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4. Thyroid nodules in xeroderma pigmentosum patients: a feature of premature aging

Author

Kouatcheu, S. D., Marko, J., Tamura, D., Khan, S. G., Lee, C. R., DiGiovanna, J. J., and Kraemer, K. H.

Abstract

Purpose: Xeroderma pigmentosum (XP) is an autosomal recessive disease with defective DNA repair, a markedly increased risk of skin cancer, and premature aging. Reports from North Africa have described thyroid nodules in XP patients, but thyroid nodule prevalence has never been determined in XP patients enrolled in our natural history study at the National Institutes of Health (NIH). Methods: We performed thyroid ultrasound examinations on all 29 XP patients examined from 2011 to 2019 and assessed nodule malignancy using the Thyroid Imaging Reporting and Data System. Thyroid nodule prevalence was also obtained from comparison cohorts. DNA sequencing was performed on thyroid tissue from XP patients who had surgery for thyroid cancer. Results: Thyroid nodules were identified in 18/29 XP patients (62%). The median age of patients with thyroid nodules in our XP cohort (20 years) was younger than that of three comparison groups: 36 years (California study—208 subjects), 48 years (Korean study—24,757 subjects), and 52 years (NIH—682 research subjects). Multiple (2–4) thyroid nodules were found in 12/18 (67%) of the patients with nodules. Autopsy examination revealed follicular adenomas in 4/8 (50%) additional XP patients. DNA sequencing revealed rare mutations in two other XP patients with papillary thyroid cancer. Conclusions: XP patients have an increased incidence of thyroid nodules at an early age in comparison to the general population. These finding confirm another premature aging feature of XP.

Published
2021
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9. your letters.

Author

Howell, Melinda, Knox, Assata, Johnson, Sandra, Stovall, Karen, Bishop, Daphne Pierre, Campbell, Alicia, Washington, Shanetha, Lunsford, Maurice, Andrich, Gladys, Anderson, Volencia, Riley, Clarice, Lester, Monica, Alston, Tamura D., Foster, Ayanna, Purdy-Porter, Sanpri, Lyons, Cynthia, Griffin, Alisa L., Brown, Saundra, Howard Jr., Charmlin L., and Bent, Ericka

Subjects
LETTERS to the editor, AFRICAN American actors, CASTING of plays, AFRICAN American women, DIABETES, DISEASES
Abstract

Several letters to the editor are presented in response to articles in the March 2008 issue, including "Black Hollywood: A Celebration of Our Excellence," "Great Expectations" and "What Black Women Need to Know About Diabetes."

Published
2008

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