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Fu, Xinian. Traditional Chinese architecture: twelve essays, ed. by Nancy S. Steinhardt; tr. by Alexandra Harrer. Princeton, 2017. 390p bibl index ISBN 9780691159997 cloth, $49.95; ISBN 9781400885138 ebook, contact publisher [...]

55-0937 Fl 28 CIP Deconstructing the High Line: postindustrial urbanism and the rise of the elevated park, ed. by Christoph Lindner and Brian Rosa. Rutgers, 2017. 259p bibl index ISBN [...]

Malone, Patrick. Architecture, mentalities and meaning. Routledge, 2017. 227p bbil index ISBN 9781138056961 cloth, $140.00; ISBN 9781315164847 ebook, $28.95 55-3115 NA2500 CIP Malone begins by defining concepts he will be [...]

55-0048 HT361 CIP Madanipour, Ali. Cities in time: temporary urbanism and the future of the city. Bloomsbury, 2017. 198p bibl index ISBN 9781474220729 cloth, $114.00; ISBN 9781474220712 pbk, $29.95; ISBN [...]

Sample, Hilary. Maintenance architecture. MIT, 2016. 192p index ISBN 9780262034975 cloth, $25.95; ISBN 9780262335348 ebook, $18.95 54-5032 NA2542 CIP Cofounder of the NYC-based architectural firm MOS, Sample dedicates this book [...]

Shields, Jennifer A. E. Collage and architecture. Routledge, 2014. 274p bibl index ISBN 9780415533263, $170.00; ISBN 9780415533270 pbk, $44.95 52-0654 NA2750 2013-16495 CIP Architect Shields (UNC Charlotte) explores the idea [...]

Hirsh, Max. Airport urbanism: infrastructure and mobility in Asia. Minnesota, 2016. 201 p index afp ISBN 9780816696093 cloth, $87.50; ISBN 9780816696109 pbk, $25.00; ISBN 9780815727996 ebook, contact publisher for price [...]

53-5116 NA2543 2015-45159 MARC Gooden, Mario. Dark space: architecture, representation, black identity. Columbia Books on Architecture and the City, 2016. 137p afp ISBN 9781941332139 pbk, $20.00 Dark Space consists of [...]

Engler, Mira. Cut and paste urban landscape: the work of Gordon Cullen. Routledge, 2016. 271 p bibl index ISBN 9781138848832 cloth, $160.00; ISBN 9781315725970 ebook, contact publisher for price 53-4676 [...]

Le Corbusier: the measures of man, ed. by Olivier Cinqualbre and Frederic Migayrou; [tr.] by Rita Eustace, Robert McInnes, and Sarah Tolley. Centre Pompidou/Scheldegger & Spiess, 2015. 255p bibl ISBN [...]

Chow, Renee Y. Changing Chinese cities: the potentials of field urbanism. Hawai'i, 2015. 185p bibl index afp ISBN 9780824853839 cloth, $45.00 (cc) 53-2810 HT147 2014-47932 CIP As the title suggests, [...]

51-0676 F474 2012-45255 CIP Campbell, Tracy. The Gateway Arch: a biography, Yale, 2013. 217p bibl index afp ISBN 0300169493, $26.00; ISBN 9780300169492, $26.00 Campbell (history, Univ. of Kentucky) provides revealing [...]

Marina, Areli. The Italian piazza transformed: Parma in the communal age. Pennsylvania State, 2012. 198p bibl index afp ISBN 9780271050706, $84.95 50-1285 NA9072 2011-14230 CIP This book by Marina (Univ. [...]

49-6694 HT166 MARC Shane, David Grahame. Urban design since 1945--a global perspective. Wiley, 2011. 360p bibl index afp ISBN 9780470515259, $125.00; ISBN 9780470515266 pbk, S45.00 This ambitious book by Shane [...]

48-6978 HT167 2010-21982 CIP Calthorpe, Peter. Urbanism in the age of climate change. Island Press, 2011. 139p bibl index afp ISBN 9781597267205, $35.00 This book argues that changes in urban [...]

We have previously shown that 12 days of high‐dose calcineurin inhibition induced tolerance in MHCinbred miniature swine receiving MHC‐mismatched lung, kidney, or co‐transplanted heart/kidney allografts. However, if lung grafts were procured from donation after brain death (DBD), and transplanted alone, they were rejected within 19‐45 days. Here, we investigated whether donor brain death with or without allograft ischemia would also prevent tolerance induction in kidney or heart/kidney recipients. Four kidney recipients treated with 12 days of calcineurin inhibition received organs from donors rendered brain dead for 4 hours. Six heart/kidney recipients also treated with calcineurin inhibition received organs from donors rendered brain dead for 4 hours, 8 hours, or 4 hours with 4 additional hours of cold storage. In contrast to lung allograft recipients, all isolated kidney or heart/kidney recipients that received organs from DBD donors achieved long‐term survival (>100 days) without histologic evidence of rejection. Proinflammatory cytokine gene expression was upregulated in lungs and hearts, but not kidney allografts, after brain death. These data suggest that the deleterious effects of brain death and ischemia on tolerance induction are organ‐specific, which has implications for the application of tolerance to clinical transplantation. Donor brain death prevents tolerance induction in lung, but not isolated kidney or heart plus kidney, allograft recipients, suggesting that the deleterious effects of brain death on tolerance induction are organ specific.

Transcending architecture: contemporary views on sacred space, ed. by Julio Bermudez. Catholic University of America, 2014. 332p bibl index afp ISBN 9780813226798 pbk, $34.95; ISBN 9780813226804 ebook, $34.95 53-0063 NA4600 [...]

Village in the city: Asian variations of urbanisms of inclusion, [ed.] by Bruno de Meulder, Yanliu Lin, and Kelly Shannon. Park Books, 2014. (Dist. by Antique Collector's Club) 166p (UFO: [...]

Lin, Wei-Cheng. Building a sacred mountain: the Buddhist architecture of China's Mount Wutai. Washington, 2014. 321 p bibl index afp ISBN 9780295993522 cloth, $60.00 52-2368 DS793 2013-31629 CIP Lin (UNC [...]

Cairns, Stephen. Buildings must die: a perverse view of architecture, by Stephen Cairns and Jane M. Jacobs. MIT, 2014. 298p bibl Index afp ISBN 9780262026932 cloth, $32.95 52-1226 NA2540 2013-28480 [...]

Wilkins, Ann Thomas. Cass Gilbert's West Virginia state capitol, by Ann Thomas Wilkins and David G. Wilkins. West Virginia University Press, 2014. 306p bibl index afp ISBN 9781938228469, $44.99 51-6565 [...]

National Association of City Transportation Officials. Urban street design guide. Island Press, 2013. 180p bibl ISBN 1610914945, $50.00; ISBN 9781610914949, $50.00 51-3603 HE305 M A R C This modest offering [...]

Ewing, Reid. Measuring urban design: metrics for livable places, by Reid Ewing and Otto Clemente with Kathryn M. Neckerman et al. Island Press, 2013. 183p bibl index afp ISBN 9781610911931, [...]

Since the first attempt of pig‐to‐primate liver xenotransplantation (LXT) in 1968, survival has been limited. We evaluated a model utilizing α‐1,3‐galactosyltransferase knockout donors, continuous posttransplant infusion of human prothrombin concentrate complex, and immunosuppression including anti–thymocyte globulin, FK‐506, methylprednisone, and costimulation blockade (belatacept, n = 3 or anti‐CD40 mAb, n = 1) to extend survival. Baboon 1 remained well until postoperative day (POD) 25, when euthanasia was required because of cholestasis and plantar ulcers. Baboon 2 was euthanized following a seizure on POD 5, despite normal liver function tests (LFTs) and no apparent pathology. Baboon 3 demonstrated initial stable liver function but was euthanized on POD 8 because of worsening LFTs. Pathology revealed C4d positivity, extensive hemorrhagic necrosis, and a focal cytomegalovirus inclusion. Baboon 4 was clinically well with stable LFTs until POD29, when euthanasia was again necessitated by plantar ulcerations and rising LFTs. Final pathology was C4d negative and without evidence of rejection, inflammation, or thrombotic microangiopathy. Thus, nearly 1‐mo rejection‐free survival has been achieved following LXTin two of four consecutive recipients, demonstrating that the porcine liver can support life in primates for several weeks and has encouraging potential for clinical application as a bridge to allotransplantation for patients with acute‐on‐chronic or fulminant hepatic failure. The addition of costimulation blockade, in conjunction with exogenous coagulation factors, prolongs survival following pig‐to‐primate liver xenotransplantation, achieving the longest survivals reported to date.

The emergence of skin‐containing vascularized composite allografts (VCAs) has provided impetus to understand factors affecting rejection and tolerance of skin. VCAtolerance can be established in miniature swine across haploidentical MHCbarriers using mixed chimerism. Because the deceased donor pool for VCAs does not permit MHCantigen matching, clinical VCAs are transplanted across varying MHCdisparities. We investigated whether sharing of MHCclass I or IIantigens between donors and recipients influences VCAskin tolerance. Miniature swine were conditioned nonmyeloablatively and received hematopoietic stem cell transplants and VCAs across MHCclass I (n = 3) or class II(n = 3) barriers. In vitroimmune responsiveness was assessed, and VCAskin‐resident leukocytes were characterized by flow cytometry. Stable mixed chimerism was established in all animals. MHCclass II–mismatched chimeras were tolerant of VCAs. MHCclass I–mismatched animals, however, rejected VCAskin, characterized by infiltration of recipient‐type CD8+lymphocytes. Systemic donor‐specific nonresponsiveness was maintained, including after VCArejection. This study shows that MHCantigen matching influences VCAskin rejection and suggests that local regulation of immune tolerance is critical in long‐term acceptance of all VCAcomponents. These results help elucidate novel mechanisms underlying skin tolerance and identify clinically relevant VCAtolerance strategies. The specificity of MHC antigen matching between donors and recipients determines skin tolerance in vascularized composite allografts in a mixed chimerism‐based miniature swine model.

In our studies of life‐supporting α‐1,3‐galactocyltransferase knockout (GalT‐KO)pig‐to‐baboon kidneys, we found that some recipients developed increased serum creatinine with growth of the grafts, without histological or immunological evidence of rejection. We hypothesized that the rapid growth of orthotopic pig grafts in smaller baboon recipients may have led to deterioration of organ function. To test this hypothesis for both kidneys and lungs, we assessed whether the growth of outbred (Yorkshire) organ transplants in miniature swine was regulated by intrinsic (graft) or extrinsic (host environment) factors. Yorkshire kidneys exhibited persistent growth in miniature swine, reaching 3.7 times their initial volume over 3 mo versus 1.2 times for miniature swine kidneys over the same time period. Similar rapid early growth of lung allografts was observed and, in this case, led to organ dysfunction. For xenograft kidneys, a review of our results suggests that there is a threshold for kidney graft volume of 25 cm3/kg of recipient body weight at which cortical ischemia is induced in transplanted GalT‐KOkidneys in baboons. These results suggest that intrinsic factors are responsible, at least in part, for growth of donor organs and that this property should be taken into consideration for growth‐curve–mismatched transplants, especially for life‐supporting organs transplanted into a limited recipient space. Factors intrinsic to transplanted organs play a role in subsequent growth of those organs, suggesting that this property should be considered for growth‐curve mismatched transplants, especially when transplanting life‐supporting organs into limited recipient space.

We previously reported that transplantation (Tx) of prevascularized donor islets as composite islet‐kidneys (IK) reversed diabetic hyperglycemia in both miniature swine and baboons. In order to enhance this strategy's potential clinical applicability, we have now combined this approach with hematopoietic stem cell (HSC) Tx in an attempt to induce tolerance in nonhuman primates. IKs were prepared by isolating islets from 70% partial pancreatectomies and injecting them beneath the autologous renal capsule of five rhesus monkey donors at least 3 months before allogeneic IK Tx. HSC Tx was performed after mobilization and leukapheresis of the donors and conditioning of the recipients with total body irradiation, T cell depletion, and cyclosporine. One IKwas harvested for histologic analysis and four were transplanted into diabetic recipients. IK Tx was performed either 20–22 (n = 3) or 208 (n = 1) days after HSC Tx. All animals accepted IKs without rejection. All recipients required >20 U/day insulin before IK Tx to maintain <200 mg/dL, whereas after IK Tx, three animals required minimal doses of insulin (1–3 U/day) and one animal was insulin free. These results constitute a proof‐of‐principle that this IKtolerance strategy may provide a cure for both end‐stage renal disease and diabetes without the need for immunosuppression. The authors report the successful use of transient mixed hematopoietic chimerism to induce tolerance of composite islet‐kidneys across a one‐haplotype major histocompatibility complex barrier in rhesus monkeys.

50-6573 NA6230 MARC Al-Kodmany, Kheir. The future of the city: tall buildings and urban design, by Kheir Al-Kodmany and Mir M. Ali. WIT Press, 2013. 445p bibl index ISBN 9781845644109, [...]

50-4253 NA2500 2010-942920 MARC The SAGE handbook of architectural theory, ed. by C. Greig Crysler, Stephen Cairns, and Hilde Heynen. SAGE Publications, 2012. 753p bibl index afp ISBN 9781412946131, $150.00 [...]

50-3673 NA2500 MARC Coates, Nigel. Narrative architecture. Wiley, 2012. 168p bibl index ISBN 9780470057452, 5120.00; ISBN 9780470057445 pbk, 550.00; ISBN 9781119963202 e-book, contact publisher for price This book provides a [...]

50-1859 NK1520 2011-49246 CIP Hosey, Lance. The shape of green: aesthetics, ecology, and design. Island Press, 2012. 200p bibl index afp ISBN 9781610910316, $60.00; ISBN 9781610910323 pbk, $30.00 This book [...]

49-5456 NA2543 2011-4587 CIP Design things, by A. Telier et al. MIT, 2011. 239p bibl index afp ISBN 0262016273, $30.00; ISBN 9780262016278, $30.0 This book is the first in a [...]

49-2478 NA2500 2010-29289 CIP Taylor, William M. Prospects for an ethics of architecture, by William M.Taylor and Michael P. Levine. Routledge, 2011. 217p bibl indexes ISBN 978041558971 O, $155.00; ISBN [...]

We sought to determine the effects of exogenous administration of human coagulation factors following pig‐to‐baboon liver xenotransplantation (LXT) using GalT‐KOswine donors. After LXT, baboons received no coagulation factors (historical control, n = 1), bolus administration of a human prothrombin concentrate complex (hPCC; 2.5 mL/kg, n = 2), continuous infusion of hPCC(1.0 mL/h, n = 1) or continuous infusion of human recombinant factor VIIa (1 µg/kg per hour, n = 3). The historical control recipient demonstrated persistent thrombocytopenia despite platelet administration after transplant, along with widespread thrombotic microangiopathy (TMA). In contrast, platelet levels were maintained in bolus hPCCrecipients; however, these animals quickly developed large‐vessel thrombosis and TMA,leading to graft failure with shortened survival. Recipients of continuous coagulation factor administration experienced either stabilization or an increase in their circulating platelets with escalating doses. Furthermore, transfusion requirements were decreased, and hepatic TMAwas noticeably absent in recipients of continuous coagulation factor infusions compared with the historical control and bolus hPCCrecipients. This effect was most profound with a continuous, escalating dose of factor VIIa. Further studies are warranted because this regimen may allow for prolonged survival following LXT. The authors investigate a novel approach of administering exogenous human coagulation factor following pig‐to‐baboon liver xenotransplantation, which appears to maintain circulating platelets, limit transfusion requirements, and prevent thrombotic microangiopathy. See the related brief communication from Buhler et al on page 1917.

We investigated the contributions of direct and indirect T cell antigen recognition pathways to the immune response to porcine antigens in naïve baboons and baboon recipients of pig xenografts. In naïve baboons, in vitroculture of peripheral blood T cells with intact pig cells (direct xenorecognition pathway) or pig cell sonicates and baboon antigen‐presenting cells (indirect xenorecognition pathway) induced the activation and expansion of xenoreactive T cells producing proinflammatory cytokines, interleukin‐2 and interferon‐γ. Primary indirect xenoresponses were mediated by preexisting memory T cells, whose presence is not typically observed in primary alloresponses. Next, baboons were conditioned with a nonmyeloablative regimen before short‐term immunosuppression and transplantation of xenogeneic peripheral blood progenitor cells and a kidney, heart, or pancreatic islets from a miniature swine. All transplants were rejected acutely within 30 days after their placement. Posttransplantation, we observed an inhibition of the direct xenoresponse but a significant expansion of indirectly activated proinflammatory T cells. These results suggest that additional treatment to suppress indirect T cell immunity in primates may be required to achieve tolerance of pig xenografts through hematopoietic chimerism. Mixed hematopoietic chimerism combined with costimulation blockade and conventional immunosuppression inhibits direct but not indirect xenoresponses by T cells. See also the article on page 1715by Navarro‐Alvarez et al.

A 12‐day course of high‐dose tacrolimus induces tolerance of major histocompatibility complex–mismatched lung allografts in miniature swine but does not induce tolerance of heart allografts unless a kidney is cotransplanted. To determine whether lungs share with kidneys the ability to induce cardiac allograft tolerance, we investigated heart–lung cotransplantation using the same induction protocol. Hearts (n = 3), heart–kidneys (n = 3), lungs (n = 6), and hearts–lungs (n = 3) were transplanted into fully major histocompatibility complex–mismatched recipients treated with high‐dose tacrolimus for 12 days. Serial biopsy samples were used to evaluate rejection, and in vitroassays were used to detect donor responsiveness. All heart–kidney recipients and five of six lung recipients demonstrated long‐term graft survival for longer than 272 days, while all heart recipients rejected their allografts within 35 days. Tolerant recipients remained free of alloantibody and showed persistent donor‐specific unresponsiveness by cell‐mediated lympholysis/mixed‐lymphocyte reaction. In contrast, heart–lung recipients demonstrated rejection of both allografts (days 47, 55, and 202) and antidonor responsiveness in vitro. In contrast to kidneys, lung cotransplantation leads to rejection of both heart and lung allografts, indicating that lungs do not have the same tolerogenic capacity as kidneys. We conclude that cells or cell products present in kidney, but not heart or lung allografts, have a unique capacity to confer unresponsiveness on cotransplanted organs, most likely by amplifying host regulatory mechanisms. Lungs, unlike kidneys, do not induce cardiac allograft tolerance, suggesting that a cell or cell product unique to the kidney confers unresponsiveness upon cotransplanted organs.

Our recent studies in an inbred swine model demonstrated that both peripheral and intra‐graft regulatory cells were required for the adoptive transfer of tolerance to a second, naïve donor‐matched kidney. Here, we have asked whether both peripheral and intra‐graft regulatory elements are required for adoptive transfer of tolerance when only a long‐term tolerant (LTT) kidney is transplanted. Nine highly‐inbred swine underwent a tolerance‐inducing regimen to prepare LTT kidney grafts which were then transplanted to histocompatible recipients, with or without the peripheral cell populations required for adoptive transfer of tolerance to a naïve kidney. In contrast to our previous studies, tolerance of the LTT kidney transplants alone was achieved without transfer of additional peripheral cells and without strategies to increase the number/potency of regulatory T cells in the donor. This tolerance was systemic, since most subsequent, donor‐matched challenge kidney grafts were accepted. These results confirm the presence of a potent tolerance‐inducing and/or tolerance‐maintaining cell population within LTT renal allografts. They suggest further that additional peripheral tolerance mechanisms, required for adoptive transfer of tolerance to a naïve donor‐matched kidney, depend on peripheral cells that, if not transferred with the LTT kidney, require time to develop in the adoptive host. Tolerated renal allografts contain a potent tolerance‐inducing and/or ‐maintaining cell population sufficient for adoptive transfer of tolerance to a naïve recipient.

49-1883 N72 2010-28286 CIP Lavin, Sylvia. Kissing architecture. Princeton, 2011. 122p afp ISBN 9780691149233 pbk, $16.95 This is the inaugural offering in 'POINT: Essays on Architecture,' a series of deliberately [...]

49-1882 NA7432 MARC Knapp, Ronald G. Chinese houses of Southeast Asia: the eclectic architecture of sojourners and settlers, photographs by A. Chester Ong. Tuttle Publishing, 2010. 288p bibl index ISBN [...]

49-0669 NA2500 2010-43539 CIP Mallgrave, Harry Francis. An introduction to architectural theory: 1968 to the present, by Harry Francis Mallgrave and David Goodman. Wiley-Blackwell, 2011. 276p bibl index ISBN 9781405180634, [...]

48-0088 NA9070 2009-34019 CIP Gatje, Robert E Great public squares: an architect's selection, W.W. Norton, 2010. 224p bibl index ISBN 9780393731736, $65.00 This book is a labor of love, based [...]

47-3614 NA6232 2009-4272 CIP Flowers, Benjamin. Skyscraper: the politics and power of building New York City in the twentieth century. Pennsylvania, 2009. 232p bibl index afp ISBN 9780812241846, $39.95 Flowers [...]

47-1568 LB3205 2008-21837 CIP Taylor, Anne. Linking architecture and education: sustainable design for learning environments, by Anne Taylor with Katherine Enggass. New Mexico, 2009. 451p bibl index afp ISBN 9780826334077 [...]

47-1253 NA712 2008-37336 CIP Mumford, Eric. Defining urban design: CIAM architects and the formation of a discipline, 1937-69. Yale, 2009. 262p bibl index afp ISBN 9780300138887, $55.00 This thorough, meticulously [...]