Search

AbstractIn this study, the effects of Sideritis trojanaessential oil on memory, anxiety, and depression were investigated in rats subjected to AlCl3-induced dementia. The major constituents of S. trojanaessential oil were analyzed as carvacrol (42.32%), carvone (18.69%), and α-pinene (4.54%). Rats were divided into five groups: Control, positive control (donepezil), AlCl3-only applicated, AlCl3with 40% S. trojanaessential oil applicated, and AlCl3with 80% S. trojanaessential oil applicated groups. The essential oil was administered for 30 days, after that, the rats were subjected to behavioral tests. In the forced swimming test, S. trojanaessential oil application demonstrated antidepressant-like effects. In the elevated plus maze and open field tests, S. trojanaessential oil application exhibited anxiolytic-like effects. Furthermore, the application of S. trojanaessential oil ameliorated memory impairment induced by AlCl3by increasing spontaneous alternation in the Y-maze test. Furthermore, S. trojanaessential oil application reduced the level of malondialdehyde and increased catalase activity, demonstrating antioxidant activity. Molecular docking analyses were performed between the major compounds of S. trojanaessential oil and the AMPA receptor to evaluate possible mechanisms of action leading to neuroprotection. Carvacrol, carvone, and α-pinene were shown to possess strong binding abilities to the AMPA receptor, which may result in allosteric modulation of the receptor. This study demonstrated the neuroprotective effects of S. trojanaessential oil in an animal model induced by AlCl3application, suggesting its potential protective role against central nervous system disorders.

The cardiovascular risk has been increased in chronic kidney disease associated with chronic inflammation and atherosclerosis. Decoy receptor 3, is a member of the TNF receptor superfamily and associated with inflammation and atherosclerosis. The aim of our study is to determine the relationship, between serum DcR3 levels and inflammatory markers in patients with renal transplantation, those receiving dialysis treatment and cases with chronic renal failure that did not receive replacement therapy, and to evaluate their correlation with USG findings.

The cardiovascular risk has been increased in chronic kidney disease associated with chronic inflammation and atherosclerosis. Decoy receptor 3, is a member of the TNF receptor superfamily and associated with inflammation and atherosclerosis. The aim of our study is to determine the relationship, between serum DcR3 levels and inflammatory markers in patients with renal transplantation, those receiving dialysis treatment and cases with chronic renal failure that did not receive replacement therapy, and to evaluate their correlation with USG findings.