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Human pituitary tumor transforming gene 1 (PTTG1) is an oncogenic transcription factor that is overexpressed in many malignancies, especially cancers with metastatic potential, while transgelin-2 (TAGLN2) is an actin-binding protein shown to be a tumor suppressor. However, the expression and clinical significance of PTTG1 and TAGLN2 in pancreatic cancer remain unclear. The present study aimed to investigate the expression and clinical significance of PTTG1 and TAGLN2 in human primary pancreatic cancer. Seventy-five cases of human pancreatic cancer tissues were collected. The expression of PTTG1 and TAGLN2 protein was assessed using immunohistochemistry (IHC) through tissue microarray procedure. The clinicopathologic characteristics of all patients were analyzed. As a result, the expression of PTTG1 and TAGLN2 in cancerous tissues showed the positive staining mainly in the cytoplasm, and they were found in cancerous tissues with higher strong reactivity rate compared with the adjacent non-cancer tissues (ANCT) (56.0% vs22.7%, P<0.001; 100% vs84%, P=0.002), elevating with the ascending order of tumor malignancy. Furthermore, the positive expression of PTTG1 was associated with the gender of pancreatic cancer patients, but did not correlate with their age, pathological styles, tumor size, tumor sites, TNM staging, perineural infiltration and distant metastasis (each P>0.05). In addition, Spearman rank correlation analysis showed the positive correlation of PTTG1 with TAGLN2 (r=0.624, P<0.001). Taken together, PTTG1 and TAGLN2 are highly expressed in human pancreatic cancer, and the positive expression of PTTG1 is associated with the gender of cancer patients, suggesting that it may represent a potential therapeutic target for the treatment of pancreatic cancer.

The long-term results of conservative treatment of fractures of the mandibular condyle by intermaxillary fixation have been evaluated. One hundred cases were divided into two groups, 25 children, aged below 16 years and 75 adults. Fractures were classified into five groups as undisplaced, displaced, intracapsular, medial dislocation and anterior dislocation and were followed up for periods of 1–20 years. The results of treatment were evaluated on the basis of: 1) radiographic assessment of condylar remodelling; 2) facial appearance and clinical examination of joint function; 3) cephalometric assessment of facial growth in the children; 4) masticatory function tests for the recovery of function, also in the children. The results justify conservative treatment of condylar fractures in children, regardless of the type, but open reduction is indicated in adults with marked medial or anterior dislocation.