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Surgeon visual estimation of shoulder range of motion (ROM) is commonplace in the outpatient office setting and routinely reported in clinical research, but the reliability and accuracy of this practice remain unclear. The purpose of this study is to establish the reliability and accuracy of remote visual estimation of shoulder ROM in healthy volunteers and symptomatic patients among a large group of shoulder surgeons. Our hypothesis is that remote visual estimation would be reliable and accurate compared with the digital goniometer method.

Molded antibiotic shoulder spacers allow for intraoperative customization of antibiotics and multiple size options. The purpose of this study was to evaluate the efficacy of an anatomic intraoperatively molded spacer in the two-stage treatment of infection and to assess the safety of early rehabilitation when the capsule and rotator cuff are present. During 2014 and 2015, 27 shoulders were treated with a molded antibiotic cement spacer as part of a two-stage treatment. Indications included periprosthetic joint infection (n=18), native shoulder infection (n=8), and infection after internal fixation (n=1). All patients were followed for a minimum of 2 years. Mean follow-up time was 29.6 months. Patients were allowed to perform motion exercises (group I; n=16) or were instructed to avoid motion (group II; n=11) after spacer implantation, depending on the condition of their rotator cuff. Infection was eradicated in 23 of the 27 shoulders (85%). At most recent follow-up, pain scores were lower in group I. Mean final elevation was 115° in group I compared with 93° in group II. Mean final active external rotation was 36°, with no difference between the groups. In 3 (4%) shoulders with significant proximal humeral bone loss, the spacer became rotationally unstable. An anatomic intraoperatively molded spacer can be implanted safely in two-stage treatment for deep infection and has a reasonable rate of eradication. When adequate capsule and rotator cuff tissue is present, early motion in between stages can be safely recommended with a trend toward improved forward elevation at final follow-up and may facilitate the second stage reimplantation. [Molded antibiotic shoulder spacers allow for intraoperative customization of antibiotics and multiple size options. The purpose of this study was to evaluate the efficacy of an anatomic intraoperatively molded spacer in the two-stage treatment of infection and to assess the safety of early rehabilitation when the capsule and rotator cuff are present. During 2014 and 2015, 27 shoulders were treated with a molded antibiotic cement spacer as part of a two-stage treatment. Indications included periprosthetic joint infection (n=18), native shoulder infection (n=8), and infection after internal fixation (n=1). All patients were followed for a minimum of 2 years. Mean follow-up time was 29.6 months. Patients were allowed to perform motion exercises (group I; n=16) or were instructed to avoid motion (group II; n=11) after spacer implantation, depending on the condition of their rotator cuff. Infection was eradicated in 23 of the 27 shoulders (85%). At most recent follow-up, pain scores were lower in group I. Mean final elevation was 115° in group I compared with 93° in group II. Mean final active external rotation was 36°, with no difference between the groups. In 3 (4%) shoulders with significant proximal humeral bone loss, the spacer became rotationally unstable. An anatomic intraoperatively molded spacer can be implanted safely in two-stage treatment for deep infection and has a reasonable rate of eradication. When adequate capsule and rotator cuff tissue is present, early motion in between stages can be safely recommended with a trend toward improved forward elevation at final follow-up and may facilitate the second stage reimplantation. [Orthopedics. 2019; 42(4):211–218.]

To determine whether the Summary Outcome Determination (SOD) score had exhibited a high level of physician-patient agreement in surgical patients.

Increased polyamine synthesis is known to play an important role in prostate cancer. We aimed to explore its functional significance in prostate tumor initiation and its link to androgen receptor (AR) signaling. For this purpose, we generated a new cell line derived from normal epithelial prostate cells (RWPE-1) with overexpression of ornithine decarboxylase (ODC) and used it for in vitroand in vivoexperiments. We then comprehensively analyzed the expression of the main metabolic enzymes of the polyamine pathway and spermine abundance in 120 well-characterized cases of human prostate cancer and high-grade prostate intraepithelial neoplasia (HGPIN). Herein, we show that the ODC-overexpressing prostate cells underwent malignant transformation, revealing that ODC is sufficient for de novo tumor initiation in 94% of injected mice. This oncogenic capacity was acquired through alteration of critical signaling networks, including AR, EIF2, and mTOR/MAPK. RNA silencing experiments revealed the link between AR signaling and polyamine metabolism. Human prostate cancers consistently demonstrated up-regulation of the main polyamine enzymes analyzed (ODC, polyamine oxidase, and spermine synthase) and reduction of spermine. This phenotype was also dominant in HGPIN, rendering it a new biomarker of malignant transformation. In summary, we report that ODC plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as HGPIN.

Head and neck cancer is one of the most common cancers worldwide. MR imaging–based diffusion and perfusion techniques enable the noninvasive assessment of tumor biology and physiology, which supplement information obtained from standard structural scans. Diffusion and perfusion MR imaging techniques provide novel biomarkers that can aid monitoring in pretreatment, during treatment, and posttreatment stages to improve patient selection for therapeutic strategies; provide evidence for change of therapy regime; and evaluate treatment response. This review discusses pertinent aspects of the role of diffusion and perfusion MR imaging and computational analysis methods in studying head and neck cancer.

To investigate the repeatability of the quantitative magnetic resonance imaging (MRI) metric (apparent diffusion coefficient ADC) derived from reduced field-of-view diffusion-weighted (rFOV DWI) on thyroid glands in a clinical setting.

Both anatomic and reverse total shoulder arthroplasty have demonstrated excellent results in patients with arthritis. The deltopectoral approach is commonly utilized for both procedures, and the subscapularis is typically taken down. Multiple variations of subscapularis repairs are known, but subscapularis failure postoperatively can lead to poor clinical outcomes. We present a case of a standard anatomic total shoulder arthroplasty subscapularis repair with a specific suture configuration and a metallic button. In this technique, both Krackow and Mason-Allen suture techniques are utilized to approximate the tendon down to the bone. The patient described recovered quickly after the surgery, and he has demonstrated excellent results. These results are similar to those seen by the senior author while utilizing this technique, and after transitioning to this technique, postoperative subscapularis failures have been infrequently appreciated.

The coronoid process serves as an important constraint that provides ulnohumeral joint stability. We describe a novel approach to coronoid fractures that minimizes surgical dissection, without compromising fracture visualization. We present the case of a 65-year-old woman who sustained an anteromedial facet fracture of the coronoid process. The elbow demonstrated intractable posteromedial instability and the inability to maintain reduction even up to 90 degrees. This report describes a surgical approach to the coronoid process that minimizes extensive soft tissue dissection. It is a variation of the previously described approach by Taylor and Scham, although it can achieve a similar exposure without elevation of the entirety of the flexor-pronator mass. Our approach involves a limited skin incision, followed by elevation of enough of the flexor-pronator mass such that adequate visualization of the posterior medial collateral ligament (which was repaired), anteromedial facet, and the fractured fragment of coronoid were achieved. Moreover, this approach enables the course of the ulnar nerve to remain unaltered.

Reverse total shoulder arthroplasty has demonstrated excellent results for patients with glenohumeral arthritis and a deficient rotator cuff. Patients requiring a reverse total shoulder arthroplasty with substantial glenoid erosion pose a difficult problem. The operative surgeon must correct the version of the glenoid while maintaining secure glenoid fixation. Techniques demonstrating this are currently lacking in the literature. We present a case of an elderly patient with glenoid erosion causing a significantly abnormal glenoid version. In this technique, the cut portion of the humeral head was utilized as bone graft. The head was shaped to restore the glenoid version, and the graft was held in place with glenoid insertion techniques. The patient described recovered quickly after the surgery, and she has demonstrated excellent results. These results are similar to those seen by the senior author while utilizing this technique. This is currently our preferred method of addressing glenoid version abnormalities in reverse total shoulder arthroplasty.

The integrity of elbow soft tissues affects radiocapitellar joint stability in the presence of bipolar radial head (RH) prostheses. This study examined the effect on radiocapitellar stability of monopolar designs versus bipolar RH prostheses in an elbow model with a surgically controlled terrible triad injury.

Prostate-specific antigen screening has led to a downstaging of prostate cancer that has resulted in overdiagnosis and overtreatment of the disease. The review discusses the potential role of imaging in identifying low-risk prostate cancer and enabling more appropriate management of the disease.

Several letters to the editor are presented in response to articles from past issues such as "Progressives in the Obama Moment," and "Orthogonian Visions," from the September 1, 2008 issue.

This report describes 2 cases of a posteroinferior capitellum impaction osteochondral injury with associated avulsion of the supinator crest resulting from a fall onto an extended upper extremity. The injury pattern in both cases was detected on x-ray films, although fully appreciated on computed tomographic imaging. Posterolateral rotatory instability occurred in both patients. One patient underwent early operative intervention (4 days postinjury) and returned to normal within 5 weeks. Surgery was delayed for the second patient (13 weeks), who initially experienced unfavorable outcomes, although stability was ultimately restored operatively. To our knowledge, this injury pattern has not previously been described as the focus of a report.

Under ethical review board approval, 27 previously untreated DLBCL patients prior to receiving standard doxorubicin-based therapy were studied noninvasively using 3D localized, 1H-decoupled, nuclear Overhauser-enhanced phosphorus MR spectroscopy at 1.5 T.As only complete response (CR) is clinically meaningful in achieving durable remissions of DLBCL, we divided these patients by response at six months into CR and all the other responses (not complete response, NCR). In the 17 CR patients, the PMR was significantly lower than in the ten NCR patients (PMR mean ± 95% CI, 1.46 ± 0.21 vs. 2.47 ± 0.24, p < 3 × 10-6). The prediction of response using a Fisher test was significant for the PMR alone (p < 1 × 10-4; sensitivity of 1.00, specificity of 0.70) and improved further when combined with the IPI (p < 2 × 10-6; sensitivity of 1.0, specificity of 0.90). The progression-free survival (PFS) strongly correlated with the PMR alone (p < 4 × 10-8) and with the PMR and IPI as covariates (p < 1 × 10-7) by the Cox regression model. Using the Kaplan-Meier model, the PMR discriminated 64% of patients with PFS below 11 months (p < 1 × 10-7), while as covariate with the IPI it discriminated 82% of these patients (p < 2 × 10-7).Our results show that the PMR contains information that predicts outcome to standard therapy in DLBCL patients. This prediction improves when the PMR is combined with the IPI. While the PME alone identifies 64% of those patients who will go on to show an extremely poor response with a progression-free survival below 11 months, the combination of the PME and IPI identify 82% of these patients. In conclusion, we have successfully demonstrated that the PMR can be an important determinant in predicting response to treatment in patients with DLBCL, especially when integrated with the IPI.1) Cancer: principles and practice of oncology. 6th ed. Philadelphia, PA, Lippincott, Williams & Wilkins, 2001; 2) Smith MR, Non-Hodgkin's lymphoma. St. Louis, MO, Mosby, 1966; 3) Arias-Mendoza F, Brown TR, Dis. Markers, 2003;19:49-68; 4)Griffiths JR, et al, Lancet 1983;1:1435-6No relevant conflicts of interest to declare.