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La enfermedad de McArdle o glucogenosis tipo V es una enfermedad rara debida al déficit de miofosforilasa muscular, lo que produce incapacidad para degradar el glucógeno a este nivel. Los pacientes presentan fatiga, dolor y calambres de forma habitual. Además, tras un ejercicio intenso o situación estresante, están expuestos a lisis celular. Esto se puede manifestar en forma de mioglobinuria y rabdomiólisis, síndrome clínico potencialmente grave si no se trata con rapidez.

A survey by National Center (NatCen) for Social Research on more than 10,000 families with children under 15 to distinguish between self-employed parents with, and without parents was conducted. The results show that almost half of the self-employed mothers chose self-employment to accommodate employment with family responsibilities.

One of the problems associated with the modern biomaterials used in prostheses is osteolysis, which, although its exact origin is unknown, has been associated with wear particles. Osteoblasts seem to participate directly in this phenomenon. This paper investigates in vitrocellular response to the wear particles from the metal substrate and ceramic covering αalumina of a new titanium yttrium aluminum alloy, MA 956, that has been proposed as a biomaterial because of its exceptional mechanical and electrochemical properties. The effect of different sizes 10 and 80 μm of MA 956 and αalumina particles on osteoblast function was studied in primary human bone cell cultures. Cells were harvested from trabecular bone fragments obtained during knee arthroplasty. Osteoblastic cell response to the particles was measured by assaying Cterminal type I procollagen PICP, alkaline phosphatase, and osteocalcin secretion, with and without 1.25OH2D3stimulation, in the cellconditioned medium. Both sizes of MA 956 and αalumina particles decreased PICP secretion in nonstimulated osteoblastic cells, but this secretion was not affected in the cultures stimulated with 1.25OH2D3. Only the 10 μm αalumina particles inhibited alkaline phosphatase activity in 1.25OH2D3stimulated and nonstimulated cultures. The rise in osteocalcin levels after 1.25OH2D3stimulation was lower in the presence of the 10 μm MA 956 particles than in the presence of αalumina particles. Although both materials seem to have directly affected in vitroosteoblastic cell function, the increase in osteocalcin levels after 1.25OH2D3stimulation was lower after exposure to MA 956 particles than the increase observed after exposure to αalumina particles. Therefore, it does not seem that osteocalcin stimulated bone resorption, suggesting that MA 956 would be less likely to provoke osteolysis. © 2000 John Wiley & Sons, Inc.

SummaryA double-blind, placebo-controlled study was carried out in 100 patients undergoing major surgery to investigate the efficacy of a new low molecular weight heparin (LMWH) preparation in the prevention of deep venous thrombosis. Patients were allocated at random to receive either placebo or LMWH (7500 AXaU) each day by subcutaneous injection (abdominal fold method), starting 2 hours before the operation and continuing for the following 7 days. Clinical and laboratory tests revealed deep venous thrombosis in 3 (6%) patients in the placebo group whereas no thrombotic episodes were observed in any of the patients treated with LMWH. Blood loss during the peri-operative and post-operative period and the number of blood units transfused were not significantly different in the two groups. Moreover, no side-effects were revealed in the LMWH group that could be attributed to the drug.