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3. Severe periphlebitis, peripheral retinal ischemia, and preretinal neovascularization in patients with multiple sclerosis

Author

Vine, Andrew K.

Subjects
Multiple sclerosis -- Complications, Retinal diseases -- Causes of, Vasculitis -- Case studies, Neovascularization -- Causes of, Ischemia -- Causes of, Health
Abstract

Two patients with definite multiple sclerosis and marked retinal periphlebitis developed occlusive peripheral retinal vasculitis, which resulted in peripheral retinal ischemia and peripheral retinal neovascularization. Results of investigation for other causes of peripheral proliferative retinopathies were negative in both patients although one patient had a positive anticardiolipin antibody. Both patients have been followed up for over seven years and have maintained good visual acuity with mild regression of the preretinal neovascularization without laser intervention. An analysis of these two cases and six other reported cases indicates that severe periphlebitis can evolve into occlusive peripheral vasculitis, which results in peripheral retinal neovascularization in patients with multiple sclerosis.

Published
1992

6. Avulsed Retinal Veins without Retinal Breaks

Author

Vine, Andrew K.

Abstract

A localized segment of a retinal vein can be avulsed or torn from the retina by vitreous traction without a concurrent retinal break or tear. Eight eyes in eight patients (five women and three men, 20 to 69 years old) with avulsed retinal veins without retinal breaks showed a wide range of underlying retinal abnormalities, including background diabetic retinopathy, pars planitis, and involutional proliferative retinopathies. Such avulsed retinal veins often cause recurrent vitreous hemorrhage. Despite vitreous hemorrhages in six of the eight eyes, the visual prognoses were excellent in all eyes. An avulsed retinal vein must be considered in the differential diagnosis of those patients with proliferative retinopathies who have vitreous hemorrhage.

Published
1984
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7. Hydroxychloroquine Therapy in Massive Total Doses Without Retinal Toxicity

Author

Johnson, Mark W. and Vine, Andrew K.

Abstract

To assess the relationship between hydroxychloroquine retinal toxicity and total dose, we selectively reviewed the histories of patients who had received an additive dose exceeding 1,000 g. No retinopathy was found in nine patients treated with massive total hydroxychloroquine doses ranging from 1,054 to 3,923 g. Eight of these patients were taking recommended daily doses of 400 mg/day or less and showed no evidence of toxicity. The remaining patient treated with 600 mg/day showed evidence of preretinopathy in one eye.

Published
1987
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10. Atypical, Severe Toxoplasmic Retinochoroiditis in Elderly Patients

Author

Johnson, Mark W., Greven, Craig M., Jaffe, Glenn J., Sudhalkar, Hemali, and Vine, Andrew K.

Abstract

Background:The diagnosis of toxoplasmic retinochoroiditis is based primarily on characteristic ocular findings, with supportive serologic evidence. Clinical recognition of atypical presentations is critical for timely antiparasitic drug therapy.

Published
1997
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11. The Endophthalmitis Vitrectomy Study

Author

Johnson, Mark W., Doft, Bernard H., Kelsey, Sheryl F., Barza, Michael, Wilson, Louis A., Barr, Charles C., Wisniewski, Stephen R., Vine, Andrew K., Blodi, Barbara A., Elner, Susan G., Johnson, Mark W., Jessup, Laurie M., Khanderia, Sharad, Pierson, Carl L., Jessup, Laurie M., Willis, Julie, McIver, Frances, Stanley, Sally, Sneed, Scott R., Capone, Antonio, Aaberg, Thomas M., Lim, Jennifer I., Sternberg, Paul, Coffman, Diana S., Moore, Cameile N., Gardner, Susanne K., Nolte, Frederick S., Fremstad, Ann, Gibbs, Deborah, Gilman, James, Swords, Ray, Aguilar, H.Edith, Meredith, Travis A., Lakhanpal, Vinod, Christian, Faith D., Hood, A., Schwalbe, Richard S., Christian, Faith D., Billings, Emery E., Buie, William, Mallonee, James J., Millar, Mary Ann, Verbeek, Sharon, Campochiaro, Peter A., Palardy, Carol B., Reynolds, Lois, Dick, James D., Palardy, Carol B., Cain, Dennis, D'Amico, Donald J., Frederick, Albert R., Morley, Michael G., Pesavento, Richard D., Puliafito, Carmen A., Topping, Trexler M., Finn, Susan M., Raymond, Laura A., Baker, Ann Sullivan, Paton, Barbara, Evans, Claudia, Napoli, Jeffrey, Kierman, Christine, Makris, Kathryn, McInnes, Tom, Reidy, Wini T., White, Ruth, Garfinkel, Richard A., Pilkerton, A.Raymond, Frantz, Robert A., Abernathy, Gill B., Barbaccia, Jay G., Ensey, H.Russell, Ormes, Carol A., Park, Choong H., Caplan, Joel, Russell, Kathryn, Toma, Robert, Packo, Kirk H., de Bustros, Serge, Flood, Timothy P., Glazer, Louis, DeAlba, Maggie, Evanich, Evangeline, Montwill, Michael A., Rothman, Jeri J., Ruderman, Gail, Beard, Melodie, Landau, William, Shen, Min H., Gordon, Martha, Graff, Sharon, Kwiatkowski, Kathy, Pappas, Loreen, Bryant, Douglas, Doherty, Don, Morini, Frank, Arredondo, Linda, Garretson, Bruce R., Gerena, Carlos, Hunt, Maureen, Kinnaird, Sharon M., Neri, Toni, Rice, Thomas A., Novak, Michael A., Rowe, Pamela S., Jamieson, Scott, Newberry, Deborah, Rech, Glenn R., Dul, Michael J., Kinser, Livia, Strozewski, Krystyna, Clark-Rath, Susan, DeLisio, Marty, Dempsey, David L., Kukula, Donna, Pinter-Smith, Anne, Rowe, Pamela S., Smith-Brewer, Sheila, Ludwig, Tracey, Chambers, Robert B., Davidorf, Frederick H., Taylor, Cindy S., Hale, Karen N., Buesching, William J., Chaudhuri, Chhanda, Cover, Nanci J., Shortlidge, Gail R., Cover, Nanci J., Keating, Michael J., Savage, Scott J., Andrzejewska, Paula, Cometet, Susan, Milliron, Jill D., Richmond, Rob, Schneider, Lori, Weisenberger, Debra, Cantrill, Herbert L., Ramsay, Robert C., Brallier, Amy B., Johnson, Timothy P., Rossing, Edith E., Knauth, Kathleen A., Monahan, Martha M., Oestreich, Neal W., Oestreich, Neal W., Clark, Kenneth F., Glennen, Anita M., Yarian, David L., Green, Stuart N., Leff, Steven R., Masciulli, Leo, Lucido, Margaret M., Ludwig, Edward J., Marano, Charlotte L., Peters, Linda, Joho, Kim, Volkert, Doris C., Andersen, Finn, Coffey, Donna, Schlosser, Alex, Honeywell, Ann, Mames, Robert N., Driebe, William T., Stern, George A., Francis, Amye, Zam, Z.Suzanne, Cooper, Rhonda, Gaskins, Darla, Shamis, Diana J., Willingham, Melinda, Barker, Kay, Rosa, Harry, Friedman, Scott M., Gardner, Thomas W., Blankenship, George W., Coyle, Carole J., Bero, Christopher J., Halas, Cindy, Schick, Suzanne, Walker, Jean, Cunningham, Denise, Lambert, H.Michael, Clogston, Pamela S., Frady, Pamela M., Gardner, S.Neal, Osato, Michael S., Frady, Pamela M., Carr, Louise, Shigley, James, Frady, Pamela M., Lopez, Pedro F., Chong, Lawrence P., Frambach, Donald A., CisnerosMargaret^Padilla, Lupe, Yee, Edmond Ming, Nakamura, Tamako, Walonker, A.Frances, Morales, Ronald, Nichols, Tracy, Huete, Maria E., Liggett, Peter E., Ober, Richard R., Quillen-Thomas, Beth, Williams, Mark, Barr, Charles C., Bloom, Steven M., Greene, Pamela J., Whittington, Greg K., Martin, Mark E., Watson, Glen, Jenkins-Curry, Betty, Gilkey, Leigh A., Huelsman, Steven, Han, Dennis P., Burton, Thomas C., Mieler, William F., Pulido, Jose S., Reeser, Frederick H., Newman, Janet L., Werner, Kathy A., Pisarzewicz, Paul J., Reinerio, Nina A., Walloch, Mary Lee K., Wilmer, Zuzana, Laabs, Jan, Picchiottino, Ruth, Phillips, Jim, Picchiottino, Ruth, Wipplinger, Walter, Abrams, Gary W., Jurkiewicz, Dale T., Leet, Margaret L., Mandel, Paul, Metzger, Kim, Suchla, Lori, Zarling, Denise, Balles, Mark W., Ryan, Edwin H., Knobloch, William H., Cook, Sally M., Luke, Darlette G., Ferrieri, Patricia, Schiminsky, Norynne M., Genia, Anne, Philiph, David A., Stinson, Elizabeth K., Wright, Linda M., McMichael, William C., Mielke, Sandy J., Wright, Linda M., Ponwith, Lisa J., Pavan, Peter Reed, Pautler, Scott E., Coats, Marion L., Kirk, Nancy M., Millard, Sharon M., Castellano, Frank C., Edwards, Charlotte R., Marquardt, Angela, McCormack, Amy J., McCormick, Michael T., Renshaw, Bernard, Restuccia, Angela, Campbell, Monica, Christopher, Nell, Garrett, L.Scott, Halkias, Demetrios G., Hothersall, Kim, Mickler, Karen, Minnick, Thomas S., Burr, Cheryl, Millard, Sharon M., Burr, Cheryl, Saxon, Wyatt, Arcacha, Miguel A., Carlton, Steve, Edison, Sonya K., Mallis, Marc J., Sayers, Tamre L., Sudds, Thomas W., Tiberia, Robert J., Wolabaugh, Sherry, Bradford, Reagan H., Parke, David W., Wolf, Thomas C., Shofner, Janie M., Tobey, Lee E., Jensen, Harold G., Sanchez, Dinah, Shofner, Janie, Burris, Russell, Drake, Kellie K., Grissom, Kay R., Rowsey, J.James, Wilkinson, Charles P., Brown, Gary C., Benson, William E., Federman, Jay L., Lucier, Alfred C., Maguire, Joseph I., Sarin, Lov K., Shakin, Eric P., Sivalingam, Arunan, Tasman, William, Vander, James F., Ward, Nancy, Weisbecker, Clement A., Agnew, Caroline L., Lambert, Richard, Torner, Terrance, Carlson, Kathy, Franchine, Gerrie, Serfass, Michelle S., Doft, Bernard H., Bergren, Robert L., Lobes, Louis A., Olsen, Karl R., Rinkoff, Jeffrey S., Metz, Donna J., Leonard, Margaret N., Karenchak, Lisa M., Kowalski, Regis P., Wellman, Lynn A., Wilcox, Linda A., Campbell, Alan F., Steinberg, David R., Vagstad, Gary L., Flook, Kimberly A., Good, Mary M., Keenen, Beverly J., Mellinger, Kim A., Margherio, Raymond R., Abrams, Gary W., Cox, Morton S., Murphy, Patrick L., Trese, Michael T., Werner, Jane C., Williams, George A., Manatrey, Patricia E., Prote, Janet L., Lucarotti, Richard, Martin, Susan, Band, Jeff, Bostic, Grace, Gumming, Kristi, Manatrey, Patricia E., Mitchell, Beth, Regan, Virginia S., Bridges, Craig, Cox, Sam, Houston, Gary, Johnson, John, Streasik, Pat, Wood, Betty, Blumenkranz, Mark S., Cayo, Lisa, Kaye, Virginia, Valenzuela, Carmen Luz, Orgel, Ira K., Poliner, Lon S., Tornambe, Paul E., Cannon, Sarah V., Nielsen, Janet L., Carlson, Anne, Chan, Pauline, Drake, Lynne, Grim, Martha, Peterson, Corky, Borg, Lynn A., Gillyatt, Joann, Beyer, Conny, Hammer, Mark E., Grizzard, W.Sanderson, Shannon, Theresa L., Traynom, Janet R., Collado, Melinda J., McManus, Dennis W., Sweeney, Daniel E., Adams, Donald H., Watson, Thomas T., Traynom, Janet R., Shannon, Theresa L., Traynom, Janet R., Antworth, Michael V., Araos, Johanna Glacy, Greenwald, Mark A., Habib, Mohsen, Myers, Sandra K., Ockers, Karen M., Thibodeau, Judy-Ann, Watkins, Brett, Nelsen, Philip T., Rosenthal, J.Gregory, Mintz, Fay V., Biedenbach, Michael, Leonardy, Nicholas J., Orgel, Ira K., Lawniczak, Sue M., Bork, Chuck, Hageage, George, Hunter, Evelyn B., Marshall, MarLynn J., Roman, Patricia, Hill, Rick, Hofbauer, Thomas, Lemanowicz, Jack, Cupples, Howard P., Guzman, Gladys I., Brodeur, Richard J., Yee, Donald, Delaha, Edward C., Geyer, Stanley L., Slovis, Stacey, Shields, William J., Lauber, Susan, Michelitsch, Karl, Barza, Michael, Kassoff, Aaron, Leonard, Margaret N., Watling, Sharon, Wilson, Louis A., Buehler, JoAnne C., McVay, Jeffrey, Kelsey, Sheryl F., Wisniewski, Stephen R., Podobinski, Gale K., Sillett, Robert L., Groer, Shirley, Avery, Brian, Belle, Steven H., Boles, James, Henry, Linda, Shema, Sarah J., Titus-Emstoff, Linda, Davis, Matthew, Magli, Yvonne L., Hubbard, Larry, Thomas, Suzanne, Everett, Donald F., Mowery, Richard, Davis, Matthew, Doft, Bernard H., Everett, Donald, Kelsey, Sheryl F., Nelsen, Philip T., Packo, Kirk H., Rice, Thomas A., Davis, Kathryn, Azen, Stanley, Covey, Preston, McCuen, Brooks, Packer, Andrew, Robin, Jeffrey, Doft, Bernard H., Everett, Donald, Kelsey, Sheryl F., and Davis, Matthew

Abstract

Purpose:The authors determine if specific features of the clinical presentation of acute postoperative endophthalmitis correlate with the microbiologic culture results.

Published
1997
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14. Geographic Atrophy of the Retinal Pigment Epithelium

Author

Maguire, Paul and Vine, Andrew K.

Abstract

We followed the clinical course of 29 eyes with geographic atrophy of the retinal pigment epithelium and identified three phases of the disease through which the eyes progressively evolved. In the initial phase, eyes showed focal discrete areas of atrophy of the retinal pigment epithelium in the parafoveal area. These eyes retained good visual acuity for many years. The second phase was characterized by foveal involvement in which there was a precipitous loss in visual acuity. Foveal involvement included coarse foveal granularity, thinning of the foveal retinal pigment epithelium, increasing encirclement of the fovea with focal areas of atrophy, and minimal macular drusen. The end stage of the disease was a confluent, usually circular, area of atrophy that involved the entire central macula.

Published
1986
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15. Retinal Detachment Following Penetrating Keratoplasty

Author

Musch, David C., Meyer, Roger F., Sugar, Alan, and Vine, Andrew K.

Abstract

• The time-related risk of retinal detachment during the follow-up of 1146 penetrating keratoplasty procedures was evaluated, using survival analysis techniques. Twenty-eight retinal detachments were observed during follow-up. The Kaplan-Meier estimate of the risk of developing retinal detachment increased from 1.5% at three months to 2.1% at one year after surgery. Further follow-up showed a gradual increase in the cumulative proportion developing retinal detachment to 4.7% at 3.5 years after surgery. Of the preoperative and intraoperative factors available for study, performing an anterior vitrectomy during penetrating keratoplasty was associated with a greater risk of postoperative retinal detachment. The outcome of visual acuity following retinal detachment in these patients' eyes was poor; five patients could not perceive light with the affected eye, and 82% (23/28) had visual acuity of 20/200 or less.

Published
1986
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17. Recombinant Tissue Plasminogen Activator to Lyse Experimentally Induced Retinal Arterial Thrombi

Author

Vine, Andrew K., Maguire, Paul T., Martonyi, Csaba, and Kincaid, Marilyn C.

Abstract

We evaluated the efficacy of intravenously administered recombinant tissue plasminogen activator to lyse laser-induced arterial thrombi in the stroke-prone, spontaneously hypertensive rat model. The arterial thrombi were confirmed histologically, and assessed by color photographs and fluorescein angiography before and after intravenous tissue plasminogen activator or saline therapy. Experimental animals received tissue plasminogen activator (1 mg/kg of body weight) given intravenously over one hour, and control animals received similar volumes of normal saline. Tissue plasminogen activator was effective in lysing experimental retinal arterial thrombi.

Published
1988
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18. Vitreous Fluorophotometry in Rats With Streptozocin-Induced Diabetes

Author

Vine, Andrew K., Kisly, Anne M., Betz, A. Lorris, and Howatt, William F.

Abstract

• Vitreous fluorophotometry (VF) has been used to study the blood-retinal barrier in rats with streptozocin-induced diabetes. Subsequent investigations have shown that many variables other than diabetes influence VF values. With the use of a commercially available fluorophotometer, we assessed VF measurements in diabetic rats while simultaneously measuring other variables, including plasma fluorescein level, free plasma fluorescein level, and blood pH. Mean total plasma fluorescein concentration, mean free plasma fluorescein concentration, and mean midvitreous fluorescein concentration were significantly decreased in diabetic animals. The mean ratio of midvitreous fluorescein concentration to total plasma fluorescein concentration was significantly increased in diabetic animals. In comparison with nondiabetic animals, the diabetic animals showed no significant difference in blood pH or mean ratio of free plasma fluorescein concentration to total plasma fluorescein concentration. Our findings confirm an early derangement of the blood-retinal barrier in diabetic rats.

Published
1984
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19. Proliferative Lupus Retinopathy

Author

Vine, Andrew K. and Barr, Charles C.

Abstract

• Preretinal neovascularization in response to retinal vascular occlusions developed in two patients receiving treatment for systemic lupus erythematosus. In both patients, the preretinal neovascularization was asymptomatic and was discovered on routine ocular examination. One patient required bilateral peripheral ablative argon-laser therapy for florid preretinal neovascularization. This patient had severe occlusive retinal vasculitis despite serologic evidence of remission of the underlying disease process.

Published
1984
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20. Scapuloiliac dysostosis

Author

Blane, Caroline E., Holt, John F., and Vine, Andrew K.

Abstract

Scapuloiliac dysostosis is a rare skeletal syndrome (Taybi, 1983). This case report, the fourth in the medical literature, includes additional distinct skeletal features not previously reported. Malformations of the ears and eyes were also present.The infant was first evaluated at C. S. Mott Children's Hospital at two weeks of age. The mother was 32 years old (G6P4A2) and the father was 35 years old. The pregnancy had been uneventful and the child has three normal siblings. The parents reported no family history of bony disease. The radiograph of the skull revealed cranium bifidum and flattening of the orbital roofs (Fig. 1). The pinnae of the ears were severely malformed and lowset. The left external auditory canal was occluded and the right one narrowed. Ocular hypertelorism and a small superior coloboma of each superior eyelid were present.

Published
1984
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22. Spontaneous Collapse of a Primary Iris Cyst Associated With an Iris Nevus

Author

Sneed, Scott R. and Vine, Andrew K.

Abstract

Primary iris cysts are unusual ocular abnormalities that may be congenital. We describe a primary iris cyst associated with an iris nevus that spontaneously collapsed within a 1-year followup period. REPORT OF A CASE. —A 13-year-old white boy was seen on February 21, 1989, for evaluation of a pigmented iris lesion. The patient had no previous history of ocular surgery or trauma and had not been receiving topical medications. Visual acuity was 20/20 OU. Intraocular pressures and dilated fundus examination results were normal. Slit-lamp examination of the right eye was unremarkable. Slit-lamp examination of the left eye revealed a flat, pigmented lesion occupying a portion of the nasal iris. A focal area of increased pigmentation was present in the adjacent anterior chamber angle by gonioscopy. A round, pigmented iris cyst extending from the

Published
1991
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23. Free Plasma Fluorescein

Author

Kisly, Anne and Vine, Andrew K.

Abstract

TO THE EDITOR. —In our experiments with vitreous fluorophotometry, we measured levels of free plasma sodium fluorescein using a pressure dialysis technique (Amicon ultrafiltration membranes). We have made some observations with this technique that other investigators may find helpful.In early experiments, we collected plasma samples from animals undergoing vitreous fluorophotometry for free fluorescein determination, and processed these samples at the end of the day. These plasma samples were centrifuged in the ultrafiltration membranes after having been stored at room temperature for one to six hours. During the progression of our work, we have evaluated the effect of different ways of handling the plasma on the resulting free plasma fluorescein determinations.We measured the free plasma fluorescein concentration immediately after blood was withdrawn from the animal and compared these initial values with values from the same plasma that had been stored in sealed test tubes. Three aliquots were measured to

Published
1985
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