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Scientists have made the discovery that a significant portion of the human genome is transcribed into RNA molecules that do not code for proteins, known as noncoding RNA (ncRNA). This challenges the previous belief that most of the genome was "junk DNA" with no biological function. These ncRNA molecules have been found to play a role in gene regulation and may be involved in diseases like cancer. Researchers are now investigating the possibility of targeting ncRNAs with drugs or using them as drugs themselves. There are different types of ncRNAs, including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), each with their own functions and mechanisms of action. The role and significance of ncRNA in human biology is still being debated, but it holds potential for future medical applications. [Extracted from the article]

2024 AUG 17 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Life Science have been published. According to news [...]

2024 AUG 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained […]

aTyr Pharma, Inc., a clinical stage biotechnology company engaged in the discovery and development of first-in-class medicines from its proprietary tRNA synthetase platform, announced that it has completed enrollment in [...]

2024 JUL 20 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 JUL 20 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 JUL 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

A quiz concerning the Karnataka Common Entrance Test (CET) 2024 paper from MTBiology Today focused on topics including cardiovascular physiology, reproductive biology, and genetics, confirming extensive overlap with questions from Modern Tutoring Guides (MTG) Books."

2024 JUN 15 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 JUN 1 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 JUN 1 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 MAY 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 MAY 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 MAY 18 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on molecular genetics and genomic medicine is now available. [...]

2024 MAY 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on Biotechnology - Genome Mining have been published. According [...]

2024 APR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 APR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Gram-Positive Bacteria. According to news reporting originating [...]

Biochemist Ting Zhu of Westlake University in Hangzhou, China, is working on creating mirror-image versions of the key molecular ingredients of life. He aims to assemble these components into synthetic cell-like entities that can replicate and metabolize, potentially leading to the development of valuable drugs. Zhu has successfully synthesized mirror-image versions of DNA, RNA, and enzymes involved in DNA replication and protein synthesis. He is now working on creating a mirror-image ribosome, which would be a significant step towards understanding the origins of life on Earth. Despite the challenges, Zhu is determined to continue his research and explore the possibilities of alternative life forms. [Extracted from the article]

2024 MAR 30 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 FEB 24 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2024 FEB 10 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Current study results on interferons have been published. According to news originating [...]

2024 JAN 6 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Data detailed on Life Science have been presented. According to news reporting [...]

In this study, the mitochondrial genome of Eulaelaps silvestris , which parasitizes Apodemus chevrieri , was sequenced and assembled to fill the gap in understanding the molecular evolution of the genus Eulaelaps. The E. silvestris mitochondrial genome is a double-stranded DNA molecule with a length of 14 882 bp, with a distinct AT preference for base composition and a notably higher AT content than GC content. The arrangement between genes is relatively compact, with a total of 10 gene intergenic regions and 12 gene overlap regions. All protein-coding genes had a typical ATN initiation codon, and only 2 protein-coding genes had an incomplete termination codon T. Out of the 13 protein-coding genes, the 5 most frequently used codons ended in A/U, with only 1 codon ending in G/C had an relative synonymous codon usage value >1. Except for trnS1 and trnS2 , which lacked the D arm, all other tRNAs were able to form a typical cloverleaf structure; and there were a total of 38 mismatches in the folding process of tRNA genes. Unlike the gene arrangement order of the arthropod hypothetical ancestor, the E. silvestris mitochondrial genome underwent fewer rearrangements, mainly near tRNA genes and control regions. Both the maximum likelihood tree and the Bayesian tree showed that the family Haemogamasidae is most closely related to the family Dermanyssidae. The results not only provide a theoretical basis for studying the phylogenetic relationships of the genus Eulaelaps , but also provide molecular evidence that the family Haemogamasidae does not belong to the subfamily Laelapidae. [ABSTRACT FROM AUTHOR]

2023 DEC 30 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 DEC 16 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 DEC 14 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- According to news reporting based on a preprint abstract, our journalists obtained the following [...]

2023 DEC 2 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 NOV 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 NOV 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 NOV 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New study results on neurology have been published. According to news reporting [...]

2023 NOV 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 OCT 14 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 OCT 7 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators discuss new findings in antisense technology. According to news reporting from [...]

Echinolaelaps echidninus is a gamasid mite that is of medical and veterinary significance as parasites and vectors of disease agents, which can carry pathogens of zoonosis such as Rickettsia tsutsugamushi , Rickettsia Q fever , Rickettsia mooseri , Rickettsia pox pathogens , Corynebacterium pseudotuberculosis and Leptospira. At present, only single mitochondrial genes have been analysed for E. echidninus in the world, and no complete mitochondrial genome has been reported. However, information carried by a single gene is limited. Therefore, the complete mitochondrial genome of E. echidninus was determined for the first time by Illumina Hiseq X-Ten platform in this study. The mitochondrial genome is 15 736 bp in length and contains 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes and a control region of 1561 bp in length. Codon analysis of 13 protein-coding genes revealed that UUU, UUA, AUU, AUA and AAU were the most frequently used, while cox2 had the fastest evolutionary rate and cob the slowest. Comparative analysis of genome structure and breakpoint distances of the mitochondrial genomes of 23 species in 17 genera from 10 families of Gamasida deposited in GenBank revealed a novel gene arrangement type of the E. echidninus mitochondrial genome, and different degrees of rearrangement among different taxa of Gamasida. Phylogenetic analyses of Gamasida were performed using the maximum likelihood and Bayesian inference methods. Echinolaelaps echidninus was clustered with Dermanyssoidea and formed a more supportive sister group with Varroa destructor. This study provides novel insights into rearrangement patterns and evolution of mitochondrial genomes of Gamasida. [ABSTRACT FROM AUTHOR]

In recent years, bat-associated pathogens, such as 2019 novel coronavirus, have been ravaging the world, and ectoparasites of bats have received increasing attention. Penicillidia jenynsii is a member of the family Nycteribiidae which is a group of specialized ectoparasites of bats. In this study, the complete mitochondrial genome of P. jenynsii was sequenced for the first time and a comprehensive phylogenetic analysis of the superfamily Hippoboscoidea was conducted. The complete mitochondrial genome of P. jenynsii is 16 165 base pairs (bp) in size, including 13 protein-coding genes (PCGs), 22 transfer RNA genes, 2 ribosomal RNA genes and 1 control region. The phylogenetic analysis based on 13 PCGs of the superfamily Hippoboscoidea known from the NCBI supported the monophyly of the family Nycteribiidae, and the family Nycteribiidae was a sister group with the family Streblidae. This study not only provided molecular data for the identification of P. jenynsii , but also provided a reference for the phylogenetic analysis of the superfamily Hippoboscoidea. [ABSTRACT FROM AUTHOR]

A quiz concerning the topics including principles of inheritance and variation and molecular basis of inheritance for class XII is presented.

2023 SEP 30 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

AN2 Therapeutics announced that it has received a research grant from the Bill & Melinda Gates Foundation to discover novel, boron containing small molecules for the treatment of tuberculosis and [...]

2023 SEP 23 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

2023 SEP 21 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- According to news reporting based on a preprint abstract, our journalists obtained the following [...]

2023 SEP 16 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on Escherichia coli is now available. According to news [...]

2023 JUL 1 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- According to news reporting based on a preprint abstract, our journalists obtained [...]

Ticks are a group of blood-sucking ectoparasites that play an important role in human health and livestock production development as vectors of zoonotic diseases. The phylogenetic tree of single genes cannot accurately reflect the true kinship between species. Based on the complete mitochondrial genome analysis one can help to elucidate the phylogenetic relationships among species. In this study, the complete mitochondrial genome of Dermacentor steini (isolate Longyan) was sequenced and compared with the mitochondrial genes of 3 other Chinese isolates (Nanchang, Jinhua and Yingtan). In Dermacentor steini 4 isolates had identical or similar mitochondrial genome lengths and an overall variation of 0.76% between sequences. All nucleotide compositions showed a distinct AT preference. The most common initiation and stop codons were ATG and TAA, respectively. Fewer base mismatches were found in the tRNA gene of D. steini (isolate Longyan), and the vicinity of the control region and tRNA gene was a hot rearrangement region of the genus Dermacentor. Maximum likelihood trees and Bayesian trees indicate that D. steini is most closely related to Dermacentor auratus. The results enrich the mitochondrial genomic data of species in the genus Dermacentor and provide novel insights for further studies on the phylogeographic classification and molecular evolution of ticks. [ABSTRACT FROM AUTHOR]

The article offers specially designed column helps students to self analyze their understanding on specified chapters and Self check table helps to check student readiness.

The article discusses research on the creation of cells that are invulnerable to viruses. Topics include the recoding of DNA in relation to transfer RNAs (tRNAs), the work of a team led by biologist Nili Ostrov in developing the bacterium rE.coli-57, and the possible uses of the bacterium's viral immunity in drug development. The work of geneticist George Church is noted.

The complete circular mitogenome of Paragonimus skrjabini miyazakii (Platyhelminthes: Paragonimidae) from Japan, obtained by PacBio long-read sequencing, was 17 591 bp and contained 12 protein-coding genes (PCGs), 2 mitoribosomal RNA and 22 transfer RNA genes. The atp 8 gene was absent, and there was a 40 bp overlap between nad 4L and nad 4. The long non-coding region (4.3 kb) included distinct types of long and short repeat units. The pattern of base usage for PCGs and the mtDNA coding region overall in Asian and American Paragonimus species (P. s. miyazakii , P. heterotremus , P. ohirai and P. kellicotti) and the Indian form of P. westermani was T > G > A > C. On the other hand, East-Asian P. westermani used T > G > C > A. Five Asian and American Paragonimus species and P. westermani had TTT/Phe, TTG/Leu and GTT/Val as the most frequently used codons, whereas the least-used codons were different in each species and between regional forms of P. westermani. The phylogenetic tree reconstructed from a concatenated alignment of amino acids of 12 PCGs from 36 strains/26 species/5 families of trematodes confirmed that the Paragonimidae is monophyletic, with 100% nodal support. Paragonimus skrjabini miyazakii was resolved as a sister to P. heterotremus. The P. westermani clade was clearly separate from remaining congeners. The latter clade was comprised of 2 subclades, one of the East-Asian and the other of the Indian Type 1 samples. Additional mitogenomes in the Paragonimidae are needed for genomic characterization and are useful for diagnostics, identification and genetic/ phylogenetic/ epidemiological/ evolutionary studies of the Paragonimidae. [ABSTRACT FROM AUTHOR]

A recent report from the University of Illinois Urbana-Champaign discusses research on the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1), which plays a role in learning and memory. The study found that Arc protein has similarities to viral Group-specific antigen (Gag) protein and facilitates intercellular RNA transfer through virus-like capsids. The researchers identified that phosphatidylinositol-3-phosphate (PI3P) mediates Arc capsid assembly and secretion through the endosomal-multivesicular body (MVB) pathway. Understanding this secretion pathway provides insights into Arc's role in intercellular cargo transfer and highlights similarities and differences between trafficking mechanisms of structurally similar capsid proteins. [Extracted from the article]

A recent preprint abstract discusses the challenges of identifying sites of RNA modifications and introduces a method called PhOxi-seq that can detect enzyme-dependent m2G sites in various types of RNA. The authors describe an optimized workflow and a bioinformatic pipeline that can detect these sites in low abundant mRNAs. They generated a database of high confidence sites of THUMPD3-dependent m2G in multiple RNA classes within a human cancer cell line and also identified non-THUMPD3 controlled sites throughout the transcriptome. It is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

Researchers at Islamic Azad University have conducted a study on personalized medicine, specifically focusing on single nucleotide polymorphisms (SNPs) and their impact on protein sequence variation. The human genome consists of three billion base pairs, with approximately one percent of genetic variation between individuals. SNPs are important genetic differences between people and can be found in various regions of DNA, such as the promoter region, exons, introns, and untranslated regions. Understanding these genetic variations can aid in the treatment process, patient management, and prognosis, particularly in relation to cancer, neurological, and immunological diseases. This research provides valuable insights into the role of genetic diversity in personalized medicine. [Extracted from the article]

A recent study conducted at Western University in London, Canada, explores the impact of mistranslation on the transcriptome of Drosophila melanogaster, a species of fruit fly. Mistranslation, which occurs when an incorrect amino acid is incorporated into a polypeptide, has diverse effects on multicellular eukaryotes and is linked to various human diseases. The study found that the mistranslation of proline to serine in male and female flies resulted in sex-specific differences in gene expression and cellular processes. These findings have important implications for understanding the sex-specific impact of mistranslation on disease and potential therapeutic interventions. [Extracted from the article]