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Byline: Deepak. Mittal, Veereshwar. Bhatnagar, Sandeep. Agarwala, Maddur. Srinivas, Manisha. Jana, Arun. Gupta, Nibhriti. Das, Manoj. Singh Aims: The aim of this study is to evaluate hepatic artery resistive index [...]

Byline: Vikram. Khanna, Veereshwar. Bhatnagar, Sandeep. Agarwala, Maddur. Srinivas, Nibhriti. Das, Manoj. Singh Aim: To evaluate the incidence of portal hypertension (PHT) in biliary atresia (BA) patients and to monitor [...]

Supplemental Digital Content is available in the text.Children with neuroblastoma (NB) and opsoclonus-myoclonus-ataxia syndrome (OMAS) have a favorable oncologic outcome and overall survival. In contrast, despite intensive multidrug immunomodulation, the neurologic outcome is complicated by the relapsing nature of the neurologic symptoms and long-term neurobehavioral sequelae. Being associated with low-risk NB, there exists an ambiguity in the current literature regarding the administration of chemotherapy in these children. We reviewed our archives for children with NB-OMAS over a 22-year (January 1996 to January 2018) period. Eighteen children (10 female) with a median age at diagnosis of 23 months had NB-OMAS and were included. They had stage 1 (9/18; 50%), 2 (1/18; 5.5%), 3 (7/18; 39%), and 4 (1/18; 5.5%) disease according to the International Neuroblastoma Staging System. Multimodality therapy included surgery (16/18; 89%), chemotherapy (11/18; 61%), and immunomodulatory therapy (10/18; 55%). Complete oncologic remission was achieved in all children. Relapse of OMAS and presence of neurologic sequelae were observed in 1 (5.5%) and 5 (28%) cases, respectively. Presence of neurologic sequelae was significantly associated with low-tumor stage (P=0.036) and treatment without chemotherapy (P=0.003). Chemotherapy administration was the only variable significantly predicting a favorable neurologic outcome (95% confidence interval: 0.26-1.40, P=0.01). To conclude, our study including a limited cohort of patients highlights a favorable neurologic outcome associated with chemotherapy administration in children with NB-OMAS. However, further studies with larger sample size need to be conducted before drawing any definite conclusions.

Byline: Karunesh. Chand, Veereshwar. Bhatnagar, Sandeep. Agarwala, Maddur. Srinivas, Nibhriti. Das, Manoj. Singh, Raju. Sharma Background and Aims: Symptomatic portal hypertension (PHT) as a complication of the choledochal cyst (CDC) [...]

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