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2024 AUG 17 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Idiopathic ANCA-associated vasculitis (AAV) that is double-positive for MPO-ANCA and PR3-ANCA is associated with worse remission rates compared with MPO-AAV and PR3-AAV, according to investigators. The findings are from a [...]

The Kidney Disease: Improving Global Outcomes organization has published a new guideline for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The 46-page document, published in a supplement to [...]

Even mild kidney impairment in patients with ANCA-associated vasculitis (AAV) is associated with an increased risk for end-stage kidney disease (ESKD), emphasizing the importance of diagnosing AAV early when kidney [...]

Patients who have ANCA-associated vasculitis (AAV) with renal involvement and who test positive for monoclonal protein (M-protein) have different clinicopathologic features compared with those who test negative, according to investigators. [...]

PHILADELPHIA—Investigators who studied a cohort of patients with ANCA-associated vasculitis (AAV) with glomerulonephritis and severe kidney involvement found that men present with higher serum creatinine levels and are more likely [...]

2023 OCT 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in heart failure. According to news reporting originating [...]

Margaret Perry looks at what nurses need to known about this common skin infection [ABSTRACT FROM AUTHOR]

Mitochondrial DNA (mtDNA), but not nuclear DNA (nDNA), is elevated in the plasma of patients with ANCA-associated vasculitis (AAV) and is a novel indicator of disease activity, investigators reported in [...]

Findings from a recent study support performing a follow-up kidney biopsy in patients with ANCA-associated vasculitis, according to investigators. Faten Aqeel, MD, of Johns Hopkins University School of Medicine in [...]

JPMorgan analyst Anupam Rama spoke to Apellis Pharmaceuticals after the American Society of Retina Specialists' Research and Safety in Therapeutics Committee reported six cases of intraocular inflammation with retinal vasculitis [...]

The American Society of Retina Specialists' Research and Safety in Therapeutics Committee distributed a notification to its members on Saturday indicating that six cases of occlusive retinal vasculitis have been [...]

The article focuses on the control and management of auricular vasculopathies using laser biostimulation, highlighting its effectiveness in delivering specific doses tailored to the severity, size, and evolution of lesions. Topics include the pathogenesis of vasculitis, differential diagnosis, and therapeutic approaches in veterinary dermatology, emphasizing the growing role of laser biostimulation in minimizing systemic effects and providing targeted treatment for various skin conditions.

A recent report from the Division of Infectious Diseases and Immunology discusses the pathogenesis of Kawasaki Disease (KD), a febrile condition and systemic vasculitis that primarily affects children under 5 years of age. If left untreated, KD can lead to coronary artery aneurysms and long-term cardiovascular complications. The report highlights the role of the NLRP3 inflammasome and interleukin-1 (IL-1) signaling pathway in the disease's pathophysiology. The authors suggest that targeting IL-1 may have therapeutic potential for children with KD. [Extracted from the article]

A case report published by the Connective Tissue Diseases Research Center discusses a 38-year-old female patient with ankylosing spondylitis (AS) who developed skin lesions, including purpuric skin lesions and ischemia of her right foot digits, after starting treatment with adalimumab. The patient was diagnosed with moderate-sized vascular vasculitis associated with adalimumab use. Discontinuation of adalimumab and treatment with high dose glucocorticoids and cyclophosphamide resulted in the resolution of her ischemic lesions. The case highlights the importance of considering drug-related side effects in patients with new skin lesions, particularly in the context of rheumatic diseases such as AS. [Extracted from the article]

Researchers from the Hospital of the University of Pennsylvania have described a case of pembrolizumab-induced vasculitis, a condition characterized by inflammation of blood vessels. The case involved a 76-year-old man with a history of malignant pleural mesothelioma who underwent FDG-PET/CT imaging for restaging. The images showed FDG uptake over the right hepatic and splenic artery, indicating vasculitis. The patient was treated with oral glucocorticoids, and subsequent imaging showed resolution of the vasculitis. This study highlights the importance of recognizing and appropriately treating vasculitis caused by immune checkpoint inhibitors like pembrolizumab. [Extracted from the article]

A recent study on giant cell arteritis (GCA) has been published, focusing on the pharmacological advances in its treatment. GCA is a persistent, idiopathic condition characterized by granulomatous vasculitis of the medium and large vessels. The study emphasizes the importance of early detection and prompt therapy to prevent vascular problems associated with delayed diagnosis. Glucocorticoids are currently the mainstay of GCA treatment, but their long-term use can lead to severe side effects. The study explores the potential therapeutic options for GCA, including tocilizumab and other biological drugs such as abatacept, baricitinib, upadacitinib, mavrilimumab, secukinumab, ustekinumab, and anakinra. [Extracted from the article]

A study conducted at the Mayo Clinic in Rochester, Minnesota, provides new insights into Proteinase 3-specific Antineutrophil Cytoplasmic Antibody (PR3-ANCA)-associated vasculitis, a type of vasculitis that is linked to granulomatosis with polyangiitis (GPA). The study highlights the role of B cells in the pathogenesis of PR3-ANCA-associated vasculitis and discusses the current and future targeted treatments for this condition. The researchers emphasize the need for more effective and less toxic therapies to address the remaining mortality and morbidity associated with PR3-ANCA-associated vasculitis. This research has been peer-reviewed and is available in The Lancet Rheumatology. [Extracted from the article]

A recent study conducted by researchers at the University Centre for Cardiovascular Science focused on the challenges of monitoring disease activity in large vessel vasculitis (LVV). The researchers found that simultaneous 18F-fluorodeoxyglucose positron emission tomography with magnetic resonance imaging (PET/MRI) can effectively assess vascular inflammation and provide high-definition structural imaging with minimal radiation exposure. They developed a PET/MRI-specific Vasculitis Activity using MR PET (VAMP) score, which accurately distinguishes active from inactive disease and detects changes in disease activity over time. The study suggests that PET/MRI could be a valuable tool for tracking disease activity and evaluating treatment response in LVV, and further research is warranted. [Extracted from the article]

The article discusses recent findings on aortitis, emphasizing its challenges in diagnosis and treatment due to its rarity and varying presentations. Topics discussed include the complex surgical techniques used to address paravisceral inflammatory aortic pseudoaneurysms, the successful management of a patient experiencing acute mesenteric ischemia, and the resolution of inflammation with steroid treatment.

The article reports on a study from Nippon Medical School that evaluates the hemodynamics of coronary artery lesions (CALs) in patients after Kawasaki disease. Topics include the comparison of coronary fractional flow reserve (FFR) and myocardial flow reserve (MFR), the relationship between myocardial blood flow (MBF), and their combined use in assessing CALs.

The article presents new insights into Granulomatosis with Polyangiitis (GPA), highlighting the crucial role of ANCA in diagnosis and the ongoing challenges of biopsy and disease management. Topics include advancements in classification criteria, the importance of ANCA detection, and the need for improved disease activity markers.

The article provides an update on noninfectious retinal vasculitis (RV), emphasizing its diverse clinical presentations, causes, and treatment approaches. Topics include the classification and management of noninfectious RV, its association with systemic diseases, and the use of advanced imaging and therapies.

The article highlights a significant breakthrough in vasculitis research by Trinity College Dublin and Lund University, using Artificial Intelligence (AI) and big data to improve the understanding of autoimmune diseases. Topics discussed include the novel classification of Antineutrophil Cytoplasm Antibody (ANCA)-associated vasculitis, the role of federated datasets in more accurate disease predictions, and the potential for personalized treatments to enhance patient care.

The article highlights a study on plasma proteome profiling to distinguish between active and inactive giant cell arteritis (GCA) and non-disease controls. Topics include the identification of distinct protein signatures for different GCA states, the effectiveness of machine learning models in differentiating these states, and the potential for these findings to aid in discovering biomarkers for GCA.

A new study published by researchers from the Division of Cardiothoracic Surgery explores the occurrence of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, a rare autoimmune disorder. The study presents a case of a 74-year-old male who developed acute ANCA-associated vasculitis after coronary artery bypass grafting. The patient experienced symptoms such as shortness of breath, orthopnea, and acute kidney injury. The case emphasizes the importance of considering uncommon causes of cardiovascular disease and unexpected outcomes following coronary artery bypass grafting. [Extracted from the article]

A recent study conducted by Anhui Medical University in China investigated the relationship between coagulation profiles and clinical characteristics of Kawasaki Disease (KD), as well as the effectiveness of intravenous immunoglobulin (IVIG) therapy. The study found that coagulation disorders were more common in KD patients compared to healthy controls, but could be improved with IVIG therapy. Patients with complete KD had longer clotting times compared to those with incomplete KD after IVIG therapy. Additionally, higher levels of certain coagulation markers were associated with a higher risk of coronary artery abnormalities. The study concluded that coagulation disorders are linked to the severity of KD, IVIG nonresponsiveness, and the occurrence of coronary artery involvement, and can be treated with a combination of IVIG and aspirin. [Extracted from the article]

A recent study conducted at the Affiliated Hospital of Qingdao University in China provides new insights into Takayasu's arteritis, a primary systemic vasculitis that affects large blood vessels. The study focuses on a case of an adolescent female patient who initially experienced numbness and weakness in her limbs, which later developed into severe hypertension. The patient was diagnosed with Takayasu's arteritis and subsequently experienced multiple cerebral hemorrhages. After surgery and treatment with tocilizumab, the patient's condition improved. The researchers recommend considering Takayasu's arteritis when evaluating hypertension in young patients and emphasize the importance of timely diagnosis and standardized treatment. [Extracted from the article]

The article presents new findings from the Medical University of South Carolina on Kawasaki disease, focusing on the effectiveness of various risk-scoring systems in predicting coronary artery dilation in a North American cohort. Topics discussed include the Harada score's higher sensitivity in identifying at-risk patients, the ineffectiveness of other scoring systems (Egami, Kobayashi, Sano), and the need for supplementary diagnostic methods to enhance the Harada score's specificity.

A patent has been issued for a stabilization device and system for integrated catheters. The device aims to reduce mechanical phlebitis and increase the dwell time of peripheral intravenous catheters (PIVCs) by providing mechanical stabilization. The device includes a platform with a contoured recess to secure the catheter, as well as a dressing to cover the platform and catheter. The platform is made of a foam-like material and has adhesive on both sides, with the skin-adhering side adhering to the patient's skin and the catheter-securing side adhering to the integrated catheter. The dressing includes a transparent polymeric film and a textile pad with a cutout for viewing the catheter tube. The patent is assigned to Becton Dickinson and Company. [Extracted from the article]

A study conducted at Johns Hopkins University in Baltimore, Maryland, has reported findings on giant cell arteritis, a condition characterized by inflammation of the blood vessels. The study focused on a 73-year-old woman who presented with vision loss, scalp tenderness, and jaw claudication. Laboratory tests and imaging confirmed the diagnosis of giant cell arteritis. This research provides valuable insights into the diagnosis and management of this condition. [Extracted from the article]

Researchers at the Medical University of South Carolina have conducted a systematic review on Cogan Syndrome, a rare autoimmune disease that affects the eyes and ears. The study aimed to determine factors associated with steroid responsiveness and the efficacy of biologic disease-modifying anti-rheumatic drugs (DMARDs) in treating the syndrome. The review found that patients with vestibular symptoms were more likely to be steroid-resistant, and those treated with biologic DMARDs showed higher rates of audiological improvement compared to conventional DMARDs or steroids alone. Further research is needed to better understand the vestibular symptoms and the timing of biologic DMARDs in managing Cogan Syndrome. [Extracted from the article]

A recent study conducted by the University of Barcelona has provided new information about the diagnosis of giant cell arteritis (GCA). The study analyzed the diagnostic utility of an algorithm based on clinical and ultrasound evaluation of patients with suspected GCA. The results showed that ultrasound alone had an overall diagnostic efficiency of 72.5%, which improved to 80.5% when combined with 18F-FDG-PET/CT. The study concluded that a negative ultrasound is sufficient to rule out GCA in cases of low clinical suspicion, while 18F-FDG-PET/CT may be useful in patients with high suspicion and negative or indeterminate ultrasound results. [Extracted from the article]

Researchers from Peking Union Medical College in Beijing, China have conducted a study on Takayasu's Arteritis, a cardiovascular disease. The study aimed to explore the value of monitoring serum interleukin-6 (IL-6) levels in predicting the effectiveness and safety of tocilizumab (TCZ) treatment in refractory Takayasu arteritis (TAK). The study found that the change in IL-6 levels after 6 months of TCZ treatment compared to the baseline can predict the overall treatment response at 12 months, 24 months, and sustained improvement. The study did not find a correlation between IL-6 dynamics and the occurrence of adverse events. [Extracted from the article]