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Byline: Gloria. Trujillo-Sanchez, Alejandro. Rosa, Jose. Navarro-Partida, Luis. Haro-Morlett, Juan. Altamirano-Vallejo, Arturo. SantosSir,We appreciate the authors for their keen interest in our article.[1] We cautiously analyzed their observations and concerns [...]

Byline: Gloria. Trujillo-Sanchez, Alejandro. Gonzalez-De La Rosa, Jose. Navarro-Partida, Luis. Haro-Morlett, Juan. Altamirano-Vallejo, Arturo. Santos Purpose: The purpose of this study was to evaluate the feasibility and safety of office-based [...]

Metabolic-associated fatty liver disease (MAFLD) is the most common liver disease worldwide, several studies have shown that gut microbiota had a strong impact in MAFLD developing. This study aimed to evaluate the effect of a supplementation with a mixture of Mexican foods (MexMix): nopal, cacao and cricket on gut-liver axis.

NASH is characterized by hepatic lipid accumulation and inflammation and Jmjd2b up-regulation has been linked with this illness progression. Pirfenidone is an antifibrotic agent with anti-inflammatory and antioxidant effects recognized to decrease NASH features. Here, we report epigenetics mechanisms related to PFD-induced histone modifications involved in experimental NASH. This study aimed to investigate PFD as an epigenetic regulator in the Jmjd2b pathway by demethylating H3k9me3 in a NASH animal model.

Hepatocellular carcinoma (HCC) is the most frequent hepatic neoplasia, where oxidative, fibrogenic, proliferative, and epigenetic processes are altered. Pirfenidone (PFD) has been shown to have important hepatoprotective properties. However, its efficacy in HCC development is unknown. This study aimed to 1) determine whether PFD has antioxidative, antifibrogenic and antiproliferative effects and 2) determine PFD effects on epigenetic regulation mechanisms.

Hepatocellular carcinoma (HCC) is the most frequent hepatic neoplasia, where oxidative, fibrogenic, proliferative, and epigenetic processes are altered. Pirfenidone (PFD) has been shown to have important hepatoprotective properties. However, its efficacy in HCC development is unknown. This study aimed to 1) To determine whether PFD has antioxidative, antifibrogenic and antiproliferative effects. 2) To determine PFD effects on epigenetic regulation mechanisms.

One of the main mechanisms in the development and progression of nonalcoholic steatohepatitis involves oxidative and endoplasmic reticulum stress. Several studies have reported therapeutic effects of Moringa oleifera leaf extracts in different animal and cellular models due to their antioxidant, anti-inflammatory and lipid-lowering effects. This study aimed to evaluate the effect of Moringa oleifera aqueous extract on biomarkers of oxidative stress in a murine model of non-alcoholic steatohepatitis.

• Background: Cysticercosis is one of the parasitic diseases that most frequently affects the eye. The most common and severe manifestations of ocular infection are secondary to posterior segment involvement, which often leads to blindness and atrophy of the eye. The pathogenesis of ocular injury in this disease is poorly understood. The authors have developed an experimental animal model for intravitreous cysticercosis using New Zealand rabbits and Taenia crassiceps cysticerci.

OBJECTIVE: To determine the extent of preservation in the inner retina in retinitis pigmentosa (RP). METHODS: We analyzed sectioned maculae of 21 postmortem eyes with RP and 19 age-matched, normal, postmortem eyes. Eyes were divided into 2 groups: severe and moderate RP. Cell nuclei were counted in the outer nuclear, inner nuclear, and ganglion cell layers within thirty 100-μm intervals from the foveola to 1500-μm eccentricity. RESULTS: Statistically significant (P≤.05) loss of both the outer nuclear and ganglion cell layers was present in the groups with moderate and severe RP when compared with the control groups. However, even in the group with severe RP, 30% of the ganglion cells were histologically intact. Similarly, 78% and 88% of the inner nuclear layer cells were preserved in the groups with severe and moderate RP, respectively. Different inheritance modes showed no statistically significant differences in any of the retinal layers. CONCLUSIONS: Despite a statistically significant (P≤.05) loss of cells found in all retinal layers, a large percentage of the inner retinal neurons remained histologically intact. Current experimental therapies, such as photoreceptor transplantation and implantation of a visual prosthesis, are based on the premise that some inner retinal neurons are preserved after death of photoreceptors in RP. Our observations support this assumption.

Liver cancer is one of the main causes of death related to cancer worldwide; its etiology is related with infections by C or B hepatitis virus, alcohol consumption, smoking, obesity, nonalcoholic fatty liver disease, diabetes, and iron overload, among other causes. Several kinds of primary liver cancer occur, but we will focus on hepatocellular carcinoma (HCC). Numerous cellular signaling pathways are implicated in hepatocarcinogenesis, including YAP-HIPPO, Wnt-β-catenin, and nuclear factor-κB (NF-κB); these in turn are considered novel therapeutic targets. In this review, the role of lipid metabolism regulated by peroxisome proliferator-activated receptor gamma (PPARγ) in the development of HCC will also be discussed. Moreover, recent evidence has been obtained regarding the participation of epigenetic changes such as acetylation and methylation of histones and DNA methylation in the development of HCC. In this review, we provide detailed and current information about these topics. Experimental models represent useful tools for studying the different stages of liver cancer and help to develop new pharmacologic treatments. Each model in vivo and in vitro has several characteristics and advantages to offer for the study of this disease. Finally, the main therapies approved for the treatment of HCC patients, first- and second-line therapies, are described in this review. We also describe a novel option, pirfenidone, which due to its pharmacological properties could be considered in the future as a therapeutic option for HCC treatment.

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