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Your search keyword '"Severinsen, Marianne T."' showing total 11 results
Start Over Author "Severinsen, Marianne T." Publication Type Magazines
11 results on '"Severinsen, Marianne T."'

2. Stringent or nonstringent complete remission and prognosis in acute myeloid leukemia: a Danish population-based study

Author

Øvlisen, Andreas K., Oest, Anders, Bendtsen, Mette D., Bæch, John, Johansen, Preben, Lynggaard, Line S., Mølle, Ingolf, Mortensen, Thomas B., Weber, Duruta, Ertner, Gideon, Schöllkopf, Claudia, Thomassen, Jesper Q., Nielsen, Ove Juul, Østgård, Lene Sofie Granfeldt, Bøgsted, Martin, Dybkær, Karen, Johnsen, Hans E., and Severinsen, Marianne T.

Abstract

Stringent complete remission (sCR) of acute myeloid leukemia is defined as normal hematopoiesis after therapy. Less sCR, including non-sCR, was introduced as insufficient blood platelet, neutrophil, or erythrocyte recovery. These latter characteristics were defined retrospectively as postremission transfusion dependency and were suggested to be of prognostic value. In the present report, we evaluated the prognostic impact of achieving sCR and non-sCR in the Danish National Acute Leukaemia Registry, including 769 patients registered with classical CR (ie, <5% blasts in the postinduction bone marrow analysis). Individual patients were classified as having sCR (n = 360; 46.8%) or non-sCR (n = 409; 53.2%) based on data from our national laboratory and transfusion databases. Survival analysis revealed that patients achieving sCR had superior overall survival (hazard ratio [HR], 1.34; 95% confidence interval [CI], 1.10-1.64) as well as relapse-free survival (HR, 1.25; 95% CI, 1.03-1.51) compared with those with non-sCR after adjusting for covariates. Cox regression analysis regarding the impact of the stringent criteria for blood cell recovery identified these as significant and independent variables. In conclusion, this real-life register study supports the international criteria for response evaluation on prognosis and, most importantly, documents each of the 3 lineage recovery criteria as contributing independently.

Published
2018
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3. Association of Traditional Cardiovascular Risk Factors With Venous Thromboembolism

Author

Mahmoodi, Bakhtawar K., Cushman, Mary, Anne Næss, Inger, Allison, Matthew A., Jan Bos, Willem, Brækkan, Sigrid K., Cannegieter, Suzanne C., Gansevoort, Ron T., Gona, Philimon N., Hammerstrøm, Jens, Hansen, John-Bjarne, Heckbert, Susan, Holst, Anders G., Lakoski, Susan G., Lutsey, Pamela L., Manson, JoAnn E., Martin, Lisa W., Matsushita, Kunihiro, Meijer, Karina, Overvad, Kim, Prescott, Eva, Puurunen, Marja, Rossouw, Jacques E., Sang, Yingying, Severinsen, Marianne T., ten Berg, Jur, Folsom, Aaron R., and Zakai, Neil A.

Abstract

Supplemental Digital Content is available in the text.

Published
2017
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4. Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study

Author

Crobach, Monique J. T., Anijs, Rayna J. S., Brækkan, Sigrid K., Severinsen, Marianne T., Hammerstrøm, Jens, Skille, Hanne, Kristensen, Søren R., Paulsen, Benedikte, Tjønneland, Anne, Versteeg, Henri H., Overvad, Kim, Hansen, John-Bjarne, Næss, Inger A., and Cannegieter, Suzanne C.

Abstract

•The risk of death for patients with cancer-related VTE was increased by 3.4-fold, compared with patients with cancer but without VTE.•The occurrence of VTE increased the mortality risk consistently throughout different cancer types, independent of tumor severity.

Published
2023
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6. Human MICL Is An Early Marker In Myeloid Differentiation and Identifies a Subgroup Of CML Patients With Expanded Granulocyte-Macrophage Progenitor Populations At Diagnosis

Author

van Kooten Niekerk, Peter Buur, Roug, Anne Stidsholt, Petersen, Charlotte Christie, Nederby, Line, Nyvold, Charlotte Guldborg, Bjerrum, Ole Weis, Dimitrijevic, Andreja, Severinsen, Marianne T., Stentoft, Jesper, and Hokland, Peter

Abstract

Stentoft: Novartis: Consultancy, Financial support for relevant congress participation Other, Membership on an entity’s Board of Directors or advisory committees, Research Funding; Bristol-Myers-Squibb: Membership on an entity’s Board of Directors or advisory committees, Research Funding; Danish Regions: Membership on an entity’s Board of Directors or advisory committees. Hokland:Novartis: Research Funding.

Published
2013
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7. Human MICL Is An Early Marker In Myeloid Differentiation and Identifies a Subgroup Of CML Patients With Expanded Granulocyte-Macrophage Progenitor Populations At Diagnosis

Author

van Kooten Niekerk, Peter Buur, Roug, Anne Stidsholt, Petersen, Charlotte Christie, Nederby, Line, Nyvold, Charlotte Guldborg, Bjerrum, Ole Weis, Dimitrijevic, Andreja, Severinsen, Marianne T., Stentoft, Jesper, and Hokland, Peter

Abstract

Although chronic myeloid leukemia (CML) originates from a primitive hematopoietic stem cell (HSC), it is the more differentiated progenitor cells that drive the expansion of the malignant clone. In addition, previous studies of chronic phase CML have shown that, despite the marked leukocytosis observed here, megakaryocyte-erythroid progenitors dominate the progenitor fraction. We sought to elucidate this by employing the new marker for leukemic stem cells, the human myeloid inhibitory C-type lectin-like receptor (hMICL), in the study of progenitor cell expansion in CML.

Published
2013
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8. High Early Death Rate with Excellent Survival Beyond Day 30 in Acute Promyelocytic Leukemia Confirmed in Unselected Patients: Results of a Population-Based Registry Study

Author

Norgaard, Jan M., Ostgard, Lene Sofie Granfeldt, Kjeldsen, Eigil, Holm, Mette S., Kjeldsen, Lars, Kallenbach, Maria, Severinsen, Marianne T., Johansen, Preben, Friis, Lone S., Weber, Duruta, Kerndrup, Gitte, Preiss, Birgitte, Jensen, Morten K., Dufva, Inge H., Timshel, Susanne, Andersen, Mette K., and Nielsen, Ove J.

Abstract

No relevant conflicts of interest to declare.

Published
2012
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9. High Early Death Rate with Excellent Survival Beyond Day 30 in Acute Promyelocytic Leukemia Confirmed in Unselected Patients: Results of a Population-Based Registry Study

Author

Norgaard, Jan M., Ostgard, Lene Sofie Granfeldt, Kjeldsen, Eigil, Holm, Mette S., Kjeldsen, Lars, Kallenbach, Maria, Severinsen, Marianne T., Johansen, Preben, Friis, Lone S., Weber, Duruta, Kerndrup, Gitte, Preiss, Birgitte, Jensen, Morten K., Dufva, Inge H., Timshel, Susanne, Andersen, Mette K., and Nielsen, Ove J.

Abstract

Abstract 3542

Published
2012
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