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Environmental exposures have a significant influence on the chronic health conditions plaguing children and adults. Although the Developmental Origins of Health and Disease (DOHaD) paradigm historically has focused on nutrition, an expanding body of research specifically communicates the effects of chemical exposures on early-life development and the propagation of non-communicable disease across the lifespan. This paper provides an overview of 20 years of research efforts aimed at identifying critical windows of susceptibility to environmental exposures and the signaling changes and epigenetic influences associated with disease progression. DOHaD grants funded by the National Institute of Environmental Health Sciences (NIEHS) in 1991, 2001 and 2011 are identified by grant-analysis software, and each portfolio is analyzed for exposures, disease endpoints, windows of exposure, study design and impact on the field based on publication data. Results show that the 1991 and 2001 portfolios comprised metals, PCBs and air pollutants; however, by 2011, the portfolio has evolved to include or expand the variety of endocrine disruptors, pesticides/persistent organic pollutants and metals. An assortment of brain-health endpoints is most targeted across the portfolios, whereas reproduction and cancer increase steadily over the same time period, and new endpoints like obesity are introduced by 2011. With mounting evidence connecting early-life exposures to later-life disease, we conclude that it is critical to expand the original DOHaD concept to include environmental chemical exposures, and to continue a research agenda that emphasizes defining sensitive windows of exposure and the mechanisms that cause disease.

2022 NOV 24 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Current study results on Oncology - Breast Cancer have been published. According to news [...]

Introduction Point of care testing is becoming increasingly popular; it has been defined as any laboratory test performed outside a hospital's central laboratory.[1] Several factors are associated with the growing [...]

Information management in bedside testing programs can be made more effective through the electronic transfer of patient data to central computer systems. Faster preparation of bills, easier tracking of test use, improved problem and result reporting as well as better data review are the benefits of centralized electronic collection of data. However, central computer systems need to be carefully evaluated before they can be used in bedside testing programs., Electronic transfer and consolidation of bedside testing data enhance quality assurance, access to test results, and monitoring of test utilization. IMPROVING THE MANAGEMENT of information is one of the greatest [...]