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Flexible pressure sensors with high sensitivity and wide pressure response range are attracting considerable research interest for their potential applications as e-skins. Nowadays, it seems a dilemma to realize high-performance, multifunctional pressure sensors with a cost-effective, scalable strategy, which can simplify wearable sensing systems without additional signal processing, enabling device miniaturization and low power consumption. Herein, pressure sensors with ultrahigh sensitivity and a broad response pressure range are developed with a low-cost, facile method by combining strain-induced percolation behavior and contact area contributions. Because of their special surface structure and strain-induced conductive network formation behavior, these unique pressure sensors exhibit wide sensing range of 1 Pa to 500 kPa, ultrahigh sensitivity (1 × 106and 3.1 × 104kPa–1in the pressure ranges of 1 Pa to 20 kPa and 20–500 kPa, respectively), fast signal response (<50 ms), low detection limit (1 Pa), and high stability over 500 loading/unloading cycles. These characteristics allow the devices to work as e-skins to monitor human pulse signals and finger touch. Moreover, these sensors illustrate precise electrical response to mechanical vibration, bending, and temperature stimuli, which afford the ability of detecting cell phone call-in vibration signals, joint bending, spatial pressure, and temperature distributions, indicating promising applications in next-generation wearable, multifunctional e-skins.