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2. Concomitant or Sequential Chronic Lymphocytic Leukemia (CLL) and Chronic Myeloid Leukemia (CML): A Molecular and Clinical Survey

Author

Said, Carla, Heimann, P., Dessars, B., Phong, Dinh, Cantiniaux, B., Meuleman, N., and Bron, D.

Abstract

A 75-year-old man presented with B-CLL followed by a CML. We retrospectively analyzed the frozen BM and PB lymphocytes that evidenced 2 distinct clonal proliferations: one is a B CD5+/CD19+lymphocyte population, without BCR-ABL fusion; the other is the CD19+mononuclear cell population expressing traces of BCR-ABL, 3 years before the occurrence of CML. We suggest that (1) the emergence of the Ph+clone after the treatment of CLL is probably related to RFC-induced immunosuppression, and (2) the long DFS of CLL might be due to the current TK inhibitor treatment

Published
2009
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