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A recent study conducted by researchers from Naval Medical University in Shanghai, China, found that pilots have a high prevalence of dyslipidemia, a type of hyperlipidemia. The study analyzed physical examination data from 1,253 pilot inpatients and identified four risk factors associated with hyperlipidemia in pilots: thrombin time, carbohydrate antigen 199, lymphocyte count, and rheumatoid factor. The researchers suggest that pilot health management should be personalized and focus on addressing these risk factors through diet and lifestyle modifications. The study has been peer-reviewed and published in Experimental and Therapeutic Medicine. [Extracted from the article]

A systematic review and meta-analysis conducted by researchers at Wollo University explored the association between prothrombin time (PT), thrombin time (TT), and activated partial thromboplastin time (APTT) levels with preeclampsia (PE), a leading cause of maternal and infant mortality. The study included 30 articles involving 5,964 individuals and found that PT and APTT levels were significantly increased in PE patients compared to normotensive pregnant mothers, while the increase in TT levels was not statistically significant. The researchers suggest that evaluating these coagulation parameters could serve as easily accessible and cost-effective clinical indicators for assessing PE, but further multicenter longitudinal studies are needed. [Extracted from the article]

A study conducted by the U.S. Food and Drug Administration (FDA) investigated the concentration of thrombin, a blood protein, at the time of clot formation. The researchers analyzed 5758 blood samples under various conditions and found that the Thrombin at Clot Time (TCT) parameter is often close to 10% of the thrombin peak height (TPH). However, TCT can vary depending on the sample's TPH value, with samples having high TPH associated with elevated TCT. The study suggests that TCT could serve as an additional marker for the procoagulant potential in plasma samples. [Extracted from the article]

A study conducted by investigators at Sichuan University in Chengdu, China, examined the effects of hemolysis on routine coagulation tests when tested on an optical coagulation analyzer. The researchers found that hemolysis caused a statistically significant decrease in prothrombin time (PT) and a statistically significant increase in partial thromboplastin time (APTT). However, there were no significant differences in other coagulation parameters such as fibrinogen, thrombin time, D-dimer, or fibrinogen degradation products. The study concluded that while hemolysis can affect coagulation test results, there is no need to reject hemolyzed samples when tested on the specific analyzer used in the study. The researchers also noted that falsely elevated antithrombin activity results could potentially lead to misdiagnosis in patients with severe diseases. [Extracted from the article]

Audiology, Biomarkers, Blood Coagulation Factors, Diagnostics and Screening, Ear Diseases and Conditions, Enzymes and Coenzymes, Health and Medicine, Hearing Diseases and Conditions, Hearing Disorders, Hearing Loss, Hematology, Nervous System Diseases and Conditions, Neurologic Manifestations, Otolaryngology, Peptide Hydrolases, Sensation Disorders, Sensorineural Hearing Loss, Serine Endopeptidases, Thrombin Keywords: Audiology; Biomarkers; Blood Coagulation Factors; Diagnostics and Screening; Ear Diseases and Conditions; Enzymes and Coenzymes; Health and Medicine; Hearing Diseases and Conditions; Hearing Disorders; Hearing Loss; Hematology; Nervous System Diseases and Conditions; Neurologic Manifestations; Otolaryngology; Peptide Hydrolases; Sensation Disorders; Sensorineural Hearing Loss; Serine Endopeptidases; Thrombin EN Audiology Biomarkers Blood Coagulation Factors Diagnostics and Screening Ear Diseases and Conditions Enzymes and Coenzymes Health and Medicine Hearing Diseases and Conditions Hearing Disorders Hearing Loss Hematology Nervous System Diseases and Conditions Neurologic Manifestations Otolaryngology Peptide Hydrolases Sensation Disorders Sensorineural Hearing Loss Serine Endopeptidases Thrombin 102 102 1 09/11/23 20230914 NES 230914 2023 SEP 14 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- A new study on sensorineural hearing loss is now available. [Extracted from the article]

Keywords: Angiology; Diagnostics; Health and Medicine; Radiology EN Angiology Diagnostics Health and Medicine Radiology 106 106 1 05/15/23 20230516 NES 230516 2023 MAY 18 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Current study results on diagnostics have been published. Angiology, Diagnostics, Health and Medicine, Radiology. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a retrospective study involving 329 patients treated with idarucizumab for reversal of the effects of dabigatran etexilate between 1 April 2016 and 31 December 2018 at three hospitals in New Zealand, three patients [ I ages and sexes not stated i ] were described; they developed gastrointestinal bleeding (n=1), postoperative bleeding (n=1) and subdural haematoma with prolonged dilute thrombin clotting time (dTCT; n=1) during anticoagulant therapy with dabigatran etexilate. The patient, who developed gastrointestinal bleeding, resumed dabigatran etexilate, and the gastrointestinal bleeding recurred [ I not all outcomes stated i ]. [Extracted from the article]