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The genetic and genomic basis of sex differences in blood pressure (BP) traits remain unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide association studies of BP traits using the UK Biobank resource, identifying 1,346 previously reported and 29 new BP trait-associated loci. Among associated loci, 412 were female-specific (Pfemale≤ 5 × 10−8; Pmale> 5 × 10−8) and 142 were male-specific (Pmale≤ 5 × 10−8; Pfemale> 5 × 10−8); these sex-specific loci were enriched for hormone-related transcription factors, in particular, estrogen receptor 1. Analyses of gene-by-sex interactions and sexually dimorphic effects identified four genomic regions, showing female-specific associations with diastolic BP or pulse pressure, including the chromosome 13q34-COL4A1/COL4A2locus. Notably, female-specific pulse pressure-associated loci exhibited enriched acetylated histone H3 Lys27 modifications in arterial tissues and a female-specific association with fibromuscular dysplasia, a female-biased vascular disease; colocalization signals included Chr13q34: COL4A1/COL4A2, Chr9p21: CDKN2B-AS1and Chr4q32.1: MAP9regions. Sex-specific and sex-biased polygenic associations of BP traits were associated with multiple cardiovascular traits. These findings suggest potentially clinically significant and BP sex-specific pleiotropic effects on cardiovascular diseases.

Abdominal aortic aneurysm (AAA) is a common disease with substantial heritability. In this study, we performed a genome-wide association meta-analysis from 14 discovery cohorts and uncovered 141 independent associations, including 97 previously unreported loci. A polygenic risk score derived from meta-analysis explained AAA risk beyond clinical risk factors. Genes at AAA risk loci indicate involvement of lipid metabolism, vascular development and remodeling, extracellular matrix dysregulation and inflammation as key mechanisms in AAA pathogenesis. These genes also indicate overlap between the development of AAA and other monogenic aortopathies, particularly via transforming growth factor β signaling. Motivated by the strong evidence for the role of lipid metabolism in AAA, we used Mendelian randomization to establish the central role of nonhigh-density lipoprotein cholesterol in AAA and identified the opportunity for repurposing of proprotein convertase, subtilisin/kexin-type 9 (PCSK9) inhibitors. This was supported by a study demonstrating that PCSK9loss of function prevented the development of AAA in a preclinical mouse model.

Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD. Integrative functional annotations prioritized genes that are likely to be regulated in vascular smooth muscle cells and artery fibroblasts and implicated in extracellular matrix biology. One locus containing the tissue factor gene F3, which is involved in blood coagulation cascade initiation, appears to be specific for SCAD risk. Several associated variants have diametrically opposite associations with CAD, suggesting that shared biological processes contribute to both diseases, but through different mechanisms. We also infer a causal role for high blood pressure in SCAD. Our findings provide novel pathophysiological insights involving arterial integrity and tissue-mediated coagulation in SCAD and set the stage for future specific therapeutics and preventions.

ABSTRACTDuring the emergence of a novel pandemic, predictive modelling process is more important in the phase of public health planning and response. Relating models to data provides a view into unseen variables, such as the occurrence of cryptic transmission and the prevalence of infection. These models allow exploration of counterfactuals and hypothetical interventions. Predictive modelling is a valuable model based on the clear definition and estimation of the variables. Researchers or policy makers who use the model outputs have a clear understanding of what can and cannot be achieved by this method. The results of this study are suggested that substantially more cases were present in many countries than were reported in the official statistics. In this paper we have identified the potential discrepancy between reported cases and true disease burden provided a crucial early warning to the international community. In this research paper we proposed statistical modelling and data-driven computer simulations provided accurate projections of global epidemic dispersal, quantifying the role of physical distancing in places and reductions in international travel on the spatiotemporal pattern of spread of COVID-19 based on Linear regression analysis.

IMPORTANCE: The emerging genetic basis of spontaneous coronary artery dissection (SCAD) has been defined as both partially complex and monogenic in some patients, involving variants predominantly in genes known to underlie vascular connective tissue diseases (CTDs). The effect of these genetic influences has not been defined in high-risk SCAD phenotypes, and the identification of a high-risk subgroup of individuals may help to guide clinical genetic evaluations of SCAD. OBJECTIVE: To identify and quantify the burden of rare genetic variation in individuals with SCAD with high-risk clinical features. DESIGN, SETTING, AND PARTICIPANTS: Whole-exome sequencing (WES) was performed for subsequent case-control association analyses and individual variant annotation among individuals with high-risk SCAD. Genetic variants were annotated for pathogenicity by in-silico analysis of genes previously defined by sequencing for vascular CTDs and/or SCAD, as well as genes prioritized by genome-wide association study (GWAS) and colocalization of arterial expression quantitative trait loci. Unbiased genome-wide association analysis of the WES data was performed by comparing aggregated variants in individuals with SCAD to healthy matched controls or the Genome Aggregation Database (gnomAD). This study was conducted at a tertiary care center. Individuals in the Canadian SCAD Registry genetics study with a high-risk SCAD phenotype were selected and defined as peripartum SCAD, recurrent SCAD, or SCAD in an individual with family history of arteriopathy. MAIN OUTCOMES AND MEASURES: Burden of genetic variants defined by DNA sequencing in individuals with high-risk SCAD. RESULTS: This study included a total of 336 participants (mean [SD] age, 53.0 [9.5] years; 301 female participants [90%]). Variants in vascular CTD genes were identified in 17.0% of individuals (16 of 94) with high-risk SCAD and were enriched (OR, 2.6; 95% CI, 1.6-4.2; P = 7.8 × 10−4) as compared with gnomAD, with leading significant signals in COL3A1 (OR, 13.4; 95% CI, 4.9-36.2; P = 2.8 × 10−4) and Loeys-Dietz syndrome genes (OR, 7.9; 95% CI, 2.9-21.2; P = 2.0 × 10−3). Variants in GWAS-prioritized genes, observed in 6.4% of individuals (6 of 94) with high-risk SCAD, were also enriched (OR, 3.6; 95% CI, 1.6-8.2; P = 7.4 × 10−3). Variants annotated as likely pathogenic or pathogenic occurred in 4 individuals, in the COL3A1, TGFBR2, and ADAMTSL4 genes. Genome-wide aggregated variant testing identified novel associations with peripartum SCAD. CONCLUSIONS AND RELEVANCE: In this genetic study, approximately 1 in 5 individuals with a high-risk SCAD phenotype harbored a rare genetic variant in genes currently implicated for SCAD. Genetic screening in this subgroup of individuals presenting with SCAD may be considered.

Coronary CT angiography has potential value as an alternative noninvasive imaging tool for primary diagnosis of spontaneous coronary artery dissection (SCAD) or surveillance after SCAD, and as a secondary imaging modality when invasive angiography is inconclusive or for exclusion of alternate diagnoses.

The association of blood hemoglobin (Hb) concentration and red blood cell (RBC) count with arterial stiffness is not well-defined. Herein, we examined the associations of brachial–ankle pulse wave velocity (baPWV) and augmentation index (AI) with Hb level and RBC count from a population cohort in and around Beijing, China. A total of 3994 participants (57.1 ± 8.8 years old) were included in our analysis. Blood routine examination, baPWV, and possible covariates were examined. The mean Hb, RBC count, AI corrected for a heart rate of 75 bpm (AIP75), and baPWV were 131.4 ± 17.1 g/l, 4.2 ± 0.5 1012/l, 80.2 ± 12.0%, and 1665.3 ± 377.1 cm/s, respectively, consistent with previously described cohorts. RBC counts and Hb levels were positively associated with baPWV (βfor 1012/l RBC: 50.08 cm/s, 95% confidence interval [CI]: 30.54–69.63, p< 0.001; βfor 10 g/l Hb: 9.05 cm/s, 95% CI: 3.35–14.76, p= 0.002) and AIP75 (βfor 1012/l RBC: 1.33%, 95% CI: 0.55–2.12, p< 0.001; βfor 10 g/l Hb: 0.34%, 95% CI: 0.12−0.57, p= 0.003), despite adjustment for covariates. The average levels of baPWV in the third–fourth quartile RBC groups were higher than in the first quartile (Q1) group (p< 0.001 for all). The average levels of baPWV in the fourth quartile Hb groups were higher than in the Q1 Hb group (p= 0.038). Mean AIP75 levels in the third−fourth RBC and Hb groups were higher than in the Q1 groups (p< 0.05 for all). In conclusion, circulating blood Hb levels and RBC counts are positively associated with arterial stiffness in our community-based study.

Genome-wide association studies identify genomic variants associated with human traits and diseases. Most trait-associated variants are located within cell-type-specific enhancers, but the molecular mechanisms governing phenotypic variation are less well understood. Here, we show that many enhancer variants associated with red blood cell (RBC) traits map to enhancers that are co-bound by lineage-specific master transcription factors (MTFs) and signaling transcription factors (STFs) responsive to extracellular signals. The majority of enhancer variants reside on STF and not MTF motifs, perturbing DNA binding by various STFs (BMP/TGF-ß-directed SMADs or WNT-induced TCFs) and affecting target gene expression. Analyses of engineered human blood cells and expression quantitative trait loci verify that disrupted STF binding leads to altered gene expression. Our results propose that the majority of the RBC-trait-associated variants that reside on transcription-factor-binding sequences fall in STF target sequences, suggesting that the phenotypic variation of RBC traits could stem from altered responsiveness to extracellular stimuli.

Loss-of-function mutations in phospholipase C-ε1 (PLCE1) have been detected in patients with nephrotic syndrome, but other family members with the same mutation were asymptomatic, suggesting additional stressor are required to cause the full phenotype. Consistent with these observations, we determined that global Plce1-deficient mice have histologically normal glomeruli and no albuminuria at baseline. Angiotensin II (ANG II) is known to induce glomerular damage in genetically susceptible individuals. Therefore, we tested whether ANG II enhances glomerular damage in Plce1-deficient mice. ANG II increased blood pressure equally in Plce1-deficient and wild-type littermates. Additionally, it led to 20-fold increased albuminuria and significantly more sclerotic glomeruli in Plce1-deficient mice compared with wild-type littermates. Furthermore, Plce1-deficient mice demonstrated diffuse mesangial expansion, podocyte loss, and focal podocyte foot process effacement. To determine whether these effects are mediated by hypertension and hyperfiltration, rather than directly through ANG II, we raised blood pressure to a similar level using DOCA + salt + uninephrectomy and norepinephrine. This caused a fivefold increase in albuminuria in Plce1-deficient mice and a significant increase in the number of sclerotic glomeruli. Consistent with previous findings in mice, we detected strong PLCE1transcript expression in podocytes using single cell sequencing of human kidney tissue. In hemagglutinin-tagged Plce1transgenic mice, Plce1 was detected in podocytes and also in glomerular arterioles using immunohistochemistry. Our data demonstrate that Plce1deficiency in mice predisposes to glomerular damage secondary to hypertensive insults.

Barium Bismuth Ferrite nanoparticles having the general formula Ba1-xBixFeO3were successfully made by the sol-gel system, using nitrates as the fundamental material. Tartaric acid and polyvinyl alcohol were used as chelating agents. The synthesized nanoparticle powder was sintered at 650 ̊C and 750 ̊C for 3 hours. Filtering with dilute nitric acid and distilled water is used to remove the impurities. The structural, optical, and dielectric properties were determined at room temperature. Using X-ray diffraction (XRD) analysis, structure, lattice parameter, microstrain, and dislocation density were calculated. Using the Scherrer equation, the peak's crystalline size was ascertained. In FTIR, the vibrational modes of the octahedral and tetrahedral metal complexes in the sample have been studied using the wavenumber in this range. The synthesized nanocomposite contains morphological features, such as interconnecting agglomerates with spherical, irregular, or non-uniform elongated shapes, as demonstrated by SEM images. The activation energy for relaxation and activation energy for conduction was measured from the Cole-Cole plot and the AC conductivity versus frequency plot respectively. The determined activation energies from the two investigations were relatively close to one another. The Barium Bismuth Ferrite nanoparticles samples at room temperature indicate that the samples have implicit candidates for information storage devices for spintronic devices. In the high frequency range, all samples depending upon the temperature demonstrate excellent dielectric behaviour and small dielectric loss, and with stable dielectric constant, these samples make their prospective for the practical application in spintronic devices the main goal of this work.

This article offers a brief overview about cyber-physical systems enabled by blockchain (CPS). Dissects various blockchain-enabled CPS reported on the operations and blockchain characteristics used in the literature. Base of its time sensitiveness and throughput requirements, we identify and categories key common CPS operations that can be activated by blockchain. We also develop blockchain features and categories in terms of diverse levels of benefits to CPS like security, privacy, immutability, tolerance of defects, interoperability's, data origin, atomicity, automation, information/service sharing and trust. This paper provides an overview of the concept of intelligent cities as well as emerging technologies and a quick overview of cyber-physical systems. It then discusses CPS' potential role in the development of intelligent city apps and some real-life examples of CPS adaptation for city smart projects. A decentralized database based on distributed ledgers has been introduced. Distributed ledgers are a distributed database with a network connection node. These nodes include ledgers that list transactions with timestamps.

Genome-wide association studies (GWASs) have identified numerous variants associated with polygenic traits and diseases. However, with few exceptions, a mechanistic understanding of which variants affect which genes in which tissues to modulate trait variation is lacking. Here, we present genomic analyses to explain trait heritability of blood pressure (BP) through the genetics of transcriptional regulation using GWASs, multiomics data from different tissues, and machine learning approaches. Approximately 500,000 predicted regulatory variants across four tissues explain 33.4% of variant heritability: 2.5%, 5.3%, 7.7%, and 11.8% for kidney-, adrenal-, heart-, and artery-specific variants, respectively. Variation in the enhancers involved shows greater tissue specificity than in the genes they regulate, suggesting that gene regulatory networks perturbed by enhancer variants in a tissue relevant to a phenotype are the major source of interindividual variation in BP. Thus, our study provides an approach to scan human tissue and cell types for their physiological contribution to any trait.

In this paper we have proposed a priority based Erlang service distribution with k-phases for cloud computing architecture. The multiple users from the public cloud entering into two serially connected M/M/sand M/Ek/1 (Erlang service queue) queues are served based on the non-pre-emptive priority discipline. We have assumed each user of different priority class i, (i≥ 2) desired to wait until the current user is being served if priority of the service is similar, as per FCFS policy. If the servers are free, users can enter into the M/M/squeue, then enter into the M/Ek/1 queue with probability ϕand leave the system after service completion or leave the system with probability (1 - ϕ) without entering into the ESQ. We have obtained waiting time for both the queues in the cloud system and shown numerically the total waiting time is lower than the existing system.

Spontaneous coronary artery dissection (SCAD) has emerged as an important cause of acute coronary syndrome, myocardial infarction, and sudden death, particularly among young women and individuals with few conventional atherosclerotic risk factors. Patient-initiated research has spurred increased awareness of SCAD, and improved diagnostic capabilities and findings from large case series have led to changes in approaches to initial and long-term management and increasing evidence that SCAD not only is more common than previously believed but also must be evaluated and treated differently from atherosclerotic myocardial infarction. High rates of recurrent SCAD; its association with female sex, pregnancy, and physical and emotional stress triggers; and concurrent systemic arteriopathies, particularly fibromuscular dysplasia, highlight the differences in clinical characteristics of SCAD compared with atherosclerotic disease. Recent insights into the causes of, clinical course of, treatment options for, outcomes of, and associated conditions of SCAD and the many persistent knowledge gaps are presented.

We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD.

Most genome-wide association studies have been of European individuals, even though most genetic variation in humans is seen only in non-European samples. To search for novel loci associated with blood lipid levels and clarify the mechanism of action at previously identified lipid loci, we used an exome array to examine protein-coding genetic variants in 47,532 East Asian individuals. We identified 255 variants at 41 loci that reached chip-wide significance, including 3 novel loci and 14 East Asian–specific coding variant associations. After a meta-analysis including >300,000 European samples, we identified an additional nine novel loci. Sixteen genes were identified by protein-altering variants in both East Asians and Europeans, and thus are likely to be functional genes. Our data demonstrate that most of the low-frequency or rare coding variants associated with lipids are population specific, and that examining genomic data across diverse ancestries may facilitate the identification of functional genes at associated loci.

In recent years, security and privacy preservation are key problems in the systems, electronic health data exchange can help to improving diagnostic accuracy. Due to its immutability, blockchain has been presented as a potential method for achieving Global Network Record (GNR) sharing with security and privacy preservation in recent days. This paper offers a safe and privacy-preserving GNR sharing CB-SMO method for diagnostic improvements in CPS (Cyber Physical System) e-Health systems based on blockchain technology. To begin, two types of approaches are employed, such as consortium blockchain, which are built by inventing data structures as well as consensus processes. The SMO is in charge of storing GNR, while the consortium blockchain maintains track of the GNR's secured indicators. To protect the information, access control, privacy preservation, as well as secure search, all documents, including the GNR, keywords, and the patients' identify, is public key encrypted with keyword search. Moreover, while developing extra blocks to the blockchains, block producers must show evidence of compliance, which ensures data consistency. The suggested protocol can satisfy the security goals, according to the security analysis. In addition, we test the performance of the suggested method using Apache JMeter. The prediction accuracy rate of the proposed work is 99% at a reasonable cost of time.

Biometrics is one important class of security systems which is gaining widespread significance in recent times. Almost all real-time applications in practice today ranging from banking to public and private sectors utilise biometric system of authentication for employee identification, client services. The biometric data are usually stored in a large database which bears a direct consequence on the security of stored biometric features. The proposed system is a multimodal biometric system developed for passport verification incorporating three biometric traits such as iris, fingerprint and finger vein. A multi-resolution frequency domain approximation technique has been utilised for efficient feature extraction followed by a fusion rule for matching to decide upon the authenticity of the use. The proposed system has been implemented using a real-time fingerprint scanner and the classification rate observed from the experimental results indicates the superiority of the developed system.

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. These life-course associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10−8). Overall, approximately 15% of variance in BW was captured by assays of fetal genetic variation. Using genetic association alone, we found strong inverse genetic correlations between BW and systolic blood pressure (Rg= −0.22, P = 5.5 × 10−13), T2D (Rg= −0.27, P = 1.1 × 10−6) and coronary artery disease (Rg= −0.30, P = 6.5 × 10−9). In addition, using large -cohort datasets, we demonstrated that genetic factors were the major contributor to the negative covariance between BW and future cardiometabolic risk. Pathway analyses indicated that the protein products of genes within BW-associated regions were enriched for diverse processes including insulin signalling, glucose homeostasis, glycogen biosynthesis and chromatin remodelling. There was also enrichment of associations with BW in known imprinted regions (P = 1.9 × 10−4). We demonstrate that life-course associations between early growth phenotypes and adult cardiometabolic disease are in part the result of shared genetic effects and identify some of the pathways through which these causal genetic effects are mediated.

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure–associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure–related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.

A nanocrystalline TiO2was successfully synthesized using simple aqueous peroxo route and subsequently the surface characterization of TiO2was carried out using X-ray diffraction and Scanning electron microscopy. The synthesized nanocrystalline TiO2successfully decomposed the aqueous remazol brown dye solution under UV light irradiation with and without ozone. The effects of pH, TiO2dose and irradiation time for decomposition of dye solution were also evaluated. The maximum dye decomposition efficiency of 96.6 % was achieved with the minimal time of 45 min by UV/TiO2/O3treatment. The present study clearly indicates that the peroxo route TiO2nanoparticle is a promising material for industrial waste water treatment.

This paper analyses the contrast of qualitative and quantitative of piston and steel microstructure images. A simple discrimination metric (DMHE) is developed to avoid the drawbacks of conventional histogram equalization for gray scale images. The proposed technique uses both global and local information to remap the intensity levels that help to improve the image contrast. The original histogram is divided into sub-histograms with respect to the mean value. Discrimination metrics are used so that high contrast per pixel between real image and upgraded image is obtained. The simulation results show that the proposed method performed well for mechanical component material of piston and steel microstructure images. Parameters like structural similarity index and contrast per pixel are used to analyze the image quality. Keywords-Piston and Steel microstructure, Contrast Enhancement, Two level Histogram Equalization, Discrimination Metric.

Surface treatment is a new improved treatment procedure which espouses the mitigation of root cause of failures and improves the internal properties of case-hardened alloy steel. Coating is one of the Surface treatment processes applied on the case hardened alloy steel by which a sign of tremendous improvement is shown in wear resistance. This is due to increase in hardness by coating fine particles of oxides of ceramics (OC) and tungsten carbide (WC) on the surface of alloy steel. The coating makes the surface of alloy steel completely devoid of retain austenite formation which is usually formed in other conventional heat treatment processes. An analysis has been made on the surface treated alloy steel which is coated with diverse blends of fine particles of OC and WC. The investigation of coating consists of numerous metallurgical processes to identify the coating powder specification, coating process, coating characteristics, micro-structure and wear resistance property for the surface treated alloy steel. The exploration reveals the best alternative among the coating blends of fine particles which are taken for analysis on base alloy steel.

Statins are bestknown for their lipidlowering effects and have been shown to significantly impact the natural progression of coronary atherosclerosis. The mechanism through which they exert this effect is thought to be primarily due to their ability to reduce lowdensity lipoprotein cholesterol levels. However, there is increasing evidence that statins exert a myriad of other beneficial effects on the vascular wall, thus altering the course of atherosclerotic disease. This article will review the prevention trial literature as it pertains to the effects of statin therapy on atherosclerosis.

Owing to high dielectric constants and coupled magnetic properties at room temperature, multiferroics related materials have wide application in many fields like multi-layer ferroic capacitors and multifunctional devices. Nickel ferrite, barium titanate composite is prepared from co-precipitation method and sintered at high temperature (1273 K). Intrinsic stretching vibrations observed in FTIR spectra at 594 cm−1. X-ray measurements detected the presence of their single phases (tetragonal perovskite crystal). Variations of AC dielectric constant in these samples have been studied. The influence of the phase content on the dielectric constant and loss tangent conductivity was also studied. The AC measurement yields smaller variations at a low range of frequency and more variations in higher frequency ranges indicate amplification of confined states with the availability of large charge carriers. A magnetic measurement reveals that the soft ferromagnetic properties of 68.356 emu g−1and 20.465 emu g−1at room temperature.

Renal artery aneurysms (RAAs) may reflect a systemic dysplastic arteriopathy, independent of a recognized connective tissue disease. It is hypothesized that RAAs are associated with an increased risk of intracranial aneurysms (IcAs). The objective of this study was to better define the association of IcAs in women with RAAs.

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