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Summary The concentration of CK and LDH in the cerebrospinal fluid was determined in 290 patients with head injuries. The highest concentration of these enzymes appeared in patients with the most severe brain injury. CK correlated somewhat better than LDH with the severity of the head injury. In the group with moderate head injuries there was no significant difference statistically between patients with increased CK level and patients with normal CK level in the cerebrospinal fluid with regard to the duration of posttraumatic headache, dizziness or working disability.