23 results on '"Saksida, Lisa M."'
Search Results
2. Rats spontaneously discriminate purely visual, two-dimensional stimuli in tests of recognition memory and perceptual oddity
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Forwood, Suzanna E., Bartko, Susan J., Saksida, Lisa M., and Bussey, Timothy J.
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Form perception -- Evaluation ,Form perception -- Models ,Recognition (Psychology) -- Evaluation ,Stimuli (Psychology) -- Evaluation ,Health ,Psychology and mental health - Abstract
Animal models have been central to advances made in understanding the neural basis of human cognition, but maximizing the use of animal models requires tasks that match those used to assess human subjects. Tasks used in humans frequently use visual 2-dimensional stimuli, assess l-trial learning, and require little pretraining. This article describes novel versions of 2 tasks for the rat, spontaneous object recognition and spontaneous oddity preference, both of which use purely visual, 2-dimensional picture-card stimuli, test 1-trial learning, and require no pretraining. Rats showed robust memory for a variety of picture-card stimuli, demonstrating almost no loss of memory for some of the stimulus types even after a 2-hr delay period. Rats were able to show spontaneous oddity preference for all 3 visual stimulus types tested (photos, shapes, and patterns), as well as for 3-dimensional objects. These 2 tasks are quick to administer, involve no fearful learning associations, and require a simple apparatus. They may be particularly useful for high-throughput pharmacological or genetic screening using rodent models. Keywords: perception, object, visual screening test, declarative memory, vision
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- 2007
3. Discrimination of multidimensional visual stimuli by mice: intra- and extradimensional shifts
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Brigman, Jonathan L., Bussey, Timothy J., Saksida, Lisa M., and Rothblat, Lawrence A.
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Visual discrimination -- Research ,Mice -- Research ,Animal behavior -- Research ,Health ,Psychology and mental health - Abstract
A visual discrimination protocol similar to that used with monkeys was adapted to measure attentional set-shifting in mice. An automated touchscreen procedure with compound visual stimuli was used to train mice to attend to 1 of 2 stimulus dimensions (lines or shapes). On a 2nd problem with new stimuli, the mice were required to attend to the same dimension (intradimensional [ID] shift) or switch to the previously irrelevant dimension (extradimensional [ED] shift). Mice readily learned the initial compound discrimination and following shift problem, but there was no ID-ED difference. The fact that mice can be tested with stimuli and task sequences similar to those used with primates suggests that this method can be used to directly compare higher cognitive functions in diverse species. Keywords: mouse, visual discrimination, set-shifting, executive function, animal learning
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- 2005
4. The spontaneous location recognition task for assessing spatial pattern separation and memory across a delay in rats and mice
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Reichelt, Amy C., Kramar, Cecilia P., Ghosh-Swaby, Olivia R., Sheppard, Paul A. S., Kent, Brianne A., Bekinschtein, Pedro, Saksida, Lisa M., and Bussey, Timothy J.
- Abstract
Keeping similar memories distinct from one another is a critical cognitive process without which we would have difficulty functioning in everyday life. Memories are thought to be kept distinct through the computational mechanism of pattern separation, which reduces overlap between similar input patterns to amplify differences among stored representations. At the behavioral level, impaired pattern separation has been shown to contribute to memory deficits seen in neuropsychiatric and neurodegenerative diseases, including Alzheimer’s disease, and in normal aging. This protocol describes the use of the spontaneous location recognition (SLR) task in mice and rats to behaviorally assess spatial pattern separation ability. This two-phase spontaneous memory task assesses the extent to which animals can discriminate and remember object locations presented during the encoding phase. Using three configurations of the task, the similarity of the to-be-remembered locations can be parametrically manipulated by altering the spatial positions of objects—dissimilar, similar or extra similar—to vary the load on pattern separation. Unlike other pattern separation tasks, SLR varies the load on pattern separation during encoding, when pattern separation is thought to occur. Furthermore, SLR can be used in standard rodent behavioral facilities with basic expertise in rodent handling. The entire protocol takes ~20 d from habituation to testing of the animals on all three task configurations. By incorporating breaks between testing, and varying the objects used as landmarks, animals can be tested repeatedly, increasing experimental power by allowing for within-subjects manipulations.
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- 2021
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5. Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing
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Yang, Sujeong, Gigout, Sylvain, Molinaro, Angelo, Naito-Matsui, Yuko, Hilton, Sam, Foscarin, Simona, Nieuwenhuis, Bart, Tan, Chin Lik, Verhaagen, Joost, Pizzorusso, Tommaso, Saksida, Lisa M., Bussey, Timothy M., Kitagawa, Hiroshi, Kwok, Jessica C. F., and Fawcett, James W.
- Abstract
Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice. We first confirmed that aged mice (20-months) showed memory and plasticity deficits. They were able to retain or regain their cognitive ability when CSs were digested or PNNs were attenuated. We then explored the role of C6S in memory and neuroplasticity. Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains. These animals showed very early memory loss at 11 weeks old. Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.
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- 2021
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6. An optimized acetylcholine sensor for monitoring in vivo cholinergic activity
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Jing, Miao, Li, Yuexuan, Zeng, Jianzhi, Huang, Pengcheng, Skirzewski, Miguel, Kljakic, Ornela, Peng, Wanling, Qian, Tongrui, Tan, Ke, Zou, Jing, Trinh, Simon, Wu, Runlong, Zhang, Shichen, Pan, Sunlei, Hires, Samuel A., Xu, Min, Li, Haohong, Saksida, Lisa M., Prado, Vania F., Bussey, Timothy J., Prado, Marco A. M., Chen, Liangyi, Cheng, Heping, and Li, Yulong
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The ability to directly measure acetylcholine (ACh) release is an essential step toward understanding its physiological function. Here we optimized the GRABACh(GPCR-activation-based ACh) sensor to achieve substantially improved sensitivity in ACh detection, as well as reduced downstream coupling to intracellular pathways. The improved version of the ACh sensor retains the subsecond response kinetics, physiologically relevant affinity and precise molecular specificity for ACh of its predecessor. Using this sensor, we revealed compartmental ACh signals in the olfactory center of transgenic flies in response to external stimuli including odor and body shock. Using fiber photometry recording and two-photon imaging, our ACh sensor also enabled sensitive detection of single-trial ACh dynamics in multiple brain regions in mice performing a variety of behaviors.
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- 2020
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7. Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation
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Hailwood, Jonathan M., Heath, Christopher J., Phillips, Benjamin U., Robbins, Trevor W., Saksida, Lisa M., and Bussey, Timothy J.
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Disruptions to motivated behaviour are a highly prevalent and severe symptom in a number of neuropsychiatric and neurodegenerative disorders. Current treatment options for these disorders have little or no effect upon motivational impairments. We assessed the contribution of muscarinic acetylcholine receptors to motivated behaviour in mice, as a novel pharmacological target for motivational impairments. Touchscreen progressive ratio (PR) performance was facilitated by the nonselective muscarinic receptor antagonist scopolamine as well as the more subtype-selective antagonists biperiden (M1) and tropicamide (M4). However, scopolamine and tropicamide also produced increases in non-specific activity levels, whereas biperiden did not. A series of control tests suggests the effects of the mAChR antagonists were sensitive to changes in reward value and not driven by changes in satiety, motor fatigue, appetite or perseveration. Subsequently, a sub-effective dose of biperiden was able to facilitate the effects of amphetamine upon PR performance, suggesting an ability to enhance dopaminergic function. Both biperiden and scopolamine were also able to reverse a haloperidol-induced deficit in PR performance, however only biperiden was able to rescue the deficit in effort-related choice (ERC) performance. Taken together, these data suggest that the M1 mAChR may be a novel target for the pharmacological enhancement of effort exertion and consequent rescue of motivational impairments. Conversely, M4 receptors may inadvertently modulate effort exertion through regulation of general locomotor activity levels.
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- 2019
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8. Discrimination of Computer-Graphic Stimuli by Mice: A Method for the Behavioral Characterization of Transgenic and Gene-Knockout Models
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Bussey, Timothy J., Saksida, Lisa M., and Rothblat, Lawrence A.
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Clinical neuropsychology -- Research ,Genetically modified mice -- Behavior ,Health ,Psychology and mental health - Abstract
An automated method is described for the behavioral testing of mice in an apparatus that allows computer-graphic stimulus material to be presented. Mice responded to these stimuli by making a nose-poke toward a computer monitor that was equipped with a touchscreen attachment for detecting responses. It was found that C57BL/6 mice were able to solve single-pair visual discriminations as well as 3-pair concurrent visual discriminations. The finding that mice are capable of complex visual discriminations introduces the possibility of testing mice on nonspatial tasks that are similar to those used with rats, monkeys, and humans. Furthermore, the method seems particularly well suited to the comprehensive behavioral assessment of transgenic and gene-knockout models.
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- 2001
9. Translational approaches to evaluating motivation in laboratory rodents: conventional and touchscreen-based procedures
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Phillips, Benjamin U, Lopez-Cruz, Laura, Hailwood, Jonathan, Heath, Christopher J, Saksida, Lisa M, and Bussey, Timothy J
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•An overview of methods used to evaluate motivation in different species is presented.•Touchscreens are suggested as translational tools for the study of motivation.•We encourage the development and optimisation of touchscreen-based motivational tasks.
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- 2018
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10. Cognitive enhancing effects of voluntary exercise, caloric restriction and environmental enrichment: a role for adult hippocampal neurogenesis and pattern separation?
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Kent, Brianne A, Oomen, Charlotte A, Bekinschtein, Pedro, Bussey, Timothy J, and Saksida, Lisa M
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•Physical exercise, dietary restriction, and enriched environments are associated with improved cognition and increased adult hippocampal neurogenesis.•Increased adult hippocampal neurogenesis is associated with improved pattern separation on memory tasks.•Recent evidence suggests that improved pattern separation may underlie the cognitive improvements from physical exercise and dietary restriction.
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- 2015
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11. Adult hippocampal neurogenesis and its role in cognition
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Oomen, Charlotte A., Bekinschtein, Pedro, Kent, Brianne A., Saksida, Lisa M., and Bussey, Timothy J.
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Adult hippocampal neurogenesis (AHN) has intrigued neuroscientists for decades. Several lines of evidence show that adult‐born neurons in the hippocampus are functionally integrated and contribute to cognitive function, in particular learning and memory processes. Biological properties of immature hippocampal neurons indicate that these cells are more easily excitable compared with mature neurons, and demonstrate enhanced structural plasticity. The structure in which adult‐born hippocampal neurons are situated—the dentate gyrus—is thought to contribute to hippocampus function by disambiguating similar input patterns, a process referred to as pattern separation. Several ideas about AHN function have been put forward; currently there is good evidence in favor of a role for AHN in pattern separation. This function of AHN may be understood within a ‘representational‐hierarchical’ view of brain organization. WIREs Cogn Sci2014, 5:573–587. doi: 10.1002/wcs.1304
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- 2014
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12. BDNF in the Dentate Gyrus Is Required for Consolidation of “Pattern-Separated” Memories
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Bekinschtein, Pedro, Kent, Brianne A., Oomen, Charlotte A., Clemenson, Gregory D., Gage, Fred H., Saksida, Lisa M., and Bussey, Timothy J.
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Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as “pattern separation.” In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in the dentate gyrus of the hippocampus is associated with exposure to landmarks delineating similar, but not dissimilar, spatial locations, suggesting that BDNF is expressed on an “as-needed” basis for pattern separation.
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- 2013
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13. The touchscreen operant platform for testing learning and memory in rats and mice
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Horner, Alexa E, Heath, Christopher J, Hvoslef-Eide, Martha, Kent, Brianne A, Kim, Chi Hun, Nilsson, Simon R O, Alsiö, Johan, Oomen, Charlotte A, Holmes, Andrew, Saksida, Lisa M, and Bussey, Timothy J
- Abstract
An increasingly popular method of assessing cognitive functions in rodents is the automated touchscreen platform, on which a number of different cognitive tests can be run in a manner very similar to touchscreen methods currently used to test human subjects. This methodology is low stress (using appetitive rather than aversive reinforcement), has high translational potential and lends itself to a high degree of standardization and throughput. Applications include the study of cognition in rodent models of psychiatric and neurodegenerative diseases (e.g., Alzheimer's disease, schizophrenia, Huntington's disease, frontotemporal dementia), as well as the characterization of the role of select brain regions, neurotransmitter systems and genes in rodents. This protocol describes how to perform four touchscreen assays of learning and memory: visual discrimination, object-location paired-associates learning, visuomotor conditional learning and autoshaping. It is accompanied by two further protocols (also published in this issue) that use the touchscreen platform to assess executive function, working memory and pattern separation.
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- 2013
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14. The touchscreen operant platform for testing working memory and pattern separation in rats and mice
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Oomen, Charlotte A, Hvoslef-Eide, Martha, Heath, Christopher J, Mar, Adam C, Horner, Alexa E, Bussey, Timothy J, and Saksida, Lisa M
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The automated touchscreen operant chamber for rats and mice allows for the assessment of multiple cognitive domains within the same testing environment. This protocol presents the location discrimination (LD) task and the trial-unique delayed nonmatching-to-location (TUNL) task, which both assess memory for location. During these tasks, animals are trained to a predefined criterion during ∼20–40 daily sessions. In LD sessions, touching the same location on the screen is rewarded on consecutive trials, followed by a reversal of location-reward contingencies. TUNL, a working memory task, requires animals to 'nonmatch' to a sample location after a delay. In both the LD and TUNL tasks, spatial similarity can be varied, allowing assessment of pattern separation ability, a function that is thought to be performed by the dentate gyrus (DG). These tasks are therefore particularly useful in animal models of hippocampal, and specifically DG, function, but they additionally permit discernment of changes in pattern separation from those in working memory.
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- 2013
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15. The touchscreen operant platform for assessing executive function in rats and mice
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Mar, Adam C, Horner, Alexa E, Nilsson, Simon R O, Alsiö, Johan, Kent, Brianne A, Kim, Chi Hun, Holmes, Andrew, Saksida, Lisa M, and Bussey, Timothy J
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This protocol details a subset of assays developed within the touchscreen platform to measure various aspects of executive function in rodents. Three main procedures are included: extinction, measuring the rate and extent of curtailing a response that was previously, but is no longer, associated with reward; reversal learning, measuring the rate and extent of switching a response toward a visual stimulus that was previously not, but has become, associated with reward (and away from a visual stimulus that was previously, but is no longer, rewarded); and the 5-choice serial reaction time (5-CSRT) task, gauging the ability to selectively detect and appropriately respond to briefly presented, spatially unpredictable visual stimuli. These protocols were designed to assess both complementary and overlapping constructs including selective and divided visual attention, inhibitory control, flexibility, impulsivity and compulsivity. The procedures comprise part of a wider touchscreen test battery assessing cognition in rodents with high potential for translation to human studies.
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- 2013
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16. A new touchscreen test of pattern separation effect of hippocampal lesions
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McTighe, Stephanie M., Mar, Adam C., Romberg, Carola, Bussey, Timothy J., and Saksida, Lisa M.
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Researchers are becoming increasingly interested in the role of the hippocampus in pattern separation, a process which keeps items distinct in memory. In this study, we develop and test a new automated touchscreen-based method for studying pattern separation in rodents. Rats were trained to discriminate locations on a computer screen that varied in their similarity, that is, their distance apart on the screen. Animals with lesions of the dorsal hippocampus were impaired when the locations discriminated were close together but not when they were far apart, indicating impaired pattern separation. This test provides an automated test of pattern separation, which adds to an expanding battery of cognitive tests that can be carried out using the touchscreen testing method.
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- 2009
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17. Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit.
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Brigman, Jonathan L, Feyder, Michael, Saksida, Lisa M, Bussey, Timothy J, Mishina, Masayoshi, and Holmes, Andrew
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N-Methyl-D-aspartate receptors (NMDARs) mediate certain forms of synaptic plasticity and learning. We used a touchscreen system to assess NR2A subunit knockout mice (KO) for (1) pairwise visual discrimination and reversal learning and (2) acquisition and extinction of an instrumental response requiring no pairwise discrimination. NR2A KO mice exhibited significantly retarded discrimination learning. Performance on reversal was impaired in NR2A KO mice during the learning phase of the task; with no evidence of heightened perseverative responses. Acquisition and extinction of an instrumental behavior requiring no pairwise discrimination was normal in NR2A KO mice. The present findings demonstrate a significant and selective deficit in discrimination learning following loss of NR2A.
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- 2008
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18. The touchscreen cognitive testing method for rodents: how to get the best out of your rat.
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Bussey, Timothy J, Padain, Tina L, Skillings, Elizabeth A, Winters, Boyer D, Morton, A Jennifer, and Saksida, Lisa M
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The touchscreen testing method for rodents is a computer-automated behavioral testing method that allows computer graphic stimuli to be presented to rodents and the rodents to respond to the computer screen via a nose-poke directly to the stimulus. The advantages of this method are numerous; however, a systematic study of the parameters that affect learning has not yet been conducted. We therefore sought to optimize stimuli and task parameters in this method. We found that when parameters were optimized, Lister Hooded rats could learn rapidly using this method, solving a discrimination of two-dimensional stimuli to a level of 80% within five to six sessions lasting approximately 30 min each. In a final experiment we tested both male and female rats of the albino Sprague-Dawley strain, which are often assumed to have visual abilities far too poor to be useful for studies of visual cognition. The performance of female Sprague-Dawley rats was indistinguishable from that of their male counterparts. Furthermore, performance of male Sprague-Dawley rats was indistinguishable from that of their Lister Hooded counterparts. Finally, Experiment 5 examined the ability of Lister Hooded rats to learn a discrimination between photographic stimuli. Under conditions in which parameters were optimized, rats were remarkably adept at this discrimination. Taken together, these experiments served to optimize the touchscreen method and have demonstrated its usefulness as a high-throughput method for the cognitive testing of rodents.
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- 2008
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19. Perirhinal cortex resolves feature ambiguity in configural object recognition and perceptual oddity tasks.
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Bartko, Susan J, Winters, Boyer D, Cowell, Rosemary A, Saksida, Lisa M, and Bussey, Timothy J
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The perirhinal cortex (PRh) has a well-established role in object recognition memory. More recent studies suggest that PRh is also important for two-choice visual discrimination tasks. Specifically, it has been suggested that PRh contains conjunctive representations that help resolve feature ambiguity, which occurs when a task cannot easily be solved on the basis of features alone. However, no study has examined whether the ability of PRh to resolve configural feature ambiguity is related to its role in object recognition. Therefore, we examined whether bilateral excitotoxic lesions of PRh or PPRh (perirhinal plus post-rhinal cortices) in the rat would cause deficits in a configural spontaneous object recognition task, and a configural simultaneous oddity discrimination task, in which the task could not be solved on the basis of features, but could only be solved using conjunctive representations. As predicted by simulations using a computational model, rats with PPRh lesions were impaired during a minimal-delay configural object recognition task. These same rats were impaired during a zero-delay configural object recognition task. Furthermore, rats with localized PRh lesions were impaired in a configural simultaneous oddity discrimination task. These findings support the idea that PRh contains conjunctive representations for the resolution of feature ambiguity and that these representations underlie a dual role for PRh in memory and perception.
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- 2007
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20. Scopolamine infused into perirhinal cortex improves object recognition memory by blocking the acquisition of interfering object information.
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Winters, Boyer D, Bartko, Susan J, Saksida, Lisa M, and Bussey, Timothy J
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In a previous study, we reported apparently paradoxical facilitation of object recognition memory following infusions of the cholinergic muscarinic receptor antagonist scopolamine into the perirhinal cortex (PRh) of rats. We attributed these effects to the blockade by scopolamine of the acquisition of interfering information. The present study tested this possibility directly by modifying the spontaneous object recognition memory task to allow the presentation of a potentially interfering object either before the sample phase or in the retention delay between the sample and choice phases. Presentation of an object between the sample and choice phases disrupted subsequent recognition of the sample object (retroactive interference), and intra-PRh infusions of scopolamine prior to the presentation of the irrelevant object prevented this retroactive interference effect. Moreover, presentation of an irrelevant object prior to the sample phase interfered proactively with sample object recognition, and intra-PRh infusions of scopolamine prior to the presentation of the pre-sample object prevented this proactive interference effect. These results suggest that blocking muscarinic cholinergic receptors in PRh can disrupt the acquisition of potentially interfering object information, thereby facilitating object recognition memory. This finding provides further, strong evidence that acetylcholine is important for the acquisition of object information in PRh.
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- 2007
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21. The Perceptual-Mnemonic/Feature Conjunction Model of Perirhinal Cortex Function
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Bussey, Timothy J., Saksida, Lisa M., and Murray, Elisabeth A.
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The perirhinal cortex was once thought to be “silent cortex”, virtually ignored by researchers interested in the neurobiology of learning and memory. Following studies of brain damage associated with cases of amnesia, perirhinal cortex is now widely regarded as part of a “medial temporal lobe (MTL) memory system”. This system is thought to be more or less functionally homogeneous, having a special role in declarative memory, and making little or no contribution to other functions such as perception. In the present article, we summarize an alternative view. First, we propose that components of the putative MTL system such as the hippocampus and perirhinal cortex have distinct and dissociable functions. Second, we provide evidence that the perirhinal cortex has a role in visual discrimination. In addition, we propose a specific role for perirhinal cortex in visual discrimination: the contribution of complex conjunctive representations to the solution of visual discrimination problems with a high degree of “feature ambiguity”. These proposals constitute a new view of perirhinal cortex function, one that does not assume strict modularity of function in the occipito-temporal visual stream, but replaces this idea with the notion of a hierarchical representational continuum.
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- 2005
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22. Perirhinal cortex and feature-ambiguous discriminations.
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Bussey, Timothy J, Saksida, Lisa M, and Murray, Elisabeth A
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- 2006
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23. Measuring Motivation and Reward‐Related Decision Making in the Rodent Operant Touchscreen System
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Heath, Christopher J., Phillips, Benjamin U., Bussey, Timothy J., and Saksida, Lisa M.
- Abstract
This unit is designed to facilitate implementation of the fixed and progressive ratio paradigms and the effort‐related choice task in the rodent touchscreen apparatus to permit direct measurement of motivation and reward‐related decision making in this equipment. These protocols have been optimized for use in the mouse and reliably yield stable performance levels that can be enhanced or suppressed by systemic pharmacological manipulation. Instructions are also provided for the adjustment of task parameters to permit use in mouse models of neurodegenerative disease. These tasks expand the utility of the rodent touchscreen apparatus beyond the currently available battery of cognitive assessment paradigms. © 2016 by John Wiley & Sons, Inc.
- Published
- 2016
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