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Your search keyword '"Stefania Lymperi"' showing total 2 results
Start Over Author "Stefania Lymperi" Publication Type Magazines
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2. The Microanatomy of the Leukemic Stem Cell Niche in Murine Chronic Myelogenous Leukemia

Author

Meister, Melanie, Spencer, Joel A, Wu, Juwell, Zhao, Cher, Stefania, Lymperi, Ferraro, Francesca, Lo Celso, Cristina, Scadden, David T., Van Etten, Richard A., Lin, Charles, and Krause, Daniela S.

Abstract

Objectives and background: Constituents of the bone marrow microenvironment (BMM) influence the proliferation, differentiation and location of hematopoietic stem and progenitor cells (HSPC). Dependent on their maturation stage, different subsets of HSPC are localized at distinct sites in the BMM. This location depends on HSPC-intrinsic, as well as HSPC-extrinsic factors. The BMM protects leukemic stem cells (LSC) from treatment with tyrosine kinase inhibitors or chemotherapy. We, therefore, investigated the microanantomy of the LSC niche hypothesizing that it may differ from the normal HSPC niche.

Published
2014
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