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Central blood pressure (BP) has been suggested to be a better predictor of cardiovascular disease risk than brachial BP. Arterial stiffness increases central BP by early returning of the reflection pressure wave from peripheral arteries. Curiously, type 2 diabetes and insulin resistance have been favorably associated with central hemodynamics. Major initiators of insulin resistance—such as serum free fatty acid (FFA)—are thus suspected of potentially being involved in central hemodynamics. To confirm that insulin signaling is an important modulator of central hemodynamics, we investigated this hypothesis in a large-scale general population.