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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtcvs.2006.06.021 Byline: Artyom Sedrakyan (a)(b), Albert Wu (b)(c), George Sedrakyan (d), Marie Diener-West (e), Maryann Tranquilli (a), John Elefteriades (a) Abbreviations: ACT, activated clotting time; CABG, coronary artery bypass graft; ECM, extracellular matrix; DHCA, deep hypothermic cardiac arrest; KIU, kallikrein inactivation unit Abstract: Previous studies of aprotinin use in thoracic aortic surgery, limited in size and design, reported minimal information regarding outcomes other than blood loss and transfusion. The evaluation of impact of aprotinin on surgical outcomes in a large sample is needed. Author Affiliation: (a) Department of Surgery, Yale University School of Medicine, New Haven, Conn (b) Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (c) Health Services Research and Development Center, Johns Hopkins University, Baltimore, Md (d) Nork-Marash Cardiac Surgery Hospital, Yerevan, Armenia (e) Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md. Article History: Received 1 November 2005; Accepted 6 June 2006 Article Note: (footnote) The chart review, data collection, and data analysis conducted in this study were supported by an investigator-initiated proposal and subsequent phase IV funding by Bayer Pharmaceuticals Corporation, West Haven, Conn, the manufacturer of aprotinin. Artyom Sedrakyan and John Elefteriades report lecture fees and grant support from Bayer Pharmaceuticals Corporation.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jtcvs.2004.07.042 Byline: Artyom Sedrakyan (a)(b), Tom Treasure (c), John Browne (a)(b), Harlan Krumholz (d), Carlos Sharpin (a), Jan van der Meulen (a)(b) Abstract: Atrial tachyarrhythmia is the most common complication after general thoracic surgery and is associated with significant morbidity, longer hospital stay, and higher costs. We sought to determine whether the use of antiarrhythmic medications is associated with a reduced rate of postoperative atrial tachyarrhythmia. Author Affiliation: (a) Royal College of Surgeons of England, London, United Kingdom (b) Health Services Research Unit, Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom (c) Cardiothoracic Unit, Guy's Hospital, London, United Kingdom (d) Department of Medicine and Division of Health Policy, Yale University School of Medicine, New Haven, Conn. Article History: Received 17 June 2004; Revised 27 July 2004; Accepted 28 July 2004

Objectives: Albumin and nonprotein colloids (starches, dextran, and others) are used frequently as blood volume expanders in coronary artery bypass graft (CABG) surgery. The objective of this study was to [...]

There is growing enthusiasm for coronary artery bypass grafting (CABG) without cardiopulmonary bypass (CPB). Although deleterious effects of CPB are known, it remains to be proven that avoiding CPB will result in reduction in morbidity. We sought to determine whether off-pump surgery is associated with reduced occurrence of adverse outcomes as compared with CABG with CPB.

Despite proven blood transfusion benefits, aprotinin may be underused in coronary artery bypass grafting. Reluctance to use aprotinin may stem from safety concerns. The current objective was to evaluate clinical outcomes (mortality, myocardial infarction, renal failure, stroke, atrial fibrillation) in patients undergoing coronary artery bypass grafting who receive aprotinin by performing a quantitative overview of published, randomized, controlled trials.

Postoperative chemotherapy is currently not recommended for resected non–small cell lung cancer in many countries and centers. Recently, results of several large randomized clinical trials were reported with conflicting evidence. Accordingly, we sought to determine whether postoperative chemotherapy is associated with improved survival compared with that after surgical intervention alone.