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2. Iron out, mitophagy in! A way to slow down hepatocellular carcinoma.

Author

Aman Y, Cao S, and Fang EF

Subjects
Ferritins, Humans, Iron metabolism, Mitophagy, Carcinoma, Hepatocellular genetics, Liver Neoplasms genetics
Abstract

Mitochondrial homeostasis is necessary for the maintenance of cellular function and neuronal survival. Mitochondrial quality is tightly regulated by mitophagy, in which defective/superfluous mitochondria are degraded and recycled. Here, Hara et al demonstrate that induction of mitophagy via iron depletion suppresses the development of hepatocellular carcinoma (HCC). This work suggests turning up mitophagy as a potential therapeutic strategy against liver cancer., (© 2020 The Authors.)

Published
2020
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