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Several plumes of dissolved, chlorinated solvents, including trichloroethylene, have been identified in a solesource aquifer near the former Northrop Grumman Bethpage Facility and Naval Weapons Industrial Reserve Plant sites in southeastern Nassau County, New York. Past investigations have documented that the groundwater contamination originated from this industrial area and now extends to the south, in the direction of groundwater flow. The intermixed plumes are commonly referred to as the “Navy Grumman groundwater plume.” Detailed groundwater-flow modeling was needed for the New York State Department of Environmental Conservation (NYSDEC) to evaluate design options necessary for the construction, operation, optimization, maintenance, and monitoring of a groundwater extraction and treatment cleanup plan selected in a December 2019 Amended Record of Decision by the NYSDEC to comprehensively address these plumes. Consequently, the NYSDEC began a cooperative study with the U.S. Geological Survey in 2020 to better understand the local hydrogeologic framework using two independent approaches to characterize aquifer heterogeneity and update an existing regional groundwater-flow model to provide transient boundary conditions for new inset groundwater-flow models of the plume area. We developed these detailed inset models for the two independent aquifer characterizations using history-matching techniques coupled with a novel approach to risk-based management optimization of the remedial design. We also used the updated regional model to assess this optimized groundwater extraction and treatment design for potential saltwater intrusion. The ensembles of parameters resulting from history matching provided a platform with which to evaluate capture by water-supply and remedial wells using particle-tracking techniques. Using the ensemble to select a risk stance, we performed multiobjective optimization to identify various configurations of remedial pumping that are consistent with external constraints and that favor potentially competing objectives. Multiple solutions provide tradeoffs that NYSDEC can consider. In general, pumping redistribution may help to prevent further contamination migration downgradient. These and other study results are intended to support decisions for the remedial design focused on the local area encompassing the full extent of the Navy Grumman groundwater plume. [ABSTRACT FROM AUTHOR]

In 2016, the U.S. Geological Survey began a multiyear cooperative study with the New York State Department of Environmental Conservation to evaluate the sustainability of Long Island’s sole-source aquifer system through hydrogeologic mapping, compilation of groundwater chloride concentrations, and groundwater flow modeling. In the initial phase of the islandwide study, the hydrogeologic framework and extent of saltwater intrusion in aquifers in Kings, Queens, and Nassau Counties on western Long Island, N.Y., were investigated. The aquifer system underlying western Long Island has been under stress from pumping of public, irrigation (golf course), and industrial supply wells. Saltwater intrusion has occurred from surrounding embayments (East River, Long Island Sound, Jamaica Bay, and the Atlantic Ocean) due to pumping. Eighteen boreholes were drilled and cores taken during 2019–21 to collect hydrogeologic, geochemical, and geophysical data to delineate the complex subsurface hydrogeology and extent of saltwater intrusion within the study area. Evaluation of the new cores, reexamination of legacy core descriptions, and analysis of borehole geophysical logs was used to refine the previously published hydrogeologic framework of Pleistocene and Cretaceous unconsolidated sediments in the area, including delineation of a previously undefined hydrogeologic unit between the Magothy aquifer and the Raritan confining unit, herein named the “upper Raritan aquifer.” The upper Raritan aquifer was first recognized in southeastern Nassau County from an analysis of about 50 closely spaced boreholes with high-resolution core descriptions and gammaray (gamma) logs. Further analysis of borehole logs across the study area indicated that the upper Raritan aquifer was also present in Kings and Queens Counties. Nuclear magnetic resonance (NMR) logging was used for the first time on Long Island to provide estimates of the hydraulic properties of the major aquifer and confining units. Unlike other geophysical logs that record responses to the rock matrix and fluid properties and are strongly dependent on mineralogy, NMR logs record responses to the presence of hydrogen protons in the formation fluid to determine water fraction and pore-size distribution. NMR log analysis provided estimates of the clay-bound, capillary-bound, and mobile water fractions and hydraulic conductivity of aquifers and confining units penetrated by five wells in Nassau County. Pumpage for public-supply and industrial wells on Long Island began in the 1870s with small, localized suppliers of populated areas in Kings and Queens Counties. By 1904–16, pumpage for public water supply in Kings County averaged 21 million gallons per day, and averaged 37 million gallons per day in Queens County, mostly from the upper glacial aquifer. Saltwater intrusion was reported as early as the beginning of the 20th century and included the upper glacial- Jameco-Magothy and Lloyd-North Shore aquifer systems. By 1936, pumping in central Kings County created a major cone of depression in the water table extending to the south shore of much of Kings County and into southwestern Queens County. Saltwater intrusion has caused the shutdown of public-supply wells in Kings, Queens, and Nassau Counties. A large saltwater intrusion wedge in the Lloyd aquifer was indicated in southern Queens County in the early part of the 20th century, and the saltwater interface may have been onshore predevelopment. Most of Kings and Queens Counties are intruded with saltwater in both the upper glacial-Jameco-Magothy and Lloyd-North Shore aquifers systems. Saltwater increased during the 20th century and continues to increase to the present (2023) in the Lloyd-North Shore aquifer system in Great Neck and Manhasset Neck in northern Nassau County. A major wedge of saltwater intrusion in the upper glacial-Jameco- Magothy aquifer in southwestern Nassau County appears to be increasing. [ABSTRACT FROM AUTHOR]

Digital hydrogeologic maps were developed in eight study areas in upstate New York by the U.S. Geological Survey in cooperation with the New York State Department of Environmental Conservation. The digital maps define the hydrogeologic framework of the valley-fill aquifers and surrounding till-covered uplands in the vicinity of the villages of Ellenville and Wurtsboro and hamlets of Woodbourne and South Fallsburg in Sullivan and Ulster Counties, town of Greene in Chenango County, city of Cortland and town of Cincinnatus in Cortland County, city of Jamestown in Chautauqua County, city of Olean and village of Ellicottville in Cattaraugus County, and villages of Fishkill and Wappinger Falls in Dutchess County. The hydrogeologic framework provided the foundation for groundwater-flow models that were used in the delineation of areas contributing groundwater flow to production wells screened in four of the eight valley-fill aquifers considered in this study. The hydrogeologic framework for the other four study areas was developed for potential future use in groundwater contributing-area studies. Data used in the creation of all digital surfaces and thicknesses included published surficial geology; aquifer maps and hydrogeologic sections; light detection and ranging (lidar) datasets; the Soil Survey Geographic Database; and lithologic well logs from the National Water Information System, New York State Department of Environmental Conservation, New York State Department of Transportation, and Empire State Organized Geologic Information System databases. Digital maps of the surficial geology; thickness of the surficial sand and gravel aquifers; and tops of the confining lacustrine silt and clay units, confined sand and gravel aquifers, and bedrock surfaces were created by using ArcGIS (a geographic information system). All surfaces and thicknesses were generated by using one of the following ArcGIS interpolation tools: Topo to Raster, Natural Neighbors, Kriging, or Empirical Bayesian Kriging. The datasets developed in this study provide a greater understanding of the underlying hydrogeologic framework in glacial valley-fill aquifers and can be applied in the evaluation of groundwater-supply development and protection. [ABSTRACT FROM AUTHOR]

In the Chenango River Basin of central New York, unconfined and confined glacial valley-fill aquifers are an important source of drinking-water supplies. The risk of contaminating water withdrawn by wells that tap these aquifers might be reduced if the areas contributing recharge to the wells are delineated and these areas protected from land uses that might affect the water quality. The U.S. Geological Survey, in cooperation with the New York State Department of Environmental Conservation and the New York State Department of Health, began an investigation in 2019 to improve understanding of groundwater flow and delineate areas contributing recharge to 16 production wells clustered in three study areas in the basin as part of an effort to protect the source of water to these wells. Areas contributing recharge were delineated on the basis of numerical steady-state groundwater-flow models representing long-term average hydrologic conditions. In the Cortland study area, four water suppliers operate 10 production wells that withdraw a total average rate of 2,480 gallons per minute from an unconfined aquifer consisting of well-sorted sand and gravel deposits. Simulated areas contributing recharge to these wells at their average pumping rates covered a total area of 6.93 square miles. Simulated areas contributing recharge extend upgradient from the wells to upland till deposits and to groundwater divides. Some simulated areas contributing recharge include isolated areas remote from the wells. Short simulated groundwater traveltimes from recharging locations to discharging wells indicated that the wells are vulnerable to contamination from land-surface activities; 50 percent of the traveltimes were 10 years or less. Land cover in some of the areas contributing recharge included a substantial amount of urban and agriculture land use. The groundwater-flow model of the Cortland study area was calibrated to available hydrologic data by inverse modeling using nonlinear regression. The parameter variancecovariance matrix from model calibration was used to create parameter sets that reflect the uncertainty of the parameter estimates and the correlation among parameters to evaluate the uncertainty associated with the single, predicted contributing areas to the wells. This analysis led to contributing areas expressed as a probability distribution. Because of the effects of parameter uncertainty, the size of the probabilistic contributing areas was larger than the size of the single, predicted contributing area for the wells. Thus, some areas not in the single, predicted contributing area might actually be in the contributing area, including additional areas of urban and agriculture land use that have the potential to contaminate groundwater. Additional areas that might be in the contributing area included recharge originating near the pumping wells that have relatively short groundwater-flow paths and traveltimes. In each of the Greene and Cincinnatus study areas, one water supplier operates three wells that are screened near the top of the bedrock surface in a confined aquifer consisting of poorly to well-sorted sand and gravel deposits. This confined aquifer is overlain by a lacustrine confining unit of very fine sand, silt, and clay, which in turn is overlain by a thin unconfined aquifer of sand and gravel. The groundwater-flow models for these two areas were manually calibrated because of the limited hydrologic data. Simulated areas contributing recharge to the Greene study area wells covered a total area of 0.35 square mile for the average pumping rate of 170 gallons per minute. The contributing areas extended southeastward of the wells to the groundwater divide in the till uplands. The contributing areas also included remote, isolated areas on the opposite side of the Chenango River from the wells primarily in the till uplands. For the Cincinnatus study area wells, which have a low average pumping rate (34 gallons per minute), the simulated contributing areas totaled 0.06 square mile and were on the same side of the river as the wells, but they are isolated areas remote from the wells primarily in the till-covered bedrock uplands. Land cover in these contributing areas for both study areas is primarily agriculture and forested, with the contributing areas to the Greene study area wells also including some urban land uses. Because the Greene and Cincinnatus study area wells are screened relatively deep and some flow paths to the wells partly travel through the confining unit, which impedes the connection with surface sources of recharge, overall groundwater traveltimes are greater than for wells in the Cortland study area. Fifty percent of Cortland study area wells, but only 9 and 44 percent of Greene and Cincinnatus study area wells, respectively, have groundwater traveltimes of 10 years or less. [ABSTRACT FROM AUTHOR]

In southeastern New York, the villages of Ellenville, Wurtsboro, Woodridge, the hamlet of Mountain Dale, and surrounding communities in the Neversink River and Rondout Creek drainage basins rely on wells that pump groundwater from valley-fill glacial aquifers for public water supply. Glacial aquifers are vulnerable to contamination because they are highly permeable and have a shallow depth to water table. To protect the quality of these water resources, water managers need accurate information about the areas that contribute recharge to production wells that pump from these aquifers. The New York State Department of Environmental Conservation and the New York State Department of Health designated eight priority wells in this region for which water supply protection is of primary concern. The U.S. Geological Survey, in cooperation with the New York State Department of Environmental Conservation and the New York State Department of Health, began an investigation in 2019 with the general objectives of (1) improving understanding of regional groundwater-flow system, (2) delineating areas contributing recharge to eight priority production wells, and (3) quantifying the uncertainty of these contributing areas in a probabilistic way that can be used to inform decisionmaking related to priority well source-water protection. To complete these objectives, a MODFLOW 6 groundwater model was created encompassing the eight priority wells and the surrounding flow system, which includes parts of the Neversink River and Rondout Creek Basins in Sullivan County and Ulster County, New York. The model was built using Python tools (such as flopy, modflow-setup, and sfrmaker) that facilitate transparent and repeatable model development using existing datasets. The model parameters were estimated with a stepwise approach using an iterative ensemble smoother implementation of the Parameter ESTimation 1U.S. Geological Survey 2INTERA Geoscience and Engineering Solutions software PEST++ (version 5.0.0). We evaluated initial "best guess" parameter bounds with a prior Monte Carlo analysis. Results of the first prior Monte Carlo analysis were used to make informed adjustments to model parameter bounds (typically resulting in expanded bounds), and a second prior Monte Carlo analysis was run to identify improved ranges for model parameters during history matching. The history matching effort produced an ensemble of parameter values for the groundwater-flow model that spans the range of values within prior uncertainty bounds. The ensemble is informed by the historical observation data, within a reasonable range of uncertainty on those observations. This history-matched ensemble was used in a particle tracking Monte Carlo analysis to delineate the areas contributing recharge to priority wells. The groundwater-flow and particle tracking (MODPATH7) models were run once for each ensemble member. Deterministic contributing areas computed for each ensemble member were aggregated to produce maps showing the probability that a location contributes recharge to priority wells. Finally, the particle tracking Monte Carlo analysis was repeated for six pumping scenarios, representing a wide range of possible pumping levels, to incorporate uncertainty in future pumping rates related to population growth or other management decisions. Increasing pumping rates generally led to larger contributing recharge areas and larger areas of high probability that a location contributes recharge to priority wells. These maps show the overall uncertainty of the areas contributing recharge to priority wells in the study area and provide a tool for risk-based decision making for protection of well source water. [ABSTRACT FROM AUTHOR]

Mid-morning on November 19, found me alertly slinking between a cedar swamp and a standing cornfield. I moved along a step at a time, looking for sign and, hopefully, finding […]

A personal narrative is presented which explores the author's experience of bird watching and photographing Bohemian waxwings at the Snake River Canyon in Idaho.

The article suggests six tips for wildlife watchers to make their time afield more productive.

Levels of Hsp90 and Hsp27 in CLL patients correlate with stage of disease or apoptosis, while Hsp72 in serum is affected by corticosteroid treatment. Mechanisms behind carcinogenesis and resistance of tumor cells to treatment regimes remain elusive. The major stress proteins Hsp72, Hsp90, and Hsp27 are credible candidates to provide this resistance, as their overexpression in many cancer types is well documented. In addition to being present inside tumor cells, where they confer resistance to apoptosis, Hsp72, in particular, is presented externally, embedded in the cell membrane of cancer cells. This study aimed to investigate the localization of Hsp72, Hsp90, and Hsp27 in leukocytes from patients with CLL and age‐matched control subjects. CLL patients were found to express significantly higher levels of iHsp90 (CLL=2463 MFI; control=748 MFI) and iHsp27 (CLL=2190 MFI; control=1031 MFI) in lymphocytes than that expressed by lymphocytes from control subjects. Furthermore, expression of iHsp90 was shown to be related to stage of disease, and expression of iHsp27 correlated with levels of active caspase‐3. Patients were found to express very high levels or very low levels of sHsp72 and iHsp72 in CD5+/CD19+cells, although surface and intracellular datasets did not correlate. Levels of extracellular Hsp72 circulating in the serum were found to correlate with internal levels of Hsp72 and were also found to be significantly lower in patients receiving corticosteroid treatment than in patients not receiving corticosteroid treatment. Finally, analysis of the number of circulating Tregs revealed significantly elevated numbers in CLL patients compared with control subjects.

Molecules that behave as danger signals are produced when the body is perceived to be under attack, and they alert the immune system to the problem. The immune system can then mount an appropriate response. Two molecules that have received attention as potential danger signals are heat shock protein 72 (Hsp72) and high mobility group box 1 (HMGB1), which are intracellular proteins but are released when cells are under stress, in particular, when necrosis occurs. This review considers the similarities between these two molecules and then contrasts their mechanism of action and problems that can arise when they are overpresented in the extracellular environment. It is proposed that Hsp72 and HMGB1 are members of a suite of danger molecules that provide a fingerprint of the threat, or stressor, to tissue or organism integrity.

Focuses on the creation of a reusable custom server control for computers. Addition of a Javascript code to a DataGrid item command button; Addition of a Web Control :ibrary project to the solution; Use of the contro on an ASP.NET web; View of the edit template column with the selected control.

Two trials were conducted to study the effect of zeranol implants on growth and sexual development of bull calves. Trial 1 compared the effects of implanting with 72 mg of zeranol at 48 d of age (branding), at 215 d of age, or at both times with nonimplanted control bulls. Implanting at branding resulted in decreased scrotal circumference, testicle weight and proportion of bulls that could produce an ejaculate at 14 mo of age (P<.01). Implanting at 215 d of age had no effect on any of these traits. Growth rate was not increased by implanting at either time but was decreased (P<.02) in animals implanted at both times when compared with control bulls. In trial 2, both bulls and steers were implanted with zeranol and compared with nonimplanted control bulls and steers. Thirty-six-milligram implants were given at 21, 103, 260 and 343 d of age. Scrotal circumference, testicle weight and serum testosterone concentrations decreased (P<.01) and the occurrence of penis abnormalities increased (P<.01) in implanted bulls compared with control bulls. By the time of slaughter, however, testosterone concentrations were equal in control and implanted bulls; and the difference in scrotal circumference was diminishing. This is interpreted as evidence that as the bulls get older, they can overcome the effect of the implants. Carcass weights were heavier in implanted steers than in control steers but were lighter in implanted bulls than in control bulls (P<.02). Carcasses of implanted bulls had higher quality scores and more marbling than control bulls, but carcasses of implanted steers had lower quality scores and less marbling than control steers (both interactions, P<.01). Implanting bulls with zeranol at an early age resulted in restricted sexual development but not in total sterility. Repeated zeranol implants throughout the growing and finishing phase enhanced carcass quality in bulls slaughtered at 14 to 16 mo of age.

Williams, John H. and Julie A. Kauer.Properties of carbachol-induced oscillatory activity in rat hippocampus. J. Neurophysiol.78: 2631–2640, 1997. The recent resurgence of interest in carbachol oscillations as an in vitro model of theta rhythm in the hippocampus prompted us to evaluate the circuit mechanisms involved. In extracellular recordings, a regularly spaced bursting pattern of field potentials was observed in both CA3 and CA1 subfields in the presence of carbachol. Removal of the CA3 region abolished oscillatory activity observed in CA1, suggesting that the oscillatory generator is located in CA3. An α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, 6,7-dinitroquinoxaline-2,3-dione (DNQX), blocked carbachol oscillations, indicating that AMPA receptor-mediated synaptic currents are necessary for the population oscillation. Moreover, the spread of oscillatory activity into CA1 required intact N-methyl-d-aspartate receptors. These data are more consistent with epileptiform bursting than with theta rhythm described in vivo. In the presence of carbachol, individual CA3 pyramidal cells exhibited a slow, rhythmic intrinsic oscillation that was not blocked by DNQX and that was enhanced by membrane hyperpolarization. We hypothesize that this slower oscillation is the fundamental oscillator that participates in triggering the population oscillation by exciting multiple synaptically connected CA3 neurons. γ-aminobutyric acid-A (GABAA) receptors are not necessary for carbachol to elicit synchronous CA3 field events but are essential to the bursting pattern observed. Neither GABABnor metabotropic glutamate receptors appear to be necessary for carbachol oscillations. However, both nicotinic and M1 and M3 muscarinic cholinergic receptors contribute to the generation of this activity. These results establish the local circuit elements and neurotransmitter receptors that contribute to carbachol-induced oscillations and indicate that carbachol-induced oscillations are fundamentally distinct from theta rhythm in vivo.

Heat shock proteins (Hsps) are known to be induced in response to short-term stress. The present study aimed to evaluate the potential of Hsp70 as a biomarker of stress produced by increased temperature, osmotic pressure, and exposure to cadmium and sodium chloride in marine macroalgae and fresh water plant species. An indirect competitive enzyme-linked immunosorbent assay (IC-ELISA) was developed with a working range of 0.025–10 μgml−1using a monoclonal antibody raised against purified Hsp70 of Phaseolus aureus(mung bean). Fucus serratus(toothed wrack), Chondrus crispus(Stackhouse or Carrageen moss), Ulva lactuca(sea lettuce) and Lemna minor(common duckweed) sample extracts were stressed for up to 24 h and then tested in the IC-ELISA. The presence of Hsp70 and cross-reactivity of the monoclonal antibody was confirmed by Western blot. The heat shock response was confirmed in each species using a 2-h 42°C treatment. Following heat shock, Hsp70 concentrations increased to a peak at 2 h (F. serratus) or 4 h (L. minor), after which concentrations decreased. Osmotic and cadmium stresses also resulted in elevated Hsp70 concentrations in samples of F. serratusand L. minorwhen compared with unstressed controls. In both, osmotic and metal stress, the production of Hsp70 increased to a maximum and subsequently decreased as the stressor levels increased. Results suggest that Hsp70 IC-ELISA could potentially be applied to the detection of stress in these aquatic species, although it would probably be most effective when used in conjunction with other measurements to provide a stressor-specific biomarker profile or fingerprint.

A possible connection between nickel and the pathogenesis of psoriasis is indicated in at least 2 diverse studies.1,2 Bromide absorption has been proposed as a beneficial factor in psoriasis treatment at the Dead Sea, and bromide salts were found to have an antiproliferative effect on cell growth in cultures.3 A pilot study was designed to evaluate the effect of oral nickel and bromide therapy on psoriasis vulgaris. SUBJECTS AND METHODS. This was a 2-period (12 weeks in each period), placebo-controlled, crossover study with a 48-hour washout between periods (the biological half-life of serum nickel ranges from 11-28 hours).4 Patients were evaluated at baseline and every 4 weeks thereafter. Eligible patients with at least 5% body surface area of plaque-type psoriasis were recruited from the clinic (Steven A. Smith, MD, Dermatology PC, Tulsa, Okla) patient database. Patients were instructed to discontinue all psoriasis treatments at least 2 weeks

The article presents photographs of the American Society for Testing Materials's first president Carleton G. Lutts and first vice president John J. Cavanagh, Jr.

Several letters to the editor are presented in response to the article "It all started 40 years ago" in the June 2009 issue, a discussion on the Junior World Orienteering Championships (JWOC) selection and a discussion on the impact of the 1955 Lobethal event in the establishment of Orienteering as a national sport.

A letter to the editor is presented in response to the article "Formerly gay?," by Amy Frykholm, from the May 15, 2007 issue.

A letter to the editor is presented in response to the article "Voters and values," by David Heim in the August 8, 2006 issue.

A letter to the editor is presented in response to the article "Going Catholic" by Jason Byassee, featured in the August 22, 2006 issue.