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Cytomegalovirus (CMV) is a member of the Herpesvirus that commonly follows a silent or self-limiting course in immunocompetent patients. In immunocompromised patients, CMV can result in end-organ damage, requiring more aggressive treatments and supportive care. CMV hepatitis, is a rare, but known self-limiting complication affecting immunocompromised patients that generally does not require anti-viral therapy. In this case report, we describe an 18-month-old immunocompetent female with an acute cytomegalovirus infection presenting as acute hepatitis and a right upper quadrant mass that was treated with dexamethasone.