1. The Longitudinal Dynamics and Natural History of Clonal Hematopoiesis
- Author
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Fabre, Margarete A, Guillherme de Almeida, Jose, Fiorillo, Edoardo, Mitchell, Emily, Damaskou, Aristi, Rak, Justyna, Orru, Valeria, Marongiu, Michele, Vijayabaskar, MS, Baxter, Joanna E, Hardy, Claire, Abascal, Federico, Spencer Chapman, Michael, Williams, Nicholas, Nangalia, Jyoti, Martincorena, Inigo, Campbell, Peter J, Mckinney, Eoin F, Cucca, Francesco, Gerstung, Moritz, and Vassiliou, George S
- Abstract
Human cells acquire somatic mutations throughout life, some of which can drive clonal expansion. Such expansions are frequent in the hematopoietic system of healthy individuals and have been termed clonal hematopoiesis (CH). While CH predisposes to myeloid neoplasia and some non-hematological diseases, we have limited understanding of how and when CH develops, what factors govern its behavior, how it interacts with aging and how these variables relate to malignant progression.
- Published
- 2021
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