1. Randomized trial of the effect of zinc supplementation on the mental health of school-age children in Guatemala
- Author
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DiGirolamo, Ann M., Ramirez-Zea, Manuel, Wang, Meng, Flores-Ayala, Rafael, Martorell, Reynaldo, Neufeld, Lynnette M., Ramakrishnan, Usha, Sellen, Daniel, Black, Maureen M., and Stein, Aryeh D.
- Subjects
Dietary supplements -- Research ,Dietary supplements -- Demographic aspects ,Child psychopathology -- Care and treatment ,Child psychopathology -- Research ,Zinc in the body -- Health aspects ,Zinc in the body -- Research ,Food/cooking/nutrition ,Health - Abstract
Background: Rates of mental illness in children are increasing throughout the world. Observational studies of depression, anxiety, and attention-deficit hyperactivity disorder suggest that zinc is an alternative treatment. Objective: We examined the effect of zinc supplementation on the mental health of school-age children in Guatemala. Design: From January to October 2006, we conducted a 6-mo randomized, double-blind, controlled trial comparing zinc supplementation (10 mg ZnO/d for 5 d/wk) with a placebo (10 mg glucose) in 674 Guatemalan children in grades 1-4. Outcome measures included internalizing (ie, depression and anxiety) and externalizing (ie, hyperactivity and conduct disorder) problem behaviors, positive behaviors (ie, socialization and leadership), and serum zinc concentrations. Results: Zinc and placebo groups did not differ significantly in any behavioral measures at baseline or at follow-up. At baseline, 21.4% of children had serum zinc concentrations doi: 10.3945/ajcn.2010.29686
- Published
- 2010