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1. Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model

Author

Walweel, K., Boon, A.C., See Hoe, L.E., Obonyo, N.G., Pedersen, S.E., Diab, S.D., Passmore, M.R., Hyslop, K., Colombo, S.M., Bartnikowski, N.J., Bouquet, M., Wells, M.A., Black, D.M., Pimenta, L.P., Stevenson, A.K., Bisht, K., Skeggs, K., Marshall, L., Prabhu, A., James, L.N., Platts, D.G., Macdonald, P.S., McGiffin, D.C., Suen, J.Y., and Fraser, J.F.

Abstract

Organs procured following brain stem death (BSD) are the main source of organ grafts for transplantation. However, BSD is associated with inflammatory responses that may damage the organ and affect both the quantity and quality of organs available for transplant. Therefore, we aimed to investigate plasma and bronchoalveolar lavage (BAL) pro-inflammatory cytokine profiles and cardiovascular physiology in a clinically relevant 6-hour ovine model of BSD.

Published
2021
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