Secure new packs and VC with all active WWE 2K24 locker codes Active WWE 2K24 locker codes enable you to claim free packs and cards in MyFaction [...]

Byline: Ben Wilson Dallas Stars shine brightest on top of the NHL 25 best teams list The NHL 25 best teams list is in - and the Dallas Stars are [...]