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Background: Among working people with serious mental illness (WPSMI), return to work (RTW) is controlled by several factors. Identifying these factors can help prevent long-term sick leave absence and work disability. We aimed to identify facilitators and barriers of RTW in WPSMI admitted to a psychiatric hospital and clinic affiliated with the Hamadan University of Medical Sciences, Iran.Methods: This qualitative study was conducted in 2020 on 27 participants with SMI and their families, supervisors, coworkers, managers, and mental health professionals (MHPs). The participants were selected through purposive sampling and subjected to semi-structured interviews. Forty interviews were conducted and analyzed using conventional content analysis.Results: Nine hundred initial codes were extracted and categorized into 34 subcategories and eight categories. Categories that emerged as facilitators of RTW include emotional availability, information availability and use, practical assistance of others, employment facilitation by the society, and supervisor’s flexibility. Categories identified as barriers are imposed effects of mental illness, poor self-concept, and social obstacles.Conclusion: WPSMI experience some facilitators and barriers in RTW. Therefore, MHPs and politicians are recommended to consider these factors in vocational rehabilitation plans.

Positioning is performed to provide support, comfort and physiological stability of preterm infants. This observational study aimed to compare the physiological parameters of preterm infants with respiratory distress in different postures in Neonatal Intensive Care Unit. Ninety five preterm infants with respiratory distress under continuous positive airway pressure or positive end-expiratory pressure were selected by non-probability sampling. Each infant was placed 120 min respectively in prone, right-lateral, supine and left-lateral postures. The arterial oxygen saturation, heart rate and respiratory rate were measured every 5 min in each posture and the mean values were recorded during 120 min every 60 min. The mean arterial oxygen saturation value was significantly higher in prone and left-lateral postures compared to supine (p < .01). While the respiratory and heart rates were not significantly change between any four postures. Based on results, prone and left-lateral postures had better outcomes than supine in terms of arterial oxygen saturation.

In this study, the role of adenosine A1 receptors of the hippocampal CA1 region in entorhinal cortex‐kindled seizures was investigated in rats. Animals were kindled by daily electrical stimulation of the entorhinal cortex. In fully kindled rats, N6‐cyclohexyladenosine (CHA; a selective A1 receptor agonist) and 1, 3‐dimethyl‐8‐cyclopenthylxanthine (CPT; a selective A1 receptor antagonist) were microinfused bilaterally into the hippocampal CA1 region. Rats were stimulated and seizure parameters were measured. Results obtained showed that CHA (10 and 50 μ moles) decreased the afterdischarge duration (ADD) in the hippocampal CA1 region and entorhinal cortex, stage 5 seizure duration (S5D) and seizure duration (SD) only at the dose of 50 μ moles, and significantly increased the latency to stage 4 (S4L). Intrahippocampal CPT increased ADD and S5D, and significantly reduced the latency to stage 4 (S4L) at the dose of 10 lmoles. Pretreatment of rats with CPT (5 μ moles) before CHA (50 μ moles), significantly reduced the effect of CHA on seizure parameters. The results suggest that the CA1 region of the hippocampus plays an important role in spreading seizure spikes from the entorhinal cortex to other brain regions and activation of adenosine A1 receptors in this region participates in the anticonvulsant effects of adenosine agonists.