1. Cytotoxic Cytochalasins from Marine-Derived Fungus Arthrinium arundinis.
- Author
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Junfeng Wang, Zhen Wang, Zhiran Ju, Junting Wan, Shengrong Liao, Xiuping Lin, Tianyu Zhang, Xuefeng Zhou, Hao Chen, Zhengchao Tu, and Yonghong Liu
- Subjects
DRUG therapy for tuberculosis ,CHROMATOGRAPHIC analysis ,FUNGAL metabolism ,ANTIBIOTICS ,BIOLOGICAL assay ,CELL culture ,CELL lines ,CRYSTALLOGRAPHY ,HETEROCYCLIC compounds ,ISONIAZID ,MASS spectrometry ,MOLECULAR structure ,NUCLEAR magnetic resonance spectroscopy ,PHARMACEUTICAL chemistry ,RESEARCH funding ,TOXICITY testing ,TUMORS ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Four new cytochalasins, arthriniumnins A-D (1-4), a new natural product, ketocytochalasin (5), as well as five known cytochalasin analogues (6-10) were isolated and identified from the fungus Arthrinium arundinis ZSDS1-F3 from the sponge Phakellia fusca. Their structures were elucidated by NMR spectroscopic and mass spectrometric analyses, as well as single crystal X-ray diffraction. Compounds 6 and 9 showed cytotoxicity against K562, A549, Huh-7, H1975, MCF-7, U937, BGC823, HL60, Hela, and MOLT-4 cell lines, with IC
50 values ranging from 1.13 to 47.4 µM. [ABSTRACT FROM AUTHOR]- Published
- 2015
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