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Start Over Author "Tian, Ji-Lai" Publication Type Magazines
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1. Novel hybrids from N-hydroxyarylamide and indole ring through click chemistry as histone deacetylase inhibitors with potent antitumor activities

Author

Cai, Mao, Hu, Jie, Tian, Ji-Lai, Yan, Huang, Zheng, Chen-Guo, and Hu, Wan-Le

Abstract

Novel hybrids 8a–8owere designed and synthesized, and most of them showed promising anti-cancer activities, particularly for 8n, which had significant antiproliferative activities and HDAC1 selectivity superior to SAHA, induced cell cycling arrest at G0/G1 phase, and promoted the expression of the acetylation for histone H3 and tubulin in vitro.

Published
2015
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