1. D-dimer and CA 125 levels in patients with ovarian cancer during antineoplastic therapy: prognostic significance for the success of anti-cancer treatment
- Author
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Mirshahi, S.S., Pujade-Lauraine, E., Soria, C., Mirshahi, M., Fretault, J., Bernadou, A., and Soria, J.
- Subjects
Ovarian cancer -- Prognosis ,Antineoplastic agents -- Health aspects ,Fibrin -- Physiological aspects ,Chemotherapy -- Management ,Health - Abstract
In patients with ovarian cancer before they receive chemotherapy, the level of fibrin degradation products (D-dimer), is correlated with the tumor load. In this study, the evolution of D-dimer was compared in patients receiving antineoplastic therapy with the evolution of the disease. The patients could be classified into three groups. In Group 1 (nine patients), both plasma CA 125 (a tumor-associated antigen) and D-dimer remained elevated; the prognosis was always poor. In Group 2 (eight patients), CA 125 and D-dimer decreased simultaneously, complete remission was observed in two patients, and significant residual tumor was observed in the other. In Group 3 (nine patients), despite an important decrease in CA 125, D-dimer remained elevated during therapy. In this group, complete remission was observed in six patients, and the three others showed a large decrease in their tumor load. The combination of a decrease in CA 125 levels with a continuous enhanced level of D-dimer during chemotherapy identified a subgroup of patients with a favorable prognosis. Cancer 1992; 69:2289-2292.
- Published
- 1992