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In this study, heterocyclic compounds containing 3-((4-bromophenyl)diazenyl)-5-(methylthio)-6-(phenylsulfonyl)pyrazolo-[1,5-a]pyrimidine-2,7-diamine (compound II) and 4-(methylthio)-3-phenylsulfonyl)benzo[4,5]imidazo[1,2-a]pyrimidin-2-amine (compound III) were prepared and their chemical structures were confirmed by spectral data. The new compounds were screened for antimicrobial activity against six different microbial strains when physically incorporated into polyurethane varnish formula and printing ink paste. Experimental coatings were manufactured on laboratory scale and applied by brush onto glass and steel panels. Results of the biological activity indicated that polyurethane varnishes and printing ink paste containing compounds II and III exhibit a very good antimicrobial effect. The physical and mechanical resistances of the polyurethane varnish formulations were also studied to evaluate any drawbacks associated with this addition. The studies revealed that the physical incorporation of compounds II and III enhances slightly the physical and mechanical properties.

2Acetyl1methyl1Hbenzimidazole reacts with dimethylformamidedimethylacetal DMFDMA to afford the corresponding E11methyl1Hbenzimidazol2yl3N,Ndimethylaminoprop2enone. The latter compound reacts regioselectively with some nitrilimines and nitrile oxides to afford the corresponding pyrazole and isoxazole derivatives, respectively. These reaction products react with hydrazine hydrate to give the novel pyrazolo3,4dpyridazine and isoxazolo3,4dpyridazine derivatives, respectively.

Pyrimidine derivatives (IVb) and (IVc) show equipotent cytotoxic activities against HST116 colon tumor cell line compared with reference compound doxorubicin.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.