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Alzheimerʼs disease (AD) is a critical neurodegenerative disease that manifests as progressive intellectual decline and is pathologically characterized by a progressive loss of neurons in the brain. Despite extensive research on this topic, the pathogenesis of AD is not fully understood, while the beta-amyloid (A β) hypothesis remains the dominant one and only a few symptomatic drugs are approved for the treatment of AD. Ginseng has been widely reported as an effective herbal medicine for the treatment of neurodegenerative diseases such as dementia. Therefore, we explore the protective effects of ginseng in AD by a network pharmacological approach based on the pathogenesis of A β. Twenty-one major ginsenosides are screened based on ultraperformance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) data. Among them, MAPK8, MAPK9, BACE1, FLT1, CDK2, and CCR5 are the core targets. By molecular docking and validation with the in vitro cell model APPswe-SH-SY5Y, we find that ginsenosides Rg3 and Ro have good neuroprotective effects and can reduce the expression of A β1 – 42 in APPswe-SH-SY5Y. Finally, through RT-qPCR experiment, we find that ginsenoside Rg3 targeted MAPK8, FLT1, and CCR5, while ginsenoside Ro targeted MAPK8, MAPK9, FLT1, and CCR5 for its potential anti-AD efficacy. [ABSTRACT FROM AUTHOR]

The thick and hard roof (THR) is a significant factor that induces rock burst incidents. Traditional deep-hole blasting methods struggle to effectively relieve pressure for the high-level THR on a large scale. Although the horizontal staged hydraulic fracturing technology can crack high-level rock stratas, its impact on roof fracture still needs to be clarified, and there need to be more effective methods to evaluate its pressure relief effect. This paper conducted a comparative engineering test of local hydraulic fracturing pressure relief and load reduction on the working face to address this gap. The key layer theory and mine earthquake distribution were used to identify potential hazards of rock strata and the fracturing strata. Revealed the spatial and temporal evolution rules of microseisms induced by mining work, the failure mechanism of high-energy mine earthquakes, the evolution characteristics of source mechanical parameters, and the evolution characteristics of the stope stress field. The results indicate that after fracturing microseisms during mining presented exhibit a uniform distribution of high frequency and low energy. The fracture fragmentation of the roof rock was reduced, and the range of mining disturbance was minimized. High-energy mine earthquakes induced by mining are transferred to the goaf. Simultaneously, the corner frequency and stress decrease while the rupture radius and the shear component of the failure mechanism increase. The integrity of the THR is compromised, and fracture propagates and slips along the pre-crack. The roof of the working face experiences localized pressure, with decreased periodicity and intensity, reducing the overall static load level of the coal seam under the fracturing area. The research findings serve as a valuable reference for further investigations into the mechanism and risk assessment of hydraulic fracturing in preventing and controlling rock burst.

This article presents a novel thruster fault diagnosis approach for an autonomous underwater vehicle. In the novel approach, a time-frequency entropy enhancement is used to extract feature, and then a boundary constraint–assisted relative gray relational grade is applied to identify thruster fault. The time-frequency entropy enhancement is developed from the smoothed pseudo Wigner–Ville distribution combined with Shannon entropy. First, the energy distributions of autonomous underwater vehicle dynamic signals are given in the time-frequency plane. And then the energy concentration in the energy distribution is enhanced based on a serial signal processing, including wavelet decomposition, modified Bayes’ classification algorithm, and two dimensional convolution operation, successively. After that the Shannon entropy of the energy distribution is calculated. The boundary constraint–assisted relative gray relational grade comes from the gray relational analysis. A mapping function between the relative gray relational grade and the fault severity is established. And then the boundary constraints of relative gray relational grades at each standard fault level are determined. Moreover, the mapping function is modified based on the boundary constraints. Experiments are performed on an experimental prototype autonomous underwater vehicle in a pool. The experimental results demonstrate the effectiveness of the developed approaches in terms of improving the sensitivity of the fault feature to the fault severity, compared with the smoothed pseudo Wigner–Ville distribution combined with Shannon entropy, and increasing the identification accuracy, compared with the gray relational analysis.

As shallow coal reserves continue to deplete rapidly, deep mining has become an unavoidable course of action. In the process of deep coal mining, affected by blasting, mining, and excavation, the coal-rock interface often encounters the action of compression-shear composite load. The interface crack directly affects the stability of the coal-rock structure. Uniaxial compression experiments have been conducted on rock and coal-like material with pre-existing interfacial oblique cracks to study the crack propagation criterion of the rock and coal-like material interface. An image acquisition system is used to record the surface speckle field of the whole process of specimen failure. The strain fields and stress intensity factor of the sample at different times are obtained by digital image correlation. At the same time, the stress field near the crack tip is calculated. The results show that with the increase of loading, two strains of localization bands are formed on the surface of the specimen. One of the strain-localized bands starts at the lower tip of the prefabricated crack and propagates along the vertical interface. The other starts at the upper tip of the prefabricated damage and propagates along the interface direction. It can be seen that the lower tip of the prefabricated crack enters into the crack fracture process zone earlier than the upper tip. The strain localization band narrows gradually with the load increase, and then macro cracks appear. The initiation of two tips is suitable for different fracture criteria. The lower tip is dominated by the maximum circumferential tensile stress, and the upper tip is dominated by shear stress. The specimens eventually fracture along the interface. The evolution of the strain field during the failure process of rock and coal-like material can reflect the generation and propagation of the crack.

Artificial compound eyes (ACEs) endowed with durable superhydrophobicity, wide field-of-view (FOV), and antireflection properties are extremely appealing in advanced micro-optical systems. However, the simple and high-efficiency fabrication of ACEs with these functions is still a major challenge. Herein, inspired by moth eyes, ACEs with hierarchical macro/micro/nano structures were fabricated using the combination of nanotip-focused electrohydrodynamic jet (NFEJ) printing and air-assisted deformation processes. The NFEJ printing enables the direct and maskless fabrication of hierarchical micro/nanolens arrays (M/NLAs) without intermediate steps. The introduction of M/NLAs on the eye surface significantly improves the water hydrophobic performance with a water contact angle of 161.1° and contact angle hysteresis (CAH) of 4.2° and generally decreases the reflectance by 51% in the wavelength range of 350–1600 nm in comparison to the macroeye without any structures. The contact angle remains almost unchanged, and the CAH slightly increases from 4.2° to 8.7° after water jet impact for 20 min, indicating a durable superhydrophobicity. Moreover, the results confirm that the durable superhydrophobic ACEs with antireflection properties exhibit excellent imaging quality and a large FOV of up to 160° without distortion.