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ABSTRACTThis paper explores online brand advocacy (OBA) in a tourism destination context. Through a Social Influence Theory lens, it explores the ways in which residents and overseas tourists discuss Australia as a destination brand on social media. By analyzing a big dataset of social media user-generated content (UGC), this study sought to identify the key dimensions evident in positively valenced social media UGC, to see whether these dimensions varied between residents and overseas tourists, and to see whether the dimensions reflected OBA. The analyses found online destination brand advocacy (ODBA) had five dimensions: Destination Acknowledgement (hashtags), Destination Insights, Destination Positivity and Experience Sharing, Destination Brand Defence and Positive Virtual Visual Cues. The results have implications for the ways destination management organisations (DMOs) use social media. Suggestions for DMOs about incorporating ODBA in their marketing and branding strategies, are given at the conclusion of this paper. Some theoretical implications, specifically the need to further investigate ODBA, are also outlined.

Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membrane permeabilization model1. Recently, the clinically vital but also highly renal-toxic small-molecule natural product amphotericin B was instead found to kill fungi primarily by forming extramembraneous sponge-like aggregates that extract ergosterol from lipid bilayers2–6. Here we show that rapid and selective extraction of fungal ergosterol can yield potent and renal-sparing polyene antifungals. Cholesterol extraction was found to drive the toxicity of amphotericin B to human renal cells. Our examination of high-resolution structures of amphotericin B sponges in sterol-free and sterol-bound states guided us to a promising structural derivative that does not bind cholesterol and is thus renal sparing. This derivative was also less potent because it extracts ergosterol more slowly. Selective acceleration of ergosterol extraction with a second structural modification yielded a new polyene, AM-2-19, that is renal sparing in mice and primary human renal cells, potent against hundreds of pathogenic fungal strains, resistance evasive following serial passage in vitro and highly efficacious in animal models of invasive fungal infections. Thus, rational tuning of the dynamics of interactions between small molecules may lead to better treatments for fungal infections that still kill millions of people annually7,8and potentially other resistance-evasive antimicrobials, including those that have recently been shown to operate through supramolecular structures that target specific lipids9.

AbstractThis study investigates the effects of employees' perceived values-congruence within an organisation affect employees' beliefs about organisational change. Specifically, we investigated the effects employees' perceived values-congruence with their organisation, supervisor and colleagues had on beliefs about an organisational change implementation and tested whether these relationships were mediated by employees' felt trust and perceptions of the quality of their organisations' communication, as suggested by the literature. Data from 251 respondents who had undergone an organisational change within the last 6 months were analysed. Support was found for the influence all three types of perceived values-congruence (i.e. congruence with their organisation, supervisor and colleagues) had on change-related beliefs and strong support was found for the mediation role played by trust and the quality of communication.

AbstractIncreasing numbers of people are working part-time (PT) hours, sometimes involuntarily (IPT). Australia has the fourth highest percentage of PT employees among Organization for Economic Co-operation and Development countries (26%). This study examines relationships between work design factors and workplace inclusion for PT employees and identifies how perceived inclusion and work engagement of PT and IPT employees compares with full-time (FT) employees. Data were collected using an online questionnaire distributed to employees in Australia. A part-time work design model was developed and tested across two independent samples using partial least squares. Results suggest that PT and IPT employees feel less included in the workplace compared to FT employees. PT employees also perceive their roles to be less task interdependent. A key finding was that PT employees' perceived inclusion was related to proactive behaviors, autonomy, and job crafting, in addition to hours worked. Implications for the management of PT employees are discussed.

I've been enjoying your 50th anniversary article series on the Apollo lunar landings these last several years. Many of the historical details and photographs are new to me, and the [...]