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49 results on '"Weir, Bruce"'

2. Estimation of Jacquard’s genetic identity coefficients with bi-allelic variants by constrained least-squares

Author

Graffelman, Jan, Weir, Bruce S., and Goudet, Jérôme

Abstract

The Jacquard genetic identity coefficients are of fundamental importance in relatedness research. We address the estimation of these coefficients as well as other relationship parameters that derive from them such as kinship and inbreeding coefficients using a concise matrix framework. Estimation of the Jacquard coefficients via likelihood methods and the expectation–maximization algorithm is computationally very demanding for large numbers of polymorphisms. We propose a constrained least squares approach to estimate the Jacquard coefficients. A simulation study shows constrained least squares achieves root-mean-squared errors that are comparable with those of the maximum likelihood approach, in particular when founder allele frequencies are unknown, while obtaining enormous computational savings.

Published
2025
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3. Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function

Author

Zhang, Yuankai, Liu, Xue, Wiggins, Kerri L., Kurniansyah, Nuzulul, Guo, Xiuqing, Rodrigue, Amanda L., Zhao, Wei, Yanek, Lisa R., Ratliff, Scott M., Pitsillides, Achilleas, Aguirre Patiño, Juan Sebastian, Sofer, Tamar, Arking, Dan E., Austin, Thomas R., Beiser, Alexa S., Blangero, John, Boerwinkle, Eric, Bressler, Jan, Curran, Joanne E., Hou, Lifang, Hughes, Timothy M., Kardia, Sharon L.R., Launer, Lenore J., Levy, Daniel, Mosley, Thomas H., Nasrallah, Ilya M., Rich, Stephen S., Rotter, Jerome I., Seshadri, Sudha, Tarraf, Wassim, González, Kevin A., Ramachandran, Vasan, Yaffe, Kristine, Nyquist, Paul A., Psaty, Bruce M., DeCarli, Charles S., Smith, Jennifer A., Glahn, David C., González, Hector M., Bis, Joshua C., Fornage, Myriam, Heckbert, Susan R., Fitzpatrick, Annette L., Liu, Chunyu, Satizabal, Claudia L., Aguilera, Norma, Ament, Seth, Ammous, Farah, Arnett, Donna K, Becker, Diane, Bis, Joshua, Blue, Elizabeth, Boerwinkle, Eric, Breaux, Camille, Bressler, Jan, Chaar, Dima, MHI, Clarkson-Townsend, Danielle, Cooper, Brigidann, Coresh, Josef, Correa, Adolfo, DeStefano, Anita, Ding, Jingzhong, Fardo, David, Fitzpatrick, Annette, Fornage, Myriam, French, Jennifer, Glahn, David, Gonzalez, Hector, Granot-Hershkovitz, Einat, Hanly, Patrick, Hayden, Kathleen, Heckbert, Susan, Heemann, Scott, Horvath, Steve, Hoth, Karin, Hughes, Timothy, Jaiswal, Sidd, Jian, Xueqiu, Katsumata, Yuriko, Kho, Minjung, Kooperberg, Charles, Launer, Lenore, Lin, Honghuang, Litkowski, Elizabeth, Longstreth, Will, Martin, Alexandra, Mayeux, Richard, Mikulla, Julie, Miller, Amy, Misra, Biswapriya, Mosley, Thomas, Nyquist, Paul, O'Connell, Jeff, Olivier, Michael, Peloso, Gina, Perry, James, Psaty, Bruce, Purcell, Shaun, Raffield, Laura, Ranaweera, Yugandi, Reiner, Alex, Rotter, Jerome, Sargurupremraj, Muralidharan, Sarnowski, Chloé, Satizabal, Claudia, Schellenberg, Gerard, Schoenbein, Bonnie L, Seshadri, Sudha, Shade, Lincoln, Short, Meghan I, Simino, Jeannette, Smith, Jennifer, Smith, Mallorie, Smoller, Sylvia, Snively, Beverly, Soemedi, Rachel, Sokolow, Sophie, Thorington, Daune, Thornton, Timothy A., Yanek, Lisa, Yang, Qiong, Yu, Miao, Zare, Habil, Zhao, Wei, Abecasis, Goncalo, Abhyankar, Avinash, Aldred, Micheala, Arking, Dan, Ashley-Koch, Allison, Aviv, Abraham, Barnes, Kathleen, Barron-Casella, Emily, Battle, Stephanie, Blackwell, Thomas, Burkardt, Deepika, Castellani, Christina A, Comhair, Suzy, Cooper, Brigidann, Correa, Adolfo, Crockett, Phyllis, de Andrade, Mariza, DeMeo, Dawn, DePaoli, Maria Rizzo, Ding, Jun, Dobski, Christine, Erzurum, Serpil, Farha, Samar, Fetterman, Jessica, Floyd, Caitlin, Fu, Mao, Gist, Amber, Granot-Hershkovitz, Einat, Gu, C. Charles, Heemann, Scott, Hernandez, Ryan, Hong, Yun Soo, Hsu, Yi-Hsiang, Justice, Anne, Lange, Leslie, Levy, Dan, Lin, Honghuang, Liu, Chunyu, Longchamps, Ryan, Ma, Jiantao, Manson, JoAnn, Markus, Tammy, McDonald, Merry-Lynn, McGarvey, Stephen, Mikulla, Julie, Montgomery, Courtney, Musunuri, Rajeeva Lochan, O'Connell, Jeff, Oppong, Richard, Pankratz, Nathan, Qian, Yong, Rotter, Jerome, Shaw, Jessica R, Smith, Albert Vernon, Sofer, Tamar, Streeten, Elizabeth, Tang, Weihong, Taylor, Kent D., Telen, Marilyn, Thompson, Shelby, Thorington, Daune, Tiwari, Hemant, Walsh, Ann, Wan, Emily, Wang, Cuicui, Wang, Heming, Wang, Penglong, Weir, Bruce, Williams, L. Keoki, Wilson, James, Xiao, Shujie, Xu, Weiling, Yang, Yu-Chung, and Zhao, Wei

Published
2023
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6. Through the eyes of a 10 year old: for the past decade, Noise Solutions has been keeping a lid on Alberta's boom - and conquering giants on the side

Author

Weir, Bruce

Subjects
Alberta. Energy and Utilities Board -- Laws, regulations and rules, Noise reduction systems (Electronics) -- Product development, Noise reduction systems (Electronics) -- Usage, Noise pollution -- Laws, regulations and rules, Petroleum services industry -- Service development, Petroleum services industry -- History, Petroleum services industry -- Growth, Petroleum industry -- Safety and security measures, Government regulation, Company service development, Company growth, Business, international, Travel, recreation and leisure
Published
2007

7. Measures of human population structure show heterogeneity among genomic regions

Author

Weir, Bruce S., Cardon, Lon R., Anderson, Amy D., Neilsen, Dahlia M., and Hill, William G.

Subjects
Human population genetics -- Research, Chromosomes -- Research, Health
Abstract

An analysis was presented on the estimates of genetic population structure, using three samples and Human Haplotype Map (HapMap) data. The result showed that substantial heterogeneity of genetic population structure values was found between segments within chromosomes, although there was similarity between two data sets.

Published
2005

8. Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Author

Wainschtein, Pierrick, Jain, Deepti, Zheng, Zhili, Cupples, L. Adrienne, Shadyab, Aladdin H., McKnight, Barbara, Shoemaker, Benjamin M., Mitchell, Braxton D., Psaty, Bruce M., Kooperberg, Charles, Liu, Ching-Ti, Albert, Christine M., Roden, Dan, Chasman, Daniel I., Darbar, Dawood, Lloyd-Jones, Donald M., Arnett, Donna K., Regan, Elizabeth A., Boerwinkle, Eric, Rotter, Jerome I., O’Connell, Jeffrey R., Yanek, Lisa R., de Andrade, Mariza, Allison, Matthew A., McDonald, Merry-Lynn N., Chung, Mina K., Fornage, Myriam, Chami, Nathalie, Smith, Nicholas L., Ellinor, Patrick T., Vasan, Ramachandran S., Mathias, Rasika A., Loos, Ruth J. F., Rich, Stephen S., Lubitz, Steven A., Heckbert, Susan R., Redline, Susan, Guo, Xiuqing, Chen, Y. -D Ida, Laurie, Cecelia A., Hernandez, Ryan D., McGarvey, Stephen T., Goddard, Michael E., Laurie, Cathy C., North, Kari E., Lange, Leslie A., Weir, Bruce S., Yengo, Loic, Yang, Jian, and Visscher, Peter M.

Abstract

Analyses of data from genome-wide association studies on unrelated individuals have shown that, for human traits and diseases, approximately one-third to two-thirds of heritability is captured by common SNPs. However, it is not known whether the remaining heritability is due to the imperfect tagging of causal variants by common SNPs, in particular whether the causal variants are rare, or whether it is overestimated due to bias in inference from pedigree data. Here we estimated heritability for height and body mass index (BMI) from whole-genome sequence data on 25,465 unrelated individuals of European ancestry. The estimated heritability was 0.68 (standard error 0.10) for height and 0.30 (standard error 0.10) for body mass index. Low minor allele frequency variants in low linkage disequilibrium (LD) with neighboring variants were enriched for heritability, to a greater extent for protein-altering variants, consistent with negative selection. Our results imply that rare variants, in particular those in regions of low linkage disequilibrium, are a major source of the still missing heritability of complex traits and disease.

Published
2022
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9. From Mendel to quantitative genetics in the genome era: the scientific legacy of W. G. Hill

Author

Charlesworth, Brian, Goddard, Michael E., Meyer, Karin, Visscher, Peter M., Weir, Bruce S., and Wray, Naomi R.

Abstract

The quantitative geneticist W. G. (‘Bill’) Hill, awardee of the 2018 Darwin Medal of the Royal Society and the 2019 Mendel Medal of the Genetics Society (United Kingdom), died on 17 December 2021 at the age of 81 years. Here, we pay tribute to his multiple key scientific contributions, which span population and evolutionary genetics, animal and plant breeding and human genetics. We discuss his theoretical research on the role of linkage disequilibrium (LD) and mutational variance in the response to selection, the origin of the widely used LD metric r2in genomic association studies, the genetic architecture of complex traits, the quantification of the variation in realized relationships given a pedigree relationship and much more. We demonstrate that basic theoretical research in quantitative and statistical genetics has led to profound insights into the genetics and evolution of complex traits and made predictions that were subsequently empirically validated, often decades later.

Published
2022
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10. Rank-invariant estimation of inbreeding coefficients

Author

Zhang, Qian S., Goudet, Jérôme, and Weir, Bruce S.

Abstract

The two alleles an individual carries at a locus are identical by descent (ibd) if they have descended from a single ancestral allele in a reference population, and the probability of such identity is the inbreeding coefficient of the individual. Inbreeding coefficients can be predicted from pedigrees with founders constituting the reference population, but estimation from genetic data is not possible without data from the reference population. Most inbreeding estimators that make explicit use of sample allele frequencies as estimates of allele probabilities in the reference population are confounded by average kinships with other individuals. This means that the ranking of those estimates depends on the scope of the study sample and we show the variation in rankings for common estimators applied to different subdivisions of 1000 Genomes data. Allele-sharing estimators of within-population inbreeding relative to average kinship in a study sample, however, do have invariant rankings across all studies including those individuals. They are unbiased with a large number of SNPs. We discuss how allele sharing estimates are the relevant quantities for a range of empirical applications.

Published
2022
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11. Three artists to watch

Author

Weir, Bruce

Subjects
Artists -- Works, Artists -- Criticism and interpretation, Humanities, Political science
Published
2006

12. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

Author

Taliun, Daniel, Harris, Daniel N., Kessler, Michael D., Carlson, Jedidiah, Szpiech, Zachary A., Torres, Raul, Taliun, Sarah A. Gagliano, Corvelo, André, Gogarten, Stephanie M., Kang, Hyun Min, Pitsillides, Achilleas N., LeFaive, Jonathon, Lee, Seung-been, Tian, Xiaowen, Browning, Brian L., Das, Sayantan, Emde, Anne-Katrin, Clarke, Wayne E., Loesch, Douglas P., Shetty, Amol C., Blackwell, Thomas W., Smith, Albert V., Wong, Quenna, Liu, Xiaoming, Conomos, Matthew P., Bobo, Dean M., Aguet, François, Albert, Christine, Alonso, Alvaro, Ardlie, Kristin G., Arking, Dan E., Aslibekyan, Stella, Auer, Paul L., Barnard, John, Barr, R. Graham, Barwick, Lucas, Becker, Lewis C., Beer, Rebecca L., Benjamin, Emelia J., Bielak, Lawrence F., Blangero, John, Boehnke, Michael, Bowden, Donald W., Brody, Jennifer A., Burchard, Esteban G., Cade, Brian E., Casella, James F., Chalazan, Brandon, Chasman, Daniel I., Chen, Yii-Der Ida, Cho, Michael H., Choi, Seung Hoan, Chung, Mina K., Clish, Clary B., Correa, Adolfo, Curran, Joanne E., Custer, Brian, Darbar, Dawood, Daya, Michelle, de Andrade, Mariza, DeMeo, Dawn L., Dutcher, Susan K., Ellinor, Patrick T., Emery, Leslie S., Eng, Celeste, Fatkin, Diane, Fingerlin, Tasha, Forer, Lukas, Fornage, Myriam, Franceschini, Nora, Fuchsberger, Christian, Fullerton, Stephanie M., Germer, Soren, Gladwin, Mark T., Gottlieb, Daniel J., Guo, Xiuqing, Hall, Michael E., He, Jiang, Heard-Costa, Nancy L., Heckbert, Susan R., Irvin, Marguerite R., Johnsen, Jill M., Johnson, Andrew D., Kaplan, Robert, Kardia, Sharon L. R., Kelly, Tanika, Kelly, Shannon, Kenny, Eimear E., Kiel, Douglas P., Klemmer, Robert, Konkle, Barbara A., Kooperberg, Charles, Köttgen, Anna, Lange, Leslie A., Lasky-Su, Jessica, Levy, Daniel, Lin, Xihong, Lin, Keng-Han, Liu, Chunyu, Loos, Ruth J. F., Garman, Lori, Gerszten, Robert, Lubitz, Steven A., Lunetta, Kathryn L., Mak, Angel C. Y., Manichaikul, Ani, Manning, Alisa K., Mathias, Rasika A., McManus, David D., McGarvey, Stephen T., Meigs, James B., Meyers, Deborah A., Mikulla, Julie L., Minear, Mollie A., Mitchell, Braxton D., Mohanty, Sanghamitra, Montasser, May E., Montgomery, Courtney, Morrison, Alanna C., Murabito, Joanne M., Natale, Andrea, Natarajan, Pradeep, Nelson, Sarah C., North, Kari E., O’Connell, Jeffrey R., Palmer, Nicholette D., Pankratz, Nathan, Peloso, Gina M., Peyser, Patricia A., Pleiness, Jacob, Post, Wendy S., Psaty, Bruce M., Rao, D. C., Redline, Susan, Reiner, Alexander P., Roden, Dan, Rotter, Jerome I., Ruczinski, Ingo, Sarnowski, Chloé, Schoenherr, Sebastian, Schwartz, David A., Seo, Jeong-Sun, Seshadri, Sudha, Sheehan, Vivien A., Sheu, Wayne H., Shoemaker, M. Benjamin, Smith, Nicholas L., Smith, Jennifer A., Sotoodehnia, Nona, Stilp, Adrienne M., Tang, Weihong, Taylor, Kent D., Telen, Marilyn, Thornton, Timothy A., Tracy, Russell P., Van Den Berg, David J., Vasan, Ramachandran S., Viaud-Martinez, Karine A., Vrieze, Scott, Weeks, Daniel E., Weir, Bruce S., Weiss, Scott T., Weng, Lu-Chen, Willer, Cristen J., Zhang, Yingze, Zhao, Xutong, Arnett, Donna K., Ashley-Koch, Allison E., Barnes, Kathleen C., Boerwinkle, Eric, Gabriel, Stacey, Gibbs, Richard, Rice, Kenneth M., Rich, Stephen S., Silverman, Edwin K., Qasba, Pankaj, Gan, Weiniu, Papanicolaou, George J., Nickerson, Deborah A., Browning, Sharon R., Zody, Michael C., Zöllner, Sebastian, Wilson, James G., Cupples, L. Adrienne, Laurie, Cathy C., Jaquish, Cashell E., Hernandez, Ryan D., O’Connor, Timothy D., and Abecasis, Gonçalo R.

Abstract

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of improving diagnosis, treatment and prevention of these diseases. The initial phases of the programme focused on whole-genome sequencing of individuals with rich phenotypic data and diverse backgrounds. Here we describe the TOPMed goals and design as well as the available resources and early insights obtained from the sequence data. The resources include a variant browser, a genotype imputation server, and genomic and phenotypic data that are available through dbGaP (Database of Genotypes and Phenotypes)1. In the first 53,831 TOPMed samples, we detected more than 400 million single-nucleotide and insertion or deletion variants after alignment with the reference genome. Additional previously undescribed variants were detected through assembly of unmapped reads and customized analysis in highly variable loci. Among the more than 400 million detected variants, 97% have frequencies of less than 1% and 46% are singletons that are present in only one individual (53% among unrelated individuals). These rare variants provide insights into mutational processes and recent human evolutionary history. The extensive catalogue of genetic variation in TOPMed studies provides unique opportunities for exploring the contributions of rare and noncoding sequence variants to phenotypic variation. Furthermore, combining TOPMed haplotypes with modern imputation methods improves the power and reach of genome-wide association studies to include variants down to a frequency of approximately 0.01%.

Published
2021
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13. Whole Genome Sequencing Identifies CRISPLD2as a Lung Function Gene in Children With Asthma

Author

Kachroo, Priyadarshini, Hecker, Julian, Chawes, Bo L., Ahluwalia, Tarunveer S., Cho, Michael H., Qiao, Dandi, Kelly, Rachel S., Chu, Su H., Virkud, Yamini V., Huang, Mengna, Barnes, Kathleen C., Burchard, Esteban G., Eng, Celeste, Hu, Donglei, Celedón, Juan C., Daya, Michelle, Levin, Albert M., Gui, Hongsheng, Williams, L. Keoki, Forno, Erick, Mak, Angel C.Y., Avila, Lydiana, Soto-Quiros, Manuel E., Cloutier, Michelle M., Acosta-Pérez, Edna, Canino, Glorisa, Bønnelykke, Klaus, Bisgaard, Hans, Raby, Benjamin A., Lange, Christoph, Weiss, Scott T., Lasky-Su, Jessica A., Abe, Namiko, Abecasis, Goncalo, Albert, Christine, Palmer Allred, Nicholette (Nichole), Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Arking, Dan, Arnett, Donna K., Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Barnard, John, Barnes, Kathleen, Barr, R. Graham, Barron-Casella, Emily, Beaty, Terri, Becker, Diane, Becker, Lewis, Beer, Rebecca, Begum, Ferdouse, Beitelshees, Amber, Benjamin, Emelia, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Boerwinkle, Eric, Borecki, Ingrid, Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Bunting, Karen, Burchard, Esteban, Cardwell, Jonathan, Carty, Cara, Casaburi, Richard, Casella, James, Chaffin, Mark, Chang, Christy, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Chen, Yii-Der Ida, Cho, Michael H., Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L. Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, Das, Sayantan, David, Sean, Davis, Colleen, Daya, Michelle, de Andrade, Mariza, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Do, Ron, Duan, Qing, Duggirala, Ravi, Durda, Peter, Dutcher, Susan, Eaton, Charles, Ekunwe, Lynette, Ellinor, Patrick, Emery, Leslie, Farber, Charles, Farnam, Leanna, Fingerlin, Tasha, Flickinger, Matthew, Fornage, Myriam, Franceschini, Nora, Fu, Mao, Fullerton, Stephanie M., Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Yan, Gass, Margery, Gelb, Bruce, Geng, Xiaoqi (Priscilla), Germer, Soren, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gogarten, Stephanie, Gong, Da-Wei, Goring, Harald, Gu, C. Charles, Guan, Yue, Guo, Xiuqing, Haessler, Jeff, Hall, Michael, Harris, Daniel, Hawley, Nicola, He, Jiang, Heavner, Ben, Heckbert, Susan, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hixson, James, Hokanson, John, Holly, Kramer, Hong, Elliott, Hoth, Karin, (Agnes) Hsiung, Chao, Huston, Haley, Hwu, Chii Min, Irvin, Marguerite Ryan, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Jhun, Min A., Johnsen, Jill, Johnson, Andrew, Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kachroo, Priyadarshini, Kang, Hyun Min, Kaplan, Robert, Kardia, Sharon, Kathiresan, Sekar, Kaufman, Laura, Kelly, Shannon, Kenny, Eimear, Kessler, Michael, Khan, Alyna, Kinney, Greg, Konkle, Barbara, Kooperberg, Charles, Krauter, Stephanie, Lange, Christoph, Lange, Ethan, Lange, Leslie, Laurie, Cathy, Laurie, Cecelia, LeBoff, Meryl, Lee, Seunggeun Shawn, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Levy, Dan, Lewis, Joshua, Li, Yun, Lin, Honghuang, Lin, Keng Han, Liu, Simin, Liu, Yongmei, Loos, Ruth, Lubitz, Steven, Lunetta, Kathryn, Luo, James, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Manson, JoAnn, Margolin, Lauren, Martin, Lisa, Mathai, Susan, Mathias, Rasika, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGarvey, Stephen, Mei, Hao, Meyers, Deborah A., Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L., Mitchell, Braxton, Montasser, May E., Musani, Solomon, Mwasongwe, Stanford, Mychaleckyj, Josyf C., Nadkarni, Girish, Naik, Rakhi, Natarajan, Pradeep, Nekhai, Sergei, Nickerson, Deborah, North, Kari, O'Connell, Jeff, O'Connor, Tim, Ochs-Balcom, Heather, Pankow, James, Papanicolaou, George, Parker, Margaret, Parsa, Afshin, Penchev, Sara, Peralta, Juan Manuel, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Lawrence S., Phillips, Sam, Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Prokopenko, Dmitry, Psaty, Bruce, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rafaels, Nicholas, Raffield, Laura, Ramachandran, Vasan, Rao, D.C., Rasmussen-Torvik, Laura, Ratan, Aakrosh, Redline, Susan, Reed, Robert, Regan, Elizabeth, Reiner, Alex, Rice, Ken, Rich, Stephen, Roden, Dan, Roselli, Carolina, Rotter, Jerome, Ruczinski, Ingo, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Sakornsakolpat, Phuwanat, Salimi, Shabnam, Salzberg, Steven, Sandow, Kevin, Sankaran, Vijay, Scheller, Christopher, Schmidt, Ellen, Schwander, Karen, Schwartz, David, Sciurba, Frank, Seidman, Christine, Seidman, Jonathan, Sheehan, Vivien, Shetty, Amol, Shetty, Aniket, Sheu, Wayne Hui-Heng, Shoemaker, M. Benjamin, Silver, Brian, Silverman, Edwin, Smith, Jennifer, Smith, Josh, Smith, Nicholas, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne, Streeten, Elizabeth, Sung, Yun Ju, Su-Lasky, Jessica, Sylvia, Jody, Szpiro, Adam, Sztalryd, Carole, Taliun, Daniel, Tang, Hua, Taub, Margaret, Taylor, Kent, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Tinker, Lesley, Tirschwell, David, Tiwari, Hemant, Tracy, Russell, Tsai, Michael, Vaidya, Dhananjay, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wan, Emily, Wang, Fei Fei, Watson, Karol, Weeks, Daniel E., Weir, Bruce, Weiss, Scott, Weng, Lu-Chen, Willer, Cristen, Williams, Kayleen, Williams, L. Keoki, Wilson, Carla, Wilson, James, Wong, Quenna, Xu, Huichun, Yanek, Lisa, Yang, Ivana, Yang, Rongze, Zaghloul, Norann, Zekavat, Maryam, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zheng, Xiuwen, Zhi, Degui, Zhou, Xiang, Zody, Michael, and Zoellner, Sebastian

Abstract

Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to use whole genome sequencing (WGS) data to identify regions of common genetic variation contributing to lung function in individuals with a diagnosis of asthma.

Published
2019
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14. A genetic-association study of circulating coagulation factor VIII and von Willebrand factor levels

Author

de Vries, Paul S., Reventun, Paula, Brown, Michael R., Heath, Adam S., Huffman, Jennifer E., Le, Ngoc-Quynh, Bebo, Allison, Brody, Jennifer A., Temprano-Sagrera, Gerard, Raffield, Laura M., Ozel, Ayse Bilge, Thibord, Florian, Jain, Deepti, Lewis, Joshua P., Rodriguez, Benjmain A. T., Pankratz, Nathan, Taylor, Kent D., Polasek, Ozren, Chen, Ming-Huei, Yanek, Lisa R., Carrasquilla, German D., Marioni, Riccardo E., Kleber, Marcus E., Trégouët, David-Alexandre, Yao, Jie, Li-Gao, Ruifang, Joshi, Peter K., Trompet, Stella, Martinez-Perez, Angel, Ghanbari, Mohsen, Howard, Tom E., Reiner, Alex P., Arvanitis, Marios, Ryan, Kathleen A., Bartz, Traci M., Rudan, Igor, Faraday, Nauder, Linneberg, Allan, Ekunwe, Lynette, Davies, Gail, Delgado, Graciela E., Suchon, Pierre, Guo, Xiuqing, Rosendaal, Frits R., Klaric, Lucija, Noordam, Raymond, van Rooij, Frank, Curran, Joanne E., Wheeler, Marsha M., Osburn, William O., O'Connell, Jeffrey R., Boerwinkle, Eric, Beswick, Andrew, Psaty, Bruce M., Kolcic, Ivana, Souto, Juan Carlos, Becker, Lewis C., Hansen, Torben, Doyle, Margaret F., Harris, Sarah E., Moissl, Angela P., Deleuze, Jean-François, Rich, Stephen S., van Hylckama Vlieg, Astrid, Campbell, Harry, Stott, David J., Soria, Jose Manuel, de Maat, Moniek P. M., Almasy, Laura, Brody, Lawrence C., Auer, Paul L., Abe, Namiko, Abecasis, Gonçalo, Aguet, Francois, Albert, Christine, Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Ardlie, Kristin, Arking, Dan, Arnett, Donna K, Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Ayas, Najib, Balasubramanian, Adithya, Barnard, John, Barnes, Kathleen, Barr, R. Graham, Barron-Casella, Emily, Barwick, Lucas, Beaty, Terri, Beck, Gerald, Becker, Diane, Becker, Lewis, Beer, Rebecca, Beitelshees, Amber, Benjamin, Emelia, Benos, Takis, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Blue, Nathan, Boerwinkle, Eric, Bowden, Donald W., Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Brown, Deborah, Bunting, Karen, Burchard, Esteban, Bustamante, Carlos, Buth, Erin, Cade, Brian, Cardwell, Jonathan, Carey, Vincent, Carrier, Julie, Carson, April P., Carty, Cara, Casaburi, Richard, Casas Romero, Juan P, Casella, James, Castaldi, Peter, Chaffin, Mark, Chang, Christy, Chang, Yi-Cheng, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Ida Chen, Yii-Der, Cho, Michael, Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Chung, Ren-Hua, Clish, Clary, Comhair, Suzy, Conomos, Matthew, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L. Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, David, Sean, Davis, Colleen, Daya, Michelle, de Andrade, Mariza, de las Fuentes, Lisa, de Vries, Paul, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Dinh, Huyen, Doddapaneni, Harsha, Duan, Qing, Dugan-Perez, Shannon, Duggirala, Ravi, Durda, Jon Peter, Dutcher, Susan K., Eaton, Charles, Ekunwe, Lynette, El Boueiz, Adel, Ellinor, Patrick, Emery, Leslie, Erzurum, Serpil, Farber, Charles, Farek, Jesse, Fingerlin, Tasha, Flickinger, Matthew, Fornage, Myriam, Franceschini, Nora, Frazar, Chris, Fu, Mao, Fullerton, Stephanie M., Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Shanshan, Gao, Yan, Gass, Margery, Geiger, Heather, Gelb, Bruce, Geraci, Mark, Germer, Soren, Gerszten, Robert, Ghosh, Auyon, Gibbs, Richard, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gogarten, Stephanie, Gong, Da-Wei, Goring, Harald, Graw, Sharon, Gray, Kathryn J., Grine, Daniel, Gross, Colin, Gu, C. Charles, Guan, Yue, Guo, Xiuqing, Gupta, Namrata, Haessler, Jeff, Hall, Michael, Han, Yi, Hanly, Patrick, Harris, Daniel, Hawley, Nicola L., He, Jiang, Heavner, Ben, Heckbert, Susan, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hixson, James, Hobbs, Brian, Hokanson, John, Hong, Elliott, Hoth, Karin, Hsiung, Chao (Agnes), Hu, Jianhong, Hung, Yi-Jen, Huston, Haley, Hwu, Chii Min, Irvin, Marguerite Ryan, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Johnsen, Jill, Johnson, Andrew, Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kang, Hyun Min, Kaplan, Robert, Kardia, Sharon, Kelly, Shannon, Kenny, Eimear, Kessler, Michael, Khan, Alyna, Khan, Ziad, Kim, Wonji, Kimoff, John, Kinney, Greg, Konkle, Barbara, Kooperberg, Charles, Kramer, Holly, Lange, Christoph, Lange, Ethan, Lange, Leslie, Laurie, Cathy, Laurie, Cecelia, LeBoff, Meryl, Lee, Jiwon, Lee, Sandra, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Levy, Dan, Lewis, Joshua, Li, Xiaohui, Li, Yun, Lin, Henry, Lin, Honghuang, Lin, Xihong, Liu, Simin, Liu, Yongmei, Liu, Yu, Loos, Ruth J. F., Lubitz, Steven, Lunetta, Kathryn, Luo, James, Magalang, Ulysses, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Manning, Alisa, Manson, JoAnn, Martin, Lisa, Marton, Melissa, Mathai, Susan, Mathias, Rasika, May, Susanne, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGarvey, Stephen, McGoldrick, Daniel, McHugh, Caitlin, McNeil, Becky, Mei, Hao, Meigs, James, Menon, Vipin, Mestroni, Luisa, Metcalf, Ginger, Meyers, Deborah A, Mignot, Emmanuel, Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L, Mitchell, Braxton D., Moll, Matt, Momin, Zeineen, Montasser, May E., Montgomery, Courtney, Muzny, Donna, Mychaleckyj, Josyf C, Nadkarni, Girish, Naik, Rakhi, Naseri, Take, Natarajan, Pradeep, Nekhai, Sergei, Nelson, Sarah C., Neltner, Bonnie, Nessner, Caitlin, Nickerson, Deborah, Nkechinyere, Osuji, North, Kari, O'Connell, Jeff, O'Connor, Tim, Ochs-Balcom, Heather, Okwuonu, Geoffrey, Pack, Allan, Paik, David T., Palmer, Nicholette, Pankow, James, Papanicolaou, George, Parker, Cora, Peloso, Gina, Peralta, Juan Manuel, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Lawrence S, Pleiness, Jacob, Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Psaty, Bruce, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rafaels, Nicholas, Raffield, Laura, Rajendran, Mahitha, Ramachandran, Vasan S., Rao, D. C., Rasmussen-Torvik, Laura, Ratan, Aakrosh, Redline, Susan, Reed, Robert, Reeves, Catherine, Regan, Elizabeth, Reiner, Alex, Reupena, Muagututi‘a Sefuiva, Rice, Ken, Rich, Stephen, Robillard, Rebecca, Robine, Nicolas, Roden, Dan, Roselli, Carolina, Rotter, Jerome, Ruczinski, Ingo, Runnels, Alexi, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Sabino, Ester Cerdeira, Saleheen, Danish, Salimi, Shabnam, Salvi, Sejal, Salzberg, Steven, Sandow, Kevin, Sankaran, Vijay G., Santibanez, Jireh, Schwander, Karen, Schwartz, David, Sciurba, Frank, Seidman, Christine, Seidman, Jonathan, Sériès, Frédéric, Sheehan, Vivien, Sherman, Stephanie L., Shetty, Amol, Shetty, Aniket, Hui-Heng Sheu, Wayne, Shoemaker, M. Benjamin, Silver, Brian, Silverman, Edwin, Skomro, Robert, Smith, Albert Vernon, Smith, Jennifer, Smith, Josh, Smith, Nicholas, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Snyder, Michael, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne M., Storm, Garrett, Streeten, Elizabeth, Su, Jessica Lasky, Sung, Yun Ju, Sylvia, Jody, Szpiro, Adam, Taliun, Daniel, Tang, Hua, Taub, Margaret, Taylor, Kent D., Taylor, Matthew, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Threlkeld, Machiko, Tinker, Lesley, Tirschwell, David, Tishkoff, Sarah, Tiwari, Hemant, Tong, Catherine, Tracy, Russell, Tsai, Michael, Vaidya, Dhananjay, Van Den Berg, David, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wang, Fei Fei, Wang, Heming, Wang, Jiongming, Watson, Karol, Watt, Jennifer, Weeks, Daniel E., Weinstock, Joshua, Weir, Bruce, Weiss, Scott T, Weng, Lu-Chen, Wessel, Jennifer, Willer, Cristen, Williams, Kayleen, Williams, L. Keoki, Wilson, Carla, Wilson, James, Winterkorn, Lara, Wong, Quenna, Wu, Joseph, Xu, Huichun, Yanek, Lisa, Yang, Ivana, Yu, Ketian, Zekavat, Seyedeh Maryam, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zhu, Xiaofeng, Ziv, Elad, Zody, Michael, Zoellner, Sebastian, Lindstrom, Sara, Wang, Lu, Smith, Erin N., Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A., Pattee, Jack W., Haessler, Jeffrey, Brumpton, Ben M., Chasman, Daniel I., Suchon, Pierre, Chen, Ming-Huei, Turman, Constance, Germain, Marine, Wiggins, Kerri L., MacDonald, James, Braekkan, Sigrid K., Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rabecca D., Nielsen, Jonas B., Giulianini, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Bammler, Theo K., Frazer, Kelly A., McCauley, Bryan M., Taylor, Kent, Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken E., Deleuze, Jean-François, O'Donnell, Chris J., Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R., Heit, John A., Psaty, Bruce M., Tang, Weihong, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M., Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, AlexandreTrégouët, David, Smith, Nicholas L., Mitchell, Braxton D., Ben-Shlomo, Yoav, Fornage, Myriam, Hayward, Caroline, Mathias, Rasika A., Kilpeläinen, Tuomas O., Lange, Leslie A., Cox, Simon R., März, Winfried, Morange, Pierre-Emmanuel, Rotter, Jerome I., Mook-Kanamori, Dennis O., Wilson, James F., van der Harst, Pim, Jukema, J. Wouter, Ikram, M. Arfan, Blangero, John, Kooperberg, Charles, Desch, Karl C., Johnson, Andrew D., Sabater-Lleal, Maria, Lowenstein, Charles J., Smith, Nicholas L., and Morrison, Alanna C.

Abstract

•We identified 7 new genetic regions for factor VIII levels, 1 for von Willebrand factor levels, and 3 in a combined analysis.•Silencing B3GNT2and CD36reduced factor VIII release in vitro.Silencing B3GNT2, CD36, and PDIA3reduced von Willebrand factor release.

Published
2024
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16. An APOOPseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels

Author

Montasser, May E., O’Hare, Elizabeth A., Wang, Xiaochun, Howard, Alicia D., McFarland, Rebecca, Perry, James A., Ryan, Kathleen A., Rice, Kenneth, Jaquish, Cashell E., Shuldiner, Alan R., Miller, Michael, Mitchell, Braxton D., Zaghloul, Norann A., Chang, Yen-Pei C., Abe, Namiko, Abecasis, Goncalo, Albert, Christine, Allred, Nicholette P., Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Debora, Arking, Dan, Arnett, Donna K, Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Barnard, John, Barnes, Kathleen, Graham Barr, R., Barron-Casella, Emily, Beaty, Terri, Becker, Diane, Becker, Lewis, Beer, Rebecca, Begum, Ferdouse, Beitelshees, Amber, Benjamin, Emelia, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Boerwinkle, Eric, Borecki, Ingrid, Bowler, Russel, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Bunting, Karen, Burchard, Esteban, Cardwell, Jonathan, Carlson, Sara, Carty, Cara, Casaburi, Richard, Casella, James, Chaffin, Mark, Chang, Christy, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Ida Chen, Yii-Der, Cho, Michael, Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, Das, Sayantan, David, Sean, Davis, Colleen, Daya, Michelle, de Andrade, Mariza, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Do, Ron, Duan, Qing, Duggirala, Ravi, Durda, Peter, Dutcher, Susan, Eaton, Charles, Ekunwe, Lynette, Ellinor, Patrick, Emery, Leslie, Farber, Charles, Farnam, Leanna, Fingerlin, Tasha, Flickinger, Matthew, Fornage, Myriam, Franceschini, Nora, Fu, Mao, Fullerton, Malia, Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Yan, Gass, Margery, Gelb, Bruce, Geng, Xiaoqi (Priscilla), Germer, Soren, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gogarten, Stephanie, Gong, Da-Wei, Goring, Harald, Charles Gu, C., Guan, Yue, Guo, Xiuqing, Haessler, Jeff, Hall, Michael, Harris, Daniel, Hawley, Nicola, He, Jiang, Heavner, Ben, Heckbert, Susan, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hixson, James, Hokanson, John, Hong, Elliott, Hoth, Karin, Hsiung, Chao (Agnes), Huston, Haley, Hwu, Chii Min, Irvin, Marguerite, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Jhun, Min A, Johnsen, Jill, Johnson, Andrew, Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kang, Hyun Min, Kaplan, Robert, Kardia, Sharon, Kathiresan, Sekar, Kaufman, Laura, Kelly, Shannon, Kenny, Eimear, Kessler, Michael, Khan, Alyna, Kinney, Greg, Konkle, Barbara, Kooperberg, Charles, Kramer, Holly, Krauter, Stephanie, Lange, Christoph, Lange, Ethan, Lange, Leslie, Laurie, Cathy, Laurie, Cecelia, LeBoff, Meryl, Lee, Seunggeun, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Levy, Dan, Lewis, Joshua, Li, Yun, Lin, Honghuang, Lin, Keng Han, Liu, Simin, Liu, Yongmei, Loos, Ruth, Lunetta, Kathryn, Luo, James, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Manson, JoAnn, Margolin, Lauren, Martin, Lisa, Mathai, Susan, Mathias, Rasika, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGarvey, Stephen, Mei, Hao, Meyers, Deborah, Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L, Mitchell, Braxton, Musani, Solomon, Mwasongwe, Stanford, Mychaleckyj, Josyf C, Nadkarni, Girish, Naik, Rakhi Johns, Natarajan, Pradeep, Nekhai, Sergei, Nickerson, Deborah, North, Kari, O’Connell, Jeff, O’Connor, Tim, Heather, Ochs-Balcom, Pankow, James, Papanicolaou, George, Parker, Margaret, Parsa, Afshin, Pattison, Jessica Tangarone, Penchev, Sara, Peralta, Juan Manuel, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Larry, Phillips, Sam, Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Prokopenko, Dmitry, Psaty, Bruce, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rafaels, Nicholas, Raffield, Laura, Ramachandran, Vasan, Rao, D.C., Rasmussen-Torvik, Laura, Ratan, Aakrosh, Redline, Susan, Reed, Robert, Regan, Elizabeth, Reiner, Alex, Rice, Ken, Rich, Stephen, Roden, Dan, Roselli, Carolina, Rotter, Jerome, Ruczinski, Ingo, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Sakornsakolpat, Phuwanat, Salimi, Shabnam, Salzberg, Steven, Sandow, Kevin, Sankaran, Vijay, Scheller, Christopher, Schmidt, Ellen, Schwander, Karen, Schwartz, David, Sciurba, Frank, Seidman, Christine, Sheehan, Vivien, Shetty, Amol, Shetty, Aniket, Hui-Heng Sheu, Wayne, Benjamin Shoemaker, M., Silver, Brian, Silverman, Edwin, Smith, Jennifer, Smith, Josh, Smith, Nicholas, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne, Streeten, Elizabeth, Sung, Yun Ju, Sylvia, Jody, Szpiro, Adam, Sztalryd, Carole, Taliun, Daniel, Tang, Hua, Taub, Margaret, Taylor, Kent, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Tinker, Lesley, Tirschwell, David, Tiwari, Hemant, Tracy, Russell, Tsai, Michael, Vaidya, Dhananjay, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wan, Emily, Fei Wang, Fei, Watson, Karol, Weeks, Daniel E., Weir, Bruce, Weiss, Scott, Weng, Lu-Chen, Willer, Cristen, Williams, Kayleen, Keoki Williams, L., Wilson, Carla, Wilson, James, Wong, Quenna, Xu, Huichun, Yanek, Lisa, Yang, Ivana, Yang, Rongze, Zaghloul, Norann, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zheng, Xiuwen, Zhi, Degui, Zhou, Xiang, Zody, Michael, and Zoellner, Sebastian

Abstract

Supplemental Digital Content is available in the text.

Published
2018
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17. The sexy apps: two young Calgarians are proving that GPS applications don't have to be dull

Author

Weir, Bruce

Subjects
CSI Wireless Inc. -- Product development, Global Positioning System -- Usage, Global Positioning System -- Product development, Theft -- Prevention, Telecommunications equipment industry -- Product development, Global Positioning System, Telecommunications equipment industry, Business, international, Travel, recreation and leisure
Published
2008

18. Ralph Hedlin: Collector and champion of western Canadian art

Author

Weir, Bruce

Subjects
Western Canada -- Social aspects, Hedlin, Ralph -- Biography, Hedlin, Ralph -- Donations, Art, Canadian -- Collections and collecting, Personality profile, Humanities, Political science, Glenbow Museum -- Collections and collecting
Published
2004

19. Modern Methods of DNA Interpretation.

Author

Curran, James M. and Weir, Bruce S.

Subjects
*DNA fingerprinting, *GENEALOGY, *ALLELES, *DNA, *CHARTS, diagrams, etc.
Abstract

The article focuses on deoxyribonucleic acid (DNA) fingerprinting and its forensic application. Topics discussed are genetic fingerprinting discovered by professor Alec Jeffreys in 1984, statistical representation of DNA evidence considering the randomness with which parents transmit genes to their children, and glossary of related words and charts and graphs related to sequence of allele and electropherogram of DNA.

Published
2016
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21. Three major haplotypes of the β2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorderPlease cite this article as follows: Diatchenko L, Anderson AD, Slade GD, Fillingim RB, Shabalina SA, Higgins TJ, Sama S, Belfer I, Goldman D, Max MB, Weir BS, Maixner W. 2006. Three Major Haplotypes of the β2 Adrenergic Receptor Define Psychological Profile, Blood Pressure, and the Risk for Development of a Common Musculoskeletal Pain Disorder. Am J Med Genet Part B 141B:449–462.

Author

Diatchenko, Luda, Anderson, Amy D., Slade, Gary D., Fillingim, Roger B., Shabalina, Svetlana A., Higgins, Tomas J., Sama, Swetha, Belfer, Inna, Goldman, David, Max, Mitchell B., Weir, Bruce S., and Maixner, William

Abstract

Adrenergic receptor β2 (ADRB2) is a primary target for epinephrine. It plays a critical role in mediating physiological and psychological responses to environmental stressors. Thus, functional genetic variants of ADRB2 will be associated with a complex array of psychological and physiological phenotypes. These genetic variants should also interact with environmental factors such as physical or emotional stress to produce a phenotype vulnerable to pathological states. In this study, we determined whether common genetic variants of ADRB2 contribute to the development of a common chronic pain condition that is associated with increased levels of psychological distress and low blood pressure, factors which are strongly influenced by the adrenergic system. We genotyped 202 female subjects and examined the relationships between three major ADRB2 haplotypes and psychological factors, resting blood pressure, and the risk of developing a chronic musculoskeletal pain condition—Temporomandibular Joint Disorder (TMD). We propose that the first haplotype codes for lower levels of ADRB2 expression, the second haplotype codes for higher ADRB2 expression, and the third haplotype codes for higher receptor expression and rapid agonist‐induced internalization. Individuals who carried one haplotype coding for high and one coding for low ADRB2 expression displayed the highest positive psychological traits, had higher levels of resting arterial pressure, and were about 10 times less likely to develop TMD. Thus, our data suggest that either positive or negative imbalances in ADRB2 function increase the vulnerability to chronic pain conditions such as TMD through different etiological pathways that imply the need for tailored treatment options. © 2006 Wiley‐Liss, Inc.

Published
2006
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22. It was one of my brothers

Author

Anderson, Amy and Weir, Bruce

Abstract

Abstract: When DNA evidence is used to implicate a suspect, it may be of interest to know whether it is likely that the suspect's near relatives also share the suspect's DNA profile. In this study we discuss methods for evaluating the probability that at least one of a set of the suspect's full or half-siblings shares the suspect's DNA profile. We present three such methods: exact calculation, estimation via Monte Carlo simulations, and estimation by means of sandwiching the probability between an upper and a lower bound. We show that, under many circumstances, this upper bound itself provides an extremely quick and accurate estimate of the probability that at least one of the relatives matches the suspect's profile.

Published
2006
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23. Optimal testing strategies for large, sparse multinomial models

Author

Maiste, Paul J. and Weir, Bruce S.

Subjects
*CONTINGENCY tables, *DISTRIBUTION (Probability theory), *MATHEMATICAL statistics, *STATISTICAL hypothesis testing
Abstract

Much has been written in the literature on testing for independence in contingency tables. A number of related topics have been studied, including the choice of test statistic, the appropriateness of asymptotic results versus exact tests, and the use of conditional or unconditional analyses. Much of the work to date has focused on relatively small contingency tables.The literature on testing for Hardy–Weinberg equilibrium (HWE) is substantive as well. Most of the focus to date has been on loci with relatively small numbers of alleles. The increased use of genetic markers with large numbers of alleles (e.g., forensic DNA profiling) is quickly dating this previous work. The size of the multinomial vectors under consideration grows quickly. Even relatively large samples will produce somewhat sparse multinomial data sets with small expected frequencies, calling asymptotic results into question.In the face of large, sparse multinomials, we provide a comprehensive comparison of test statistics and testing strategies (asymptotic versus exact, conditional versus unconditional) to test for independence (i.e., the presence of HWE) at one locus with many alleles. Attained significance level and power are evaluated. We find that Fisher''s exact test is most appropriate for small samples, and the asymptotic chi-square goodness-of-fit statistic works well with large samples, relative to the number of multinomial categories. The log-likelihood ratio statistic performs poorly. [Copyright &y& Elsevier]

Published
2004
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24. Assessing Sources of Variability in Microarray Gene Expression Data

Author

Spruill, Susan E., Lu, Jun, Hardy, Sarah, and Weir, Bruce

Abstract

Experiments using microarrays abound in genomic research, yet one factor remains in question. Without replication, how much stock can we put into the findings of microarray experiments? In addition, there is a growing desire to integrate microarray data with other molecular databases. To accomplish this in a scientifically acceptable manner, we must be able to measure the validity and quality of microarray data. Otherwise, it would be the weakest link in any integration process. Validating and evaluating the quality of data requires the ability to determine the reproducibility of results. Data obtained from a microarray experiment designed as a feasibility test provided a unique opportunity to partition and quantify several sources of variation that are likely to be present in most microarray experiments. We use this opportunity to discuss the origins of variability observed in microarray experiments and provide some suggestions for how to minimize or avoid them when designing an experiment.

Published
2002
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25. A systematic statistical linear modeling approach to oligonucleotide array experiments

Author

Chu, Tzu-Ming, Weir, Bruce, and Wolfinger, Russ

Subjects
*GENES, *CELL lines
Abstract

We outline and describe steps for a statistically rigorous approach to analyzing probe-level Affymetrix GeneChip data. The approach employs classical linear mixed models and operates on a gene-by-gene basis. Forgoing any attempts at gene presence or absence calls, the method simultaneously considers the data across all chips in an experiment. Primary output includes precise estimates of fold change (some as low as 1.1), their statistical significance, and measures of array and probe variability. The method can accommodate complex experiments involving many kinds of treatments and can test for their effects at the probe level. Furthermore, mismatch probe data can be incorporated in different ways or ignored altogether. Data from an ionizing radiation experiment on human cell lines illustrate the key concepts. [Copyright &y& Elsevier]

Published
2002
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26. Prenatal diagnosis and linkage disequilibrium with cystic fibrosis for markers surrounding D7S8

Author

Dean, Michael, Amos, Jean A., Lynch, Jennifer, Romeo, Giovanni, Devoto, Marcella, Ward, Ken, Halley, Dicky, Oostra, Ben, Ferrari, Maurizio, Russo, Silvia, Weir, Bruce S., Finn, Paula B., Collins, Francis S., and Iannuzzi, Michael C.

Abstract

Three polymorphic DNA markers surrounding the D7S8 locus were tested for their usefulness in the diagnosis of cystic fibrosis (CF) by linkage analysis. The markers correspond to the loci D7S424 and D7S426. These polymorphisms were studied by centers in the U.S., the United Kingdom, the Netherlands, and Italy, using samples from populations throughout Europe and North America. The additional information provided by these probes increased the heterogeneity of the region from 50% to 58% and was essential for a completely informative diagnosis in one family. A very high degree of linkage disequilibrium was found between these markers, which span a distance of approximately 250kb. In addition, linkage disequilibrium with CF was noted. Significant heterogeneity of linkage disequilibrium was found among the populations, both for the marker-marker pairs and between the markers and CF.

Published
1990
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27. DNA statistics in the Simpson matter

Author

Weir, Bruce S.

Abstract

On 3 October 1995, O.J. Simpson was acquitted of two murders in spite of very strong DNA evidence linking his blood to the crime. Although numerical statements describing the strength of this evidence were made, the DNA profiles included so many loci that the need for presenting numbers in this case, and in others using similarly high numbers of loci, is probably unnecessary. If numbers are to be presented, however, they should be given in the form of likelihood ratios. One thing the verdict in the Simpson case makes clear is that it is essential that the integrity of DNA evidence (with regard to collection, potential contamination or tampering) be beyond doubt.

Published
1995
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28. Haplotype analysis at the low density lipoprotein receptor locus: application to the study of familial hypercholesterolemia in Israel

Author

Berkman, Neville, Weir, Bruce, Pressman-Schwartz, Sigal, Reshef, Ayeleth, and Leitersdorf, Eran

Abstract

Summary: Familial hypercholesterolemia (FH) results from mutations in the low density lipoprotein (LDL) receptor gene. It has been shown that restriction fragment length polymorphisms (RFLPs) associated with this gene may be used for family and population studies. The present investigation is a population-based study of 19 Jewish families with hypercholesterolemia representing 9 different countries of origin. Ten RFLP sites were used to construct 24 different haplotypes from 112 chromosomes. These haplotypes vary in frequency from 0.9% to 28.6%. Five previously undescribed haplotypes, which comprise 8.1% of the sample, are reported here. The six most common haplotypes account for 70% of the sample. Segregation analysis reveals that, in Israel, distinct LDL receptor haplotypes are associated with hypercholesterolemia in 12 (63%) out of the 19 Jewish families. Five LDL receptor haplotypes co-segregate with hypercholesterolemia. Two of these haplotypes seem to be unique to specific population groups in Israel and may therefore represent founder mutations.

Published
1992
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29. The status of DNA fingerprinting.

Author

Weir, Bruce S.

Subjects
DNA fingerprinting, CRIMINAL investigation
Abstract

Reports on the status of using DNA fingerprinting in solving crimes. Matching the DNA patterns in the blood of suspects and stains found at the crime scene; Criticisms of how the chance of a coincidental match is calculated; Importance of obtaining good estimates of DNA frequencies; Report from the National Research Council suggesting forensic DNA guidelines.

Published
1993

31. ARTS PICKS & PREVIEWS.

Author

Weir, Bruce

Subjects
OPERA -- Instruction & study, EDUCATIONAL programs, DRAMA, EDUCATION, STUDENTS
Abstract

The article focuses on the importance of art in life and education. It discusses several projects of the Calgary Opera including the four-week tour of schools in Calgary and southern Alberta by members of the Emerging Artist Development Program and the Let's Create an Opera program. The Let's Create an Opera program employs composers and librettists to create an opera with the students wherein they learn something about cooperation, discipline and others.

Published
2006

32. Inbox.

Author

Miller, Chris, Hilkes, Robert, Weir, Bruce, Larkey, Trevor, Piper, Tim, Walsh, Paul, Genders, Bob, and Anderson, Keith

Subjects
RETIREMENT
Abstract

Letters to the editor are presented in response to articles in previous issues including "Assault and Pepper" in the June 2014 issue, the retirement of motoring journalist Peter Robinson, and the design and performance of the Ford FPV GT-F automobile.

Published
2014

33. WHY VIETNAM VETS ARE ANGRY.

Author

Weir, Bruce

Abstract

A letter to the editor concerning the failure of the New Zealand government to give support for the veterans in Vietnam war in 1965-1975 is presented.

Published
2008

35. Literacy teacher livens up learning of the 3Rs.

Author

Weir, Bruce

Subjects
TEACHERS, LITERACY
Abstract

Focuses on Priscilla George, a Native literacy teacher in Calgary, Alberta. Influence of personal experiences on professional life; Criticism against the approach of the government to Native literacy; Approach to teaching literacy.

Published
2000

36. Youth gain strength from conference.

Author

Weir, Bruce

Subjects
CONFERENCES & conventions, INDIGENOUS peoples
Abstract

Highlights developments of the Urban Society for Aboriginal Youth conference in Calgary, Alberta. Aims of the conference; Speakers of the conference; Emphasis on the youth.

Published
2000

37. Nadine, have you ever seen anybody die?

Author

Weir, Bruce

Subjects
SURGEONS, OPERATING room nursing
Abstract

Focuses on contributions of Nadine Caron in operating room nursing as a surgeon in Calgary, Alberta. Career history; Educational attainment; Reasons for taking the surgeon profession; Factors influencing the decision of Caron.

Published
2002

38. Avoid fear and apathy cautions NAAF founder.

Author

Weir, Bruce

Subjects
ADULT education workshops, EDUCATION of indigenous peoples
Abstract

Highlights the Blueprint For The Future, a career workshop organized by the National Aboriginal Achievement Foundation in Calgary, Alberta. Event description; Programs and activities; Participants of the workshop.

Published
2002

39. Corporations seek staffing solutions.

Author

Weir, Bruce

Subjects
CORPORATIONS, INDIGENOUS peoples -- Employment
Abstract

Focuses on the need of corporations to increase the employment of indigenous peoples in Alberta. Use of government and private sector-cost sharing, summer employment programs and hiring strategies; Application of apprenticeships, corporate tax incentives, stay-in-school program and industry-designed curriculum.

Published
2002

40. Court worker pursues additional education.

Author

Weir, Bruce

Subjects
AWARDS
Abstract

Reports the selection of Lynda Cockerill, as one of the recipient for the first Jerry P. Selinger awards in Calgary, Alberta. Date and venue of the ceremonies; Administration of the awards by the Homefront, the agency working to prevent domestic violence; Works and performance of Cockerill.

Published
2002

41. Wordfest features Aboriginal writers.

Author

Weir, Bruce

Subjects
EXHIBITIONS, AUTHORS
Abstract

Highlights the PanCanadian Wordfest 2001. Participation of aboriginal writers Lee Maracle and Eden Robinson; Works of Maracle and Robinson; Venue and location.

Published
2001

42. Canadian Forces on recruiting drive.

Author

Weir, Bruce

Subjects
MINORITIES, CANADIAN military, RECRUITING & enlistment (Armed Forces)
Abstract

Reports the recruiting drive of the Canadian Armed Forces on minorities Calgary, Alberta. Design of recruiting programs for interesting Aboriginal people in armed forces career; Goal of the military in reaching the military ranks composed of First Nations people; Limit of scope on Aboriginal entry program.

Published
2001

43. Educational model sought at Calgary symposium.

Author

Weir, Bruce

Subjects
EDUCATION, NATIVE American conferences
Abstract

Reports on the symposium on education of the First Nations in Calgary, Alberta. Discussion of delegates on the governance and resources of education; Recommendations of the delegates on the final report; Focus of the delegates on traditional and spiritual values.

Published
2001

44. Aboriginal playwrights in demand.

Author

Weir, Bruce

Subjects
DRAMA festivals, FIRST Nations of Canada, NATIVE Americans in literature
Abstract

Reports the response by Aboriginal artists on the Aboriginal Playwrights Festival in Calgary, Alberta, Canada. Organization of the festival by Crazy Horse Theatre; Reasons on the creation of a playwright festival; Selection of script presenting a contemporary portrait of the Aboriginal people.

Published
2001

45. Métis conference links past with present.

Author

Weir, Bruce

Subjects
CONFERENCES & conventions, ASSOCIATIONS, institutions, etc.
Abstract

Highlights the Power of Youth, Wisdom of Elders conference hosted by the Region III Metis Nation of Alberta. Theme; Workshop topics; Focus on youth empowerment.

Published
2001

46. Role models reach out to students.

Author

Weir, Bruce

Subjects
ROLE models, CALGARY (Alta.). Board of Education, INDIGENOUS peoples
Abstract

Reports the launching of the Aboriginal Role Model Directory by the Calgary Board of Education in Alberta. Compilation of accomplishment of Aboriginal people from variety of fields and professions; Plans on the expansion and update of the annual directory; Development of the directory through the joint effort between the Calgary Board of Education, Heritage Canada, Telus and the United Way.

Published
2001

47. Historic occasion.

Author

Weir, Bruce

Subjects
DECLARATION of intention, INDIGENOUS peoples
Abstract

Reports the signing of the Blackfoot Confederacy Declaration during the annual gathering of Siksika Nation. Terms of the declaration; Reunification of the four bands of the Blackfoot Nation; Benefit of the declaration on member aborigines.

Published
2000

48. Celebrating the arts and community leaders.

Author

Weir, Bruce

Subjects
INDIGENOUS peoples, ARTS
Abstract

Reports on the opening ceremonies of the Calgary's Aboriginal Arts Awareness Week with focus on the arts of the Aborigines in Calgary, Alberta. Development of awareness week for the people; Assessment of the achievement of the celebration by board member Adrian Wolfleg; Presentation of the Chief David Crowchild Awards.

Published
2000

49. Glenbow returns sacred objects.

Author

Weir, Bruce

Subjects
RELIGIOUS articles, MUSEUMS
Abstract

Reports the retrieval of the sacred object to the Blackfoot Confederacy by the Calgarys Glenbow Museum in Alberta. Relationship between the museum and First Nations people; Process of returning sacred objects; Preservation of native culture.

Published
2000

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