17 results on '"Tio, R A"'
Search Results
2. Evaluation of global left ventricular function assessment of non-fluorescent electromechanical endocardial mapping compared with biplane left ventricular contrast angiography
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Tan, E-S, Van der Vleuten, P., Jessurun, G., Tio, R., Zijlstra, F., and Van Gelder, I.
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Abstract: Background. Little is known about the diagnostic accuracy of global LV function assessment by electromechanical endocardial mapping (EEM). The aim of the present study was to determine the relationship between global left ventricular (LV) function measured by EEM and biplane left ventricular contrast angiography (LVA) after ST-elevation myocardial infarction (STEMI). Methods. Thirty-seven patients underwent LVA and EEM during routine coronary angiography four months after primary percutaneous intervention for STEMI. Global LV function parameters were available from both techniques in all patients. LVA was regarded as reference standard. Results. All procedures were carried out without adverse events. Average age was 55±10 years and 84% were male. EEM showed an overestimation of end-diastolic volume (EDV) and end-systolic volume (ESV) of 6.5 ml and 25.5 ml, respectively. Correlation (r) was 0.84 (p<0.001) for EDV and 0.74 (p<0.001) for ESV. Average left ventricular ejection fraction (LVEF) measured by EEM was 17.2% point (±11.3% point) lower compared with LVA (r=0.69, p<0.001). Conclusion. Although global functional parameters by EEM correlated well with LVA, the relatively large differences in terms of absolute values for ventricular volumes and LVEF render the two techniques non-interchangeable for global LV-function-data. (Neth Heart J 2010;18:72–77.)
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- 2010
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3. Reduced regional myocardial perfusion reserve is associated with impaired contractile performance in idiopathic dilated cardiomyopathy
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Tio, R., Slart, R., de Boer, R., van der Vleuten, P., de Jong, R., van Wijk, L., Willems, T., Lubbers, D., Voors, A., and van Veldhuisen, D.
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Abstract: Background. In idiopathic dilated cardiomyopathy (IDC) an imbalance between myocardial oxygen consumption and supply has been postulated. Subclinical myocardial ischaemia may contribute to progressive deterioration of left ventricular function. The relation between regional myocardial perfusion reserve (MPR) and contractile performance was investigated. Methods. Patients with newly diagnosed IDC underwent positron emission tomography (PET) scanning using both
13 N-ammonia as a perfusion tracer (baseline and dypiridamole stress), and18 F-fluorodeoxyglucose viability tracer and a dobutamine stress MRI. MPR (assessed by PET) as well as wall motion score (WMS, assessed by MRI) were evaluated in a 17-segment model. Results. Twenty-two patients were included (age 49±11 years; 15 males, LVEF 33±10%). With MRI, a total of 305 segments could be analysed. Wall motion abnormalities at rest were present in 127 (35.5%) segments and in 103 (29.9%) during dobutamine stress. Twenty-one segments deteriorated during stress and 43 improved. MPR was significantly higher in those segments that improved, compared with those that did not change or were impaired during stress (1.87±0.04 vs. 1.56± 0.07 p<0.01.) Conclusion. Signs of regional ischaemia were clearly present in IDC patients. Ischaemic regions displayed impaired contractility during stress. This suggests that impaired oxygen supply contributes to cardiac dysfunction in IDC. (Neth Heart J 2009;17:470–4.)- Published
- 2009
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4. Restenosis begets restenosis: implications for stent selection
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Wijpkema, J., Anthonio, R., Jessurun, G., Dijk, W., Tio, R., and Zijlstra, F.
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Abstract: Background. Identifying the risk for restenosis is of critical importance in the stent selection process of patients undergoing percutaneous coronary intervention (PCI). Therefore, we sought to determine if a history of clinical recurrence (CR) after PCI increases the risk of CR after treatment of a de novo lesion in another coronary artery. Methods. We retrospectively analysed all 12,763 patients who underwent PCI between 1993 and 2004 and selected patients with two or more interventions in two different native vessels. These patients were divided into two groups: patients without CR, and patients with CR after the first PCI. Clinical recurrence was defined as revascular-isation of the target vessel by either PCI or CABG within one year. Results. A total of 1010 patients with two or more interventions in two different native vessels were identified: 727 patients without and 283 patients with CR after the first PCI. Baseline patient characteristics and conventional risk factors were comparable between the two groups. Patients with a history of CR had a higher risk of CR after a second intervention in a second vessel (OR=3.4, 95% CI=2.3 to 4.9). A total of 112 patients also had a third intervention in a third native vessel: 12 patients with two CR, 30 patients with one CR and 70 patients with no CR after the first two interventions. CR rates in these patients were 50, 17 and 3%, respectively (p<;0.001). Conclusion. Patients with a history of CR have a markedly increased risk of developing CR after a second or third PCI in a different coronary artery. Therefore, in the decision-making process on whether to use a bare metal stent or drug-eluting stent, the history of CR is a simple and powerful aid. (Neth Heart J 2008;16:376-81.)
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- 2008
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5. Mechanisms involved in symptomatic myocardial bridging
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Hazenberg, A., Jessurun, G., and Tio, R.
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Abstract: Background.In patients with extensive myocardial bridging, evaluation of its clinical significance remains a challenge. Hypothesis.Sequential invasive testing is feasible and gives more insight into the pathophysiological mechanism of bridging-related angina. Methods.Twelve patients with chest pain, proven ischaemia and extensive myocardial bridging were assessed. Myocardial bridging was evaluated at rest, during intracoronary acetylcholine infusion, through coronary flow velocity and flow reserve measurements, and during dobutamine stress. Results.The mean length of the bridging segment was 24.9 mm (QCA; range 8.4-48.0 mm). Acetylcholine infusion caused severe vasospasm in two patients. In these two patients anginal symptoms were related to vasospasm and sequential testing was discontinued. In the remaining ten patients sequential testing was continued. Coronary flow reserve was normal in all patients: 3.3±0.6. In six patients reliable quantitative measurements could be performed during dobutamine stress. The mean systolic diameter of the bridging segment was 1.6±0.4 at baseline and 1.3±0.3 during dobutamine stress (mean of differences 0.38 (95% CI 0.1-0.7)). The difference between the diastolic and systolic diameter in the bridging segment increased from 0.3±0.2 mm at baseline to 1.0±0.5 mm during dobutamine infusion (mean of differences 0.6 (95% CI 0.3 to 0.9)). Conclusion.Sequential testing for bridging is feasible and may disclose endothelial dysfunction or spasm as an underlying mechanism in a minority of patients. Coronary flow reserve was preserved. Dobutamine stress unmasked further lumen reduction and may give further insight into the clinical significance of myocardial bridging in individual patients. (Neth Heart J 2008;16:10-5.)
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- 2008
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6. Cardiac overexpression of human VEGF165 by recombinant Semliki Forest virus leads to adverse effects in pressure-induced heart failure
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Loot, A., Roks, A., Westermann, D., Orzechowski, H-D., Tschöpe, C., Wilschut, J., Tio, R., van Gilst, W., and Henning, R.
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Abstract: Semliki Forest virus (SFV) is an efficient vector for cardiac gene delivery. The relatively short transgene expression induced by SFV seems appropriate for angiogenic gene therapy. We tested the effects of SFV expressing vascular endothelial growth factor (VEGF) on cardiac angiogenesis and heart failure in the mRen2 transgenic rat. Six-week-old mRen2 rats received SFV-VEGF or control virus (n=7 each) administered intracoronarily. Twelve days after transfection, cardiac capillary density and function were assessed. Capillary density in cardiac regions where SFV expression was highest had decreased by 20% in the SFV-VEGF-treated group. The decrease in capillary density was accompanied by impaired systolic function as illustrated by increased endsystolic volumes and a 34% decrease in cardiac output. We conclude that the time frame of SFV expression is sufficient to induce structural alterations, but that VEGF in mRen2 transgenic rats did not elicit the expected angiogenic effect. Rather, capillary density was decreased and subsequently cardiac function was impaired. This paradoxical finding is possibly related to the pathophysiology associated with this model and warrants caution if one is to pursue VEGF-mediated, angiogenic therapy before proceeding to a clinical setting. (Neth Heart J 2007;15:335-41.)
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- 2007
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7. Clinical characteristics, cardiac events and coronary angiographic findings in the prospective PREVEND cohort: an observational study
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Geluk, C., Tio, R., Tijssen, J., van Dijk, R., Dijk, W., Hillege, H., de Jong, P., van Gilst, W., and Zijlstra, F.
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Abstract: Background: The use of invasive procedures has mostly been studied in retrospective (multi)- national registries. Limited evidence exists on the association between microalbuminuria and coronary artery disease (CAD). Methods: The incidence of major adverse cardiac events (MACE) and invasive cardiac procedures was registered between 1997 and 2003 in 8139 subjects, without prior documented CAD, in the PREVEND cohort study (the Netherlands), in which the focus is on microalbuminuria and cardiovascular risk. Qualitative coronary angiographic analysis was performed. Results: During 5.5 years of follow-up, a first MACE occurred in 271 (3.3%) and a first coronary angiography (CAG) was performed in 264 (3.2%) subjects. Of these, 216 CAGs were available for qualitative angiographic analysis. Indications for CAG were stable angina in 129, acute coronary syndrome (ACS) in 55 and ST-elevation myocardial infarction (STEMI) in 32 subjects. Obstructive coronary artery disease was present in 61, 53 and 30 subjects, respectively. A revascularisation was performed in 50 (39%), 50 (91%) and 25 (78%) subjects, respectively. Microalbuminuria was associated with a first MACE, after adjustment for established risk factors. Microalbuminuria was present at baseline in 9% of subjects with normal coronary arteries, in 21% of subjects with one- and two-vessel CAD and in 39% of subjects with threevessel or left main CAD at CAG during follow-up (Ptrend=0.005). Conclusion: This large cohort study shows that two-thirds of diagnostic CAGs for stable angina were not followed by a revascularisation, in contrast to CAGs for STEMI or ACS. Furthermore, this study shows that microalbuminuria is associated with CAD. (Neth Heart J 2007;15:133-41.)
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- 2007
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8. Pathophysiology of vascular endothelium and circulating platelets: implications for coronary revascularisation and treatment
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Amoroso, G., Veldhuisen, D. J. van, Tio, R. A., and Mariani, M.
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- 2001
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9. An ultrafiltration catheter for monitoring of venous lactate and glucose around myocardial ischemia
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Tiessen, R. G., Tio, R. A., Hoekstra, A., Venema, K., and Korf, J.
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- 2001
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10. Comparison of zofenopril and lisinopril to study the role of the sulfhydryl‐group in improvement of endothelial dysfunction with ACE‐inhibitors in experimental heart failure
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Buikema, H, Monnink, S H J, Tio, R A, Crijns, H J G M, De Zeeuw, D, and Van Gilst, W H
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We evaluated the role of SH‐groups in improvement of endothelial dysfunction with ACE‐inhibitors in experimental heart failure. To this end, we compared the vasoprotective effect of chronic treatment with zofenopril (plus SH‐group) versus lisinopril (no SH‐group), or N‐acetylcysteine (only SH‐group) in myocardial infarcted (MI) heart failure rats.After 11 weeks of treatment, aortas were obtained and studied as ring preparations for endothelium‐dependent and ‐independent dilatation in continuous presence of indomethacin to avoid interference of vasoactive prostanoids, and the selective presence of the NOS‐inhibitor L‐NMMA to determine NO‐contribution.Total dilatation after receptor‐dependent stimulation with acetylcholine (ACh) was attenuated (−49%, P<0.05) in untreated MI (n=11), compared to control rats with no‐MI (n=8). This was in part due to impaired NO‐contribution in MI (−50%, P<0.05 versus no‐MI). At the same time the capacity for generation of biologically active NO after receptor‐independent stimulation with A23187 remained intact.Chronic treatment with n‐acetylcysteine (n=8) selectively restored NO‐contribution in total dilatation to ACh. In contrast, both ACE‐inhibitors fully normalized total dilatation to ACh, including the part mediated by NO (no significant differences between zofenopril (n=10) and lisinopril (n=8)).Zofenopril, but not lisinopril, additionally potentiated the effect of endogenous NO after A23187‐induced release from the endothelium (+100%) as well as that of exogenous NO provided by nitroglycerin (+22%) and sodium nitrite (+36%) (for all P<0.05 versus no‐MI).We conclude that ACE‐inhibition with a SH‐group has a potential advantage in improvement of endothelial dysfunction through increased activity of NO after release from the endothelium into the vessel wall. Furthermore, this is the first study demonstrating the selective normalizing effect of N‐actylcysteine on NO‐contribution to ACh‐induced dilatation in experimental heart failure.
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- 2000
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11. Humoral immune response to human cytomegalovirus in patients undergoing percutaneous transluminal coronary angioplasty.
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Tiran, A, Tio, R A, Oostenveld, E, Harmsen, M C, Tiran, B, Den Heijer, P, Monnink, S H, Wilders-Truschnig, M M, and The, T H
- Abstract
Possible causal relations between prior human cytomegalovirus (HCMV) infection and atherosclerosis and between HCMV reactivation and restenosis after coronary angioplasty have been suggested. We investigated patterns of antibodies directed to HCMV in 112 patients undergoing percutaneous transluminal coronary angioplasty (PTCA) and in a group of sex- and age-matched controls (blood donors without evidence of atherosclerosis). Levels of antibodies to HCMV were measured by enzyme-linked immunosorbent assay (ELISA) of serum samples drawn before and 5 weeks after PTCA. To further differentiate the humoral immune response, we specifically tested antibody reactivity towards four single HCMV proteins (IE2, p52, pp150, and pp65) by recombinant ELISAs. We found that 73% of PTCA patients and 69% of sex- and age-matched controls were seropositive for HCMV (odds ratio, 1.2 [not significant]). The corresponding odds ratios for matched pairs ranged in the recombinant ELISAs from 1.2 to 1.4. Patients had more often high titers of anti-HCMV antibodies (11 versus 4%; odds ratio = 3.3 [0.9 to 15.2]; P = 0.052) and high titers of anti-pp150 antibodies (13 versus 4%; odds ratio = 6.0 [1.3 to 38.8]; P = 0.008). Anti-HCMV immunoglobulin M antibodies were not detected in any patient. There was no evidence of acute HCMV reactivation after PTCA, since the titers of antibodies to the investigated recombinant proteins did not increase at 5 weeks after PTCA. Our results show a limited association between prior HCMV infection and coronary artery disease. We infer that positive anti-HCMV titers are not a major risk factor at the time of disease manifestation. However, this study cannot rule out a possible role of HCMV at earlier stages of the atherosclerotic process. Recombinant ELISAs provide a valuable tool for investigating the antiviral immune response.
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- 1999
12. Coronary vasodilation induced by captopril and zofenoprilat: evidence for a prostaglandin-independent mechanism
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Wijngaarden, J., Tio, R. A., Gilst, W. H., Graeff, P. A., Langen, C. D. J., and Wesseling, H.
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In this study, the vasodilating properties of captopril and zofenoprilat, two angiotensin-converting enzyme (ACE) inhibitors containing the sulfhydryl group, are investigated in the isolated rat heart. It is demonstrated that both compounds increase coronary flow in a dose-dependent manner. However, the mean pD2 of zofenoprilat appears to be significantly higher than the mean pD2 of captopril (4.55 ± 0.06 and 3.35 ± 0.02 respectively), indicating that zofenoprilat is about ten times more potent in increasing coronary flow than captopril. Possibly this difference in potency between captopril and zofenoprilat can be explained by their physicochemical properties. Since zofenoprilat is more lipophilic than captopril, its concentration in cardiac and vascular tissues at distribution equilibrium is thought to be higher than the tissue concentration of captopril, which may result in a more pronounced vasodilatory action.
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- 1991
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13. Prevalence of superficial mycoses in the Aosta Valley Region of Italy from 1984 to 1989
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Tio, R. and Lunardi, M.
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This report represents the results of the culture tests for fungi carried out in the Aosta Valley region of Italy from 1984 to 1989. The pathological material consisted of cutaneous scales, hair and nails. It was possible to identify 91.8% of the isolates: out of these, 36.1% were dermatophytes, 21% were Aspergillus spp, 15.6% Deuteromycetes, 15% yeasts and 4.1% members of the family Mucoraceae. The resulting data indicate that Microsporum canis was the most wide-spread species (73.7%) among the isolated dermatophytes and keratinophilic fungi (Trichophyton rubrum, T. mentagrophytes, Epidermophyton floccosum and Scopulariopsis brevicaulis): 87.5% were isolated from hair and 65.9% from the glabrous skin. The high prevalence of M. canis as the cause of dermatomycoses is discussed. Lastly the use made of the Regional Hospital's Mycology Department by health workers is discussed.
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- 1991
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14. Abstracts of papers pharmacological meeting
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Boddeke, H. W. G. M., Jap, T. J. W., Hugtenburg, J. G., Veldsema-Currie, R. D., van Zwieten, P. A., Bom, A. H., Verdouw, P. P., Rutteman, A. M., Saxena, P. R., Davidesko, D., van Charldorp, K. J., Overhaus, P. H., Batink, H. D., Croiset, Gerda, Heijnen, Cobi J., de Wied, D., Drieman, J. C., Thijssen, H. H. W., Elands, J., Barberis, C., de Kloet, E. R., Engels, F., Henricks, P. A. J., v. d. Vliet, H., Nijkamp, F. P., Folkerts, Gert, Engels, Ferdi, Nijkamp, Frans P., Gouw, M. A. M., Wilffert, B., Heemskerk, F. M. J., Schrama, L. H., de Graan, P. N. E., Gispen, W. H., Hillege, J. L., van Gilst, W. H., Scholtens, E., van der Toren, W., Wesseling, H., Mathy, M -J., de Haan, N., Spanjer, W., Janssen, B, v Essen, H, Struyker-Boudier, H., Smits, J, Leurs, R., Go, J. N. L., Bast, A., Timmerman, H., Linthorst, A. C. E., Versteeg, D. H. G., Van den Buuse, M., De Jong, W., Post, M. J., te Biesebeek, J. D., Wemer, J., van Roolj, H. H., Prins, B., Koster, A. Sj., Sweep, C. G. J., Barna, I., Logtenberg, A. W., Wiegant, V. M., te Koppele, J. M., Coles, B., Ketterer, B., Mulder, G. J., Schoemaker, R., Debets, J., Smits, J., Smits, R. P. J. M., Steinbusch, H. W. M., Mulder, A. H., de Jonge, A., van Heiningen, P. N. M., Tierney, S. A. V, van Giersbergen, P. L. M., Tio, R. A., de Langen, C. D. J., de Graeff, P. A., van Luijtelaar, M. G. P. A., Tonnaer, J. D. A. M., van Oers, J. W. A. M., Tilders, F. J. H., van Hilten, J. A., Elliott, G. R., Bonta, I. L., van Hoogdalem, E. J., Geerts, J. A. M., de Boer, A. G., Breimer, D. D., Van Oosterhout, A. J. M., Van Rhee, A. M., Van Overveld, F. J., Houben, L. A. M. J., Terpstra, G. K., Raaijmakers, J. A. M., Bruijnzeel, P. L. B., van den Bos, R., Cools, A. R., Ögren, S -O., van den Dungen, H. M., van Rees, G. P., Schoemaker, J., van den Hooff, P., Seger, M. A., Burbach, J. P. H., Urban, I. J. A., v. d. Wouw, P. A., Vleeming, W., van Rooij, H. H., Porsius, A. J., Van der Zee, C. E. E. M., Edwards, P. M., De Koning, P., Verhaagen, J., Veenstro, D. M. J., Hozenberg, M. A. C. G., von Buuren, K. J. H., Vertagen, H., Thljssen, H. H. W., ten Hoor, F., Kleinjans, J. C. S., Verrijk, R., Vleemlng, W., Werner, J., Porslus, A. J., Voorhuis, Th. A. M., van Eekelen, J. A. M., Rosenfeld, P., Westphal, H. M., and Levine, S.
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- 1987
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15. Beneficial effects of bradykinin on porcine ischemic myocardium
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Tio, R., Tobé, T., Bel, K., Langen, C., Gilst, W., and Wesseling, H.
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Summary Exogenous bradykinin was administered to pigs in which an experimental infarction was evoked by ischemia and reperfusion. Ischemia (45 min) was induced in a closed-chest model with a balloon catheter in the left anterior descending artery, reperfusion by deflating and removing the balloon. The pigs were treated with saline (n = 11) or bradykinin (0.1 mg/kg in 30 min) infusion (n = 10) during the last 15 min of the ischemic period and the first 15 min of reperfusion.
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- 1991
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16. Abstracts
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Barthelemy, O., Silvain, J., Brieger, D., Bellemain-Appaix, A., Cayla, G., Beygui, F., Lancar, R., Collet, J.P., Mercadier, A., Montalescot, G., Cha, K.S., Nam, Y.H., Kim, J.H., Park, S.Y., Park, T.H., Kim, M.H., Kim, Y.D., Lee, H.C., Ahn, M.S., Hong, T.J., Blanco, R., Blanco, F., Szarfer, J., Garcia Escudero, A., Gigena, G., Gagliardi, J., Rodriguez, A., Sarmiento, R., Affatatto, S., Riccitelli, M., Petris, A., Datcu, M.D., Pop, C., Radoi, M., Arsenescu-Georgescu, C., Petrescu, I., Petrescu, L., Serban, L., Nechita, E., Tatu-Chitoiu, G., Tatu-Chitoiu, G., Dorobantu, M., Benedek, I., Craiu, E., Sinescu, C., Ionescu, D.D., Radoi, M., Pop, C., Ginghina, C., Minescu, B., Izzo, A., Mantovani, P., Tomasi, L., Dalloglio, L., Bonatti, S., Rosiello, R., Romano, M., Agostini, F., Zanini, R., Zhao, Z.Y., Wu, Y.J., Li, J.J., Yany, Y.J., Qian, H.Y., Tang, Y.D., Timoteo, A.T., Toste, A., Lousinha, A., Ramos, R., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Cabades, C., Diez Gil, J.L., Aguar, P., Sanmiguel, D., Lopez-March, A., Marmol, R., Guerra, L., Girbes, V., Ferrando, J., Rincon De Arellano, A., Timoteo, A.T., Ramos, R., Toste, A., Oliveira, J.A., Patricio, L., Ferreira, M.L., Ferreira, R.C., Blondal, M., Ainla, T., Marandi, T., Eha, J., Timoteo, A.T., Oliveira, M.M., Silva, M.N., Cunha, P.S., Feliciano, J., Silva, S., Ferreira, R.C., Kanovsky, J., Kala, P., Parenica, J., Poloczek, M., Prymusova, K., Kubkova, L., Spinar, J., Olinic, D., Homorodean, C., Ober, M., Olinic, M., Andrioaia, C., Condac, A., Masmoudi, M., Berdaoui, B., Labidi, S., Tapia Ballesteros, C., Hernandez Luis, C., Sandin, M.G., Vegas, J.M., Andion, R., Martinez, N., Gonzalez, I.A., Alvarado, M., Amat, I.J., San Roman, J.A., Garcia Gonzalez, M.J., Arroyo Ucar, E., Hernandez Garcia, C., Dorta Martin, M., Marrero Rodriguez, F., Dragu, R., Kapeliovich, M., Hammerman, H., Silva, D., Cortez-Dias, N., Jorge, C., Silva Marques, J., Carilho Ferreira, P., Robalo Martins, S., Almeida Ribeiro, M., Calisto, C., Fiuza, M., Lopes, M.G., Milicevic, P., Panic, M., Stankovic, I., Milicevic, D., Kalezic, T., Kafedzic, S., Ilic, I., Cerovic, M., Putnikovic, B., Neskovic, A., Rott, D., Leibowitz, D., Monhart, Z., Reissigova, J., Grunfeldova, H., Jansky, P., Timoteo, A.T., Valente, B., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Villanueva Benito, I., Solla, I., Paredes, E., Diaz Castro, O., Calvo, F., Baz, J.A., Iniguez, A., Aleksova, A., Gerloni, R., Belfiore, R., Carriere, C., Barbati, G., Fabris, E., Possa, F., Nait, D., Milo, M., Sinagra, G., Marques, N., Mimoso, J., Gomes, V., Agra Bermejo, R.M., Emad Abu Assi, E.A.A., Sergio Raposeiras Roubin, S.R.R., Pilar Cabanas Grandio, P.C.G., Carlos Pena Gil, C.P.G., Jose Maria Garcia Acuna, J.M.G.A., Jose Ramon Gonzalez Juanatey, J.R.G.J., Daly, M.J., Scott, P., Owens, C.G., Tomlin, A., Smith, B., Adgey, A.A.J., Alvarez-Contreras, L.R., Juarez, U., Altamirano, A., Arias, A., Alvarez-San Gabriel, A., Gonzalez-Pacheco, H., Martinez-Sanchez, C., Rahnavardi, M., Keshtkar-Jahromi, M., Vakili, H., Gholamin, S., Razavi, S.M., Gilis-Januszewski, T., Mellwig, K.-P., Wiemer, M., Gilis-Januszewski, J., Peterschroeder, A., Koerfer, J., Horstkotte, D., Vrsalovic, M., Getaldic, B., Vrkic, N., Pintaric, H., Khan, S., Wasan, B., Moretti, L., Grossi, P., Silenzi, S., Testa, M., Candelori, L., Clementi, L.N., Forlini, M., Lando, L., Pezzuoli, M.L., Corradetti, P., Leurent, G., Pennec, P.Y., Filippi, E., Moquet, B., Hacot, J.P., Druelles, P., Rialan, A., Rouault, G., Coudert, I., Le Breton, H., Gevaert, S., Tromp, F., Vandecasteele, E., De Somer, F., Van Belleghem, Y., Bouchez, S., Martens, F., Herck, I., De Pauw, M., Spinar, J., Ludka, O., Sepsi, M., Miklik, R., Dusek, L., Tomcikova, D., Marques, N., Mimoso, J., Gomes, V., Garcia-Acuna, J.M., Aguiar-Souto, P., Raposeiras Roubin, S., Agra-Bermejo, R., Jacquet, M., Abu-Assi, E., Gonzalez-Juanatey, J.R., Ibatov, A., Labrova, R., Spinar, J., Karlik, R., Kanovsky, J., Lokaj, P., She, Q., Deng, S.B., Huang, S.H., Gu, L.J., Rong, J.I.A.N., Wu, Z.K., Li, Y., Zhang, J., Parascan, L., Campanile, A., Spinelli, L., Santulli, G., Ciccarelli, M., De Gennaro, S., Assante Di Panzillo, E., Trimarco, B., Iaccarino, G., Bobescu, E., Radoi, M., Datcu, G., Dobreanu, D., Doka, B., Charniot, J.-C., Cosson, C., Albertini, J.P., Bittar, R., Giral, P., Cherfils, C., Guillerm, E., Bonnefont-Rousselot, D., Craiu, E., Rusali, A., Cojocaru, L., Parepa, I., Koizumi, T., Iida, S., Sato, J., Kikutani, T., Muramatsu, T., Nishimura, S., Komiyama, N., Lee, W.P., Ong, B.B., Haralambos, K., Townsend, D., Rees, J.A.E., Williams, E.J., Halcox, J.P., Mcdowell, I., Damjanovic, M., Koracevic, G., Djordjevic-Radojkovic, D., Pavlovic, M., Krstic, N., Ciric-Zdravkovic, S., Stojkovic, A., Perisic, Z., Apostolovic, S., Faustino, A., Seca, L., Barra, S., Caetano, F., Providencia, R., Silva, J., Gomes, P., Costa, G., Costa, M., Leitao-Marques, A., Volkova, A.L., Arutyunov, G.P., Bylova, N.A., Dayter, I.I., Jao, Y.T.F.N., Fang, C.C., Chen, Y., Yu, C.L., Wang, S.P., Valencia, J., Perez-Berbel, P., Ruiz-Nodar, J.M., Pineda, J., Bordes, P., Quintanilla, M., Mainar, V., Sogorb, F., Santos, N., Serrao, M., Cafe, H., Silva, B., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Providencia, R.A., Gomes, P.L., Seca, L., Barra, S., Silva, J., Faustino, A., Caetano, F., Pais, J.R., Mota, P., Leitao-Marques, A.M., Farhan, S., Jarai, R., Tentzeris, I., Vogel, B., Freynhofer, M.K., Wojta, J., Huber, K., Poli, M., Trambaiolo, P., Corsi, F., De Luca, M., Mustilli, M., Lukic, V., Simonetti, M., Ferraiuolo, G., Lettino, M., Casella, G., Conte, M.R., De Luca, L., Geraci, G., Ceravolo, R., Milo, M., Pani, A., Trambaiolo, P., Fradella, G., Schratter, A., Thiele, H., Klemm, T., Demmin, K., Lehmann, D., Mende, M., Schuler, G., Pittl, U., Chernova, A., Nikulina, S.U., Naruke, T., Inomata, T., Yanagisawa, T., Maekawa, E., Mizutani, T., Shinagawa, H., Nishii, M., Takeuchi, I., Takehana, H., Izumi, T., Paulo, C., Mascarenhas, J., Patacho, M., Pimenta, J., Bettencourt, P., Nardai, S., Szabo, G.Y., Berta, B., Edes, I., Merkely, B., Delgado Silva, J., Seca, L., Baptista, R., Providencia, R., Mota, P., Costa, M., Leitao-Marques, A., Faria, R., Trigo, J., Gago, P., Mimoso, J., Marques, N., Gomes, V., Gheorghe, G., Nanea, I.T., Cristea, A., Almarichi, S., Martins, H., Saraiva, F., Baptista, R., Jorge, E., Mendes, P.L., Monteiro, P., Costa, S., Franco, F., Providencia, L.A., Nanea, T., Gheorghe, G.S., Visan, S., Paun, N., Gaber, R., Gaber, R., Delewi, R., Nijveldt, R., De Bruin, H.A., Hirsch, A., Van Der Laan, A., Bouma, B.J., Tijssen, J.P.G., Van Rossum, A.C., Zijlstra, F., Piek, J.J., Rus, H., Radoi, M., Donea, M., Ciurea, C., Ifteni, G., Casolo, G., Chioccioli, M., Magnacca, M., Del Meglio, J., Comella, A., Baratto, M., Lera, J., Salvadori, L., Tessa, C., Vignali, C., Keca, Z., Momcilov Popin, T., Panic, G., White, R., Mateen, F., Weaver, A., Dragu, R., Agmon, Y., Kapeliovich, M., Hammerman, H., Timoteo, A.T., Lousinha, A., Santos, N., Oliveira, J.A., Ferreira, M.L., Ferreira, R.C., Okisheva, E., Tsaregorodtsev, D., Sulimov, V., Amat Santos, I.J., Gonzalez, I.A., Hernandez, C., Sandin, M.G., Tapia, C., Andion, R., Alvarado, M., Campo, A., San Roman, J.A., Fredman, D., Svensson, L., Rosenqvist, M., Tadel-Kocjancic, S., Radsel, P., Knafelj, R., Gorjup, V., Noc, M., Zima, E., Jenei, Z.S., Kovacs, E., Osztheimer, I., Szabo, G.Y., Molnar, L., Horvath, A., Becker, D., Geller, L., Merkely, B., Maggi, R., Furukawa, T., Viscardi, V., Brignole, M., Leal, S.R.N., Dores, H., Rosario, I., Monge, J., Carvalho, M.J., Arroja, I., Leitao, A., Fonseca, C., Aleixo, A., Silva, A., Keuleers, S., Herijgers, P., Herregods, M.C., Budts, W., Dubois, C., Meuris, B., Verhamme, P., Flameng, W., Van De Werf, F., Adriaenssens, T., Badran, H., Elnoamany, M., Lolah, T., Tatu-Chitoiu, G., Dorobantu, M., Benedek, I., Craiu, E., Sinescu, CRINA., Ionescu, D.D., Olariu, C., Radoi, M., Pop, C., Macarie, C., Mollik, M.A.H., Hassan, A.I., Paul, T.K., Haque, M.Z., Jahan, R., Rahmatullah, M., Khatun, M.A., Rahman, M.T., Chowdhury, M.H., Bustamante Munguira, J., Tamayo, E., Garcia-Cuenca, I., Bustamante, E., Gualis, J., Gomez-Martinez, M.L., Florez, S., Gomez-Herreras, J.I., Ramirez Rodriguez, R., Ramirez Rodriguez, A.M., Garcia-Bello, M.A., Hernadez Ortega, E., Caballero Dorta, E., Garcia Quintana, A., Piro Mastraccio, V., Medina Fernandez Aceytuno, A., Assanelli, E., De Metrio, M., Rubino, M., Lauri, G., Cabiati, A., Campodonico, J., Grazi, M., Moltrasio, M., Marana, I., Marenzi, G., Lovlien, M., Schei, B., Picon-Heras, R., Acebal, C., Garcia Rubira, J.C., Vivas Balcones, D., Nunez-Gil, I., Ruiz-Mateos, B., Ibanez, B., Fernandez-Ortiz, A., Vintila, V.D., Enescu, O.A., Stoicescu, C.I., Udroiu, C., Cinteza, M., Tatu – Chitoiu, G., Vinereanu, D., Fresco, C., De Biasio, M., Muser, D., Sappa, R., Morocutti, G., Bernardi, G., Proclemer, A., Fontanella, B., Affatato, A., Ciccarese, C., Sacchini, M., Volpini, M., Bianchetti, F., Verzura, G., Dei Cas, L., Pudil, R., Blaha, V., Vojacek, J., Paraskevaidis, I., Ikonomidis, I., Parissis, J., Papadopoulos, C., Stasinos, V., Bistola, V., Anastasiou-Nana, M., Shochat, M., Shotan, A., Kazatsker, M., Gurovich, V., Asif, A., Noiman, E., Levy, Y., Blondhaim, D., Rabinovich, P., Meisel, S., Koracevic, G., Stojkovic, A., Petrovic, S., Pavlovic, M., Glasnovic, J., Tomasevic, M., Krstic, N., Djordjevic-Radojkovic, D., Sakac, D., Obradovic, S., Londono Sanchez, O., Pacreu, S., Torres, L., Mihaylov, G., Shaban, G.M., Trendafilova, E., Krasteva, V., Mudrov, T.S., Didon, J.P., Panageas, V., Vlachos, N., Pernat, A., Radan, I., Mozina, H., Izzo, A., Tomasi, L., Mantovani, P., Dalloglio, L., Pepi, P., Romano, M., Cionini, F., Baccaglioni, N., Zanini, R., Viertel, A., Havers, J., Ballard, G., Groenefeld, G., Santos, N., Branco, L.M., Oliveira, J.A., Ferreira, L., Timoteo, A.T., Fiarresga, A., Feliciano, J., Ramos, R., Ferreira, R.C., Izzo, A., Tomasi, L., Mantovani, P., Pepi, P., Lettieri, L., Dalloglio, L., Reggiani, A., Zanini, R., Garcia Gonzalez, M.J., Arroyo Ucar, E., Hernandez Garcia, C., Juarez Prera, R., Blanco Palacios, G., Dorta Martin, M., Marrero Rodriguez, F., Martin, A.-C., Manzo Silberman, S., Chaib, A., Varenne, O., Allouch, P., Salengro, E., Jegou, A., Margot, O., Spaulding, C., Diego, A., De Miguel, A., Cuellas, C., Fraile, E., Martin, J., Vega, B., Bangueses, R., Fernandez-Vazquez, F., Perez De Prado, A., Rosario, I., Dores, H., Leal, S., Correia, M.J., Monge, J.C., Arroja, I., Abecasis, J., Aleixo, A., Silva, A., Dragu, R., Agmon, Y., Kapeliovich, M., Hammerman, H., Garcia-Garcia, C., Subirana, I., Sala, J., Bruguera, J., Valle, V., Sanz, G., Fiol, M., Aros, F., Marrugat, J., Elosua, R., Barra, S.N.C., Silva, J., Gomes, P., Providencia, R., Seca, L., Leitao Marques, A., Zhao, Z.Y., Wu, Y.J., Li, J.J., Yang, Y.J., Xu, B., Tang, Y.D., Song, G.Y., G, R.L., Panic, M., Milicevic, P., Stankovic, I., Ilic, I., Kafedzic, S., Kalezic, T., Milicevic, D., Aleksic, A., Putnikovic, B., Neskovic, A., Serpytis, P., Rucinskas, K., Kalinauskas, A., Karvelyte, N., Santos De Sousa, C.I., Ferreira, S., Calaca, J., Lousada, N., Palma Reis, R., Gualandro, D.M., Seguro, L.F.B.C., Braga, F.G.M., Silvestre, O.M., Lage, R.L., Fabri, J., Oliveira, M.T., Urbano Moral, J.A., Torres Llergo, J., Solanilla Rodriguez, R., Sanchez Gonzalez, A., Martinez Martinez, A., Den Uil, C.A., Lagrand, W.K., Van Der Ent, M., Jewbali, L.S.D., Cheng, J.M., Spronk, P.E., Simoons, M.L., Mornos, C., Petrescu, L., Dragulescu, D., Ionac, A., Guardado, J., Azevedo, O., Fernandes, M., Canario-Almeida, F., Sanfins, V., Pereira, A., Almeida, J., Kaplunova, V.U., Belenkov, Y.N., Privalova, E.V., Fomin, A.A., Suvorov, A.Y., Goodkova, A., Rubakova, M.G., Kuznetsova, I.A., Semernin, E.N., Keshavarzi, F., Kojuri, J., Mikhailov, V.M., Vezhenkova, I.V., Goodkova, A.Y.A., Jarai, R., Pavlovic, I., Farhan, S., Schwarz, M., Jakl, G., Huber, K., Jarai, R., Schwarz, M., Smetana, P., Jakl, G., Perkmann, T., Farhan, S., Huber, K., Mayr, A., Mair, J., Klug, G., Schocke, M., Trieb, T., Jaschke, W., Pachinger, O., Metzler, B., Bronze Carvalho, L., Azevedo, J., Andrade, M.L., Arroja, I., Relvas, M.J., Coucello, J., Monge, J., Morais, G., Seabra, M., Aleixo, A., Afamefule, F., Luaces Mendez, M., Teijeiro-Mestre, R., Nunez-Gil, I.J., Leco-Gil, N., Madronal-Cerezo, E., Zannin, I., Ruiz, J., Orynchak, M.A., Vakalyuk, I.I., Vakalyuk, I.P., Berezin, A., Panasenko, T., Cavusoglu, Y., Cavusoglu, A., Unluoglu, I., Tek, M., Demirustu, C., Gorenek, B., Unalacak, M., Birdane, A., Yuksel, F., Ata, N., Lee, W.P., Halcox, J.P.J., Cavusoglu, Y., Beyaztas, A., Entok, E., Demirustu, C., Uslu, I., Birdane, A., Gorenek, B., Ata, N., Schaefer, A., Flierl, U., Seydelmann, N., Bauersachs, J., Calmac, L., Craiu, E., Ionescu, D.D., Nanea, T., Pop, C., Marinescu, S., Macarie, C., Tatu Chitoiu, G., Fruntelata, A.G., Dorobantu, M., Hamdi, S., Maazoun, Y., Neji, A., Farhat, O., Majdoub, M., Ben Hamda, K., Maatouk, F., Balanescu, S.M., Benedek, I., Nedelciuc, I., Deleanu, D., Dobreanu, D., Olinic, D., Petrescu, L., Ortan, F., Mot, S., Tatu Chitoiu, G., Sinnaeve, P.R., Moreels, S., Adriaenssens, T., Dubois, C., Coosemans, M., Vydt, T., Desmet, W., Sinnaeve, P.R., Moreels, S., Vydt, T., Dubois, C., Adriaenssens, T., Coosemans, M., Desmet, W., Poli, M., Trambaiolo, P., Corsi, F., De Luca, M., Mustilli, M., Lukic, V., Simonetti, M., Ferraiuolo, G., Tobing, D., Rifnaldi, R., Juzar, D., Firdaus, I., Dharma, S., Irmalita, I., Kalim, H., Bejiqi, R., Retkoceri, R., Bejiqi, H., Kryeziu, L., Kelmendi, M., Borovci, S.H., Victor, S.M., Gnanaraj, A., Deshmukh, R., Mullasari, A.S., Yahalom, M., Kaiyal, R.S., Roguin, N., Bornstein, J., Atar, S., Farah, R., Seca, L.F., Faustino, A., Silva, J., Providencia, R., Gomes, P., Barra, S., Caetano, F., Costa, M., Leitao Marques, A.M., Margato, R., Sousa, P., Ribeiro, H., Rocha, L., Correia, A., Moreira, J.I., Carvalho, H.C., Afifi, M., Abed, N., Santos, N., Serrao, M., Cafe, H., Silva, B., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Suarez-Barrientos, A., Vivas, D., Castro-Ferreira, F., Nunez-Gil, I., Franco, E., Garcia-Rubira, J.C., Fernandez-Ortiz, A., Fuster, V., Macaya, C., Ibanez Cabeza, B., Salinger, S., Perisic, Z., Milic, D., Stanojlovic, T., Apostolovic, S., Obradovic, S., Djordjevic-Radojkovic, D., Damjanovic, M., Koracevic, G., Kostic, T., Khan, M.A., Vrapi, F., Naeem, K., Davar, J., Hristova, K., Hristova, K., Pencheva, G., Radeva, R., Milanov, S., Trambaiolo, P., Poli, M., De Luca, M., Lukic, V., Mustilli, M., Corsi, F., Simonetti, M., Ferraiuolo, G., Fareed, A., Oraby, M., Nasr, G.M., Maklady, F., Dupouy, P., Sorensen, J.T., Terkelsen, C.J., Lassen, J.F., Trautner, S., Christensen, E.F., Nielsen, T.T., Botker, H.E., Andersen, H.R., Thygesen, K.A., Checco, L., Usmiani, T., Sbarra, P.L., Boffini, M., Saviolo, R., Grasso, C., Conrotto, F., Marchetti, M., Rinaldi, M., Marra, S., Moscoso Costa, F., Ferreira, J., Raposo, L., Aguiar, C., Trabulo, M., Silva, J.A., Faria, R., Mimoso, J., Marques, N., Trigo, J., Marques, V., Gomes, V., Swiatkowski, A., Kowalczyk, J., Lenarczyk, R., Chodor, P., Honisz, G., Was, T., Swierad, M., Sredniawa, B., Polonski, L., Kalarus, Z., Postadzhiyan, A.S., Velinov, H., Velchev, V., Hazarbasanov, D., Apostolova, M., Finkov, B., Petrovic, M., Panic, G., Jovelic, A., Canji, T., Srdanovic, I., Popov, T., Golubovic, M., Pavlovic, K., Cemerlic-Adjic, N., Bro-Jeppesen, J., Kjaergaard, J., Wanscher, M.C., Nielsen, S.L., Rasmussen, L.S., Hassager, C., Bro-Jeppesen, J., Kjaergaard, J., Wanscher, M.C., Rasmussen, L.S., Hassager, C., Khan, M., Crolla, E., Morley, H., Akeroyd, L., Beaini, Y., Morley, C., Dores, H., Leal, S., Rosario, I., Abecasis, J., Monge, J., Correia, M.J., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Bekeredjian, R.H., Krumsdorf, U., Rottbauer, W., Katus, H.A., Pleger, S., Providencia, R.A., Silva, J., Barra, S., Gomes, P.L., Seca, L., Botelho, A., Quintal, N., Mota, P., Leitao-Marques, A.M., Silva, B., Santos, N., Cafe, H., Faria, P., Serrao, M., Gomes, S., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Roussel, J.C., Senage, T., Perigaud, C., Habash, O., Michel, M., Treilhaud, M., Despins, P., Trochu, J.N., Baron, O., Duveau, D., Kitsiou, A.N., Giannakopoulos, K., Papadimitriou, G., Karas, S., Babic, Z., Nikolic Heitzler, V., Milicic, D., Bergovec, M., Raguz, M., Mirat, J., Strozzi, M., Plazonic, Z., Giunio, L., Steiner, R., Freynhofer, M., Brozovic, I., Bruno, V., Leherbauer, L., Djurkovic, M., Jarai, R., Willheim, M., Huebl, W., Wojta, J., Huber, K., Vogel, B., Hahne, S., Kozanli, I., Kalla, K., Jarai, R., Freynhofer, M., Smetana, P., Geppert, A., Unger, G., Huber, K., Simoes Marques Assuncao Caetano, A.F., Barra, S., Silva, J., Providencia, R., Faustino, C., Botelho, A., Mota, P., Leitao Marques, A., Ariza Sole, A., Sanchez Salado, J.C., Lorente Tordera, V., Martinez Garcia, V., Salazar Mendiguchia Y Garcia, J., Gomez Hospital, J.A., Maristany Daunert, J., Berdejo Gago, F.J., Esplugas Oliveras, E., Brzozowska-Czarnek, A., Urbanik, A., Kakouros, N., Kakouros, S., Lekakis, J., Rizos, J., Kokkinos, D., Venevtseva, J., Melnikov, A., Valiahmetov, M., Gomova, T., Perelomova, I., Ferrer Hita, J.J., Bosa-Ojeda, F., Sanchez-Grande-Flecha, A., Yanes-Bowden, G., Vargas-Torres, M.J., Rodriguez-Gonzalez, A., Rubio-Iglesias-Garcia, C., Dominguez-Rodriguez, A., Enjuanes-Grau, C., Marrero-Rodriguez, F., Parepa, I., Suceveanu, A.I., Suceveanu, A., Mazilu, L., Alexandrescu, L., Dumitru, E., Miu, V., Jitari, V., Craiu, E., Voinea, F.L., Balachandran, K.P., Schofield, R., Sankaranarayanan, R., Helm, K., Crowe, C., Singh, R., Mcdonald, J., Chuen, M.J., Kobusiak-Prokopowicz, M., Preglowska, M., Mysiak, A., Doi, T., Sakoda, T., Akagami, T., Naka, T., Tsujino, T., Masuyama, T., Ohyanagi, M., Kume, N., Mitsuoka, H., Hayashida, K., Tanaka, M., Biasucci, L.M., Della Bona, R., Biasillo, G., Leo, M., Zaninotto, M., Plebani, M., Crea, F., Biasucci, L.M., Dellabona, R., Leo, M., Biasillo, G., Zaninotto, M., Plebani, M., Crea, F., Cavusoglu, Y., Gok, B., Birdane, A., Demirustu, C., Gorenek, B., Unalir, A., Ata, N., Timuralp, B., Nikulina, N., Yakushin, S.S., Nikulina, N., Yakushin, S.S., Furmenko, G.I., Akinina, S.A., Dores, H., Ingrid, R., Leal, S., Correia, M.J., Bronze, L., Monge, J., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Djambazov, S., Zhivkov, A., Maznev, I., Ingeliev, M., Slavov, R., Cvetkova, N., Patarinski, V., Groch, L., Horak, J., Dimitrov, N., Hayrapetyan, H.G., Raposeiras Roubin, S., Abu-Assi, E., Cabanas-Grandio, P., Agra-Bermejo, R., Garcia-Acuna, J.M., Pena-Gil, C., Gonzalez-Juanatey, J.R., Barra, S.N.C., Silva, J., Providencia, R., Seca, L., Gomes, P., Leitao Marques, A., Daly, M.J., Mc Keag, N.A., Mc Cann, C.J., Cardwell, C., Young, I.S., Adgey, A.A.J., Mikhalchikova, N., Burova, N., Zaccaria, M., Palmisano, P., Palumbo, V., Ciccone, M.M., Favale, S., Chen, K.C., Yin, W.H., Liu, J.H., Goncalves, S., Santos, J.F., Amador, P., Soares, L.N., Zahidova, K., Guliyev, F., Zahidov, N., Carrilho-Ferreira, P., Cortez-Dias, N., Marques, J.S., Silva, D., Jorge, C., Robalo Martins, S., Almeida Ribeiro, M., Calisto, C., Carvalho De Sousa, J., Lopes, M.G., Cortez-Dias, N., Calisto, C., Silva, D., Jorge, C., Carrilho-Ferreira, P., Silva Marques, J., Robalo Martins, S., Correia, M.J., Carvalho De Sousa, J., Lopes, M.G., Uthoff, H., Thalhammer, C., Potocki, M., Reichlin, T., Noveanu, M., Aschwanden, M., Staub, D., Arenja, N., Socrates, T., Mueller, C., Zhao, Y., Wu, X., Xue, Q., Gao, L., Lin, H., Wang, S., Watanabe, K., Kawamura, A., Seko, T., Omura, A., Sakabe, S., Kasai, A., Starodubova, A.V., Storozhakov, G., Kisliak, O., Hautieva, F., Tursheva, M., Fedotova, N., Di Maio, R.C., Mclaughlin, J., Allen, J.D., Anderson, J.M.C., Adgey, A.A.J., Khaled Nagi, H., Abed, N., Tayeh, O., Farok, W., Mousa, A., Neuzil, P., Skoda, J., Petru, J., Sediva, L., Kralovec, S., Holy, F., Holdova, K., Jehlicka, P., Plasil, P., Reddy, V.Y., Alabakovska, S., Labudovic, D., Jovanova, S., Tosheska, K., Alabakovski, M., Jeevaratnam, K., Tee, S.P., Zhang, Y., Guzadhur, L., Gurung, I.S., Duehmke, R., Grace, A.A., Lei, M., Huang, C.L., Ishibashi, Y., Yamauchi, M., Akashi, Y., Musha, H., Miyake, F., Hnatek, T., Kamenik, L., Sedlon, P., Luxova, J., Steuerova, B., Skvaril, J., Cernohous, M., Zavoral, M., Ratkovic, N., Nemanja Djenic, N.R., Aleksandra Jovelic, A.J., Slobodan Obradovic, S.O., Branko Gligic, B.G., Kletsiou, E., Giannakopoulou, M., Bozas, E., Iliodromitis, E.K., Anastasiou-Nana, M., Papathanassoglou, E.D.E., Anton, M., Anton, G., Muraru, M., Stanojlovic, T., Salinger Martinovic, S., Radosavljevic, M., Glasnovic, J., Stanojevic, D., Zivkovic, M., Cortez-Dias, N., Jorge, C., Calisto, C., Silva, D., Carrilho-Ferreira, P., Silva Marques, J., Robalo Martins, S., Pessoa, T., Fiuza, M., Lopes, M.G., Aspromonte, N., Ronco, C., Tubaro, M., Santini, M., Colivicchi, F., Aiello, A., Cruz, D., Anzoletti Boscolo, A., Vianello, G., Valle, R., Cavusoglu, Y., Parspour, A., Birdane, A., Tek, M., Gorenek, B., Unalir, A., Ata, N., Lee, W.P., Ong, B.B., Watkins, S., Datta, D., Halcox, J.P.J., Providencia, R.A., Barra, S., Gomes, P.L., Seca, L., Silva, J., Botelho, A., Quintal, N., Pais, J.R., Mota, P., Leitao-Marques, A.M., Nikishin, A.G., Pirnazarov, M.M., Nurbaev, T.A., Motovska, Z., Fischerova, M., Osmancik, P., Maly, M., Widimsky, P., Pavli, E., Dibra, A., Mehilli, J., Dibra, L., Schoemig, A., Kastrati, A., Carmo, P., Ferreira, J., Aguiar, C., Almeida, M., Raposo, L., Teles, R., Goncalves, P., Brito, J., Silva, A., Dascenzo, F., Gonella, A., Longo, G., Pullara, A., Moretti, C., Sciuto, F., Omede, P., Biondi Zoccai, G., Trevi, G.P., Sheiban, I., Santos, N., Serrao, M., Cafe, H., Silva, B., Oliveira, R., Caires, G., Drumond, A., Araujo, J., Cafe, H.M., Silva, B., Santos, N., Faria, P., Oliveira, R., Pereira, A., Caires, G., Pereira, D., Freitas, D., Araujo, J., Pittl, U., Schratter, A., Klemm, T., Lehmann, D., Demmin, K., Mende, M., Schuler, G., Thiele, H., Salazar Mendiguchia Y Garcia, J., Ariza Sole, A., Martinez Garcia, V., Sanchez Salado, J.C., Lorente Tordera, V., Ortiz Berbel, D., Rabasa Baraibar, J.M., Esplugas Oliveras, E., Monge, J., Leal, S., Dores, H., Bronze Carvalho, L., Rosario, I., Abecasis, J., Correia, M.J., Leitao, A., Aleixo, A., Silva, A., Leone, A.M., De Caterina, A., Aurelio, A., Sciahbasi, A., Lioy, E., Trani, C., Burzotta, F., Porto, I., Rebuzzi, A.G., Crea, F., Trusinskis, K., Juhnevica, D., Strenge, K., Sondore, D., Kumsars, I., Jegere, S., Narbute, I., Grave, A., Zakke, I., Erglis, A., Mihaylov, G., Marenzi, G., Assanelli, E., Ferrari, C., Marana, I., Lauri, G., De Metrio, M., Grazi, M., Campodonico, J., Moltrasio, M., Bartorelli, A.L., Martins, H., Saraiva, F., Baptista, R., Jorge, E., Mendes, P.L., Monteiro, P., Costa, S., Franco, F., Providencia, L.A., Saeed, M., Gaber, R., Mornos, C., Cozma, D., Pescariu, S., Dragulescu, S.I., Kamal, H.S., Abdelfattah, A., Abdelbary, A.M., Elassar, H., Naggar, A., Khaled, M., Fareed, A.M., Pernes, J.M., Gaux, J.C., Oraby, M., Nasr, G.M., Maklady, F., Dupouy, P., Prull, M.W., Sasko, B., Wirdemann, H., Bittlinsky, A., Butz, T., Trappe, H.J., Perazzolo Marra, M., Cacciavillani, L., Marzari, A., De Lazzari, M., Turri, R., China, P., Corbetti, F., Iliceto, S., Stazhadze, L.L., Spiridonova, E.A., Bulanova, N.A., Ermolaev, A.A., Savic, L., Mrdovic, I., Krljanac, G., Perunicic, J., Asanin, M., Lasica, R., Matic, M., Vasiljevic, Z., Ostojic, M., Pudil, R., Tichy, M., Blaha, V., Andrys, C., Vojacek, J., Conti, A., Poggioni, C., Viviani, G., Bulletti, F., Boni, V., Luzzi, M., Vicidomini, S., Donati, M., Del Taglia, B., Pini, R., Sousa, O., Fontes-Carvalho, R., Caeiro, D., Dias Ferreira, N., Silva, G., Pereira, E., Ribeiro, J., Albuquerque, A., Gama Ribeiro, V., Murai, M., Takeda, Y., Shinmyo, T., Tanigawa, J., Hazui, H., Nakakohji, T., Ohishi, Y., Hoshiga, M., Ishihara, T., Hanafusa, T., Belohlavek, J., Rohn, V., Kunstyr, J., Lips, M., Semrad, M., Horak, J., Mlejnsky, F., Tosovsky, J., Linhart, A., Lindner, J., Sablik, Z., Samborska-Sablik, A., Drozdz, J., Gaszynski, W., Ferrer Hita, J.J., Rodriguez-Gonzalez, A., Izquierdo-Gomez, M.M., Enjuanes-Grau, C., Rubio-Iglesias-Garcia, C., Sanchez-Grande-Flecha, A., Juarez-Prera, R., Blanco-Palacios, G., Bosa-Ojeda, F., Marrero-Rodriguez, F., Lakhdar, R., Drissa, M., Drissa, M., Jedaida, B., Drissa, H., Sousa, O., Dias Ferreira, N., Sampaio, F., Caeiro, D., Fontes-Carvalho, R., Silva, G., Pereira, E., Ribeiro, J., Albuquerque, A., Gama Ribeiro, V., Hsin, H.-T., Huang, J.-H., Chiu, K.-M., Chen, Z.-S., Lin, P.-C., Chen, L.-Y., Chu, S.-H., Efthimiadis, I., Skendros, P., Sarantopoulos, A., Boura, P., Delewi, R., Nijveldt, R., Van Der Laan, A.M., Hirsch, A., Van Der Vleuten, P.A., Klees, M., Tijssen, J.G.P., Zijlstra, F., Van Rossum, A.C., Piek, J.J., Backus, B.E., Six, A.J., Kelder, J.H., Mosterd, A., Mast, E.G., Mast, T.P., Braam, R., Tio, R., Veldkamp, R., Doevendans, P.A., Delewi, R., Nijveldt, R., Van Der Laan, A.M., Hirsch, A., Van Der Vleuten, P.A., Klees, M., Tijssen, J.G.P., Zijlstra, F., Van Rossum, A.C., Piek, J.J., Paarup Dridi, N., Holmvang, L., Engstroem, T., Rekik, S., Brunet, J., Hager, F.X., Bayet, G., Meille, L., Quatre, J.M., Sainsous, J., Chu, P.-H., Tang, C.-H., Ibatov, A., Pogosova, N., Koltunov, I.E., Sapunova, I.D., Vigodin, V.A., Uhliar, R., Gilis-Januszewski, T., Mellwig, K.-P., Wiemer, M., Gilis-Januszewski, J., Peterschroeder, A., Schmidt, A., Brockmeyer, B., Horstkotte, D., Suzuki, A., Eki, Y., Higuchi, H., Yukawa, A., Yamauchi, R., Sato, Y., Endo, Y., Martinez Garcia, V., Salazar Mendigucha Garcia, J., Ariza Sole, A., Sanchez Salado, J.C., Lorente Tordera, V., Homs Vila, S., Gomez Hospital, J.A., Cequier Fillat, A., Esplugas Oliveras, E., Andion Ogando, R., Hernandez Luis, C., Sandin Fuentes, M., Tapia Ballesteros, C., Vegas Valle, J.M., Gonzalez Garcia, I.A., Duro Aguado, I.A., Palomino Doza, A.J., Gomez Salvador, I., San Roman Calvar, J.A., Nikishin, A.G., Mamarasulov, T.M., Pirnazarov, M.M., Koracevic, G., Pavlovic, M., Glasnovic, J., Damjanovic, M., Stojkovic, A., Kostic, T., Todorovic, L., Petrovic, S., Zivkovic, M., Djordjevic-Radojkovic, D., Cherneva, Z.C.H., Denchev, S.D., Heltai, K., Becker, D., Merkely, B., Nikulina, N., Yakushin, S.S., Akinina, S.A., Furmenko, G.I., Boytsov, A., Yakushin, S.S., Nikulina, N.N., Furmenko, G.I., Akinina, S.A., Dores, H., Leal, S., Rosario, I., Bronze, L., Abecasis, J., Correia, M.J., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Dores, H., Leal, S., Rosario, I., Monge, J., Abecasis, J., Correia, M.J., Bronze, L., Arroja, I., Aleixo, A., Silva, A., Rosario, I., Leal, S., Dores, H., Correia, M.J., Monge, J.C., Abecasis, J., Arroja, I., Aleixo, A., Silva, A., Palmisano, P., Zaccaria, M., Zanna, D., Marangelli, V., Caiati, C., Ciccone, M.M., Favale, S., Picon Heras, R., Loureiro, M.J., Nunez-Gil, I., Garcia Rubira, J.C., Acebal, C., Ruiz-Mateos, B., Ibanez, B., Fernandez-Ortiz, A., Macaya, C., Rosario, I., Dores, H., Leal, S., Monge, J.C., Correia, M.J., Bronze Carvalho, L., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Urazovskaya, I., Vinogradova, D., Vasilieva, E., Shpektor, A., Faustino, A., Seca, L., Barra, S., Providencia, R., Silva, J., Gomes, P., Costa, G., Caetano, F., Costa, M., Leitao-Marques, A., Conti, E., Musumeci, M.B., Lauri, F.M., Dito, E., De Giusti, M., Lallo, A., Fusco, D., Davoli, M., Volpe, M., Autore, C., Gamra, H., Dridi, Z., Hassine, M., Addad, F., Gherissi, I., Reda, A., Mahjoub, M., Bouraoui, S., Abdennadher, M., Betbout, F., Mota, P.M.F.P., Silva, J.D., Providencia, R.A., Leitao-Marques, A., Nikolic Heitzler, V., Babic, Z., Milicic, D., Bergovec, M., Raguz, M., Mirat, J., Strozzi, M., Plazonic, Z., Giunio, L., Steiner, R., Stanojevic, D., Apostolovic, S., Jankovic Tomasevic, R., Pavlovic, M., Djordjevic, V., Djordjevic Radojkovic, D., Salinger Martinovic, S., Koracevic, G., Damjanovic, M., Ilic, I., Scafa Udriste, A., Fruntelata, A., Gainoiu, E., Bogdan, S., Calmac, L., Zamfir, D., Teodorescu, C., Guran, M., Constantinescu, D., Dorobantu, M., Rosario, I., Dores, H., Leal, S., Abecasis, J., Monge, J.C., Bronze, L., Arroja, I., Fonseca, C., Aleixo, A., Silva, A., Konopka, A., Banaszewski, M., Wojtkowska, I., Stepinska, J., Vidergold, J.V., Osipova, I.V., Tavrovskaya, T.V., Galkina, J.V., Timofeev, A.V., Vorobyov, R.I., Vorobyova, E.N., Matos, L., Carvalho, A.C.C., Oliveira, W., Cintra, F., Poyares, D., Andersen, M., Martins, R., Tufik, S., Neuzil, P., Ostadal, P., Skoda, J., Holy, F., Holdova, K., Brada, J., Horakova, S., Mlcek, M., Hrachovina, V., Kittnar, O., Gorudko, I.V., Buko, I.V., Cherenkevich, S.N., Polonetsky, L.Z., Plotkin, V.Y., Timoshina, M.A., Azanchevskaya, S.V., Chromov-Borisov, N.N., Vorlat, A., Snoep, L., Claeys, M.J., Vrints, C.J., Palazzuoli, A., Caputo, M., Quatrini, I., Calabro, A., Antonelli, G., Campagna, M.S., Franci, B., Nuti, R., Maisel, A., Paulo, C., Mascarenhas, J., Patacho, M., Pimenta, J., Bettencourt, P., Negrini, M., Minora, T., Marino, P., Seregni, R., Tavlueva, E., Barbarash, O., Barbarash, L., Janota, T., Kudlicka, J., Malik, K., Wichterle, D., Hradec, J., Faria, R., Mimoso, J., Marques, N., Trigo, J., Marques, V., Gomes, V., Body, R., Carley, S.D., Mcdowell, G., Nuttall, M., Wibberley, C., France, M., Cruickshank, J.K., Mackway-Jones, K., Cavusoglu, Y., Cavusoglu, A., Unluoglu, I., Tek, M., Demirustu, C., Unalacak, M., Gorenek, B., Birdane, A., Yuksel, F., Ata, N., Leon, M., Cozma, C., Mitu, F., Matos, L., Carvalho, A.C.C., Almeida, D.R., Oliveira, W., Dias, C.B., Barra, S.N.C., Gomes, P., Silva, J., Providencia, R., Seca, L., Leitao Marques, A., Burazor, I., Burazor, M., Krstic, M., Lazovic, M., Stojkovic, A., Vukmanovic, M., Djordjevic, J., Radovanovic, Z., Ilic, D., Bosnjakovic, P., Margato, R., Ferreira, A.C., Mateus, P.S., Ribeiro, H., Fontes, P., Moreira, J.I., Teixeira, T., Silva, J.D., Costa, M., Leitao-Marques, A., Conte, G., Menozzi, A., Solinas, E., Bolognesi, M.G., Tadonio, I., Mantovani, F., Cattabiani, A., Vignali, L., Ardissino, D., Scafa Udriste, A., Fruntelata, A., Tautu, O., Calmac, L., Alexandrescu, A., Niculescu, R., Tatu-Chitoiu, G., Dorobantu, M., Djordjevic Radojkovic, D., Apostolovic, S., Perisic, Z., Damjanovic, M., Jankovic, R., Salinger Martinovic, S., Koracevic, G., Todorovic, L., Bozinovic, N., Matos, L., Carvalho, A.C.C., Almeida, D.R., Oliveira, W., Dias, C.B., Santos, C., Ferreira, J., Carmo, P., Costa, F., Brito, J., Sousa, P., Cardoso, G., Correia, I., Aguiar, C., Silva, A., Fountoulaki, K., Kastellanos, S., Voltirakis, E., Kokotos, A., Michalakeas, C., Kontsas, K., Hasioti, K., Iliodromitis, E.T., Anastasiou-Nana, M., Andion Ogando, R., Hernandez Luis, C., Sandin Fuentes, M.G., Tapia Ballesteros, C., Vegas Valle, J.M., Zatarain Nicolas, E., Amat Santos, I.J., Martinez Uruena, N., Alvarado Montes De Oca, M., San Roman Calvar, J.A., Belohlavek, J., Dytrych, V., Kovarnik, T., Smid, O., Kral, A., Linhart, A., Aroutunov, A.G., Intwala, S., Sondore, D., Juhnevica, D., Trusinskis, K., Strenge, K., Jegere, I., Narbute, I., Grave, A., Erglis, A., Shaalan, H.S.H., Pagava, Z., Agladze, R., Shakarishvili, R., Sharashidze, N., Gujejiani, L., Saatashvili, G., Martins, H., Saraiva, F., Baptista, R., Jorge, E., Mendes, P.L., Monteiro, P., Costa, S., Franco, F., Providencia, L.A., Gaber, R., Gaber, R., Hristova, K., Katova, T.Z., Kostova, V., Simova, Y., Parepa, I., Suceveanu, A.I., Suceveanu, A., Mazilu, L., Voinea, F.L., Craiu, E., Obradovic, S., Salinger, S., Vukotic, S., Rafajlovski, S., Romanovic, R., Koracevic, G., Antonijevic, N., Gligic, B., Hutyra, M., Skala, T., Horak, D., Vindis, D., Taborsky, M., Contine, A., Del Pinto, M., Angeli, F., Verdecchia, P., Borgognoni, F., Grikstaite, E., Pantano, P., Ambrosio, G., Cavallini, C., Bonanad, C., Sanchis, J., Bodi, V., Nunez, J., Bosch, X., Heras, M., Pellicer, M., Llacer, A., Seca, L.F., Fontes-Carvalho, R., Caeiro, D., Adao, L., Oliveira, M., Goncalves, H., Primo, J., Gama, V., Fresco, C., De Biasio, M., Sappa, R., Muser, D., Morocutti, G., Bernardi, G., Proclemer, A., Lombardi, C., Metra, M., Bugatti, S., Pasotti, E., Quinzani, F., Adamo, M., Villa, C., Rovetta, R., Manerba, A., Dei Cas, L., Mariani, M., Dushpanova, A., Baroni, M., Cerone, E., Nardelli, A., Gianetti, J., Berti, S., Timoteo, A.T., Oliveira, M.M., Silva, M.N., Toste, A., Ramos, R., Cunha, P.S., Feliciano, F., Soares, R., Santos, S., Ferreira, R.C., Ostadal, P., Kruger, A., Vondrakova, D., Herget, J., Di Maio, R.C., Navarro, C., Cromie, N.A., Anderson, J.M.C., Adgey, J.A.A., Tadel-Kocjancic, S., Radsel, P., Knafelj, R., Gorjup, V., Noc, M., Caeiro Pereira, D., Braga, P., Fontes Carvalho, R., Sousa, O., Rodrigues, A., Goncalves, H., Ribeiro, J., Goncalves, M., Simoes, L., Gama, V., and Borisov, K.V.
- Abstract
Background: Radial access for PCI is increasing but its use in emergency still remains confidential. We report our single center experience where all interventional cardiologists use the radial access as default strategy for primary PCI. Methods and Results: STEMI patients (n = 671) were evaluated for bleeding complications using a web-based registry (e-PARIS). In-hospital bleeding was adjudicated using various definitions (TIMI, GUSTO, STEEPLE). MACE was the composite of death, MI and stroke. In this non-selected, high risk population, 6.1% had cardiogenic shock on admission, 3.9% out-of-hospital cardiac arrest and 51.2% multivessel disease. Radial access (88%) was the default strategy as was abciximab (78%). Clopidogrel loading dose ranged from 300 to 900 mg. Pre-hospital fibrinolysis was used in 7.1%. Hemodynamic support devices (IABP, ECMO, Tandem Heart) were needed in 7.0%. In-hospital bleeding rates varied widely according to the definitions used: 2.5%, 1.5%, 5.7%, 9.2% and 10.9% with TIMI Major, GUSTO Severe, TIMI Major/minor, GUSTO Severe/moderate or STEEPLE Major, respectively. In-hospital death rate was 5.5%. One-year mortality (8.2%) was seriously impacted by in-hospital bleeding (31.6% vs 6.8%, p < 0.001). The most frequent bleeding site was gastro-intestinal (figure). GUSTO Severe/moderate bleeding was independently correlated with MACE (OR 2.60; 95%CI 1.21–5.59; p = 0.01) and radial access was a strong predictor of survival (OR 0.33; 95%CI 0.17–0.56; p = 0.002). Conclusions: The gastro-intestinal tract is the most frequent site of bleeding when the radial artery is the predominant vascular access site for primary PCI. GUSTO Severe/moderate bleeding is an independent predictor of MACE while radial access predicts survival.
- Published
- 2010
- Full Text
- View/download PDF
17. Adult Respiratory Distress Syndrome After Streptokinase
- Author
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Tio, R. A., Voorbij, R. H. A. M., and Enthoven, R.
- Published
- 1992
- Full Text
- View/download PDF
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